FR2841554B1 - Composes de maleimides marques, leur procede de preparation et leur utilisation pour le marquage de macromolecules - Google Patents

Composes de maleimides marques, leur procede de preparation et leur utilisation pour le marquage de macromolecules

Info

Publication number
FR2841554B1
FR2841554B1 FR0208203A FR0208203A FR2841554B1 FR 2841554 B1 FR2841554 B1 FR 2841554B1 FR 0208203 A FR0208203 A FR 0208203A FR 0208203 A FR0208203 A FR 0208203A FR 2841554 B1 FR2841554 B1 FR 2841554B1
Authority
FR
France
Prior art keywords
maleimides
brands
macromolecules
marking
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0208203A
Other languages
English (en)
Other versions
FR2841554A1 (fr
Inventor
Frederic Dolle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0208203A priority Critical patent/FR2841554B1/fr
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Priority to PCT/FR2003/002028 priority patent/WO2004002984A2/fr
Priority to AU2003259312A priority patent/AU2003259312A1/en
Priority to JP2004516901A priority patent/JP2006504640A/ja
Priority to US10/517,612 priority patent/US7456202B2/en
Priority to EP03761670A priority patent/EP1517903A2/fr
Priority to CA2491193A priority patent/CA2491193C/fr
Publication of FR2841554A1 publication Critical patent/FR2841554A1/fr
Application granted granted Critical
Publication of FR2841554B1 publication Critical patent/FR2841554B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nuclear Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
FR0208203A 2002-07-01 2002-07-01 Composes de maleimides marques, leur procede de preparation et leur utilisation pour le marquage de macromolecules Expired - Fee Related FR2841554B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR0208203A FR2841554B1 (fr) 2002-07-01 2002-07-01 Composes de maleimides marques, leur procede de preparation et leur utilisation pour le marquage de macromolecules
AU2003259312A AU2003259312A1 (en) 2002-07-01 2003-06-30 Marked maleimide compounds, method for preparing same and use thereof for marking macromolecules
JP2004516901A JP2006504640A (ja) 2002-07-01 2003-06-30 標識したマレイミド化合物、それを調製する方法および高分子を標識するためのその使用
US10/517,612 US7456202B2 (en) 2002-07-01 2003-06-30 Marked maleimide compounds, method for preparing same and use thereof for marking macromolecules
PCT/FR2003/002028 WO2004002984A2 (fr) 2002-07-01 2003-06-30 Composes de maleimides marques, leur procede de preparation et leur utilisation pour le marquage de macromolecules
EP03761670A EP1517903A2 (fr) 2002-07-01 2003-06-30 Composes de maleimides marques, leur procede de preparation et leur utilisation pour le marquage de macromolecules
CA2491193A CA2491193C (fr) 2002-07-01 2003-06-30 Composes de maleimides marques, leur procede de preparation et leur utilisation pour le marquage de macromolecules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0208203A FR2841554B1 (fr) 2002-07-01 2002-07-01 Composes de maleimides marques, leur procede de preparation et leur utilisation pour le marquage de macromolecules

Publications (2)

Publication Number Publication Date
FR2841554A1 FR2841554A1 (fr) 2004-01-02
FR2841554B1 true FR2841554B1 (fr) 2008-01-18

Family

ID=29725044

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0208203A Expired - Fee Related FR2841554B1 (fr) 2002-07-01 2002-07-01 Composes de maleimides marques, leur procede de preparation et leur utilisation pour le marquage de macromolecules

Country Status (7)

Country Link
US (1) US7456202B2 (fr)
EP (1) EP1517903A2 (fr)
JP (1) JP2006504640A (fr)
AU (1) AU2003259312A1 (fr)
CA (1) CA2491193C (fr)
FR (1) FR2841554B1 (fr)
WO (1) WO2004002984A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE506347T1 (de) * 2005-05-23 2011-05-15 Nihon Mediphysics Co Ltd Neue organische verbindung und verfahren zur herstellung einer mit radioaktivem halogen markierten organischen verbindung unter anwendung davon
EP1991531A1 (fr) * 2006-02-28 2008-11-19 Amgen Inc. Cinnoline et derives de quinoxaline en tant qu'inhibiteurs de phosphodiesterase 10
US7902332B2 (en) * 2006-11-30 2011-03-08 General Electric Company Fluorine-labeled compounds
FR2909881A1 (fr) * 2006-12-14 2008-06-20 Inst Nat Sante Rech Med Nouveaux conjugues, utilisables a des fins therapeutiques, et/ou a titre d'agent de diagnostic et/ou d'imagerie et leur procede de preparation
EP2036981A1 (fr) * 2007-09-12 2009-03-18 Bayer Schering Pharma Aktiengesellschaft Aptamères étiquetés avec 18F
FR2926079B1 (fr) 2008-01-03 2012-12-28 Commissariat Energie Atomique Procede de preparation d'un derive de purine marque, ledit derive et ses utilisations
GB0905438D0 (en) * 2009-03-30 2009-05-13 Ge Healthcare Ltd Radiolabelling reagents and methods
KR101229929B1 (ko) * 2010-05-28 2013-02-05 서강대학교산학협력단 1,2,3-트리아졸기를 갖는 새로운 말레이미드 화합물, 이의 제조방법 및 이를 보결그룹으로 하는 생체화합물의 ｆ­18 표지방법
JP6262331B2 (ja) 2014-03-12 2018-01-17 旭化成株式会社 樹脂組成物及び、そのシート状成型体
WO2018132550A1 (fr) 2017-01-11 2018-07-19 The General Hospital Corporation Agents d'imagerie à canaux sodiques dépendant de la tension
KR20240035820A (ko) 2021-07-09 2024-03-18 플렉시움 인코포레이티드 Ikzf2를 조절하는 아릴 화합물 및 약학 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62277331A (ja) * 1986-04-21 1987-12-02 ネオルツクス　コ−ポレイシヨン 蛋白質標識のための放射性ハロゲン化小分子
US4735792A (en) 1987-04-28 1988-04-05 The United States Of America As Represented By The United States Department Of Energy Radioiodinated maleimides and use as agents for radiolabeling antibodies
US5242680A (en) * 1991-08-23 1993-09-07 Merck & Co., Inc. Thiol-reactive maleimido-based radiolabeling reagents
JPH09165377A (ja) * 1995-12-15 1997-06-24 Seitai Kinou Kenkyusho:Kk 新規２−フルオロ芳香環−ｎ１置換イミダゾール化合物およびその［１８ｆ］フッ素標識体
CA2302360C (fr) * 1997-09-03 2005-11-15 Immunomedics, Inc. Fluoration de proteines et de peptides servant a une tomographie par emission de positrons f-18
JPH11243984A (ja) * 1998-03-04 1999-09-14 Ikeda Shokken Kk ６−［１８ｆ］フルオロ−ｌ−ドーパの合成方法
EP1218351B1 (fr) * 1999-09-13 2005-04-20 Pola Chemical Industries, Inc. Derive de nitroimidazole et agent d'imagerie diagnostique le contenant
FR2841558B1 (fr) * 2002-07-01 2004-08-13 Commissariat Energie Atomique Peptides marques ayant une affinite pour un phospholipide et utilisations

Also Published As

Publication number Publication date
FR2841554A1 (fr) 2004-01-02
CA2491193C (fr) 2013-04-16
AU2003259312A1 (en) 2004-01-19
JP2006504640A (ja) 2006-02-09
CA2491193A1 (fr) 2004-01-08
US20050249662A1 (en) 2005-11-10
EP1517903A2 (fr) 2005-03-30
US7456202B2 (en) 2008-11-25
WO2004002984A3 (fr) 2004-04-22
WO2004002984A2 (fr) 2004-01-08

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20140331