DE3851289D1 - Verfahren zur Züchtung rekombinanter Zellen. - Google Patents

Verfahren zur Züchtung rekombinanter Zellen.

Info

Publication number
DE3851289D1
DE3851289D1 DE3851289T DE3851289T DE3851289D1 DE 3851289 D1 DE3851289 D1 DE 3851289D1 DE 3851289 T DE3851289 T DE 3851289T DE 3851289 T DE3851289 T DE 3851289T DE 3851289 D1 DE3851289 D1 DE 3851289D1
Authority
DE
Germany
Prior art keywords
host cell
polypeptide factor
recombinant cells
growing recombinant
culturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3851289T
Other languages
English (en)
Other versions
DE3851289T2 (de
Inventor
Jennie P Mather
Axel Ullrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DE3851289D1 publication Critical patent/DE3851289D1/de
Application granted granted Critical
Publication of DE3851289T2 publication Critical patent/DE3851289T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE3851289T 1987-09-11 1988-09-12 Verfahren zur Züchtung rekombinanter Zellen. Expired - Fee Related DE3851289T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9747287A 1987-09-11 1987-09-11

Publications (2)

Publication Number Publication Date
DE3851289D1 true DE3851289D1 (de) 1994-10-06
DE3851289T2 DE3851289T2 (de) 1995-03-02

Family

ID=22263548

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3851289T Expired - Fee Related DE3851289T2 (de) 1987-09-11 1988-09-12 Verfahren zur Züchtung rekombinanter Zellen.

Country Status (13)

Country Link
US (4) US6232117B1 (de)
EP (1) EP0307247B1 (de)
JP (1) JP2774996B2 (de)
AT (1) ATE110773T1 (de)
AU (1) AU616201B2 (de)
CA (1) CA1307484C (de)
DE (1) DE3851289T2 (de)
DK (1) DK175589B1 (de)
ES (1) ES2064355T3 (de)
IE (1) IE63589B1 (de)
IL (1) IL87737A (de)
NZ (1) NZ226136A (de)
PT (1) PT88479B (de)

