DE3535404A1 - Verfahren zur herstellung von diphosphonsaeuren - Google Patents

Verfahren zur herstellung von diphosphonsaeuren

Info

Publication number
DE3535404A1
DE3535404A1 DE19853535404 DE3535404A DE3535404A1 DE 3535404 A1 DE3535404 A1 DE 3535404A1 DE 19853535404 DE19853535404 DE 19853535404 DE 3535404 A DE3535404 A DE 3535404A DE 3535404 A1 DE3535404 A1 DE 3535404A1
Authority
DE
Germany
Prior art keywords
diphosphonic acids
acid
ppm
acids
diphosphonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19853535404
Other languages
German (de)
English (en)
Other versions
DE3535404C2 (enExample
Inventor
Giorgio Coltano Pisa Staibano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Gentili SpA
Original Assignee
Istituto Gentili SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Gentili SpA filed Critical Istituto Gentili SpA
Publication of DE3535404A1 publication Critical patent/DE3535404A1/de
Application granted granted Critical
Publication of DE3535404C2 publication Critical patent/DE3535404C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE19853535404 1984-10-29 1985-10-03 Verfahren zur herstellung von diphosphonsaeuren Granted DE3535404A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23362/84A IT1196315B (it) 1984-10-29 1984-10-29 Procedimento per la preparazione di acidi difosfonici

Publications (2)

Publication Number Publication Date
DE3535404A1 true DE3535404A1 (de) 1986-04-30
DE3535404C2 DE3535404C2 (enExample) 1989-04-20

Family

ID=11206414

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19853535404 Granted DE3535404A1 (de) 1984-10-29 1985-10-03 Verfahren zur herstellung von diphosphonsaeuren

Country Status (13)

