DE3781855T2 - Mittel zum kalibrieren von durchflusszytometriegeraeten und anderen analysevorrichtungen. - Google Patents
Mittel zum kalibrieren von durchflusszytometriegeraeten und anderen analysevorrichtungen.Info
- Publication number
- DE3781855T2 DE3781855T2 DE8787306143T DE3781855T DE3781855T2 DE 3781855 T2 DE3781855 T2 DE 3781855T2 DE 8787306143 T DE8787306143 T DE 8787306143T DE 3781855 T DE3781855 T DE 3781855T DE 3781855 T2 DE3781855 T2 DE 3781855T2
- Authority
- DE
- Germany
- Prior art keywords
- particles
- instrument
- calibration
- signal
- beads
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004458 analytical method Methods 0.000 title abstract description 17
- 239000002245 particle Substances 0.000 claims abstract description 113
- 239000011324 bead Substances 0.000 claims description 59
- 239000003153 chemical reaction reagent Substances 0.000 claims description 37
- 238000012921 fluorescence analysis Methods 0.000 claims description 16
- 230000005855 radiation Effects 0.000 claims description 9
- 239000004033 plastic Substances 0.000 claims description 6
- 229920003023 plastic Polymers 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical group O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims description 5
- 108010004729 Phycoerythrin Proteins 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 35
- 238000000926 separation method Methods 0.000 abstract description 20
- 238000000684 flow cytometry Methods 0.000 abstract description 15
- 239000007788 liquid Substances 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 20
- 238000012360 testing method Methods 0.000 description 20
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 10
- 230000003287 optical effect Effects 0.000 description 10
- 230000035945 sensitivity Effects 0.000 description 10
- 239000000523 sample Substances 0.000 description 9
- 239000000203 mixture Substances 0.000 description 8
- 230000003595 spectral effect Effects 0.000 description 7
- 241000287828 Gallus gallus Species 0.000 description 6
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 6
- 210000003743 erythrocyte Anatomy 0.000 description 6
- 239000002953 phosphate buffered saline Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 229910000489 osmium tetroxide Inorganic materials 0.000 description 4
- 239000012285 osmium tetroxide Substances 0.000 description 4
- 108090001008 Avidin Proteins 0.000 description 3
- 238000000149 argon plasma sintering Methods 0.000 description 3
- 239000004005 microsphere Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000009795 derivation Methods 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 238000002847 impedance measurement Methods 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 108010004469 allophycocyanin Proteins 0.000 description 1
- 238000004164 analytical calibration Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 238000010185 immunofluorescence analysis Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1012—Calibrating particle analysers; References therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1012—Calibrating particle analysers; References therefor
- G01N2015/1014—Constitution of reference particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1477—Multiparameters
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/901,860 US4704891A (en) | 1986-08-29 | 1986-08-29 | Method and materials for calibrating flow cytometers and other analysis instruments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3781855D1 DE3781855D1 (de) | 1992-10-29 |
| DE3781855T2 true DE3781855T2 (de) | 1993-04-29 |
Family
ID=25414938
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8787306143T Expired - Lifetime DE3781855T2 (de) | 1986-08-29 | 1987-07-10 | Mittel zum kalibrieren von durchflusszytometriegeraeten und anderen analysevorrichtungen. |
| DE8787306145T Expired - Lifetime DE3778253D1 (de) | 1986-08-29 | 1987-07-10 | Verfahren zum kalibrieren von durchflusszytometriegeraeten. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8787306145T Expired - Lifetime DE3778253D1 (de) | 1986-08-29 | 1987-07-10 | Verfahren zum kalibrieren von durchflusszytometriegeraeten. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4704891A (enExample) |
| EP (3) | EP0257759A3 (enExample) |
| JP (3) | JPS6363942A (enExample) |
| AT (2) | ATE80947T1 (enExample) |
| DE (2) | DE3781855T2 (enExample) |
| ES (2) | ES2035068T3 (enExample) |
| GR (2) | GR3004885T3 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004044717A1 (de) * | 2004-09-10 | 2006-03-16 | BAM Bundesanstalt für Materialforschung und -prüfung | Verfahren und Kit zur Kalibrierung eines Photolumineszenzmesssystems |
| DE102007014413B4 (de) * | 2007-03-17 | 2016-02-04 | DüRR DENTAL AG | Verfahren zum Auswerten von Fluoreszenzbildsätzen und Vorrichtung zu seiner Durchführung |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK164144C (da) * | 1988-11-17 | 1992-10-12 | Slagteriernes Forskningsinst | Fremgangsmaade ved kontrol eller justering af maaleapparater med en optisk sonde og medium til anvendelse ved fremgangsmaaden |
| CA2021658C (en) * | 1989-08-25 | 2001-10-09 | Myron J. Block | Multiplex immunoassay system |
| US5853984A (en) * | 1990-06-11 | 1998-12-29 | Nexstar Pharmaceuticals, Inc. | Use of nucleic acid ligands in flow cytometry |
| IE76732B1 (en) * | 1990-08-07 | 1997-11-05 | Becton Dickinson Co | One step test for absolute counts |
| JP2913219B2 (ja) * | 1991-03-06 | 1999-06-28 | 株式会社シマ研究所 | 尿沈渣検査成績管理方法 |
| DE69218912T2 (de) * | 1991-08-28 | 1997-10-09 | Becton Dickinson Co | Schwerkraftsattraktionsmaschine zur anpassungsfähigen autoclusterbildung n-dimensionaler datenströme |
| US5451525A (en) * | 1992-02-14 | 1995-09-19 | Coulter Corporation | Method and materials for determining particle count in a flow cytometer |
| DE69326731T2 (de) | 1992-09-04 | 2000-05-18 | Becton Dickinson And Co., Franklin Lakes | Kontroll-Teilchen für die Zellzählung und Instrumentenlinearität |
| US5620842A (en) * | 1995-03-29 | 1997-04-15 | Becton Dickinson And Company | Determination of the number of fluorescent molecules on calibration beads for flow cytometry |
| JP3875754B2 (ja) * | 1995-11-17 | 2007-01-31 | シスメックス株式会社 | フローサイトメータ用標準液 |
| US6014904A (en) * | 1996-05-09 | 2000-01-18 | Becton, Dickinson And Company | Method for classifying multi-parameter data |
| JP4323571B2 (ja) | 1997-01-31 | 2009-09-02 | エックスワイ， インコーポレイテッド | 光学装置 |
| US6074879A (en) * | 1997-06-23 | 2000-06-13 | Bayer Corporation | Synthetic polymer particles for use as standards and calibrators in flow cytometry |
| US6149867A (en) | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
| US6071689A (en) | 1997-12-31 | 2000-06-06 | Xy, Inc. | System for improving yield of sexed embryos in mammals |
| US6197520B1 (en) * | 1999-08-13 | 2001-03-06 | University Of Utah Research Foundation | Solution-based color compensation adjusted for temperature and electronic gains |
| US7208265B1 (en) | 1999-11-24 | 2007-04-24 | Xy, Inc. | Method of cryopreserving selected sperm cells |
| US6809804B1 (en) | 2000-05-11 | 2004-10-26 | Becton, Dickinson And Company | System and method for providing improved event reading and data processing capabilities in a flow cytometer |
| JP2004501358A (ja) | 2000-05-11 | 2004-01-15 | ベクトン・ディキンソン・アンド・カンパニー | 最適な境界を有する平滑化された多角形を使用して散布図中のクラスタを識別するシステム |
| AU2002237689B2 (en) | 2000-11-29 | 2008-01-10 | Xy, Llc. | System to separate frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations |
| US7713687B2 (en) | 2000-11-29 | 2010-05-11 | Xy, Inc. | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
| MX337304B (es) | 2002-08-01 | 2016-02-24 | Xy Llc | Sistema de separacion de baja presion para celulas de esperma. |
| US8486618B2 (en) | 2002-08-01 | 2013-07-16 | Xy, Llc | Heterogeneous inseminate system |
| WO2004017041A2 (en) | 2002-08-15 | 2004-02-26 | Xy, Inc. | High resolution flow cytometer |
| US7169548B2 (en) | 2002-09-13 | 2007-01-30 | Xy, Inc. | Sperm cell processing and preservation systems |
| DE602004024874D1 (de) | 2003-03-28 | 2010-02-11 | Inguran Llc | Eschlechts-sortierten tierspermien |
| EP1625203B1 (en) | 2003-05-15 | 2015-04-08 | Xy, Llc | Efficient haploid cell sorting for flow cytometer systems |
| KR101135138B1 (ko) * | 2003-08-13 | 2012-04-16 | 루미넥스 코포레이션 | 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의제어 방법 |
| US6962817B2 (en) * | 2003-10-02 | 2005-11-08 | Beckman Coulter, Inc. | Reference control for optical measurement of nucleated red blood cells of a blood sample |
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| JP2008507287A (ja) | 2004-07-22 | 2008-03-13 | モンサント テクノロジー エルエルシー | 精子細胞の集団を富化する方法 |
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| JP4953710B2 (ja) * | 2005-07-12 | 2012-06-13 | シスメックス株式会社 | 尿中有形成分分析装置用標準物質 |
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| US3406121A (en) * | 1965-10-01 | 1968-10-15 | Dade Reagents Inc | Blood cell counting standard and method of preparing the same |
| US3412037A (en) * | 1966-01-26 | 1968-11-19 | Technicon Corp | Method and means for the calibration of particle counting apparatus |
| US3791517A (en) * | 1973-03-05 | 1974-02-12 | Bio Physics Systems Inc | Digital fluidic amplifier particle sorter |
| US4135821A (en) * | 1977-03-22 | 1979-01-23 | The United States Of America As Represented By The United States Department Of Energy | Calibration of optical particle-size analyzer |
| US4331862A (en) * | 1979-02-23 | 1982-05-25 | Ryan Wayne L | Method for calibrating a particle counting machine and a calibration standard therefor |
| US4380392A (en) * | 1981-03-18 | 1983-04-19 | Karabegov Mikhail A | Method and apparatus for calibration of instruments serving to count and to determine the size of particles suspended in dispersion medium |
| US4438390A (en) * | 1981-03-23 | 1984-03-20 | Coulter Electronics, Inc. | Tandem sensing zones for improved signal-to-noise ratio in particle analyzer |
| US4434647A (en) * | 1981-07-27 | 1984-03-06 | Lockheed Corporation | Dynamic spot calibration for automatic particle counters |
| US4475236A (en) * | 1981-11-12 | 1984-10-02 | Ortho Diagnostic Systems Inc. | Method for counting overlapping cell populations in a distribution histogram |
| US4499052A (en) * | 1982-08-30 | 1985-02-12 | Becton, Dickinson And Company | Apparatus for distinguishing multiple subpopulations of cells |
| JPS59184862A (ja) * | 1983-04-05 | 1984-10-20 | ベクトン・ディッキンソン・アンド・カンパニ− | 試料内細胞の複数副次集団を識別する方法と装置 |
| US4596464A (en) * | 1983-10-14 | 1986-06-24 | Ortho Diagnostic Systems, Inc. | Screening method for red cell abnormality |
-
1986
- 1986-08-29 US US06/901,860 patent/US4704891A/en not_active Expired - Lifetime
-
1987
- 1987-07-10 ES ES198787306143T patent/ES2035068T3/es not_active Expired - Lifetime
- 1987-07-10 EP EP87306144A patent/EP0257759A3/en not_active Withdrawn
- 1987-07-10 AT AT87306143T patent/ATE80947T1/de not_active IP Right Cessation
- 1987-07-10 ES ES198787306145T patent/ES2031507T3/es not_active Expired - Lifetime
- 1987-07-10 DE DE8787306143T patent/DE3781855T2/de not_active Expired - Lifetime
- 1987-07-10 AT AT87306145T patent/ATE75042T1/de not_active IP Right Cessation
- 1987-07-10 EP EP87306143A patent/EP0258982B1/en not_active Expired - Lifetime
- 1987-07-10 DE DE8787306145T patent/DE3778253D1/de not_active Expired - Lifetime
- 1987-07-10 EP EP87306145A patent/EP0258983B1/en not_active Expired - Lifetime
- 1987-08-28 JP JP62214975A patent/JPS6363942A/ja active Granted
- 1987-11-06 JP JP62280841A patent/JPS63177038A/ja active Granted
- 1987-11-06 JP JP62280840A patent/JPS63171343A/ja active Granted
-
1992
- 1992-06-11 GR GR920401228T patent/GR3004885T3/el unknown
- 1992-12-02 GR GR920402771T patent/GR3006407T3/el unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004044717A1 (de) * | 2004-09-10 | 2006-03-16 | BAM Bundesanstalt für Materialforschung und -prüfung | Verfahren und Kit zur Kalibrierung eines Photolumineszenzmesssystems |
| US7713741B2 (en) | 2004-09-10 | 2010-05-11 | Bam Bundesanstalf Fur Materialforschung Und - Prufung | Method and kit for calibrating a photoluminescence measurement |
| DE102004044717B4 (de) * | 2004-09-10 | 2010-08-26 | BAM Bundesanstalt für Materialforschung und -prüfung | Verfahren und Kit zur Kalibrierung eines Photolumineszenzmesssystems |
| DE102004044717B8 (de) * | 2004-09-10 | 2010-12-16 | BAM Bundesanstalt für Materialforschung und -prüfung | Verfahren und Kit zur Kalibrierung eines Photolumineszenzmesssystems |
| DE102007014413B4 (de) * | 2007-03-17 | 2016-02-04 | DüRR DENTAL AG | Verfahren zum Auswerten von Fluoreszenzbildsätzen und Vorrichtung zu seiner Durchführung |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0258983A2 (en) | 1988-03-09 |
| JPH0350211B2 (enExample) | 1991-08-01 |
| ATE80947T1 (de) | 1992-10-15 |
| JPH0435709B2 (enExample) | 1992-06-11 |
| GR3004885T3 (enExample) | 1993-04-28 |
| EP0258983A3 (en) | 1989-09-13 |
| EP0258982A2 (en) | 1988-03-09 |
| JPS63177038A (ja) | 1988-07-21 |
| EP0257759A3 (en) | 1989-10-18 |
| ES2035068T3 (es) | 1993-04-16 |
| EP0258982B1 (en) | 1992-09-23 |
| US4704891A (en) | 1987-11-10 |
| JPH0350212B2 (enExample) | 1991-08-01 |
| JPS63171343A (ja) | 1988-07-15 |
| DE3781855D1 (de) | 1992-10-29 |
| ATE75042T1 (de) | 1992-05-15 |
| EP0257759A2 (en) | 1988-03-02 |
| ES2031507T3 (es) | 1992-12-16 |
| DE3778253D1 (de) | 1992-05-21 |
| JPS6363942A (ja) | 1988-03-22 |
| EP0258983B1 (en) | 1992-04-15 |
| GR3006407T3 (enExample) | 1993-06-21 |
| EP0258982A3 (en) | 1989-10-25 |
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