Families Citing this family (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
JP3008208B2 (ja) * 1990-06-01 2000-02-14 武田薬品工業株式会社 新規ハイブリドーマ，その製造法および生理活性物質の製造法
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
US6825037B1 (en) 1991-02-08 2004-11-30 University Of Vermont Recombinant transferrins, transferrin half-molecules and mutants thereof
US5986067A (en) * 1991-02-08 1999-11-16 The University Of Vermont And State Agricultural College Recombinant transferrins, transferrin half-molecules and mutants thereof
WO1992013550A1 (en) * 1991-02-08 1992-08-20 The University Of Vermont And State Agricultural College Recombinant transferrins, transferrin half-molecules and mutants thereof
DE4115722A1 (de) * 1991-05-14 1992-11-19 Boehringer Mannheim Gmbh Serumfreies medium zur kultivierung von saeugerzellen
WO1993011247A1 (en) * 1991-12-06 1993-06-10 Genentech, Inc. Prohormone convertase transformed cells
US6348327B1 (en) * 1991-12-06 2002-02-19 Genentech, Inc. Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
WO1993013196A2 (en) * 1991-12-24 1993-07-08 Genzyme Corporation Method for increasing recombinant protein production
JPH0763363B2 (ja) * 1991-12-25 1995-07-12 萩原 義秀 融合細胞の取得方法
US5877016A (en) 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
US5708142A (en) 1994-05-27 1998-01-13 Genentech, Inc. Tumor necrosis factor receptor-associated factors
US5705364A (en) 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
US5721121A (en) * 1995-06-06 1998-02-24 Genentech, Inc. Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
US6656466B1 (en) 1995-06-06 2003-12-02 Genetech, Inc. Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
AUPN442295A0 (en) 1995-07-26 1995-08-17 Commonwealth Scientific And Industrial Research Organisation Regulated autocrine growth of mammalian cells
ATE242809T1 (de) 1995-09-08 2003-06-15 Genentech Inc Vegf-verwandtes protein
US6030945A (en) * 1996-01-09 2000-02-29 Genentech, Inc. Apo-2 ligand
US6998116B1 (en) 1996-01-09 2006-02-14 Genentech, Inc. Apo-2 ligand
CA2249206A1 (en) 1996-04-01 1997-10-09 Genentech, Inc. Apo-2li and apo-3 apoptosis polypeptides
US5851984A (en) * 1996-08-16 1998-12-22 Genentech, Inc. Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
US6159462A (en) * 1996-08-16 2000-12-12 Genentech, Inc. Uses of Wnt polypeptides
US6462176B1 (en) 1996-09-23 2002-10-08 Genentech, Inc. Apo-3 polypeptide
US7696327B1 (en) 1997-10-17 2010-04-13 Genentech, Inc. Antibodies to human Toll homologues
US6100076A (en) * 1997-01-31 2000-08-08 Genentech, Inc. O-fucosyltransferase
CA2277266A1 (en) 1997-01-31 1998-08-06 Genentech, Inc. O-fucosyltransferase
US6136569A (en) * 1997-02-27 2000-10-24 Genentech, Inc. Method of creating a cDNA library enriched in signal sequences
WO1999027098A2 (en) 1997-11-21 1999-06-03 Genentech, Inc. A-33 related antigens and their pharmacological uses
US6342369B1 (en) 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
US6551799B2 (en) 1999-12-07 2003-04-22 Genentech, Inc. Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
ATE393222T1 (de) 1997-09-18 2008-05-15 Genentech Inc Dcr3 polypeptid, ein tnfr homolog
DE69840631D1 (de) 1997-10-10 2009-04-16 Genentech Inc Apo-3 ligand
ATE409225T1 (de) 1997-10-29 2008-10-15 Genentech Inc Durch wnt-1 induzierbare gene
ES2313756T3 (es) 1997-10-29 2009-03-01 Genentech, Inc. Usos de polipeptido secretado wisp-1 inducido por wnt-1.
US7192589B2 (en) 1998-09-16 2007-03-20 Genentech, Inc. Treatment of inflammatory disorders with STIgMA immunoadhesins
NZ527898A (en) 1997-12-03 2005-01-28 Genentech Inc PRO347 polypeptides and nucleic acids encoding proteins with homology to cysteine-rich secretory protein-3
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
EP1037995A1 (de) 1997-12-08 2000-09-27 Genentech, Inc. Menschliches interferon-epsilon: ein typ 1 interferon
US6455250B1 (en) * 1997-12-11 2002-09-24 The Regents Of The University Of California Endonuclease compositions and methods of use
JP2002508962A (ja) 1998-01-15 2002-03-26 ジェネンテク・インコーポレイテッド Ａｐｏ−２リガンド
