DE3781855T2 - Mittel zum kalibrieren von durchflusszytometriegeraeten und anderen analysevorrichtungen. - Google Patents
Mittel zum kalibrieren von durchflusszytometriegeraeten und anderen analysevorrichtungen.Info
- Publication number
- DE3781855T2 DE3781855T2 DE8787306143T DE3781855T DE3781855T2 DE 3781855 T2 DE3781855 T2 DE 3781855T2 DE 8787306143 T DE8787306143 T DE 8787306143T DE 3781855 T DE3781855 T DE 3781855T DE 3781855 T2 DE3781855 T2 DE 3781855T2
- Authority
- DE
- Germany
- Prior art keywords
- particles
- instrument
- calibration
- signal
- beads
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004458 analytical method Methods 0.000 title abstract description 17
- 239000002245 particle Substances 0.000 claims abstract description 113
- 239000011324 bead Substances 0.000 claims description 59
- 239000003153 chemical reaction reagent Substances 0.000 claims description 37
- 238000012921 fluorescence analysis Methods 0.000 claims description 16
- 230000005855 radiation Effects 0.000 claims description 9
- 239000004033 plastic Substances 0.000 claims description 6
- 229920003023 plastic Polymers 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical group O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims description 5
- 108010004729 Phycoerythrin Proteins 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 35
- 238000000926 separation method Methods 0.000 abstract description 20
- 238000000684 flow cytometry Methods 0.000 abstract description 15
- 239000007788 liquid Substances 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 20
- 238000012360 testing method Methods 0.000 description 20
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 10
- 230000003287 optical effect Effects 0.000 description 10
- 230000035945 sensitivity Effects 0.000 description 10
- 239000000523 sample Substances 0.000 description 9
- 239000000203 mixture Substances 0.000 description 8
- 230000003595 spectral effect Effects 0.000 description 7
- 241000287828 Gallus gallus Species 0.000 description 6
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 6
- 210000003743 erythrocyte Anatomy 0.000 description 6
- 239000002953 phosphate buffered saline Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 229910000489 osmium tetroxide Inorganic materials 0.000 description 4
- 239000012285 osmium tetroxide Substances 0.000 description 4
- 108090001008 Avidin Proteins 0.000 description 3
- 238000000149 argon plasma sintering Methods 0.000 description 3
- 239000004005 microsphere Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000009795 derivation Methods 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 238000002847 impedance measurement Methods 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 108010004469 allophycocyanin Proteins 0.000 description 1
- 238000004164 analytical calibration Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 238000010185 immunofluorescence analysis Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1012—Calibrating particle analysers; References therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1012—Calibrating particle analysers; References therefor
- G01N2015/1014—Constitution of reference particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1477—Multiparameters
Landscapes
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/901,860 US4704891A (en) | 1986-08-29 | 1986-08-29 | Method and materials for calibrating flow cytometers and other analysis instruments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3781855D1 DE3781855D1 (de) | 1992-10-29 |
| DE3781855T2 true DE3781855T2 (de) | 1993-04-29 |
Family
ID=25414938
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8787306143T Expired - Lifetime DE3781855T2 (de) | 1986-08-29 | 1987-07-10 | Mittel zum kalibrieren von durchflusszytometriegeraeten und anderen analysevorrichtungen. |
| DE8787306145T Expired - Lifetime DE3778253D1 (de) | 1986-08-29 | 1987-07-10 | Verfahren zum kalibrieren von durchflusszytometriegeraeten. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8787306145T Expired - Lifetime DE3778253D1 (de) | 1986-08-29 | 1987-07-10 | Verfahren zum kalibrieren von durchflusszytometriegeraeten. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4704891A (enExample) |
| EP (3) | EP0258982B1 (enExample) |
| JP (3) | JPS6363942A (enExample) |
| AT (2) | ATE80947T1 (enExample) |
| DE (2) | DE3781855T2 (enExample) |
| ES (2) | ES2035068T3 (enExample) |
| GR (2) | GR3004885T3 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004044717A1 (de) * | 2004-09-10 | 2006-03-16 | BAM Bundesanstalt für Materialforschung und -prüfung | Verfahren und Kit zur Kalibrierung eines Photolumineszenzmesssystems |
| DE102007014413B4 (de) * | 2007-03-17 | 2016-02-04 | DüRR DENTAL AG | Verfahren zum Auswerten von Fluoreszenzbildsätzen und Vorrichtung zu seiner Durchführung |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK164144C (da) * | 1988-11-17 | 1992-10-12 | Slagteriernes Forskningsinst | Fremgangsmaade ved kontrol eller justering af maaleapparater med en optisk sonde og medium til anvendelse ved fremgangsmaaden |
| CA2021658C (en) * | 1989-08-25 | 2001-10-09 | Myron J. Block | Multiplex immunoassay system |
| US5853984A (en) * | 1990-06-11 | 1998-12-29 | Nexstar Pharmaceuticals, Inc. | Use of nucleic acid ligands in flow cytometry |
| IE76732B1 (en) * | 1990-08-07 | 1997-11-05 | Becton Dickinson Co | One step test for absolute counts |
| JP2913219B2 (ja) * | 1991-03-06 | 1999-06-28 | 株式会社シマ研究所 | 尿沈渣検査成績管理方法 |
| ES2102518T3 (es) * | 1991-08-28 | 1997-08-01 | Becton Dickinson Co | Motor de atraccion por gravitacion para el agrupamiento autoadaptativo de corrientes de datos n-dimensionales. |
| US5451525A (en) * | 1992-02-14 | 1995-09-19 | Coulter Corporation | Method and materials for determining particle count in a flow cytometer |
| DE69326731T2 (de) | 1992-09-04 | 2000-05-18 | Becton Dickinson And Co., Franklin Lakes | Kontroll-Teilchen für die Zellzählung und Instrumentenlinearität |
| US5620842A (en) * | 1995-03-29 | 1997-04-15 | Becton Dickinson And Company | Determination of the number of fluorescent molecules on calibration beads for flow cytometry |
| JP3875754B2 (ja) * | 1995-11-17 | 2007-01-31 | シスメックス株式会社 | フローサイトメータ用標準液 |
| US6014904A (en) * | 1996-05-09 | 2000-01-18 | Becton, Dickinson And Company | Method for classifying multi-parameter data |
| ATE298084T1 (de) | 1997-01-31 | 2005-07-15 | Horticulture & Food Res Inst | Optische vorrichtung und methode |
| US6074879A (en) * | 1997-06-23 | 2000-06-13 | Bayer Corporation | Synthetic polymer particles for use as standards and calibrators in flow cytometry |
| US6149867A (en) | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
| US6071689A (en) | 1997-12-31 | 2000-06-06 | Xy, Inc. | System for improving yield of sexed embryos in mammals |
| US6197520B1 (en) * | 1999-08-13 | 2001-03-06 | University Of Utah Research Foundation | Solution-based color compensation adjusted for temperature and electronic gains |
| US7208265B1 (en) | 1999-11-24 | 2007-04-24 | Xy, Inc. | Method of cryopreserving selected sperm cells |
| EP1295243A4 (en) | 2000-05-11 | 2010-09-01 | Becton Dickinson Co | SYSTEM FOR IDENTIFYING CLUSTERS IN DISPERSION DIAGRAMS INVOLVING SMOOTH POLYGONS WITH OPTIMAL LIMITS |
| US6809804B1 (en) | 2000-05-11 | 2004-10-26 | Becton, Dickinson And Company | System and method for providing improved event reading and data processing capabilities in a flow cytometer |
| US7713687B2 (en) | 2000-11-29 | 2010-05-11 | Xy, Inc. | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
| CA2468774C (en) | 2000-11-29 | 2015-06-30 | George E. Seidel | System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations |
| US8486618B2 (en) | 2002-08-01 | 2013-07-16 | Xy, Llc | Heterogeneous inseminate system |
| BRPI0313163B1 (pt) | 2002-08-01 | 2015-11-17 | Univ Colorado State | sistema de separação de células espermáticas a baixa pressão |
| AU2003265471B2 (en) | 2002-08-15 | 2009-08-06 | Xy, Llc. | High resolution flow cytometer |
| US7169548B2 (en) | 2002-09-13 | 2007-01-30 | Xy, Inc. | Sperm cell processing and preservation systems |
| DK2305172T3 (en) | 2003-03-28 | 2016-08-22 | Inguran Llc | DEVICE AND PROCEDURES TO PROVIDE SEXUAL ANIMAL SEED |
| NZ544103A (en) | 2003-05-15 | 2010-10-29 | Xy Llc | Efficient haploid cell sorting for flow cytometer systems |
| KR101135138B1 (ko) * | 2003-08-13 | 2012-04-16 | 루미넥스 코포레이션 | 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의제어 방법 |
| WO2005036164A1 (en) * | 2003-10-02 | 2005-04-21 | Beckman Coulter, Inc. | Reference control for optical measurement of nucleated red blood cells of a blood sample |
| PL2151243T3 (pl) | 2004-03-29 | 2013-03-29 | Inguran Llc | Zawiesiny plemników do sortowania na populacje wzbogacone w niosące chromosom X lub Y |
| MX2007000888A (es) | 2004-07-22 | 2007-04-02 | Monsanto Technology Llc | Procedimiento para enriquecer una poblacion de celulas de esperma. |
| JP4953710B2 (ja) * | 2005-07-12 | 2012-06-13 | シスメックス株式会社 | 尿中有形成分分析装置用標準物質 |
| ES2547643T3 (es) * | 2005-07-12 | 2015-10-07 | Sysmex Corporation | Material de referencia para un analizador de partículas |
| JP4748719B2 (ja) * | 2006-03-02 | 2011-08-17 | 国立大学法人大阪大学 | 生細胞内の特定タンパク質の定量方法および標準蛍光マイクロビーズの作製方法 |
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| US20090105963A1 (en) * | 2006-05-13 | 2009-04-23 | Jesper Laursen | Methods for Flow Cytometry Analyses of Un-Lysed Cells from Biological Fluids |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3406121A (en) * | 1965-10-01 | 1968-10-15 | Dade Reagents Inc | Blood cell counting standard and method of preparing the same |
| US3412037A (en) * | 1966-01-26 | 1968-11-19 | Technicon Corp | Method and means for the calibration of particle counting apparatus |
| US3791517A (en) * | 1973-03-05 | 1974-02-12 | Bio Physics Systems Inc | Digital fluidic amplifier particle sorter |
| US4135821A (en) * | 1977-03-22 | 1979-01-23 | The United States Of America As Represented By The United States Department Of Energy | Calibration of optical particle-size analyzer |
| US4331862A (en) * | 1979-02-23 | 1982-05-25 | Ryan Wayne L | Method for calibrating a particle counting machine and a calibration standard therefor |
| US4380392A (en) * | 1981-03-18 | 1983-04-19 | Karabegov Mikhail A | Method and apparatus for calibration of instruments serving to count and to determine the size of particles suspended in dispersion medium |
| US4438390A (en) * | 1981-03-23 | 1984-03-20 | Coulter Electronics, Inc. | Tandem sensing zones for improved signal-to-noise ratio in particle analyzer |
| US4434647A (en) * | 1981-07-27 | 1984-03-06 | Lockheed Corporation | Dynamic spot calibration for automatic particle counters |
| US4475236A (en) * | 1981-11-12 | 1984-10-02 | Ortho Diagnostic Systems Inc. | Method for counting overlapping cell populations in a distribution histogram |
| US4499052A (en) * | 1982-08-30 | 1985-02-12 | Becton, Dickinson And Company | Apparatus for distinguishing multiple subpopulations of cells |
| JPS59184862A (ja) * | 1983-04-05 | 1984-10-20 | ベクトン・ディッキンソン・アンド・カンパニ− | 試料内細胞の複数副次集団を識別する方法と装置 |
| US4596464A (en) * | 1983-10-14 | 1986-06-24 | Ortho Diagnostic Systems, Inc. | Screening method for red cell abnormality |
-
1986
- 1986-08-29 US US06/901,860 patent/US4704891A/en not_active Expired - Lifetime
-
1987
- 1987-07-10 ES ES198787306143T patent/ES2035068T3/es not_active Expired - Lifetime
- 1987-07-10 EP EP87306143A patent/EP0258982B1/en not_active Expired - Lifetime
- 1987-07-10 DE DE8787306143T patent/DE3781855T2/de not_active Expired - Lifetime
- 1987-07-10 AT AT87306143T patent/ATE80947T1/de not_active IP Right Cessation
- 1987-07-10 ES ES198787306145T patent/ES2031507T3/es not_active Expired - Lifetime
- 1987-07-10 EP EP87306144A patent/EP0257759A3/en not_active Withdrawn
- 1987-07-10 EP EP87306145A patent/EP0258983B1/en not_active Expired - Lifetime
- 1987-07-10 DE DE8787306145T patent/DE3778253D1/de not_active Expired - Lifetime
- 1987-07-10 AT AT87306145T patent/ATE75042T1/de not_active IP Right Cessation
- 1987-08-28 JP JP62214975A patent/JPS6363942A/ja active Granted
- 1987-11-06 JP JP62280841A patent/JPS63177038A/ja active Granted
- 1987-11-06 JP JP62280840A patent/JPS63171343A/ja active Granted
-
1992
- 1992-06-11 GR GR920401228T patent/GR3004885T3/el unknown
- 1992-12-02 GR GR920402771T patent/GR3006407T3/el unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004044717A1 (de) * | 2004-09-10 | 2006-03-16 | BAM Bundesanstalt für Materialforschung und -prüfung | Verfahren und Kit zur Kalibrierung eines Photolumineszenzmesssystems |
| US7713741B2 (en) | 2004-09-10 | 2010-05-11 | Bam Bundesanstalf Fur Materialforschung Und - Prufung | Method and kit for calibrating a photoluminescence measurement |
| DE102004044717B4 (de) * | 2004-09-10 | 2010-08-26 | BAM Bundesanstalt für Materialforschung und -prüfung | Verfahren und Kit zur Kalibrierung eines Photolumineszenzmesssystems |
| DE102004044717B8 (de) * | 2004-09-10 | 2010-12-16 | BAM Bundesanstalt für Materialforschung und -prüfung | Verfahren und Kit zur Kalibrierung eines Photolumineszenzmesssystems |
| DE102007014413B4 (de) * | 2007-03-17 | 2016-02-04 | DüRR DENTAL AG | Verfahren zum Auswerten von Fluoreszenzbildsätzen und Vorrichtung zu seiner Durchführung |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0257759A3 (en) | 1989-10-18 |
| GR3004885T3 (enExample) | 1993-04-28 |
| JPH0350212B2 (enExample) | 1991-08-01 |
| DE3778253D1 (de) | 1992-05-21 |
| ES2035068T3 (es) | 1993-04-16 |
| JPH0350211B2 (enExample) | 1991-08-01 |
| JPS63177038A (ja) | 1988-07-21 |
| ATE75042T1 (de) | 1992-05-15 |
| EP0257759A2 (en) | 1988-03-02 |
| JPS6363942A (ja) | 1988-03-22 |
| EP0258982A3 (en) | 1989-10-25 |
| ATE80947T1 (de) | 1992-10-15 |
| US4704891A (en) | 1987-11-10 |
| EP0258982B1 (en) | 1992-09-23 |
| EP0258983A2 (en) | 1988-03-09 |
| ES2031507T3 (es) | 1992-12-16 |
| EP0258983A3 (en) | 1989-09-13 |
| DE3781855D1 (de) | 1992-10-29 |
| EP0258982A2 (en) | 1988-03-09 |
| GR3006407T3 (enExample) | 1993-06-21 |
| JPH0435709B2 (enExample) | 1992-06-11 |
| JPS63171343A (ja) | 1988-07-15 |
| EP0258983B1 (en) | 1992-04-15 |
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