MX2016013223A - Formulacion en polvo de medio de compuesto y metodo de preparacion de medio liquido para cultivo celular. - Google Patents
Formulacion en polvo de medio de compuesto y metodo de preparacion de medio liquido para cultivo celular.Info
- Publication number
- MX2016013223A MX2016013223A MX2016013223A MX2016013223A MX2016013223A MX 2016013223 A MX2016013223 A MX 2016013223A MX 2016013223 A MX2016013223 A MX 2016013223A MX 2016013223 A MX2016013223 A MX 2016013223A MX 2016013223 A MX2016013223 A MX 2016013223A
- Authority
- MX
- Mexico
- Prior art keywords
- cell culture
- powder formulation
- culture medium
- compounded
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000000843 powder Substances 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000004113 cell culture Methods 0.000 title 1
- 239000007788 liquid Substances 0.000 title 1
- 239000006143 cell culture medium Substances 0.000 abstract 6
- 235000018102 proteins Nutrition 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 239000013589 supplement Substances 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- 235000005550 amino acid supplement Nutrition 0.000 abstract 1
- 239000002518 antifoaming agent Substances 0.000 abstract 1
- 229960001230 asparagine Drugs 0.000 abstract 1
- 235000009582 asparagine Nutrition 0.000 abstract 1
- 239000007640 basal medium Substances 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 229910001410 inorganic ion Inorganic materials 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0031—Serum-free culture media
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
- G01N31/221—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating pH value
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/14—Calcium; Ca chelators; Calcitonin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/22—Zinc; Zn chelators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/35—Polyols, e.g. glycerin, inositol
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/42—Organic phosphate, e.g. beta glycerophosphate
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/44—Thiols, e.g. mercaptoethanol
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/46—Amines, e.g. putrescine
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención proporciona una formulación en polvo de medio de cultivo celular compuesto que comprende: un polvo de medio basal y un complemento de medio de cultivo celular, en el que el complemento de medio de cultivo celular comprende y una o más sales; uno o más factores de crecimiento; uno o más iones inorgánicos; un complemento de aminoácidos que comprende uno o más de asparagina, glutamina, histidina, y serina; uno o más reguladores; y uno o más agentes antiespumantes. La invención adicionalmente proporciona métodos para elaborar una formulación en polvo de medio de cultivo celular compuesto, métodos para elaborar un medio de cultivo celular para hacer crecer células de mamíferos y métodos para producir una proteína de interés al cultivar células en el medio de cultivo celular y aislar la proteína de interés.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461978027P | 2014-04-10 | 2014-04-10 | |
| PCT/US2015/024780 WO2015157335A1 (en) | 2014-04-10 | 2015-04-07 | Compounded media powder formulation and method of preparation of liquid medium for cell culture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016013223A true MX2016013223A (es) | 2017-04-27 |
Family
ID=53055095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016013223A MX2016013223A (es) | 2014-04-10 | 2015-04-07 | Formulacion en polvo de medio de compuesto y metodo de preparacion de medio liquido para cultivo celular. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10227559B2 (es) |
| EP (1) | EP3129463B1 (es) |
| JP (1) | JP6665104B2 (es) |
| KR (1) | KR20160144429A (es) |
| CN (1) | CN106459907B (es) |
| AU (1) | AU2015243961A1 (es) |
| CA (1) | CA2945390A1 (es) |
| IL (1) | IL248218A0 (es) |
| MX (1) | MX2016013223A (es) |
| PE (1) | PE20161326A1 (es) |
| RU (1) | RU2016144057A (es) |
| SG (1) | SG11201608390SA (es) |
| WO (1) | WO2015157335A1 (es) |
| ZA (1) | ZA201607719B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202140776A (zh) | 2016-04-26 | 2021-11-01 | 美商美國泰福生技股份有限公司 | 細胞培養基 |
| CN107653222A (zh) * | 2016-07-25 | 2018-02-02 | 赵玉明 | 一种无菌液体细胞培养基的配置方法 |
| CN106011071B (zh) * | 2016-08-09 | 2019-03-01 | 海南海医药物安全性评价研究有限责任公司 | 一种原代肿瘤细胞培养组合物及其应用 |
| CA3068685A1 (en) * | 2017-06-27 | 2019-01-03 | Ajinomoto Co., Inc. | Riboflavin derivative-containing medium |
| KR102216302B1 (ko) * | 2018-09-21 | 2021-02-17 | 메디포스트(주) | 피부 세포 활성화용 조성물 및 이의 용도 |
| CN109628377A (zh) * | 2019-01-02 | 2019-04-16 | 贵州省人民医院 | 一种小鼠原代肝细胞灌注式分离及离体培养方法 |
| WO2021078938A1 (en) * | 2019-10-25 | 2021-04-29 | Fundació Centre De Regulació Genòmica | Culture media for mycoplasma |
| EP3889251A1 (en) * | 2020-03-31 | 2021-10-06 | Fundació Centre de Regulació Genòmica | Culture media for mycoplasma |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
| US5185259A (en) | 1982-05-05 | 1993-02-09 | Genentech, Inc. | Truncated human tissue plasminogen activator |
| US4853330A (en) | 1983-04-07 | 1989-08-01 | Genentech, Inc. | Human tissue plasminogen activator |
| FR2539642B1 (fr) | 1983-01-20 | 1985-12-13 | Choquenet Sa L | Filtre-presse comprenant des moyens d'extraction des boues |
| IL87737A (en) | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
| EP0429586B1 (en) | 1989-06-09 | 1995-08-02 | Gropep Pty. Ltd. | Growth hormone fusion proteins |
| US20060003447A1 (en) | 2003-12-30 | 2006-01-05 | Richard Fike | Dry powder cells and cell culture reagents and methods of production thereof |
| US6383810B2 (en) * | 1997-02-14 | 2002-05-07 | Invitrogen Corporation | Dry powder cells and cell culture reagents and methods of production thereof |
| CA2427596A1 (en) * | 2000-11-06 | 2002-05-10 | Life Technologies Corporation | Dry powder cells and cell culture reagents and methods of production thereof |
| WO2002066603A2 (en) * | 2001-02-15 | 2002-08-29 | Centocor, Inc. | Chemically defined medium for cultured mammalian cells |
| US8129504B2 (en) | 2001-08-30 | 2012-03-06 | Biorexis Technology, Inc. | Oral delivery of modified transferrin fusion proteins |
| CN1193091C (zh) * | 2002-01-25 | 2005-03-16 | 华东理工大学 | 一种适于幼仓鼠肾细胞生长与维持的无血清培养基 |
| US7632921B2 (en) | 2004-11-12 | 2009-12-15 | Bayer Healthcare Llc | Site-directed modification of FVIII |
| JP2009511060A (ja) | 2005-10-14 | 2009-03-19 | バイオレクシス ファーマシューティカル コーポレーション | ナトリウム利尿ペプチド修飾されたトランスフェリン融合タンパク質 |
| BRPI0716762A2 (pt) * | 2006-09-13 | 2013-09-24 | Abbott Lab | melhorias da cultura celular |
| JP5586235B2 (ja) * | 2007-03-02 | 2014-09-10 | ワイス・エルエルシー | ポリペプチドの産生のための細胞培養における銅およびグルタミン酸塩の使用 |
| AU2008323768A1 (en) * | 2007-11-09 | 2009-05-14 | Baxter Healthcare S.A. | Modified recombinant Factor VIII and von Willebrand Factor and methods of use |
| AU2008345231B2 (en) * | 2007-12-27 | 2014-09-11 | Takeda Pharmaceutical Company Limited | Cell culture processes |
| CN101603026B (zh) * | 2009-06-19 | 2011-01-19 | 华东理工大学 | 适于动物细胞产品生产的无动物来源低蛋白培养基 |
| CN102115728B (zh) * | 2009-12-31 | 2012-09-26 | 北京清大天一科技有限公司 | 无血清动物细胞培养基干粉、液体培养基及其制备方法 |
| US20110262965A1 (en) | 2010-04-23 | 2011-10-27 | Life Technologies Corporation | Cell culture medium comprising small peptides |
| WO2013096858A1 (en) * | 2011-12-22 | 2013-06-27 | Life Technologies Corporation | Cell culture media and methods |
-
2015
- 2015-04-07 MX MX2016013223A patent/MX2016013223A/es unknown
- 2015-04-07 KR KR1020167031066A patent/KR20160144429A/ko not_active Ceased
- 2015-04-07 SG SG11201608390SA patent/SG11201608390SA/en unknown
- 2015-04-07 EP EP15721063.4A patent/EP3129463B1/en active Active
- 2015-04-07 JP JP2016561351A patent/JP6665104B2/ja not_active Expired - Fee Related
- 2015-04-07 PE PE2016001936A patent/PE20161326A1/es not_active Application Discontinuation
- 2015-04-07 WO PCT/US2015/024780 patent/WO2015157335A1/en not_active Ceased
- 2015-04-07 CA CA2945390A patent/CA2945390A1/en not_active Abandoned
- 2015-04-07 CN CN201580028914.1A patent/CN106459907B/zh not_active Expired - Fee Related
- 2015-04-07 US US15/302,488 patent/US10227559B2/en active Active
- 2015-04-07 RU RU2016144057A patent/RU2016144057A/ru not_active Application Discontinuation
- 2015-04-07 AU AU2015243961A patent/AU2015243961A1/en not_active Abandoned
-
2016
- 2016-10-06 IL IL248218A patent/IL248218A0/en unknown
- 2016-11-09 ZA ZA2016/07719A patent/ZA201607719B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20161326A1 (es) | 2016-12-11 |
| CA2945390A1 (en) | 2015-10-15 |
| AU2015243961A1 (en) | 2016-10-27 |
| US10227559B2 (en) | 2019-03-12 |
| IL248218A0 (en) | 2016-11-30 |
| SG11201608390SA (en) | 2016-11-29 |
| KR20160144429A (ko) | 2016-12-16 |
| CN106459907B (zh) | 2020-11-06 |
| RU2016144057A3 (es) | 2018-11-22 |
| EP3129463A1 (en) | 2017-02-15 |
| CN106459907A (zh) | 2017-02-22 |
| WO2015157335A1 (en) | 2015-10-15 |
| JP6665104B2 (ja) | 2020-03-13 |
| EP3129463B1 (en) | 2021-05-26 |
| RU2016144057A (ru) | 2018-05-15 |
| ZA201607719B (en) | 2018-11-28 |
| JP2017510283A (ja) | 2017-04-13 |
| US20170191025A1 (en) | 2017-07-06 |
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