DE3248420A1 - Verfahren zur mikrobiologischen herstellung von gaerbruehen, die entweder nahezu ausschliesslich nebramycin-5' oder ein gemisch von nebramycin-2 und nebramicyn-5' in einem beliebigen im voraus festgesetzten verhaeltnis und nebramycin-4 enthalten und in diesem verwendbarer mikroorganismusstamm - Google Patents

Verfahren zur mikrobiologischen herstellung von gaerbruehen, die entweder nahezu ausschliesslich nebramycin-5' oder ein gemisch von nebramycin-2 und nebramicyn-5' in einem beliebigen im voraus festgesetzten verhaeltnis und nebramycin-4 enthalten und in diesem verwendbarer mikroorganismusstamm

Info

Publication number
DE3248420A1
DE3248420A1 DE19823248420 DE3248420A DE3248420A1 DE 3248420 A1 DE3248420 A1 DE 3248420A1 DE 19823248420 DE19823248420 DE 19823248420 DE 3248420 A DE3248420 A DE 3248420A DE 3248420 A1 DE3248420 A1 DE 3248420A1
Authority
DE
Germany
Prior art keywords
nebramycin
streptomyces tenebrarius
mng
strain
exclusively
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19823248420
Other languages
German (de)
English (en)
Other versions
DE3248420C2 (en, 2012
Inventor
Gábor Dr. 1119 Budapest Ambrus
Tibor Dr. 1138 Budapest Balogh
Miklós 9200 Mosonmagyaróvár Fábián
Imre 1095 Budapest Moravcsik
István Dr. 1131 Budapest Ott
Valéria Dr. 1147 Budapest Széll
László 1104 Budapest Tölgyesi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Original Assignee
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt filed Critical Biogal Gyogyszergyar Rt
Publication of DE3248420A1 publication Critical patent/DE3248420A1/de
Application granted granted Critical
Publication of DE3248420C2 publication Critical patent/DE3248420C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
    • C12P19/485—Having two saccharide radicals bound through only oxygen to non-adjacent ring carbons of the cyclohexyl radical, e.g. gentamycin, kanamycin, sisomycin, verdamycin, mutamycin, tobramycin, nebramycin, antibiotics 66-40B, 66-40D, XK-62-2, 66-40, G-418, G-52
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
    • C12P19/50—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin having two saccharide radicals bound through only oxygen to adjacent ring carbon atoms of the cyclohexyl radical, e.g. ambutyrosin, ribostamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE19823248420 1981-12-28 1982-12-28 Verfahren zur mikrobiologischen herstellung von gaerbruehen, die entweder nahezu ausschliesslich nebramycin-5' oder ein gemisch von nebramycin-2 und nebramicyn-5' in einem beliebigen im voraus festgesetzten verhaeltnis und nebramycin-4 enthalten und in diesem verwendbarer mikroorganismusstamm Granted DE3248420A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU813954A HU190680B (en) 1981-12-28 1981-12-28 Process for preparing 6''-0-carbamoyl-tobramycin microbiologically

Publications (2)

Publication Number Publication Date
DE3248420A1 true DE3248420A1 (de) 1983-07-21
DE3248420C2 DE3248420C2 (en, 2012) 1990-11-08

Family

ID=10966213

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19823248420 Granted DE3248420A1 (de) 1981-12-28 1982-12-28 Verfahren zur mikrobiologischen herstellung von gaerbruehen, die entweder nahezu ausschliesslich nebramycin-5' oder ein gemisch von nebramycin-2 und nebramicyn-5' in einem beliebigen im voraus festgesetzten verhaeltnis und nebramycin-4 enthalten und in diesem verwendbarer mikroorganismusstamm

Country Status (9)

Country Link
AT (1) AT379171B (en, 2012)
BE (1) BE895455A (en, 2012)
CH (2) CH658072A5 (en, 2012)
DE (1) DE3248420A1 (en, 2012)
FI (1) FI74995C (en, 2012)
FR (1) FR2519023B1 (en, 2012)
GB (1) GB2114978B (en, 2012)
HU (1) HU190680B (en, 2012)
NL (1) NL8205011A (en, 2012)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3691279A (en) * 1970-04-15 1972-09-12 Lilly Co Eli Antibiotic nebramycin and preparation thereof
US3853709A (en) * 1970-10-26 1974-12-10 Lilly Co Eli Process for preparing nebramycin factors ii and vii
US4032404A (en) * 1976-07-14 1977-06-28 Bristol-Myers Company Fermentation process for producing apramycin and nebramycin factor V'

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS ERMITTELT *

Also Published As

Publication number Publication date
HU190680B (en) 1986-10-28
DE3248420C2 (en, 2012) 1990-11-08
GB2114978A (en) 1983-09-01
AT379171B (de) 1985-11-25
FI824483L (fi) 1983-06-29
ATA470482A (de) 1985-04-15
FR2519023A1 (fr) 1983-07-01
FI74995C (fi) 1988-04-11
FI824483A0 (fi) 1982-12-28
CH658072A5 (de) 1986-10-15
NL8205011A (nl) 1983-07-18
GB2114978B (en) 1985-09-11
BE895455A (fr) 1983-06-23
CH657374A5 (de) 1986-08-29
FR2519023B1 (fr) 1985-10-25
FI74995B (fi) 1987-12-31

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Legal Events

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8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee