DE3991505B4 - Somatostatinpeptide, deren Analoga oder Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen - Google Patents

Somatostatinpeptide, deren Analoga oder Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen Download PDF

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Publication number
DE3991505B4
DE3991505B4 DE3991505A DE3991505A DE3991505B4 DE 3991505 B4 DE3991505 B4 DE 3991505B4 DE 3991505 A DE3991505 A DE 3991505A DE 3991505 A DE3991505 A DE 3991505A DE 3991505 B4 DE3991505 B4 DE 3991505B4
Authority
DE
Germany
Prior art keywords
group
somatostatin
peptide
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3991505A
Other languages
German (de)
English (en)
Other versions
DE3991505T1 (de
Inventor
Rainer Dr. Albert
Eric P Dr. Krenning
Steven W. J. Prof.Dr. Lamberts
Janos Dr. Pless
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828364A external-priority patent/GB8828364D0/en
Priority claimed from GB898916115A external-priority patent/GB8916115D0/en
Priority claimed from GB898916761A external-priority patent/GB8916761D0/en
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of DE3991505B4 publication Critical patent/DE3991505B4/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE3991505A 1988-12-05 1989-11-30 Somatostatinpeptide, deren Analoga oder Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen Expired - Lifetime DE3991505B4 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB888828364A GB8828364D0 (en) 1988-12-05 1988-12-05 Improvements in/relating to organic compounds
GB8828364.3 1988-12-05
GB8916115.2 1989-07-13
GB898916115A GB8916115D0 (en) 1989-07-13 1989-07-13 Improvements in or relating to organic compounds
GB898916761A GB8916761D0 (en) 1989-07-21 1989-07-21 Improvements in or relating to organic compounds
GB8916761.3 1989-07-21
PCT/EP1989/001448 WO1990006949A2 (en) 1988-12-05 1989-11-30 Peptide derivatives

Publications (1)

Publication Number Publication Date
DE3991505B4 true DE3991505B4 (de) 2006-04-20

Family

ID=27264222

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3991505A Expired - Lifetime DE3991505B4 (de) 1988-12-05 1989-11-30 Somatostatinpeptide, deren Analoga oder Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

Country Status (24)

Country Link
JP (2) JP2726320B2 (ar)
KR (1) KR0156541B1 (ar)
AT (1) AT403476B (ar)
AU (1) AU633859B2 (ar)
BE (1) BE1002296A5 (ar)
CA (1) CA2004532C (ar)
CH (1) CH678329A5 (ar)
DE (1) DE3991505B4 (ar)
DK (1) DK175338B1 (ar)
ES (1) ES2023533A6 (ar)
FI (1) FI102540B1 (ar)
FR (1) FR2639947B1 (ar)
GB (1) GB2225579B (ar)
HK (1) HK189995A (ar)
HU (2) HUT53375A (ar)
IE (1) IE62091B1 (ar)
IL (1) IL92534A (ar)
LU (1) LU87633A1 (ar)
MY (1) MY106120A (ar)
NL (1) NL194828C (ar)
PT (1) PT92487B (ar)
SA (1) SA96160495B1 (ar)
SE (1) SE508799C2 (ar)
WO (1) WO1990006949A2 (ar)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
IE920416A1 (en) * 1991-02-08 1992-08-12 Biomeasure Method of treating benign and malignant proliferative skin¹disease
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
AU657770B2 (en) * 1991-06-03 1995-03-23 Mallinckrodt Medical, Inc. Radiolabelled somatostatin derivatives, their preparation and use
EP0600992B1 (en) * 1991-08-29 2000-09-20 Mallinckrodt Medical, Inc. Use of gentisic acid or gentisyl alcohol for stabilising radiolabeled peptides and proteins
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
DK0629133T3 (da) * 1992-01-03 2001-04-02 Rhomed Inc Farmaceutisk anvendelse af peptidmetalioner
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
AU3606793A (en) * 1992-02-05 1993-09-03 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
WO1993018797A1 (en) * 1992-03-25 1993-09-30 Mallinckrodt Medical, Inc. Method of intraoperatively detecting and locating tumoral tissues
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
CA2113121A1 (en) * 1993-01-12 1994-07-13 Rainer Albert Peptides
WO1994017829A1 (en) * 1993-02-02 1994-08-18 Neorx Corporation Directed biodistribution of small molecules
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
SG48977A1 (en) * 1993-06-23 1998-05-18 Diatide Inc Radiolabeled peptides
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
GB9417873D0 (en) 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
GB9708265D0 (en) * 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
FI965181A (fi) 1996-12-20 1998-06-21 Map Medical Technologies Oy Polyalkoholi-peptidijohdannaiset
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
CA2443273C (en) * 2001-04-23 2011-09-27 Mallinckrodt Inc. Tc and re labeled radioactive glycosylated octreotide derivatives
CN100475271C (zh) 2003-08-20 2009-04-08 加利福尼亚大学董事会 具有抑制生长激素释放活性的促生长素抑制素类似物
EP1675625B1 (en) * 2003-09-17 2013-02-20 Board Of Regents, The University Of Texas System Mechanism-based targeted pancreatic beta cell imaging
EP2067786A1 (en) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Novel non selective analogs of somatostatin
US9480759B2 (en) 2012-11-21 2016-11-01 Serene, Llc Tin-117m somatostatin receptor binding compounds and methods

