DE2921022C2 - - Google Patents

Info

Publication number
DE2921022C2
DE2921022C2 DE2921022A DE2921022A DE2921022C2 DE 2921022 C2 DE2921022 C2 DE 2921022C2 DE 2921022 A DE2921022 A DE 2921022A DE 2921022 A DE2921022 A DE 2921022A DE 2921022 C2 DE2921022 C2 DE 2921022C2
Authority
DE
Germany
Prior art keywords
nebramycin
nutrient medium
complex
streptomyces tenebrarius
culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2921022A
Other languages
German (de)
English (en)
Other versions
DE2921022A1 (de
Inventor
Istvan Dr. Ott
Gabor Dr. Ambrus
Jozsef Dipl.-Chem.-Ing. Dr. Gyimesi
Ilona Harsanyi
Janos Dipl.-Chem.-Ing. Dr. Berdy
Valeria Dr. Szell
Tibor Dr. Balogh
Laszlo Toelgyesi
Istvanne Kadar
Laszlo Budapest Hu Nagy
Janos Dr. Erdei
Endrene Szuecs
Istvan Dr. Kaszab
Ferenc Dipl.-Chem. Fabian
Kalman Dr. Polya
Lajos Kun
Janos Vig
Jenoe Szilagyi
Csaba Dipl.-Chem. Debrecen Hu Nagy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Hungary Pharmaceutical Marketing PLC
Original Assignee
Institute for Drugs Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute for Drugs Research Ltd filed Critical Institute for Drugs Research Ltd
Publication of DE2921022A1 publication Critical patent/DE2921022A1/de
Application granted granted Critical
Publication of DE2921022C2 publication Critical patent/DE2921022C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
    • C12P19/485—Having two saccharide radicals bound through only oxygen to non-adjacent ring carbons of the cyclohexyl radical, e.g. gentamycin, kanamycin, sisomycin, verdamycin, mutamycin, tobramycin, nebramycin, antibiotics 66-40B, 66-40D, XK-62-2, 66-40, G-418, G-52
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE19792921022 1978-05-23 1979-05-23 Verfahren zur mikrobiologischen herstellung des nebramycin-komplexes Granted DE2921022A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU78GO1404A HU176103B (en) 1978-05-23 1978-05-23 Microbiological process for producing nebramycin complex

Publications (2)

Publication Number Publication Date
DE2921022A1 DE2921022A1 (de) 1979-11-29
DE2921022C2 true DE2921022C2 (en, 2012) 1987-10-15

Family

ID=10996858

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19792921022 Granted DE2921022A1 (de) 1978-05-23 1979-05-23 Verfahren zur mikrobiologischen herstellung des nebramycin-komplexes

Country Status (4)

Country Link
AT (1) AT363180B (en, 2012)
DE (1) DE2921022A1 (en, 2012)
FR (1) FR2426736B1 (en, 2012)
HU (1) HU176103B (en, 2012)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1178489A (en) * 1967-04-04 1970-01-21 Lilly Co Eli Tenebrimycin Antibiotics
US3691279A (en) * 1970-04-15 1972-09-12 Lilly Co Eli Antibiotic nebramycin and preparation thereof
US3853709A (en) * 1970-10-26 1974-12-10 Lilly Co Eli Process for preparing nebramycin factors ii and vii
US3876767A (en) * 1972-02-04 1975-04-08 Lilly Co Eli Treatment of swine dysentery with apramycin
US4032404A (en) * 1976-07-14 1977-06-28 Bristol-Myers Company Fermentation process for producing apramycin and nebramycin factor V'

Also Published As

Publication number Publication date
HU176103B (en) 1980-12-28
DE2921022A1 (de) 1979-11-29
FR2426736A1 (fr) 1979-12-21
FR2426736B1 (fr) 1985-08-09
AT363180B (de) 1981-07-10
ATA357279A (de) 1980-12-15

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee