|
US4766106A
(en)
*
|
1985-06-26 |
1988-08-23 |
Cetus Corporation |
Solubilization of proteins for pharmaceutical compositions using polymer conjugation
|
|
US5206344A
(en)
*
|
1985-06-26 |
1993-04-27 |
Cetus Oncology Corporation |
Interleukin-2 muteins and polymer conjugation thereof
|
|
US5525338A
(en)
*
|
1992-08-21 |
1996-06-11 |
Immunomedics, Inc. |
Detection and therapy of lesions with biotin/avidin conjugates
|
|
US4810638A
(en)
*
|
1986-07-24 |
1989-03-07 |
Miles Inc. |
Enzyme-labeled antibody reagent with polyalkyleneglycol linking group
|
|
ATE106249T1
(de)
*
|
1987-11-05 |
1994-06-15 |
Hybritech Inc |
Polysaccharidmodifizierte immunglobuline mit reduziertem immunogenem potential oder verbesserter pharmakokinetik.
|
|
US4847325A
(en)
*
|
1988-01-20 |
1989-07-11 |
Cetus Corporation |
Conjugation of polymer to colony stimulating factor-1
|
|
FR2626373B1
(fr)
*
|
1988-01-22 |
1993-10-15 |
Stabiligen |
Procede de preparation d'un traceur stable et traceur obtenu
|
|
US5541297A
(en)
*
|
1988-04-01 |
1996-07-30 |
Immunomedics, Inc. |
Therapeutic conjugates of toxins and drugs
|
|
US5565519A
(en)
*
|
1988-11-21 |
1996-10-15 |
Collagen Corporation |
Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
|
|
US5306500A
(en)
*
|
1988-11-21 |
1994-04-26 |
Collagen Corporation |
Method of augmenting tissue with collagen-polymer conjugates
|
|
US5510418A
(en)
*
|
1988-11-21 |
1996-04-23 |
Collagen Corporation |
Glycosaminoglycan-synthetic polymer conjugates
|
|
US5162430A
(en)
*
|
1988-11-21 |
1992-11-10 |
Collagen Corporation |
Collagen-polymer conjugates
|
|
US4902502A
(en)
*
|
1989-01-23 |
1990-02-20 |
Cetus Corporation |
Preparation of a polymer/interleukin-2 conjugate
|
|
US5166322A
(en)
*
|
1989-04-21 |
1992-11-24 |
Genetics Institute |
Cysteine added variants of interleukin-3 and chemical modifications thereof
|
|
GB8909711D0
(en)
*
|
1989-04-27 |
1989-06-14 |
Secr Defence |
Optical beam steering device
|
|
US5527528A
(en)
*
|
1989-10-20 |
1996-06-18 |
Sequus Pharmaceuticals, Inc. |
Solid-tumor treatment method
|
|
US5620689A
(en)
*
|
1989-10-20 |
1997-04-15 |
Sequus Pharmaceuuticals, Inc. |
Liposomes for treatment of B-cell and T-cell disorders
|
|
DE4004296A1
(de)
*
|
1990-02-13 |
1991-08-14 |
Hoechst Ag |
Verbesserte markierte haptene, verfahren zu deren herstellung sowie verwendung dieser markierten haptene in immunoassays
|
|
JPH04218000A
(ja)
*
|
1990-02-13 |
1992-08-07 |
Kirin Amgen Inc |
修飾ポリペプチド
|
|
SE468238B
(sv)
*
|
1990-02-28 |
1992-11-30 |
Sten Ohlson |
Laekemedel med svag affinitet
|
|
US5951972A
(en)
*
|
1990-05-04 |
1999-09-14 |
American Cyanamid Company |
Stabilization of somatotropins and other proteins by modification of cysteine residues
|
|
IE912365A1
(en)
*
|
1990-07-23 |
1992-01-29 |
Zeneca Ltd |
Continuous release pharmaceutical compositions
|
|
US5885570A
(en)
*
|
1991-01-23 |
1999-03-23 |
The General Hospital Corporation |
Induction of tolerance with modified immunogens
|
|
US5595732A
(en)
*
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
US5336782A
(en)
*
|
1991-04-24 |
1994-08-09 |
Kuraray Co., Ltd. |
Long chain carboxylic acid imide ester
|
|
US5169627A
(en)
*
|
1991-10-28 |
1992-12-08 |
Mount Sinai School Of Medicine Of The City University Of New York |
Oral pharmaceutical composition containing a polyethylene glycol-immunoglobulin G conjugate for reconstitution of secretory immunity and method of reconstituting secretory immunity
|
|
US6217869B1
(en)
|
1992-06-09 |
2001-04-17 |
Neorx Corporation |
Pretargeting methods and compounds
|
|
US5846741A
(en)
*
|
1992-08-21 |
1998-12-08 |
Immunomedics, Inc. |
Boron neutron capture therapy using pre-targeting methods
|
|
US5382657A
(en)
*
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
CA2101361A1
(en)
*
|
1992-08-27 |
1994-02-28 |
Robert A. Snow |
