DE68919892T2 - Fluoreszenz-Mikroskopvorrichtung. - Google Patents

Fluoreszenz-Mikroskopvorrichtung.

Info

Publication number
DE68919892T2
DE68919892T2 DE1989619892 DE68919892T DE68919892T2 DE 68919892 T2 DE68919892 T2 DE 68919892T2 DE 1989619892 DE1989619892 DE 1989619892 DE 68919892 T DE68919892 T DE 68919892T DE 68919892 T2 DE68919892 T2 DE 68919892T2
Authority
DE
Germany
Prior art keywords
fluorescence microscope
microscope device
fluorescence
microscope
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE1989619892
Other languages
English (en)
Other versions
DE68919892D1 (de
Inventor
Akira Tamagawa
Kazuho Ozaki
Tohru Makino
Atsuo Miyakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olympus Corp
Original Assignee
Olympus Optical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Optical Co Ltd filed Critical Olympus Optical Co Ltd
Application granted granted Critical
Publication of DE68919892D1 publication Critical patent/DE68919892D1/de
Publication of DE68919892T2 publication Critical patent/DE68919892T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
DE1989619892 1988-04-26 1989-04-25 Fluoreszenz-Mikroskopvorrichtung. Expired - Lifetime DE68919892T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10354588 1988-04-26
JP63189453A JP2749069B2 (ja) 1988-04-26 1988-07-28 蛍光顕微鏡装置

Publications (2)

Publication Number Publication Date
DE68919892D1 DE68919892D1 (de) 1995-01-26
DE68919892T2 true DE68919892T2 (de) 1995-07-06

Family

ID=26444189

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1989619892 Expired - Lifetime DE68919892T2 (de) 1988-04-26 1989-04-25 Fluoreszenz-Mikroskopvorrichtung.

Country Status (3)

Country Link
EP (1) EP0339582B1 (de)
JP (1) JP2749069B2 (de)
DE (1) DE68919892T2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19858206C2 (de) * 1998-12-17 2001-10-11 Leica Microsystems Verfahren zur Anpassung von Anregungsintensitäten bei einem Multiband-Fluoreszenz-Mikroskop und Multiband-Fluoreszenz-Mikroskop zur Durchführung des Verfahrens

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2799191B2 (ja) * 1989-08-24 1998-09-17 オリンパス光学工業株式会社 細胞内イオンの２次元濃度分布像を形成する方法
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
JPH04326316A (ja) * 1991-04-26 1992-11-16 Olympus Optical Co Ltd 顕微鏡用写真撮影装置
JP2970967B2 (ja) * 1991-11-20 1999-11-02 浜松ホトニクス株式会社 蛍光性プローブ試薬を用いた細胞内イオン濃度測定法
CA2114371C (en) * 1993-01-28 2007-10-09 Kenji Kamada Method of spectrometry and apparatus therefor
US5863504A (en) * 1995-03-16 1999-01-26 Bio-Rad Laboratories, Inc. Fluorescence imaging instrument utilizing fish
DE29620732U1 (de) * 1995-09-26 1997-04-24 Storz Karl Gmbh & Co Vorrichtung zur photodynamischen Diagnose
US6272235B1 (en) 1997-03-03 2001-08-07 Bacus Research Laboratories, Inc. Method and apparatus for creating a virtual microscope slide
US6404906B2 (en) 1997-03-03 2002-06-11 Bacus Research Laboratories,Inc. Method and apparatus for acquiring and reconstructing magnified specimen images from a computer-controlled microscope
CA2283267A1 (en) * 1997-03-07 1998-09-11 Clare Chemical Research Llc Fluorometric detection using visible light
LU90186B1 (fr) * 1997-12-22 1999-06-24 Communaute Europ Ce Batiment E Dispositif d'analyse non destructive de plantes et véhicule comportant un tel dispositif embarqué
JP2000098244A (ja) 1998-09-24 2000-04-07 Olympus Optical Co Ltd 蛍光顕微鏡
US6075613A (en) * 1999-02-26 2000-06-13 General Scanning, Inc. Optical scanner calibration device
US7518652B2 (en) 2000-05-03 2009-04-14 Aperio Technologies, Inc. Method and apparatus for pre-focus in a linear array based slide scanner
US6711283B1 (en) 2000-05-03 2004-03-23 Aperio Technologies, Inc. Fully automatic rapid microscope slide scanner
US7668362B2 (en) 2000-05-03 2010-02-23 Aperio Technologies, Inc. System and method for assessing virtual slide image quality
US7738688B2 (en) 2000-05-03 2010-06-15 Aperio Technologies, Inc. System and method for viewing virtual slides
US6544794B1 (en) * 2000-05-12 2003-04-08 Shiseido Company, Ltd. Method for visual imaging of ion distribution in tissue
US6609015B2 (en) 2001-01-18 2003-08-19 Koninklijke Philips Electronics N.V. Analysis of a composition
FR2820828B1 (fr) * 2001-02-09 2003-05-02 Commissariat Energie Atomique Dispositif d'observation d'echantillons par fluorescence, notamment de facon sequentielle
US7158294B2 (en) 2001-12-18 2007-01-02 Olympus Optical Co., Ltd. Laser scanning confocal microscope apparatus, image recording method, and recording medium
US7116440B2 (en) 2003-02-28 2006-10-03 Aperio Technologies, Inc. Image processing and analysis framework
US7257268B2 (en) 2003-02-28 2007-08-14 Aperio Technologies, Inc. Systems and methods for image pattern recognition
EP1721146B1 (de) * 2004-01-14 2008-06-18 Applera Corporation Vorrichtung und verfahren zum fluoreszenznachweis in biologischen proben
US7295316B2 (en) * 2004-01-14 2007-11-13 Applera Corporation Fluorescent detector with automatic changing filters
JP5134365B2 (ja) 2004-05-27 2013-01-30 アペリオ・テクノロジーズ・インコーポレイテッド 三次元仮想スライドを生成しかつ可視化するためのシステム及び方法
JP5099675B2 (ja) * 2004-12-28 2012-12-19 学校法人東京理科大学 蛍光分子プローブを用いた新規薬剤スクリーニング方法
JP2006189616A (ja) * 2005-01-06 2006-07-20 Nikon Corp 光路切換装置及びこれを備える倒立顕微鏡
JP5336088B2 (ja) 2005-01-27 2013-11-06 アペリオ・テクノロジーズ・インコーポレイテッド 三次元仮想スライドを可視化するためのシステム及び方法
US8164622B2 (en) 2005-07-01 2012-04-24 Aperio Technologies, Inc. System and method for single optical axis multi-detector microscope slide scanner
DE102006004232C5 (de) 2006-01-30 2013-08-01 Carl Zeiss Surgical Gmbh Mikroskopiesystem
EP2153401B1 (de) 2007-05-04 2016-12-28 Leica Biosystems Imaging, Inc. System und verfahren zur qualitätssicherstellung bei der pathologie
EP3764085A3 (de) 2008-10-24 2021-03-24 Leica Biosystems Imaging Inc. Fluoreszenz-scanner mit komplettobjektträger
JP5786110B2 (ja) 2009-12-11 2015-09-30 ライカ バイオシステムズ イメージング インコーポレイテッドＡｐｅｒｉｏ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｉｎｃ． デジタル病理画像分析における信号対雑音比の改善
CN102818798B (zh) * 2012-09-10 2014-05-07 重庆大学 一种用于肺癌呼出气体检测的荧光检测装置
CN102841082B (zh) * 2012-09-10 2014-08-20 重庆大学 双信号肺癌呼出气体检测系统

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1019841B (de) * 1955-12-16 1957-11-21 Leitz Ernst Gmbh Fluoreszenz-Mikroskop
JPS53122473A (en) * 1977-04-01 1978-10-25 Olympus Optical Co Ltd Fluorescent photometric mecroscope
JPS56130150U (de) * 1980-03-04 1981-10-02
FR2532756A1 (fr) * 1982-09-03 1984-03-09 France Henri De Systeme pour l'observation et la quantification automatiques de phenomenes susceptibles d'etre detectes par fluorescence
JPS60256443A (ja) * 1984-05-31 1985-12-18 オムロン株式会社 画像計測装置
JPS62263447A (ja) * 1986-05-10 1987-11-16 Japan Spectroscopic Co カルシウム濃度測定用螢光光度計
US4791310A (en) * 1986-10-02 1988-12-13 Syracuse University Fluorescence microscopy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19858206C2 (de) * 1998-12-17 2001-10-11 Leica Microsystems Verfahren zur Anpassung von Anregungsintensitäten bei einem Multiband-Fluoreszenz-Mikroskop und Multiband-Fluoreszenz-Mikroskop zur Durchführung des Verfahrens

Also Published As

Publication number Publication date
EP0339582B1 (de) 1994-12-14
EP0339582A3 (en) 1990-11-22
JP2749069B2 (ja) 1998-05-13
DE68919892D1 (de) 1995-01-26
JPH0228542A (ja) 1990-01-30
EP0339582A2 (de) 1989-11-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8320 Willingness to grant licences declared (paragraph 23)