NZ525914A (en) 1998-03-10 2004-03-26 Genentech Inc Novel polypeptides and nucleic acids encoding the same
EP1064376B1 (de) 1998-03-23 2006-03-15 Genentech, Inc. Gfr-alpha3 und seine verwendungen
US6228590B1 (en) 1998-03-23 2001-05-08 Genentech, Inc. Method of selection for genes encoding secreted and transmembrane proteins
US7026138B1 (en) 1998-03-23 2006-04-11 Genentech, Inc. Polynucleotides encoding GFRα3
EP3112468A1 (de) 1998-05-15 2017-01-04 Genentech, Inc. Il-17-homologe polypeptide und therapeutische verwendung davon
EP1865061A3 (de) 1998-05-15 2007-12-19 Genentech, Inc. IL-17-homologe Polypeptide und ihre therapeutische Verwendung
IL138930A0 (en) 1998-05-15 2001-11-25 Genentech Inc Il-17 homologies polypeptides and therapeutic uses thereof
US20020172678A1 (en) 2000-06-23 2002-11-21 Napoleone Ferrara EG-VEGF nucleic acids and polypeptides and methods of use
CA2344467C (en) 1998-09-22 2011-01-25 Genentech, Inc. Ucp4
US7399751B2 (en) * 1999-11-04 2008-07-15 Sertoli Technologies, Inc. Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
WO2000032624A2 (en) 1998-11-30 2000-06-08 Genentech, Inc. Uncoupling protein 5 - ucp5
US7342102B2 (en) 1998-11-30 2008-03-11 Genentech, Inc. Uncoupling protein 5 (UCP5)
EP1484338B1 (de) 1998-12-22 2007-02-07 Genentech, Inc. Verfahren und Zusammensetzung zur Hemmung des neoplastischen Zellwachstums
EP1141299A2 (de) 1998-12-23 2001-10-10 Genentech, Inc. Il-1 verwandte polypeptide
JP4716578B2 (ja) 1999-04-12 2011-07-06 ジェネンテック， インコーポレイテッド 腫瘍壊死因子相同体及びそれをコードする核酸
EP1953173B1 (de) 1999-06-15 2009-11-18 Genentech, Inc. Sekretierte und Transmembran-Polypeptide sowie Nukleinsäuren zu deren Kodierung
NZ529329A (en) 1999-08-25 2005-06-24 Immunex Corp Compositions and methods for improved cell culture
NZ531141A (en) 1999-10-20 2005-07-29 Genentech Inc Modulation of T cell differentiation for the treatment of T helper cell mediated diseases
CA2490853A1 (en) 1999-12-01 2001-06-07 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7226591B2 (en) 2000-05-22 2007-06-05 Genentech, Inc. Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
EP1897947B1 (de) 1999-12-23 2012-01-18 Genentech, Inc. IL-17-homologe Polypeptide und ihre therapeutische Verwendung
EP1757701A1 (de) 1999-12-24 2007-02-28 Genentech, Inc. Verfahren und Zusammensetzungen zur Verlängerung der Halbzeiten der Entfernung von biowirksamen Verbindungen
EP2180054A1 (de) 1999-12-24 2010-04-28 Genentech, Inc. Verfahren und Zusammenstellungen zur Verlängerung der Entsorgungshalbzeiten von bioaktiven Verbindungen
CN1425066B (zh) 2000-01-13 2010-05-26 杰南技术公司 新的stra6多肽
ATE329610T1 (de) 2000-02-16 2006-07-15 Genentech Inc Anti-april antikörper und hybridomazellen
IL151853A0 (en) 2000-04-11 2003-04-10 Genentech Inc Multivalent antibodies and uses therefor
CA2648048A1 (en) 2000-06-23 2002-01-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
EP2042597B1 (de) 2000-06-23 2014-05-07 Genentech, Inc. Zusammensetzungen und Verfahren zur Diagnose und Behandlung von Erkrankungen in Verbindung mit Angiogenese
DE60136281D1 (de) 2000-08-24 2008-12-04 Genentech Inc Methode zur inhibierung von il-22 induziertem pap1
EP1944317A3 (de) 2000-09-01 2008-09-17 Genentech, Inc. Sekretierte und Transmembran-Polypeptide sowie Nukleinsäure zu deren Kodierung
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
ES2361824T3 (es) 2000-12-20 2011-06-22 F. Hoffmann-La Roche Ag Conjugados de eritropoyetina (epo) con polietilenglicol (peg).
US7087726B2 (en) 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
JP2004528309A (ja) * 2001-03-23 2004-09-16 ナプロ バイオセラピューティクス，インコーポレイテッド 癌治療用分子複合体
US20040161817A1 (en) * 2001-06-04 2004-08-19 Corixa Corporation Compositions and methods for high-level, large-scale production of recombinant proteins
US20070160576A1 (en) 2001-06-05 2007-07-12 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
MXPA03011985A (es) 2001-06-20 2004-03-26 Genentech Inc Composiciones y metodos para el diagnostico y tratamiento de tumores.
US7060278B2 (en) 2001-08-29 2006-06-13 Genentech, Inc. Bv8 nucleic acids and polypeptides with mitogenic activity
KR101008758B1 (ko) 2001-09-18 2011-01-14 제넨테크, 인크. 종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물
EP2067472A1 (de) 2002-01-02 2009-06-10 Genentech, Inc. Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
US7164002B2 (en) 2002-02-06 2007-01-16 Genentech, Inc. FVIIa antagonists
WO2003072035A2 (en) 2002-02-22 2003-09-04 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
NZ535925A (en) 2002-04-16 2008-06-30 Genentech Inc An isolated antibody that binds to a particular polypeptide
CA2489588A1 (en) 2002-07-08 2004-01-15 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
EP2277532A1 (de) 2002-09-11 2011-01-26 Genentech, Inc. Neuartige Zusammensetzung und Verfahren zur Behandlung von Immunerkrankungen
WO2004024072A2 (en) 2002-09-11 2004-03-25 Genentech, Inc. Novel compositions and methods for the treatment of immune related diseases
EP1562587A4 (de) 2002-09-11 2006-07-19 Genentech Inc Neue zusammensetzungen und verfahren zur behandlung von immunkrankheiten
CA2498274A1 (en) 2002-09-16 2004-03-25 Genentech, Inc. Compositions and methods for the diagnosis of immune related diseases using pro7
EP1585482A4 (de) 2002-09-25 2009-09-09 Genentech Inc Neue zusammensetzungen und verfahren zur behandlung von psoriasis
EP1576137A4 (de) 2002-10-29 2010-06-30 Genentech Inc Zusammensetzungen und verfahren für die behandlung von immunkrankheiten
CA2503748A1 (en) 2002-11-08 2004-05-27 Genentech, Inc. Compositions and methods for the treatment of natural killer cell related diseases
WO2004047728A2 (en) 2002-11-26 2004-06-10 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US7285269B2 (en) * 2002-12-02 2007-10-23 Amgen Fremont, Inc. Antibodies directed to tumor necrosis factor
CN102225194B (zh) 2003-03-12 2014-07-16 健泰科生物技术公司 Bv8和/或EG-VEGF促进造血的用途
WO2004091658A1 (en) 2003-04-04 2004-10-28 Genentech, Inc. High concentration antibody and protein formulations
US20050118145A1 (en) * 2003-07-03 2005-06-02 Jannette Dufour Compositions containing sertoli cells and myoid cells and use thereof in cellular transplants
SI2784084T2 (sl) 2003-07-08 2024-02-29 Novartis Pharma Ag Antagonistična protitelesa proti IL-17 A/F heterolognim polipeptidom
WO2005019258A2 (en) 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
EP2161283B1 (de) 2003-11-17 2014-06-04 Genentech, Inc. Zusammensetzungen, die Antikörper gegen CD79b enthalten, die an Wachstumshemmer oder an zytotoxische Subtanzen gekoppelt sind und Verfahren zur Behandlung von Tumoren hämatopoetischen Ursprungs
JP2008541781A (ja) 2005-06-06 2008-11-27 ジェネンテック・インコーポレーテッド 異なる遺伝子に対するトランスジェニック動物、および遺伝子の特徴づけのためのその使用
BRPI0618178A2 (pt) * 2005-11-02 2011-08-23 Wyeth Corp métodos para adaptação de células de mamìferos
US20070231895A1 (en) * 2005-11-02 2007-10-04 Lee Gene W Methods for adapting mammalian cells
CA2629306A1 (en) 2005-11-23 2007-05-31 Genentech, Inc. Methods and compositions related to b cell assays
US20070190057A1 (en) 2006-01-23 2007-08-16 Jian Wu Methods for modulating mannose content of recombinant proteins
CA2647277A1 (en) 2006-04-05 2007-11-08 Genentech, Inc. Method for using boc/cdo to modulate hedgehog signaling
CA2649387A1 (en) 2006-04-19 2008-03-27 Genentech, Inc. Novel gene disruptions, compositions and methods relating thereto
WO2007127936A2 (en) 2006-04-27 2007-11-08 Pikamab, Inc. Methods and compositions for antibody therapy
CA2659990C (en) 2006-08-04 2016-03-22 Prolong Pharmaceuticals, Inc. Polyethylene glycol erythropoietin conjugates
EP2066174B1 (de) 2006-09-12 2017-11-08 Beth Israel Deaconess Medical Center, Inc. Zusammensetzungen mit alpha-1-antitrypsin und verwendungsverfahren dafür
SG176476A1 (en) 2006-11-02 2011-12-29 Daniel J Capon Hybrid immunoglobulins with moving parts
US20120093796A1 (en) 2007-03-22 2012-04-19 Industry Academic Cooperation Foundation, The Catholic University Of Korea Novel use of ec-sod and method for preparing thereof
