DE3569736D1 - Pyridine derivatives and their production - Google Patents
Pyridine derivatives and their productionInfo
- Publication number
- DE3569736D1 DE3569736D1 DE8585305458T DE3569736T DE3569736D1 DE 3569736 D1 DE3569736 D1 DE 3569736D1 DE 8585305458 T DE8585305458 T DE 8585305458T DE 3569736 T DE3569736 T DE 3569736T DE 3569736 D1 DE3569736 D1 DE 3569736D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- pyridine derivatives
- pyridine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003222 pyridines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59171069A JPS6150978A (ja) | 1984-08-16 | 1984-08-16 | ピリジン誘導体およびその製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3569736D1 true DE3569736D1 (en) | 1989-06-01 |
Family
ID=15916456
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585305458T Expired DE3569736D1 (en) | 1984-08-16 | 1985-07-31 | Pyridine derivatives and their production |
| DE19975017C Active DE19975017I2 (de) | 1984-08-16 | 1985-07-31 | Pyridin-Derivate und deren Herstellung. |
| DE19975020C Active DE19975020I2 (de) | 1984-08-16 | 1985-07-31 | Pyridin-Derivate und deren Herstellung. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19975017C Active DE19975017I2 (de) | 1984-08-16 | 1985-07-31 | Pyridin-Derivate und deren Herstellung. |
| DE19975020C Active DE19975020I2 (de) | 1984-08-16 | 1985-07-31 | Pyridin-Derivate und deren Herstellung. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US4628098A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0174726B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPS6150978A (cg-RX-API-DMAC7.html) |
| KR (1) | KR920002128B1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU570130B2 (cg-RX-API-DMAC7.html) |
| BG (1) | BG60415B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1255314A (cg-RX-API-DMAC7.html) |
| DE (3) | DE3569736D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK171340B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES8607288A1 (cg-RX-API-DMAC7.html) |
| GE (1) | GEP19960313B (cg-RX-API-DMAC7.html) |
| GR (1) | GR851981B (cg-RX-API-DMAC7.html) |
| HK (1) | HK4792A (cg-RX-API-DMAC7.html) |
| HU (1) | HU195210B (cg-RX-API-DMAC7.html) |
| IE (1) | IE58363B1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX9203043A (cg-RX-API-DMAC7.html) |
| NL (1) | NL930109I2 (cg-RX-API-DMAC7.html) |
| NO (2) | NO163131C (cg-RX-API-DMAC7.html) |
| PH (1) | PH20946A (cg-RX-API-DMAC7.html) |
| SG (1) | SG103291G (cg-RX-API-DMAC7.html) |
| SU (1) | SU1507211A3 (cg-RX-API-DMAC7.html) |
| UA (1) | UA7140A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA856117B (cg-RX-API-DMAC7.html) |
Families Citing this family (243)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3585252D1 (de) | 1984-07-06 | 1992-03-05 | Fisons Plc | Benzimidazole, und verfahren zu deren herstellung, deren formulierung und verwendung als magensaeuresekretionshemmende verbindungen. |
| US5433959A (en) | 1986-02-13 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
| CA1276017C (en) * | 1986-02-13 | 1990-11-06 | Takeda Chemical Industries, Ltd. | Sulfenamide derivatives and their production |
| CA1327010C (en) * | 1986-02-13 | 1994-02-15 | Tadashi Makino | Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production |
| US6749864B2 (en) | 1986-02-13 | 2004-06-15 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
| DK171989B1 (da) * | 1987-08-04 | 1997-09-08 | Takeda Chemical Industries Ltd | Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler |
| WO1989011479A1 (fr) * | 1988-05-25 | 1989-11-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Nouveaux composes fluores d'alkoxyde |
| US5223515A (en) * | 1988-08-18 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Injectable solution containing a pyridyl methylsulfinylbenzimidazole |
| JP2536173B2 (ja) * | 1988-08-18 | 1996-09-18 | 武田薬品工業株式会社 | 注射剤 |
| AT391693B (de) * | 1988-11-15 | 1990-11-12 | Cl Pharma | Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer |
| SE8804628D0 (sv) | 1988-12-22 | 1988-12-22 | Ab Haessle | New compounds |
| SE8804629D0 (sv) * | 1988-12-22 | 1988-12-22 | Ab Haessle | New therapeutically active compounds |
| IE64199B1 (en) * | 1988-12-22 | 1995-07-12 | Haessle Ab | Compound with gastric acid inhibitory effect and process for its preparation |
| ES2066120T3 (es) * | 1989-02-10 | 1995-03-01 | Takeda Chemical Industries Ltd | Uso de derivados de bencimidazol como agentes antibacterianos. |
| US5049674A (en) * | 1989-12-20 | 1991-09-17 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
| US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
| US5274099A (en) * | 1989-12-20 | 1993-12-28 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
| DE69132082T2 (de) * | 1990-10-17 | 2000-08-31 | Takeda Chemical Industries, Ltd. | Pyridin-Derivate, Verfahren zu deren Herstellung und Anwendung |
| TW209174B (cg-RX-API-DMAC7.html) | 1991-04-19 | 1993-07-11 | Takeda Pharm Industry Co Ltd | |
| WO1993006097A1 (en) * | 1991-09-20 | 1993-04-01 | Merck & Co., Inc. | Novel process for the preparation of anti-ulcer agents |
| ES2036948B1 (es) * | 1991-11-21 | 1994-09-01 | Genesis Para La Investigacion | Procedimiento de obtencion de compuestos derivados de piridina. |
| KR0144793B1 (ko) * | 1992-07-08 | 1998-07-15 | 제임스 클리프튼 보올딩 | 돼지에서 위궤양을 완화시키기 위한 벤즈이미다졸 |
| WO1994002141A1 (en) * | 1992-07-28 | 1994-02-03 | Astra Aktiebolag | Injection and injection kit containing omeprazole and its analogs |
| EP0683776B1 (de) * | 1993-02-17 | 1999-04-07 | Byk Gulden Lomberg Chemische Fabrik GmbH | Substituierte heteroarylalkylthiopyridine zur bekämpfung von helicobacter bakterien |
| ES2060541B1 (es) * | 1993-02-26 | 1995-11-16 | Vinas Lab | Nuevo procedimiento para la sintesis de un derivado de 2-(2-piridilmetilsufinil) bencimidazol, y nuevos productos intermedios obtenidos con el mismo. |
| ES2063705B1 (es) * | 1993-06-14 | 1995-07-16 | S A L V A T Lab Sa | Intermedio para la sintesis de lansoprazol y su procedimiento de obtencion. |
| CA2166327A1 (en) * | 1993-06-29 | 1995-01-12 | Bernhard Kohl | Substituted arylthioalkylthiopyridines |
| TW280770B (cg-RX-API-DMAC7.html) | 1993-10-15 | 1996-07-11 | Takeda Pharm Industry Co Ltd | |
| US5374730A (en) * | 1993-11-04 | 1994-12-20 | Torcan Chemical Ltd. | Preparation of omeprazole and lansoprazole |
| US5502195A (en) * | 1993-11-04 | 1996-03-26 | Slemon; Clarke | Sulfoxide-carboxylate intermediates of omeprazole and lansoprazole |
| CN1048980C (zh) * | 1994-03-29 | 2000-02-02 | 广东汕头鮀滨化学药业总公司 | 一种新的吡啶衍生物及其制备方法和应用 |
| AU698249B2 (en) * | 1994-06-10 | 1998-10-29 | Altana Pharma Ag | Thiopyridines for combating (helicobacter) bacteria |
| SE9402431D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
| SE504459C2 (sv) * | 1994-07-15 | 1997-02-17 | Astra Ab | Förfarande för framställning av substituerade sulfoxider |
| GB9423968D0 (en) * | 1994-11-28 | 1995-01-11 | Astra Ab | Resolution |
| SE9500422D0 (sv) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
| SE9500478D0 (sv) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
| US5708017A (en) * | 1995-04-04 | 1998-01-13 | Merck & Co., Inc. | Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors |
| HRP960232A2 (en) * | 1995-07-03 | 1998-02-28 | Astra Ab | A process for the optical purification of compounds |
| US5824339A (en) * | 1995-09-08 | 1998-10-20 | Takeda Chemical Industries, Ltd | Effervescent composition and its production |
| US6207198B1 (en) * | 1995-09-21 | 2001-03-27 | Schwarz Pharma Ag | Composition containing an acid-labile omeprazole and process for its preparation |
| SE521100C2 (sv) * | 1995-12-15 | 2003-09-30 | Astra Ab | Förfarande för framställning av en bensimidazolförening |
| US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
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| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
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| WO1998054172A1 (en) * | 1997-05-30 | 1998-12-03 | Dr. Reddy's Research Foundation | Novel benzimidazole derivatives as antiulcer agents, process for their preparation and pharmaceutical compositions containing them |
| WO1999004816A1 (en) | 1997-07-25 | 1999-02-04 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Proton pump inhibitor in therapeutic combination with antibacterial substances |
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| PT1121103E (pt) | 1998-05-18 | 2007-02-28 | Takeda Pharmaceutical | Comprimidos de desintegração oral compreendendo um benzimidazole |
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| IE990506A1 (en) * | 1998-06-26 | 2000-11-15 | Russinsky Ltd | Pyridine Building Blocks |
| SI20019A (sl) * | 1998-07-13 | 2000-02-29 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola |
| WO2000004904A1 (en) * | 1998-07-22 | 2000-02-03 | Sepracor Inc. | Pharmaceutical compositions comprising hydroxylansoprazole and uses thereof |
| ES2192394T3 (es) | 1998-08-10 | 2003-10-01 | Winston Pharmateuticals Llc | Profarmacos de inhibidores de la bomba de protones. |
| US6093734A (en) * | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
| PT1105105E (pt) | 1998-08-12 | 2006-07-31 | Altana Pharma Ag | Forma de administracao oral para piridin-2-ilmetilsulfinil-1h-benzimidazois |
| DE19843413C1 (de) * | 1998-08-18 | 2000-03-30 | Byk Gulden Lomberg Chem Fab | Neue Salzform von Pantoprazol |
| JP3926936B2 (ja) | 1998-11-16 | 2007-06-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホキシド誘導体・アセトン錯体およびその製造法 |
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| US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
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| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
| US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
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| US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
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| KR100359256B1 (ko) * | 1999-10-06 | 2002-11-04 | 한미약품공업 주식회사 | 란소프라졸의 개선된 제조방법 |
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| US20060034937A1 (en) * | 1999-11-23 | 2006-02-16 | Mahesh Patel | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
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- 1985-08-13 PH PH32628A patent/PH20946A/en unknown
- 1985-08-13 GR GR851981A patent/GR851981B/el unknown
- 1985-08-13 ZA ZA856117A patent/ZA856117B/xx unknown
- 1985-08-14 KR KR1019850005863A patent/KR920002128B1/ko not_active Expired
- 1985-08-14 CA CA000488662A patent/CA1255314A/en not_active Expired
- 1985-08-14 UA UA3947161A patent/UA7140A1/uk unknown
- 1985-08-14 SU SU3947161A patent/SU1507211A3/ru active
- 1985-08-14 ES ES546152A patent/ES8607288A1/es not_active Expired
- 1985-08-15 NO NO853226A patent/NO163131C/no not_active IP Right Cessation
- 1985-08-15 HU HU853151A patent/HU195210B/hu unknown
-
1986
- 1986-12-02 US US06/937,193 patent/US4689333A/en not_active Expired - Lifetime
-
1991
- 1991-12-04 SG SG1032/91A patent/SG103291G/en unknown
-
1992
- 1992-01-16 HK HK47/92A patent/HK4792A/en not_active IP Right Cessation
- 1992-06-19 MX MX9203043A patent/MX9203043A/es unknown
-
1993
- 1993-03-11 GE GEAP1993601A patent/GEP19960313B/en unknown
- 1993-06-29 NL NL930109C patent/NL930109I2/nl unknown
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1994
- 1994-02-11 BG BG098459A patent/BG60415B2/bg unknown
-
1995
- 1995-03-31 NO NO1995002C patent/NO1995002I1/no unknown
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Free format text: PRODUCT NAME: LANSOPRAZOL IN KOMBINATION MIT CLARITHROMYCIN UND METRONIDAZOL; REGISTRATION NO/DATE: 36286.00.00, 36286.01.00, 36288.00.00, 36288.01.00, 38409.00.00, 38409.01.00, 38411.00.00, 38411.01.00; 19980825 Spc suppl protection certif: 199 75 017 Filing date: 19990224 Free format text: PRODUCT NAME: LANSOPRAZOL IN KOMBINATION MIT AMOXICILLIN UND CLARITHROMYCIN; REGISTRATION NO/DATE: 36286.00.00, 36286.01.00, 36288.00.00, 36288.01.00, 38409.00.00, 38409.01.00, 38411.00.00, 38411.01.00; 19980825 Spc suppl protection certif: 199 75 020 Filing date: 19990224 |