Low diol polyalkylene oxide biologically active proteinaceous substances
|
|
GB9225448D0
(en)
*
|
1992-12-04 |
1993-01-27 |
Erba Carlo Spa |
Improved synthesis of polymer bioactive conjugates
|
|
KR100361933B1
(ko)
*
|
1993-09-08 |
2003-02-14 |
라 졸라 파마슈티칼 컴파니 |
화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
|
|
EP0725656A1
(en)
*
|
1993-11-03 |
1996-08-14 |
University Of Manitoba |
Cell control and suppression
|
|
US6015897A
(en)
*
|
1993-12-07 |
2000-01-18 |
Neorx Corporation |
Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota
|
|
IT1268955B1
(it)
*
|
1994-03-11 |
1997-03-18 |
Fidia Advanced Biopolymers Srl |
Esteri attivi di polisaccaridi carbossilici
|
|
US5670132A
(en)
*
|
1994-09-20 |
1997-09-23 |
Immunomedics, Inc. |
Modified radioantibody fragments for reduced renal uptake
|
|
US6908903B1
(en)
|
1994-12-07 |
2005-06-21 |
Aletheon Pharmaceuticals, Inc. |
Cluster clearing agents
|
|
US6172045B1
(en)
|
1994-12-07 |
2001-01-09 |
Neorx Corporation |
Cluster clearing agents
|
|
US5695760A
(en)
*
|
1995-04-24 |
1997-12-09 |
Boehringer Inglehiem Pharmaceuticals, Inc. |
Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
|
|
ES2299177T3
(es)
*
|
1995-05-10 |
2008-05-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Conjugados de citotoxinas que contienen dipeptidos.
|
|
US6458889B1
(en)
|
1995-12-18 |
2002-10-01 |
Cohesion Technologies, Inc. |
Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
|
|
DK2111876T3
(da)
*
|
1995-12-18 |
2011-12-12 |
Angiodevice Internat Gmbh |
Tværbundne polymerpræparater og fremgangsmåder til anvendelse deraf
|
|
US6833408B2
(en)
*
|
1995-12-18 |
2004-12-21 |
Cohesion Technologies, Inc. |
Methods for tissue repair using adhesive materials
|
|
US7883693B2
(en)
|
1995-12-18 |
2011-02-08 |
Angiodevice International Gmbh |
Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
|
|
AU1555297A
(en)
*
|
1996-02-01 |
1997-08-22 |
Biomedical Frontiers, Inc. |
Antigenic modulation of cells
|
|
US8007784B1
(en)
|
1996-06-27 |
2011-08-30 |
Albany Medical College |
Antigenic modulation of cells
|
|
US6321909B1
(en)
|
1997-02-13 |
2001-11-27 |
Sky High, Llc |
System for storing polyethylene glycol solutions
|
|
EP1415998A3
(en)
|
1997-02-21 |
2005-11-23 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and humanized anti-IL-8 monoclonal antibodies
|
|
US7122636B1
(en)
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
|
CN1250566C
(zh)
*
|
1997-06-06 |
2006-04-12 |
协和发酵工业株式会社 |
化学修饰的多肽
|
|
DE19748489A1
(de)
*
|
1997-11-03 |
1999-05-06 |
Roche Diagnostics Gmbh |
Polyethylenglykol-derivatisierte Biomoleküle und deren Verwendung in heterogenen Nachweisverfahren
|
|
US7005504B2
(en)
*
|
1998-01-22 |
2006-02-28 |
Genentech, Inc. |
Antibody fragment-peg conjugates
|
|
US6468532B1
(en)
|
1998-01-22 |
2002-10-22 |
Genentech, Inc. |
Methods of treating inflammatory diseases with anti-IL-8 antibody fragment-polymer conjugates
|
|
US6458355B1
(en)
|
1998-01-22 |
2002-10-01 |
Genentech, Inc. |
Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
|
|
US6908757B1
(en)
|
1998-03-26 |
2005-06-21 |
The Procter & Gamble Company |
Serine protease variants having amino acid deletions and substitutions
|
|
US6495136B1
(en)
|
1998-03-26 |
2002-12-17 |
The Procter & Gamble Company |
Proteases having modified amino acid sequences conjugated to addition moieties
|
|
US6569663B1
(en)
|
1998-03-26 |
2003-05-27 |
The Procter & Gamble Company |
Serine protease variants having amino acid substitutions
|
|
DE69943205D1
(de)
|
1998-08-06 |
2011-03-31 |
Mountain View Pharmaceuticals |
Peg-uricase Konjugate und Verwendung davon
|
|
ES2170042T3
(es)
|
1998-08-28 |
2004-10-01 |
Gryphon Therapeutics, Inc. |
Procedimiento para la preparacion de cadenas de poliamida de longitud precisa y sus conjugados con proteinas.
|
|
ES2220114T3
(es)
*
|
1998-10-30 |
2004-12-01 |
Novozymes A/S |
Variantes de proteinas poco alergenicas.
|
|
US6458953B1
(en)
*
|
1998-12-09 |
2002-10-01 |
La Jolla Pharmaceutical Company |
Valency platform molecules comprising carbamate linkages
|
|
CZ2002171A3
(cs)
|
1999-07-22 |
2002-06-12 |
The Procter & Gamble Company |
Proteinázový konjugát, čistící prostředek a prostředek osobní péče
|
|
US6946128B1
(en)
|
1999-07-22 |
2005-09-20 |
The Procter & Gamble Company |
Protease conjugates having sterically protected epitope regions
|
|
CZ2002212A3
(cs)
|
1999-07-22 |
2002-07-17 |
The Procter & Gamble Company |
Varianty subtilisinové proteasy mající aminokyselinové substituce v definovaných epitopových oblastech
|
|
MXPA02000843A
(es)
|
1999-07-22 |
2002-07-30 |
Procter & Gamble |
Variantes de subtilisina proteasa que tienen supresiones de aminoacidos y sustituciones en regiones de epitope definidas.
|
|
DE60025241T2
(de)
*
|
1999-09-27 |
2007-01-11 |
Chugai Seiyaku K.K. |
HäMOPOIETINREZEPTOR-PROTEIN, NR12
|
|
US7067111B1
(en)
|
1999-10-25 |
2006-06-27 |
Board Of Regents, University Of Texas System |
Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
|
|
JP2003516324A
(ja)
|
1999-11-24 |
2003-05-13 |
シェーリング コーポレイション |
転移を阻害する方法
|
|
MXPA02010275A
(es)
|
2000-04-18 |
2003-04-25 |
Schering Corp |
Usos de citocina; composiciones; metodos.
|
|
KR100784120B1
(ko)
*
|
2000-06-02 |
2007-12-12 |
보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 |
에틸렌디시스테인(ec)-약물 접합체
|
|
HK1054684A1
(zh)
|
2000-06-08 |
2003-12-12 |
La Jolla Pharmaceutical |
包含高分子量聚环氧乙烷的多价平台分子
|
|
WO2002030460A2
(en)
|
2000-10-09 |
2002-04-18 |
Isis Innovation Ltd. |
Therapeutic antibodies
|
|
US20030003048A1
(en)
*
|
2001-04-26 |
2003-01-02 |
Chun Li |
Diagnostic imaging compositions, their methods of synthesis and use
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
US7261875B2
(en)
*
|
2001-12-21 |
2007-08-28 |
Board Of Regents, The University Of Texas System |
Dendritic poly (amino acid) carriers and methods of use
|
|
EP1487865A4
(en)
|
2002-02-01 |
2005-12-14 |
Schering Corp |
USE OF CYTOKIN RELATED REAGENTS OF MAMMALS
|
|
GB0202906D0
(en)
|
2002-02-07 |
2002-03-27 |
Univ London |
Prevention of myocardial damage