US9089564B2 (en) 2007-03-22 2015-07-28 The Catholic University of Korea Industry-Academic Cooperatior Use of EC-SOD for treating angiogenesis-mediated eye diseases
EP4335863A3 (de) 2007-07-09 2024-07-24 Genentech, Inc. Verhinderung der disulfidbindungsreduktion während der rekombinanten herstellung von polypeptiden
CA2697519C (en) 2007-09-05 2018-11-20 Genentech, Inc. Biologically active c-terminal arginine-containing peptides
EP2235063B1 (de) 2007-12-28 2015-09-02 Genentech, Inc. Anti-hedgehog-antikörper
CA2720610C (en) 2008-04-07 2016-08-23 Bayer Healthcare Llc Methods of recombinant production of glycoproteins
US9511085B2 (en) 2008-08-18 2016-12-06 Medicinal Bioconvergence Research Center Method for controlling cancer metastasis or cancer cell migration by modulating the cellular level of lysyl tRNA synthetase
MX347112B (es) 2008-09-15 2017-04-12 Genentech Inc Composiciones y metodos para regular osmolaridad celular.
EP2351575B1 (de) 2008-10-10 2016-12-14 SNU R & DB Foundation Grs in der verwendung zur behandlung von krebs
KR20220047668A (ko) 2008-12-09 2022-04-18 제넨테크, 인크. 항-ｐｄ-ｌ１ 항체 및 ｔ 세포 기능을 향상시키기 위한 그의 용도
LT2464725T (lt) 2009-08-11 2020-06-10 F. Hoffmann-La Roche Ag Baltymų gamyba ląstelių mitybinėje terpėje, kurioje nėra glutamino
AU2010297530B2 (en) 2009-09-23 2013-12-19 Ratiopharm Gmbh Process for the purification of recombinant human erythropoietin (EPO), EPO thus purified and pharmaceutical compositions comprising same
CA2781887C (en) 2009-11-30 2018-03-27 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
BR112012028010A2 (pt) 2010-05-03 2017-09-26 Genentech Inc anticorpo isolado, célula, ácido nucleíco isolado, método de identificação de um primeiro anticorpo que se liga a um epítopo antigênico tat425 ligado or um anticorpo, métodos de inibir o crescimento de uma célula, de tratamento terapêutico de determinação da presença de uma proteína de tat425 e de diagnóstico da presença de um tumor em um mamífero
EA030418B1 (ru) 2010-07-12 2018-08-31 ЭйТИР ФАРМА, ИНК. ТЕРАПЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ДЛЯ ЛЕЧЕНИЯ ВОСПАЛИТЕЛЬНОГО ЗАБОЛЕВАНИЯ, ПОЛИПЕПТИД АМИНОАЦИЛ-тРНК-СИНТЕТАЗЫ (AARS)
EP2603525A1 (de) 2010-08-13 2013-06-19 F.Hoffmann-La Roche Ag Antikörper gegen il-1beta und il-18 zur behandlung von krankheiten
WO2012075238A1 (en) 2010-12-02 2012-06-07 Genentech, Inc. Novel receptor-ligand interaction and uses thereof
WO2012088383A2 (en) 2010-12-23 2012-06-28 Genentech, Inc. PILR alpha INTERACTIONS AND METHODS OF MODIFYING SAME
CN102586190B (zh) * 2011-01-11 2014-01-01 北京华安科创生物技术有限公司 高效表达重组人神经生长因子的cho细胞株及其构建方法
WO2013077534A1 (en) 2011-11-23 2013-05-30 Cell Biotech Co., Ltd. Protein p14 with anti-cancer and anti-allergy activity and pharmaceutical composition comprising the same
RU2639564C2 (ru) 2011-12-16 2017-12-21 Браскем С.А. Модифицированные микроорганизмы и способы получения бутадиена с их применением
DK2814514T3 (en) 2012-02-16 2017-12-18 Atyr Pharma Inc Histidyl tRNA synthetases for the treatment of autoimmune and inflammatory diseases
US9493744B2 (en) 2012-06-20 2016-11-15 Genentech, Inc. Methods for viral inactivation and other adventitious agents
US20130281355A1 (en) 2012-04-24 2013-10-24 Genentech, Inc. Cell culture compositions and methods for polypeptide production
DK2841087T3 (da) 2012-04-27 2017-11-20 Us Health Vaskulær endothel-vækstfaktor-antagonister og fremgangsmåder til anvendelse deraf
EP2749569A1 (de) * 2012-12-28 2014-07-02 Annibale Alessandro Puca Variante des BPIFB4-Proteins
DK2968495T3 (da) 2013-03-15 2019-10-14 Daniel J Capon Hybrid immunoglobulin indeholdende en ikke-peptid-bro
ES2665596T3 (es) 2013-03-15 2018-04-26 Glaxosmithkline Intellectual Property (No. 2) Limited Uso de compuestos intermedios de ácido tricarboxílico (ATC) para controlar la generación de amoníaco en cultivo celular
CN105121628B (zh) 2013-03-15 2020-03-24 豪夫迈·罗氏有限公司 具有抗氧化剂的细胞培养组合物和多肽生产方法
ES2708565T3 (es) 2013-03-15 2019-04-10 Atyr Pharma Inc Conjugados de Fc-histidil-ARNt sintetasa