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0083129B1 (en) * 1981-12-29 1986-02-05 Mallinckrodt Diagnostica (Holland) B.V. Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3511206A1 (de) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
DE3522638A1 (de) * 1985-06-25 1987-01-08 Diamalt Ag Neue somatostatin-derivate
AU593611B2 (en) * 1986-02-14 1990-02-15 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
CH679045A5 (ar) * 1987-06-29 1991-12-13 Sandoz Ag
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
FR2638968B1 (fr) * 1988-11-11 1994-10-07 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0083129B1 (en) * 1981-12-29 1986-02-05 Mallinckrodt Diagnostica (Holland) B.V. Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents

Also Published As

Publication number Publication date
NL8902981A (nl) 1990-07-02
GB8927255D0 (en) 1990-01-31
SE8904087D0 (sv) 1989-12-04
JP3686503B2 (ja) 2005-08-24
FR2639947B1 (fr) 1995-04-21
NL194828B (nl) 2002-12-02
AU633859B2 (en) 1993-02-11
MY106120A (en) 1995-03-31
PT92487B (pt) 1996-01-31
DK612689A (da) 1990-06-06
AU4587189A (en) 1990-06-14
HU211468A9 (en) 1995-11-28
CH678329A5 (ar) 1991-08-30
ATA901789A (de) 1997-07-15
AT403476B (de) 1998-02-25
JPH02184698A (ja) 1990-07-19
GB2225579B (en) 1993-03-17
LU87633A1 (fr) 1991-09-18
IE62091B1 (en) 1994-12-14
HUT53375A (en) 1990-10-28
FI102540B (fi) 1998-12-31
HK189995A (en) 1995-12-29
BE1002296A5 (fr) 1990-11-20
CA2004532C (en) 2000-02-22
WO1990006949A3 (en) 1990-07-26
KR0156541B1 (ko) 1998-10-15
IE893866L (en) 1990-06-05
FR2639947A1 (fr) 1990-06-08
DK175338B1 (da) 2004-08-30
FI102540B1 (fi) 1998-12-31
FI895809A0 (fi) 1989-12-04
GB2225579A (en) 1990-06-06
CA2004532A1 (en) 1990-06-05
JPH1095737A (ja) 1998-04-14
JP2726320B2 (ja) 1998-03-11
SE508799C2 (sv) 1998-11-09
SA96160495B1 (ar) 2006-08-23
HU896359D0 (en) 1990-02-28
PT92487A (pt) 1990-06-29
NL194828C (nl) 2003-04-03
DK612689D0 (da) 1989-12-05
WO1990006949A2 (en) 1990-06-28
IL92534A (en) 1994-06-24
SE8904087L (sv) 1991-06-05
ES2023533A6 (es) 1992-01-16
KR900009697A (ko) 1990-07-05

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8364 No opposition during term of opposition