DE3508355A1 - Verfahren zur herstellung von 5-fluoruracil - Google Patents

Verfahren zur herstellung von 5-fluoruracil

Info

Publication number
DE3508355A1
DE3508355A1 DE19853508355 DE3508355A DE3508355A1 DE 3508355 A1 DE3508355 A1 DE 3508355A1 DE 19853508355 DE19853508355 DE 19853508355 DE 3508355 A DE3508355 A DE 3508355A DE 3508355 A1 DE3508355 A1 DE 3508355A1
Authority
DE
Germany
Prior art keywords
uracil
reaction
phosphoric acid
fluorouracil
elemental fluorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19853508355
Other languages
German (de)
English (en)
Other versions
DE3508355C2 (enrdf_load_stackoverflow
Inventor
Eiji Tokio/Tokyo Ogura
Teruo Sagamihara Kanagawa Umemoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Onoda Cement Co Ltd
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Onoda Cement Co Ltd, Sagami Chemical Research Institute filed Critical Onoda Cement Co Ltd
Publication of DE3508355A1 publication Critical patent/DE3508355A1/de
Application granted granted Critical
Publication of DE3508355C2 publication Critical patent/DE3508355C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19853508355 1984-03-09 1985-03-08 Verfahren zur herstellung von 5-fluoruracil Granted DE3508355A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59043779A JPS60190769A (ja) 1984-03-09 1984-03-09 ５−フルオロウラシルの製造方法

Publications (2)

Publication Number Publication Date
DE3508355A1 true DE3508355A1 (de) 1985-09-12
DE3508355C2 DE3508355C2 (enrdf_load_stackoverflow) 1992-01-02

Family

ID=12673239

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19853508355 Granted DE3508355A1 (de) 1984-03-09 1985-03-08 Verfahren zur herstellung von 5-fluoruracil

Country Status (4)

Country Link
US (1) US4631342A (enrdf_load_stackoverflow)
JP (1) JPS60190769A (enrdf_load_stackoverflow)
CH (1) CH666030A5 (enrdf_load_stackoverflow)
DE (1) DE3508355A1 (enrdf_load_stackoverflow)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11559526B2 (en) * 2016-10-05 2023-01-24 Tohoku University Drug effective for lymphogenous drug administrating method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD94373A (enrdf_load_stackoverflow) *
DE2149504A1 (de) * 1970-10-05 1972-07-06 Res Inst Medicine Chem 5-Fluoruracile
GB1582308A (en) * 1977-09-07 1981-01-07 Daikin Ind Ltd Process for the fluorination of uracil

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3682917A (en) * 1970-03-25 1972-08-08 Ivan Ljudvigovich Knuniants Method for producing 5-fluorouracil
US3954758A (en) * 1970-05-27 1976-05-04 Pcr, Inc. Process for fluorinating uracil and derivatives thereof
US3846429A (en) * 1971-09-22 1974-11-05 S Giller Method of producing 5-fluorouracil
US4029661A (en) * 1971-10-04 1977-06-14 Pcr, Inc. Process for producing 5-fluorouracil and derivatives thereof in acid and/or alcohol solvents
DE2410394A1 (de) * 1973-03-07 1974-09-12 Andco Inc Verfahren zum entwaessern eines waessrigen schlamms dispergierten, fein zerkleinerten feststoffes
JPS51149287A (en) * 1975-06-17 1976-12-22 Daikin Ind Ltd Process for preparing 5-fluorouracil
JPS52133994A (en) * 1976-04-29 1977-11-09 Daikin Ind Ltd Method of fluorination
JPS6016431B2 (ja) * 1976-11-09 1985-04-25 ダイキン工業株式会社 フツ素化方法
JPS5581818A (en) * 1978-12-15 1980-06-20 Asahi Glass Co Ltd Method of fluorination
JPS606339B2 (ja) * 1979-04-28 1985-02-18 ダイキン工業株式会社 フツ素化方法
JPS5547664A (en) * 1979-06-15 1980-04-04 Pcr Manufacture of 55fluorouracil
JPS5916880A (ja) * 1982-07-16 1984-01-28 Morita Kagaku Kogyo Kk ５―フルオロウラシルの製造方法
JPS59144767A (ja) * 1983-02-04 1984-08-18 Morita Kagaku Kogyo Kk ５−フルオロウラシルの製造法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD94373A (enrdf_load_stackoverflow) *
DE2149504A1 (de) * 1970-10-05 1972-07-06 Res Inst Medicine Chem 5-Fluoruracile
GB1582308A (en) * 1977-09-07 1981-01-07 Daikin Ind Ltd Process for the fluorination of uracil

Also Published As

Publication number Publication date
CH666030A5 (de) 1988-06-30
JPH0527628B2 (enrdf_load_stackoverflow) 1993-04-21
US4631342A (en) 1986-12-23
DE3508355C2 (enrdf_load_stackoverflow) 1992-01-02
JPS60190769A (ja) 1985-09-28

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Legal Events

Date Code Title Description
8128 New person/name/address of the agent

Representative=s name: VOSSIUS, V., DIPL.-CHEM. DR.RER.NAT. TAUCHNER, P.,

8110 Request for examination paragraph 44
D2 Grant after examination
8327 Change in the person/name/address of the patent owner

Owner name: SAGAMI CHEMICAL RESEARCH CENTER, TOKIO/TOKYO, JP

8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: TAUCHNER, P., DIPL.-CHEM. DR.RER.NAT. HEUNEMANN, D., DIPL.-PHYS. DR.RER.NAT. RAUH, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANWAELTE, 8000 MUENCHEN

8339 Ceased/non-payment of the annual fee