ES2031507T3 - Metodo para calibrar citometros de flujo. - Google Patents

Metodo para calibrar citometros de flujo.

Info

Publication number
ES2031507T3
ES2031507T3 ES198787306145T ES87306145T ES2031507T3 ES 2031507 T3 ES2031507 T3 ES 2031507T3 ES 198787306145 T ES198787306145 T ES 198787306145T ES 87306145 T ES87306145 T ES 87306145T ES 2031507 T3 ES2031507 T3 ES 2031507T3
Authority
ES
Spain
Prior art keywords
particles
light
calibration
instrument
signal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787306145T
Other languages
English (en)
Inventor
Diether J. Recktenwald
Rickie S. Kerndt
Michael R. Loken
Chia Huei Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Application granted granted Critical
Publication of ES2031507T3 publication Critical patent/ES2031507T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1012—Calibrating particle analysers; References therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G01N2015/1014—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1477—Multiparameters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

UN METODO PARA CALIBRAR UN INSTRUMENTO PARA CITIMETRIA DE FLUJO, PARA UTILIZARLO EN LA OBTENCION DE AL MENOS UNA SEÑAL RELACIONADA CON LA LUZ A PARTIR DE PARTICULAS QUE PASAN A TRAVES DEL INSTRUMENTO PARA ANALISIS, METODO QUE COMPRENDE: PASAR LAS PARTICULAS DE CALIBRACION, QUE TIENEN CARACTERISTICAS RELACIONADAS CON LAS PARTICULAS A ENSAYAR, EN UNA CORRIENTE DE FLUJO LIQUIDO, DE MODO QUE CADA PARTICULA DE CALIBRACION PASA, SENCIALMENTE UNA CADA VEZ, A TRAVES DE UN HAZ DE LUZ INCIDENTE; DETECTAR UNA SEÑAL LUMINOSA PROCEDENTE DE LAS PARTICULAS DE CALIBRACION QUE PASAN A TRAVES DEL HAZ LUMINOSO; DETECTAR UNA SEÑAL DE RUIDO DE LAS PARTICULAS DE CALIBRACION QUE PASAN A TRAVES DEL HAZ DE LUZ; DETERMINAR LA RELACION DE LA SEÑAL LUMINOSA A LA SEÑAL DE RUIDO DETECTADAS; PRESENTAR LA SEÑAL COMO UN VALOR DE SEPARACION MEDIO ENTRE LAS DOS SEÑALES; COMPARAR EL VALOR DE SEPARACION MEDIO CON UN VALOR DE SEPARACION PREDETERMINADO QUE REPRESENTA UN UMBRAL PARA EL MINIMO RENDIMIENTO DEL INSTRUMENTO; Y AJUSTAR, SI NO SE HA ALCANZADO EL VALOR DE SEPARACION PREDETERMINADO, LA OPERACION DEL INSTRUMENTO, MIENTRAS SE PASAN LAS PARTICULAS DE CALIBRACION.
ES198787306145T 1986-08-29 1987-07-10 Metodo para calibrar citometros de flujo. Expired - Lifetime ES2031507T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/901,860 US4704891A (en) 1986-08-29 1986-08-29 Method and materials for calibrating flow cytometers and other analysis instruments

Publications (1)

Publication Number Publication Date
ES2031507T3 true ES2031507T3 (es) 1992-12-16

Family

ID=25414938

Family Applications (2)

Application Number Title Priority Date Filing Date
ES198787306143T Expired - Lifetime ES2035068T3 (es) 1986-08-29 1987-07-10 Kit de reactivos para ser utilizado al calibrar un instrumento para realizar analisis de fluorescencia bicromatica de particulas.
ES198787306145T Expired - Lifetime ES2031507T3 (es) 1986-08-29 1987-07-10 Metodo para calibrar citometros de flujo.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES198787306143T Expired - Lifetime ES2035068T3 (es) 1986-08-29 1987-07-10 Kit de reactivos para ser utilizado al calibrar un instrumento para realizar analisis de fluorescencia bicromatica de particulas.

Country Status (7)

Country Link
US (1) US4704891A (es)
EP (3) EP0258983B1 (es)
JP (3) JPS6363942A (es)
AT (2) ATE80947T1 (es)
DE (2) DE3778253D1 (es)
ES (2) ES2035068T3 (es)
GR (2) GR3004885T3 (es)

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Also Published As

Publication number Publication date
EP0258983A3 (en) 1989-09-13
EP0258983A2 (en) 1988-03-09
US4704891A (en) 1987-11-10
ATE75042T1 (de) 1992-05-15
EP0258982A3 (en) 1989-10-25
ES2035068T3 (es) 1993-04-16
JPH0435709B2 (es) 1992-06-11
JPS63177038A (ja) 1988-07-21
EP0258983B1 (en) 1992-04-15
JPH0350211B2 (es) 1991-08-01
EP0258982A2 (en) 1988-03-09
EP0258982B1 (en) 1992-09-23
JPS6363942A (ja) 1988-03-22
DE3781855T2 (de) 1993-04-29
JPH0350212B2 (es) 1991-08-01
EP0257759A3 (en) 1989-10-18
EP0257759A2 (en) 1988-03-02
DE3778253D1 (de) 1992-05-21
JPS63171343A (ja) 1988-07-15
ATE80947T1 (de) 1992-10-15
GR3004885T3 (es) 1993-04-28
DE3781855D1 (de) 1992-10-29
GR3006407T3 (es) 1993-06-21

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