|
|
BRPI0308585B8
(pt)
|
2002-03-13 |
2021-05-25 |
Biogen Idec Inc |
anticorpo isolado ou fragmento de ligação a antígeno do mesmo que se liga à alfavbeta6, composição, método de detecção in vitro de alfavbeta6 e construção de dna
|
|
AU2003241279A1
(en)
*
|
2002-03-26 |
2003-10-13 |
Biosynexus Incorporated |
Antimicrobial polymer conjugates
|
|
BR0316046A
(pt)
*
|
2002-11-07 |
2005-09-13 |
Univ Texas |
Conjugados de fármaco e etilenodicisteìna (ec), composições e métodos para imageamento de doença especìfica de tecido
|
|
ATE515514T1
(de)
|
2002-12-23 |
2011-07-15 |
Schering Corp |
Verwendungen von säuger-cytokin il-23 ; verwandte reagenzien
|
|
JP2006519170A
(ja)
*
|
2002-12-26 |
2006-08-24 |
マウンテン ビュー ファーマシューティカルズ,インコーポレイテッド |
サイトカイン、ケモカイン、増殖因子、ポリペプチドホルモン、およびレセプター結合活性が保存されたそのアンタゴニストのポリマー結合体
|
|
CN102319437B
(zh)
*
|
2002-12-26 |
2017-10-13 |
山景医药公司 |
具有增强的生物学效用的干扰素‑β的聚合物缀合物
|
|
US20040219214A1
(en)
*
|
2002-12-30 |
2004-11-04 |
Angiotech International Ag |
Tissue reactive compounds and compositions and uses thereof
|
|
JP2006516548A
(ja)
|
2002-12-30 |
2006-07-06 |
アンジオテック インターナショナル アクツィエン ゲゼルシャフト |
迅速ゲル化ポリマー組成物からの薬物送達法
|
|
KR100988129B1
(ko)
*
|
2003-04-30 |
2010-10-18 |
쥬리디컬 파운데이션 더 케모-세로-쎄라퓨틱 리서치 인스티튜트 |
인간 항인간 인터루킨-18 항체와 그 단편, 및 이들의이용방법
|
|
US9050378B2
(en)
*
|
2003-12-10 |
2015-06-09 |
Board Of Regents, The University Of Texas System |
N2S2 chelate-targeting ligand conjugates
|
|
KR101148445B1
(ko)
|
2004-04-28 |
2012-07-05 |
안지오디바이스 인터내셔널 게엠베하 |
가교된 생합성물질을 형성하기 위한 조성물 및 시스템, 및 이와 관련된 제조 및 사용 방법
|
|
CA2579790A1
(en)
*
|
2004-07-30 |
2006-02-09 |
Mount Sinai School Of Medicine Of New York University |
Npc1l1 and npc1l1 inhibitors and methods of use thereof
|
|
WO2006034128A2
(en)
|
2004-09-17 |
2006-03-30 |
Angiotech Biomaterials Corporation |
Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use
|
|
KR100754667B1
(ko)
|
2005-04-08 |
2007-09-03 |
한미약품 주식회사 |
비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물
|
|
US8148123B2
(en)
|
2005-04-11 |
2012-04-03 |
Savient Pharmaceuticals, Inc. |
Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
|
|
MX2007012547A
(es)
|
2005-04-11 |
2008-03-11 |
Savient Pharmaceuticals Inc |
Formas variantes de urato oxidasa y uso de las mismas.
|
|
US9534013B2
(en)
|
2006-04-12 |
2017-01-03 |
Horizon Pharma Rheumatology Llc |
Purification of proteins with cationic surfactant
|
|
KR101304289B1
(ko)
|
2005-04-11 |
2013-09-12 |
새비언트 파마수티컬즈 인크. |
유레이트 옥시다아제의 변이형 및 이의 용도
|
|
EP1877101B1
(en)
*
|
2005-04-28 |
2016-11-16 |
Ventana Medical Systems, Inc. |
Enzymes conjugated to antibodies via a peg heterobifuctional linker
|
|
AU2006239154A1
(en)
*
|
2005-04-28 |
2006-11-02 |
Ventana Medical Systems, Inc |
Nanoparticle conjugates
|
|
CN104072614B
(zh)
|
2005-07-08 |
2017-04-26 |
生物基因Ma公司 |
抗-αvβ6 抗体及其用途
|
|
WO2007058129A1
(ja)
*
|
2005-11-18 |
2007-05-24 |
Nitto Boseki Co., Ltd. |
抗原の測定法およびそれに用いるキット
|
|
AU2006318438B2
(en)
*
|
2005-11-23 |
2011-09-22 |
Ventana Medical Systems, Inc. |
Molecular conjugate
|
|
CU23556A1
(es)
|
2005-11-30 |
2010-07-20 |
Ct Ingenieria Genetica Biotech |
Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico
|
|
EP2004231A4
(en)
|
2006-04-07 |
2013-07-10 |
Nektar Therapeutics |
CONJUGATES OF ANTI-TNF-ALPHA ANTIBODY
|
|
US8758723B2
(en)
|
2006-04-19 |
2014-06-24 |
The Board Of Regents Of The University Of Texas System |
Compositions and methods for cellular imaging and therapy
|
|
US10925977B2
(en)
|
2006-10-05 |
2021-02-23 |
Ceil>Point, LLC |
Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
|
|
WO2010078376A2
(en)
*
|
2008-12-30 |
2010-07-08 |
Ventana Medical Systems, Inc. |
Fc-specific polymer-conjugated antibodies and their diagnostic use
|
|
US20100189651A1
(en)
|
2009-01-12 |
2010-07-29 |
Cytomx Therapeutics, Llc |
Modified antibody compositions, methods of making and using thereof
|
|
US9377454B2
(en)
|
2009-06-25 |
2016-06-28 |
Crealta Pharmaceuticals Llc |
Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
|
|
JP6184695B2
(ja)
|
2009-12-04 |
2017-08-23 |
ジェネンテック, インコーポレイテッド |
多重特異性抗体、抗体アナログ、組成物、及び方法
|
|
WO2012012352A2
(en)
*
|
2010-07-19 |
2012-01-26 |
Amidebio, Llc |
Modified peptides and proteins
|
|
EP2944605B1
(en)
*
|
2010-10-18 |
2018-12-05 |
University of Washington through its Center for Commercialization |
Chromophoric polymer dots
|
|
WO2014144466A1
(en)
|
2013-03-15 |
2014-09-18 |
Biogen Idec Ma Inc. |
Anti-alpha v beta 6 antibodies and uses thereof
|
|
WO2014143739A2
(en)
|
2013-03-15 |
2014-09-18 |
Biogen Idec Ma Inc. |
Anti-alpha v beta 6 antibodies and uses thereof
|
|
KR20150133576A
(ko)
*
|
2014-05-20 |
2015-11-30 |
삼성전자주식회사 |
화학적 개질된 표적화 단백질 및 그의 이용
|
|
WO2016127097A1
(en)
|
2015-02-06 |
2016-08-11 |
The Regents Of The University Of California |
Methods and compositions for improved cognition
|
|
JP2019535819A
(ja)
|
2016-11-11 |
2019-12-12 |
ホライゾン ファーマ リューマトロジー リミテッド ライアビリティ カンパニーHorizon Pharma Rheumatology Llc |
プレドニゾンおよびウリカーゼ分子の併用療法ならびにその使用
|
|
CN111278461A
(zh)
|
2017-08-16 |
2020-06-12 |
百时美施贵宝公司 |
可前药化抗体、其前药以及使用和制备方法
|
|
WO2020160325A1
(en)
|
2019-01-30 |
2020-08-06 |
Horizon Pharma Rheumatology Llc |
Reducing immunogenicity to pegloticase
|
|
WO2020163306A1
(en)
|
2019-02-04 |
2020-08-13 |
The Regents Of The University Of California |
Exercise-induced circulatory factors for amelioration of cognitive, neurological, and regenerative dysfunction during aging
|
|
US20220251206A1
(en)
|
2019-06-11 |
2022-08-11 |
Bristol-Myers Squibb Company |
Anti-ctla4 antibody prodruggable (probody) at a cdr position
|
|
CN110672836B
(zh)
*
|
2019-09-30 |
2023-03-21 |
香港大德昌龙生物科技有限公司 |
磁珠包被物及其制备方法和应用、检测试剂盒
|
|
WO2021163272A2
(en)
|
2020-02-12 |
2021-08-19 |
The Regents Of The University Of California |
Platelet factors and cognitive improvement
|
|
WO2024092238A1
(en)
|
2022-10-28 |
2024-05-02 |
Unity Biotechnology, Inc. |
Klotho polypeptide or polynucleotide for improving cognition
|
|
US12269875B2
(en)
|
2023-08-03 |
2025-04-08 |
Jeff R. Peterson |
Gout flare prevention methods using IL-1BETA blockers
|