EP2829608A1 (de) 2013-07-23 2015-01-28 Universität Bielefeld Verfahren zur Herstellung von rekombinanten Proteinen in Säugerzellen
BR112016006321B1 (pt) 2013-09-23 2022-11-16 Braskem S.A Enzima engenheirada tendo especificidade de substrato aceto acetil-coa e atividade aceto acetil-coa específica de hidrolase, micro-organismo modificado, e, processo de produção de um ou mais produtos a partir de uma fonte de carbono fermentável
HUE065394T2 (hu) 2013-11-15 2024-05-28 Hoffmann La Roche Vírusok inaktiválására szolgáló eljárások környezetbarát detergensek alkalmazásával
SI3110961T1 (sl) 2014-02-27 2020-03-31 F. Hoffmann-La Roche Ag Modulacija rasti celic in glikozilacije pri rekombinantni proizvodnji glikoproteina
PT3116486T (pt) 2014-03-14 2020-03-12 Biomolecular Holdings Llc Imunoglobulina híbrida que contém uma ligação não peptídica
MX2016013223A (es) 2014-04-10 2017-04-27 Bayer Healthcare Llc Formulacion en polvo de medio de compuesto y metodo de preparacion de medio liquido para cultivo celular.
KR101619863B1 (ko) 2014-05-23 2016-05-24 주식회사 제노포커스 신규 베타-갈락토시다아제
US11345908B2 (en) 2014-05-30 2022-05-31 Braskem S.A. Modified microorganisms comprising an optimized system for oligosaccharide utilization and methods of using same
KR101730035B1 (ko) 2015-03-20 2017-04-26 한국과학기술원 L-아스파르트산 유도체를 생산하는 변이미생물 및 이를 이용한 l-아스파르트산 유도체의 제조방법
KR101839595B1 (ko) 2015-04-13 2018-04-26 한국과학기술원 락탐의 제조방법
KR20160141123A (ko) 2015-05-28 2016-12-08 주식회사 제노포커스 고당전이 활성의 베타-갈락토시다제 변이체 및 그 용도
KR101702906B1 (ko) 2015-07-15 2017-02-22 주식회사 제노포커스 신규 알파-1,3-글루카나제
TW202340452A (zh) 2015-08-04 2023-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
KR101756338B1 (ko) 2016-01-15 2017-07-10 고려대학교 산학협력단 L-시스테인 생산용 변이미생물 및 이를 이용한 l-시스테인의 제조방법
EP3494131A4 (de) 2016-08-02 2020-04-15 Vaccinex, Inc. Verbesserte verfahren zur herstellung von polynukleotidbibliotheken in vaccinia virus/eukaryotischen zellen
EP3339444A1 (de) 2016-12-20 2018-06-27 Mabxience Research, S.L. Verfahren zur herstellung eines glycoproteins mit erhöhtem prozentualem anteil an afucosylierten glycanen
CN110536694A (zh) 2017-04-20 2019-12-03 Atyr 医药公司 用于治疗肺部炎症的组合物和方法
AU2019245243A1 (en) 2018-03-29 2020-09-03 Genentech, Inc Modulating lactogenic activity in mammalian cells
KR102658830B1 (ko) 2018-08-02 2024-04-19 에스케이이노베이션 주식회사 내열성 탄산무수화효소 변이체 및 이를 포함하는 이산화탄소 포집용 조성물
AR117327A1 (es) 2018-12-20 2021-07-28 23Andme Inc Anticuerpos anti-cd96 y métodos de uso de estos
BR112021010374A2 (pt) 2018-12-21 2021-08-24 23Andme, Inc. Anticorpos anti-il-36 e métodos de uso dos mesmos
KR102346050B1 (ko) 2019-01-25 2022-01-03 주식회사 네오믹스 미백 활성을 갖는 신규 폴리펩타이드 및 이의 용도
WO2021209512A1 (en) 2020-04-15 2021-10-21 Genentech, Inc. Method for medium treatment before inoculation
KR20230018425A (ko) 2020-05-29 2023-02-07 23앤드미 인코포레이티드 항-cd200r1 항체 및 이의 사용 방법
US20230235040A1 (en) 2020-06-22 2023-07-27 Almirall, S.A. Anti-il-36 antibodies and methods of use thereof
MX2022016453A (es) 2020-06-24 2023-02-01 Genentech Inc Lineas celulares resistentes a la apoptosis.
PE20230983A1 (es) 2020-08-07 2023-06-21 Genentech Inc Proteinas de fusion del ligando para flt3 y metodos de uso
WO2022047222A2 (en) 2020-08-28 2022-03-03 Genentech, Inc. Crispr/cas9 multiplex knockout of host cell proteins
KR102613962B1 (ko) 2020-09-07 2023-12-18 주식회사 지아이셀 코로나바이러스 유래 수용체 결합 도메인 및 뉴클레오캡시드 단백질을 포함하는 융합단백질 및 이의 용도
KR20220059399A (ko) 2020-11-02 2022-05-10 한국과학기술원 소수성 물질의 생산능이 향상된 재조합 미생물 및 이의 제조를 위한 세포막 엔지니어링 방법
CA3200954A1 (en) 2020-11-16 2022-05-19 F. Hoffmann-La Roche Ag Fab high mannose glycoforms
KR102661294B1 (ko) 2020-12-24 2024-04-30 한국과학기술원 글루타르산 수송체 유전자가 도입된 재조합 미생물 및 이를 이용한 글루타르산의 제조방법
EP4326855A1 (de) 2021-04-19 2024-02-28 Genentech, Inc. Modifizierte säugerzellen
WO2022256613A1 (en) 2021-06-04 2022-12-08 Genentech, Inc. Identification and quantitation of residual host cell proteins in protein samples
EP4402469A1 (de) 2021-09-15 2024-07-24 Genentech, Inc. Metabolomische analyse
WO2024129594A1 (en) 2022-12-12 2024-06-20 Genentech, Inc. Optimizing polypeptide sialic acid content

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55156591A (en) * 1979-05-23 1980-12-05 Ajinomoto Co Inc Method for stabilizing property of bacteria containing plasmid
US4673649A (en) 1983-07-15 1987-06-16 University Patents, Inc. Process and defined medium for growth of human epidermal keratinocyte cells
US4740461A (en) 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
AU600885B2 (en) 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs
DE3578383D1 (de) 1984-05-28 1990-08-02 Mitsui Toatsu Chemicals Mittel fuer die absorption und entweichung von wasserdampf.
WO1986000619A1 (en) 1984-07-13 1986-01-30 Chiron Corporation Prepro insulin-like growth factors i and ii
JPS6328386A (ja) 1986-07-21 1988-02-06 Asahi Chem Ind Co Ltd 細胞培養方法
JP2796547B2 (ja) * 1987-09-11 1998-09-10 ジェネンテク，インコーポレイテッド 組換え細胞培養中でのポリペプチド発現の増大法
JP2507882B2 (ja) * 1988-02-17 1996-06-19 工業技術院長 外部増殖因子非依存性増殖良好細胞株の製造法
JPH01217488A (ja) * 1988-02-26 1989-08-31 Canon Inc 板書記録装置

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US20020142467A1 (en) 2002-10-03
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DK175589B1 (da) 2004-12-13
DE3851289T2 (de) 1995-03-02
AU616201B2 (en) 1991-10-24
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EP0307247A3 (en) 1990-08-22
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PT88479A (pt) 1989-07-31
US6232117B1 (en) 2001-05-15
IL87737A (en) 1993-08-18
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AU2212088A (en) 1989-05-25
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US6235498B1 (en) 2001-05-22
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ES2064355T3 (es) 1995-02-01
DK506488D0 (da) 1988-09-12

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