Country Link
US (1) US4705651A (enExample)
JP (1) JPS61109794A (enExample)
AT (1) AT391702B (enExample)
BE (1) BE903519A (enExample)
CH (1) CH663791A5 (enExample)
DE (1) DE3535404A1 (enExample)
FR (1) FR2572406B1 (enExample)
GB (1) GB2166741B (enExample)
HK (1) HK12891A (enExample)
IT (1) IT1196315B (enExample)
LU (1) LU86133A1 (enExample)
NL (1) NL193945C (enExample)
SE (1) SE464084B (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3700772A1 (de) * 1987-01-13 1988-07-21 Inst Khim Kinetiki I Gorenija Verfahren zur herstellung von i-funktionellsubstituierten alkyliden-i,i-diphosphonsaeuren und deren gemischen
GB8825589D0 (en) * 1988-11-02 1988-12-07 Albright & Wilson Purification
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
US5183815A (en) * 1991-01-22 1993-02-02 Merck & Co., Inc. Bone acting agents
DE4223940A1 (de) * 1992-07-21 1994-01-27 Boehringer Mannheim Gmbh Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
JPH0736804U (ja) * 1993-12-25 1995-07-11 松本 純子 指圧クッションシート
US5773429A (en) * 1996-12-11 1998-06-30 Fuisz Technologies Ltd. Drug combination for treating calcium loss
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PT1107974E (pt) 1998-08-27 2006-10-31 Teva Pharma Novas formas de hidratos de alendronato de sodio, processos para a sua producao e suas composicoes farmaceuticas
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
WO2000049026A1 (en) * 1999-02-17 2000-08-24 Teva Pharmaceutical Industries, Ltd. Novel process for preparing alendronic acid
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
ES2153794B1 (es) 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
PE20011061A1 (es) 2000-02-01 2001-11-20 Procter & Gamble Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato
US6476006B2 (en) 2000-06-23 2002-11-05 Teva Pharmaceutical Industries, Ltd. Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
US6881420B2 (en) 2000-06-23 2005-04-19 Teva Pharmaceutical Industries Ltd. Compositions and dosage forms for gastric delivery of irinotecan and methods of treatment that use it to inhibit cancer cell proliferation
US7674480B2 (en) * 2000-06-23 2010-03-09 Teva Pharmaceutical Industries Ltd. Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition
US6558702B2 (en) * 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
WO2003008425A1 (fr) 2001-07-16 2003-01-30 Universite Paris 13 Nouveaux derives de bisphosphonates, leurs preparations et utilisations
CA2469779C (en) * 2001-12-21 2008-02-12 The Procter & Gamble Company Method for the treatment of bone disorders
CN1939314A (zh) 2002-05-10 2007-04-04 弗·哈夫曼-拉罗切有限公司 用于治疗和预防骨质疏松症的二膦酸
IL165227A0 (en) * 2002-05-17 2005-12-18 Tva Pharmaceutical Ind Ltd Cus of certain diluents for making bisphosphonic acids
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
SI1596870T2 (sl) * 2002-12-20 2011-07-29 Hoffmann La Roche Formulacija z visokim odmerkom ibandronata
CN1325506C (zh) * 2003-05-15 2007-07-11 中国科学院上海药物研究所 骨重吸收抑制剂阿伦膦酸及生理可接受的盐和它的制备
EP1656386B1 (en) * 2003-08-21 2009-12-09 Sun Pharmaceuticals Industries Ltd. A process for preparation of bisphosphonic acid compounds
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
US7361761B2 (en) * 2004-09-28 2008-04-22 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of bisphosphonic acid
US20080069901A1 (en) * 2004-12-10 2008-03-20 Tmrc Co. , Ltd. Therapeutic Agent for Metastatic Cancer and Cancer Metastasis Inhibitor
CN1304401C (zh) * 2004-12-28 2007-03-14 浙江工业大学 一种阿伦膦酸的制备方法
JP2008535862A (ja) 2005-04-08 2008-09-04 キメリクス，インコーポレイテッド ポックスウイルス感染の治療のための化合物、組成物および方法
EP1865967A4 (en) * 2005-04-08 2011-02-09 Chimerix Inc COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS AND OTHER DISEASES
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
ATE425171T1 (de) * 2005-12-27 2009-03-15 Ipca Lab Ltd Verbesserter herstellungsprozess von 4-amino- hydroxybutyliden-1,1-bisphosphonischer säure und ihrer salze
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
AU2009206673B2 (en) * 2008-01-25 2015-04-23 Chimerix, Inc. Methods of treating viral infections
US7964584B2 (en) * 2008-08-01 2011-06-21 Dong Wha Pharmaceutical Co., Ltd. Method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivatives or their salts, and alendronic acid or its salt
TR200900880A2 (tr) 2009-02-05 2010-08-23 Bi̇lgi̇ç Mahmut Tek bir dozaj formunda kombine edilen farmasötik bileşimler.
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
WO2011017253A1 (en) 2009-08-03 2011-02-10 Chimerix, Inc. Composition and methods of treating viral infections and viral induced tumors
EP3216789A1 (en) 2010-02-12 2017-09-13 Chimerix, Inc. Methods of treating viral infection
CA2797601A1 (en) 2010-04-26 2011-11-10 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
EP2661262B1 (en) 2011-01-06 2017-11-15 Mahmut Bilgic Improved bisphosphonate formulations
TR201100153A2 (tr) 2011-01-06 2012-07-23 Bi̇lgi̇ç Mahmut Efervesan bifosfonat formülasyonları.
AU2015217221A1 (en) 2014-02-13 2016-08-11 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
JP2017520545A (ja) 2014-07-02 2017-07-27 リガンド・ファーマシューティカルズ・インコーポレイテッド プロドラッグ化合物およびそれらの使用
CA3087932A1 (en) 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2130794A1 (de) * 1971-06-22 1973-01-11 Benckiser Gmbh Joh A 1-hydroxy-3-amino-propan-1,1-diphosphonsaeure und verfahren zu deren herstellung
DE2702631A1 (de) * 1977-01-22 1978-07-27 Henkel Kgaa Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren
EP0001584A1 (de) * 1977-10-07 1979-05-02 Henkel Kommanditgesellschaft auf Aktien Hydroxydiphosphonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Komplexierungsmittel
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060546A (en) * 1961-07-03 1977-11-29 Henkel Kommanditgesellschaft Auf Aktien Process for the manufacture of acylation products of phosphorous acid
US3366677A (en) * 1965-05-13 1968-01-30 Procter & Gamble Low temperature preparation of ethane-1-hydroxy-1, 1-diphosphonic acid
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2846835A1 (de) * 1978-10-27 1980-05-08 Benckiser Knapsack Gmbh Verfahren zur herstellung von carboxylalkan-aminoalkan-diphosphonsaeuren und -aminoarylalkan-diphosphonsaeuren
SU783300A1 (ru) * 1978-12-05 1980-11-30 Предприятие П/Я А-7346 Способ получени оксиэтилидендифосфоновой кислоты
GB2082585A (en) * 1980-08-27 1982-03-10 Vysoka Skola Chem Tech 6-amino-1-hydroxyhexylidene diphosphonic acid, salts thereof and a method of producing the acid and salts.
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
DE3151038A1 (de) * 1981-12-23 1983-07-28 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2130794A1 (de) * 1971-06-22 1973-01-11 Benckiser Gmbh Joh A 1-hydroxy-3-amino-propan-1,1-diphosphonsaeure und verfahren zu deren herstellung
DE2702631A1 (de) * 1977-01-22 1978-07-27 Henkel Kgaa Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren
EP0001584A1 (de) * 1977-10-07 1979-05-02 Henkel Kommanditgesellschaft auf Aktien Hydroxydiphosphonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Komplexierungsmittel
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren

Also Published As

Publication number Publication date
HK12891A (en) 1991-03-08
FR2572406A1 (fr) 1986-05-02
LU86133A1 (fr) 1986-03-24
NL8502949A (nl) 1986-05-16
DE3535404C2 (enExample) 1989-04-20
AT391702B (de) 1990-11-26
FR2572406B1 (fr) 1989-04-07
IT8423362A0 (it) 1984-10-29
IT8423362A1 (it) 1986-04-29
SE8504687D0 (sv) 1985-10-09
SE464084B (sv) 1991-03-04
ATA292885A (de) 1990-05-15
IT1196315B (it) 1988-11-16
US4705651A (en) 1987-11-10
JPS61109794A (ja) 1986-05-28
GB8524428D0 (en) 1985-11-06
JPH0569110B2 (enExample) 1993-09-30
NL193945C (nl) 2001-03-02
NL193945B (nl) 2000-11-01
SE8504687L (sv) 1986-04-30
GB2166741A (en) 1986-05-14
GB2166741B (en) 1988-07-20
BE903519A (nl) 1986-02-17
CH663791A5 (it) 1988-01-15

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8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition