DE29624309U1 - Dauertraglinsen - Google Patents
DauertraglinsenInfo
- Publication number
- DE29624309U1 DE29624309U1 DE29624309U DE29624309U DE29624309U1 DE 29624309 U1 DE29624309 U1 DE 29624309U1 DE 29624309 U DE29624309 U DE 29624309U DE 29624309 U DE29624309 U DE 29624309U DE 29624309 U1 DE29624309 U1 DE 29624309U1
- Authority
- DE
- Germany
- Prior art keywords
- lens
- ophthalmic lens
- ophthalmic
- macromer
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000463 material Substances 0.000 claims description 213
- 239000000203 mixture Substances 0.000 claims description 210
- -1 poly(dimethylsiloxane) Polymers 0.000 claims description 156
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 153
- 238000000034 method Methods 0.000 claims description 151
- 229910052760 oxygen Inorganic materials 0.000 claims description 128
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 127
- 239000001301 oxygen Substances 0.000 claims description 127
- 230000035699 permeability Effects 0.000 claims description 124
- 229920000642 polymer Polymers 0.000 claims description 93
- 125000004432 carbon atom Chemical group C* 0.000 claims description 88
- 230000010220 ion permeability Effects 0.000 claims description 86
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 61
- 239000000178 monomer Substances 0.000 claims description 59
- 238000006116 polymerization reaction Methods 0.000 claims description 58
- 125000002947 alkylene group Chemical group 0.000 claims description 57
- 125000000217 alkyl group Chemical group 0.000 claims description 48
- 229920001296 polysiloxane Polymers 0.000 claims description 47
- 150000002500 ions Chemical class 0.000 claims description 41
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 38
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 32
- 239000003570 air Substances 0.000 claims description 31
- 229910052757 nitrogen Inorganic materials 0.000 claims description 29
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 27
- 210000004087 cornea Anatomy 0.000 claims description 26
- 239000011162 core material Substances 0.000 claims description 24
- 238000009792 diffusion process Methods 0.000 claims description 24
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 24
- 239000007789 gas Substances 0.000 claims description 22
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 20
- 239000012530 fluid Substances 0.000 claims description 20
- 230000008961 swelling Effects 0.000 claims description 20
- 229910052786 argon Inorganic materials 0.000 claims description 19
- 229920005862 polyol Polymers 0.000 claims description 19
- 150000003077 polyols Chemical class 0.000 claims description 17
- 125000003342 alkenyl group Chemical group 0.000 claims description 16
- 230000036541 health Effects 0.000 claims description 16
- 239000003431 cross linking reagent Substances 0.000 claims description 12
- 230000037361 pathway Effects 0.000 claims description 12
- 125000003118 aryl group Chemical group 0.000 claims description 11
- 238000000576 coating method Methods 0.000 claims description 11
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 10
- 239000011248 coating agent Substances 0.000 claims description 10
- 239000012634 fragment Substances 0.000 claims description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- 230000002035 prolonged effect Effects 0.000 claims description 10
- 239000007983 Tris buffer Substances 0.000 claims description 9
- 230000005660 hydrophilic surface Effects 0.000 claims description 9
- 230000000379 polymerizing effect Effects 0.000 claims description 9
- 239000001257 hydrogen Substances 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 238000012937 correction Methods 0.000 claims description 6
- 150000002894 organic compounds Chemical class 0.000 claims description 6
- 229910001415 sodium ion Inorganic materials 0.000 claims description 6
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 5
- 125000004966 cyanoalkyl group Chemical group 0.000 claims description 5
- 125000002993 cycloalkylene group Chemical group 0.000 claims description 5
- 238000012377 drug delivery Methods 0.000 claims description 5
- 230000004048 modification Effects 0.000 claims description 5
- 238000012986 modification Methods 0.000 claims description 5
- 239000003732 agents acting on the eye Substances 0.000 claims description 4
- 238000000691 measurement method Methods 0.000 claims description 4
- 229940023490 ophthalmic product Drugs 0.000 claims description 4
- 230000029663 wound healing Effects 0.000 claims description 4
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 3
- 230000009477 glass transition Effects 0.000 claims description 3
- 230000003287 optical effect Effects 0.000 claims description 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 241000219739 Lens Species 0.000 description 353
- 239000000243 solution Substances 0.000 description 73
- 230000008569 process Effects 0.000 description 58
- 238000012360 testing method Methods 0.000 description 56
- 150000003254 radicals Chemical class 0.000 description 49
- 244000309464 bull Species 0.000 description 47
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 41
- 238000006243 chemical reaction Methods 0.000 description 41
- 150000001875 compounds Chemical class 0.000 description 39
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 36
- 238000005259 measurement Methods 0.000 description 34
- 230000033001 locomotion Effects 0.000 description 31
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 30
- 239000002904 solvent Substances 0.000 description 27
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 24
- 238000004519 manufacturing process Methods 0.000 description 23
- 239000000047 product Substances 0.000 description 23
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical class C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 20
- 230000000694 effects Effects 0.000 description 20
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 20
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 20
- RBQRWNWVPQDTJJ-UHFFFAOYSA-N methacryloyloxyethyl isocyanate Chemical compound CC(=C)C(=O)OCCN=C=O RBQRWNWVPQDTJJ-UHFFFAOYSA-N 0.000 description 20
- 239000012298 atmosphere Substances 0.000 description 19
- 239000000523 sample Substances 0.000 description 19
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 18
- UKLDJPRMSDWDSL-UHFFFAOYSA-L [dibutyl(dodecanoyloxy)stannyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[Sn](CCCC)(CCCC)OC(=O)CCCCCCCCCCC UKLDJPRMSDWDSL-UHFFFAOYSA-L 0.000 description 18
- 239000012975 dibutyltin dilaurate Substances 0.000 description 18
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 18
- 125000000732 arylene group Chemical group 0.000 description 17
- NIMLQBUJDJZYEJ-UHFFFAOYSA-N isophorone diisocyanate Chemical compound CC1(C)CC(N=C=O)CC(C)(CN=C=O)C1 NIMLQBUJDJZYEJ-UHFFFAOYSA-N 0.000 description 17
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 16
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 16
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 16
- 239000012299 nitrogen atmosphere Substances 0.000 description 16
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 16
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 16
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 16
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 16
- 239000005058 Isophorone diisocyanate Substances 0.000 description 15
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 15
- 230000015572 biosynthetic process Effects 0.000 description 15
- 239000003054 catalyst Substances 0.000 description 15
- 210000004027 cell Anatomy 0.000 description 15
- 150000002148 esters Chemical class 0.000 description 15
- 238000004381 surface treatment Methods 0.000 description 15
- 229920006395 saturated elastomer Polymers 0.000 description 14
- 238000003786 synthesis reaction Methods 0.000 description 14
- BESKSSIEODQWBP-UHFFFAOYSA-N 3-tris(trimethylsilyloxy)silylpropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C BESKSSIEODQWBP-UHFFFAOYSA-N 0.000 description 13
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 13
- 230000002209 hydrophobic effect Effects 0.000 description 13
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 12
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- 125000003277 amino group Chemical group 0.000 description 12
- 229920001577 copolymer Polymers 0.000 description 12
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 12
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 11
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 11
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 11
- 239000004205 dimethyl polysiloxane Substances 0.000 description 11
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 11
- 150000002596 lactones Chemical class 0.000 description 11
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 11
- CFVWNXQPGQOHRJ-UHFFFAOYSA-N 2-methylpropyl prop-2-enoate Chemical compound CC(C)COC(=O)C=C CFVWNXQPGQOHRJ-UHFFFAOYSA-N 0.000 description 10
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 10
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 10
- 239000012591 Dulbecco’s Phosphate Buffered Saline Substances 0.000 description 10
- 239000004743 Polypropylene Substances 0.000 description 10
- 125000003545 alkoxy group Chemical group 0.000 description 10
- 150000001408 amides Chemical class 0.000 description 10
- 125000005442 diisocyanate group Chemical group 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- 229920001155 polypropylene Polymers 0.000 description 10
- 230000005855 radiation Effects 0.000 description 10
- 238000004448 titration Methods 0.000 description 10
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 9
- XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 description 8
- 125000004103 aminoalkyl group Chemical group 0.000 description 8
- 150000001720 carbohydrates Chemical class 0.000 description 8
- 150000001735 carboxylic acids Chemical class 0.000 description 8
- 238000007872 degassing Methods 0.000 description 8
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 8
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 8
- 238000005497 microtitration Methods 0.000 description 8
- 239000002953 phosphate buffered saline Substances 0.000 description 8
- 239000011780 sodium chloride Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical compound CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- 239000008103 glucose Substances 0.000 description 7
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 description 7
- 150000002632 lipids Chemical class 0.000 description 7
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 7
- 229920001223 polyethylene glycol Polymers 0.000 description 7
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 6
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 6
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 6
- 230000002411 adverse Effects 0.000 description 6
- 125000005024 alkenyl aryl group Chemical group 0.000 description 6
- 230000001588 bifunctional effect Effects 0.000 description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 6
- 229940052303 ethers for general anesthesia Drugs 0.000 description 6
- 229920001519 homopolymer Polymers 0.000 description 6
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 6
- 239000012948 isocyanate Substances 0.000 description 6
- 150000002513 isocyanates Chemical class 0.000 description 6
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 6
- 239000010702 perfluoropolyether Substances 0.000 description 6
- 229920003023 plastic Polymers 0.000 description 6
- 239000004033 plastic Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 6
- WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 description 5
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 5
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 5
- 125000005250 alkyl acrylate group Chemical group 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 238000004132 cross linking Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 210000000744 eyelid Anatomy 0.000 description 5
- 230000004907 flux Effects 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 239000011261 inert gas Substances 0.000 description 5
- 239000000543 intermediate Substances 0.000 description 5
- 125000005395 methacrylic acid group Chemical group 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 239000002504 physiological saline solution Substances 0.000 description 5
- 239000002243 precursor Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 230000035484 reaction time Effects 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 238000010257 thawing Methods 0.000 description 5
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical class CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 description 5
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 5
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 4
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 4
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 4
- KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-vinylpyridine Chemical compound C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 description 4
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 4
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 229920000858 Cyclodextrin Polymers 0.000 description 4
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 4
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 4
- 239000005977 Ethylene Substances 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 4
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 4
- GYCMBHHDWRMZGG-UHFFFAOYSA-N Methylacrylonitrile Chemical compound CC(=C)C#N GYCMBHHDWRMZGG-UHFFFAOYSA-N 0.000 description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 150000003926 acrylamides Chemical class 0.000 description 4
- 125000005529 alkyleneoxy group Chemical group 0.000 description 4
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 4
- 239000007853 buffer solution Substances 0.000 description 4
- 239000012159 carrier gas Substances 0.000 description 4
- 239000013256 coordination polymer Substances 0.000 description 4
- 229940097362 cyclodextrins Drugs 0.000 description 4
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 4
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
- FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 description 4
- 150000002170 ethers Chemical class 0.000 description 4
- 235000012209 glucono delta-lactone Nutrition 0.000 description 4
- 229960003681 gluconolactone Drugs 0.000 description 4
- 150000008282 halocarbons Chemical class 0.000 description 4
- UFFSXJKVKBQEHC-UHFFFAOYSA-N heptafluorobutyric anhydride Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(=O)OC(=O)C(F)(F)C(F)(F)C(F)(F)F UFFSXJKVKBQEHC-UHFFFAOYSA-N 0.000 description 4
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 4
- 229930195733 hydrocarbon Natural products 0.000 description 4
- 150000002430 hydrocarbons Chemical class 0.000 description 4
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- B29D11/00009—Production of simple or compound lenses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
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Landscapes
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| EP96908116A EP0819258B1 (en) | 1995-04-04 | 1996-03-22 | Extended wear ophthalmic lens |
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| DE102011055683A1 (de) | 2011-11-24 | 2013-05-29 | Götz von Foerster | Synthetisches Schmiermittel zur Verwendung als Synovialflüssigkeitsersatz |
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-
1996
- 1996-03-22 DE DE29624309U patent/DE29624309U1/de not_active Expired - Lifetime
- 1996-03-22 SI SI9630391T patent/SI0819258T1/xx unknown
- 1996-04-02 AR AR33601496A patent/AR001497A1/es unknown
- 1996-05-07 US US08/952,416 patent/US6043328A/en not_active Expired - Lifetime
- 1996-05-07 CA CA002220217A patent/CA2220217A1/en not_active Abandoned
- 1996-05-07 WO PCT/EP1996/001888 patent/WO1996036890A1/en not_active Ceased
- 1996-05-07 AU AU58144/96A patent/AU5814496A/en not_active Abandoned
- 1996-05-07 EP EP96919684A patent/EP0826158B1/en not_active Expired - Lifetime
- 1996-05-07 BR BR9608824A patent/BR9608824A/pt not_active Application Discontinuation
- 1996-05-07 CN CN96194388A patent/CN1186550A/zh active Pending
- 1996-05-07 PL PL96323350A patent/PL323350A1/xx unknown
- 1996-05-07 AT AT96919684T patent/ATE184708T1/de not_active IP Right Cessation
- 1996-05-07 KR KR1019970708306A patent/KR19990021832A/ko not_active Withdrawn
- 1996-05-07 CZ CZ973639A patent/CZ363997A3/cs unknown
- 1996-05-07 HU HU9801139A patent/HUP9801139A3/hu unknown
- 1996-05-07 JP JP53451396A patent/JP5048173B2/ja not_active Expired - Fee Related
- 1996-05-07 DE DE69604285T patent/DE69604285T2/de not_active Expired - Lifetime
- 1996-05-13 IL IL11823796A patent/IL118237A0/xx unknown
- 1996-05-17 ZA ZA963937A patent/ZA963937B/xx unknown
-
1997
- 1997-11-18 NO NO975289A patent/NO975289L/no unknown
-
2011
- 2011-05-18 JP JP2011111611A patent/JP2011225884A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102011055683A1 (de) | 2011-11-24 | 2013-05-29 | Götz von Foerster | Synthetisches Schmiermittel zur Verwendung als Synovialflüssigkeitsersatz |
| WO2013076271A1 (de) | 2011-11-24 | 2013-05-30 | Von Foerster Goetz | Synthetisches schmiermittel zur verwendung als synovialflüssigkeitsersatz |
Also Published As
| Publication number | Publication date |
|---|---|
| AR001497A1 (es) | 1997-10-22 |
| JPH11505564A (ja) | 1999-05-21 |
| US6043328A (en) | 2000-03-28 |
| HUP9801139A3 (en) | 1998-10-28 |
| NO975289L (no) | 1998-01-16 |
| MX9708910A (es) | 1998-03-31 |
| PL323350A1 (en) | 1998-03-30 |
| NO975289D0 (no) | 1997-11-18 |
| DE69604285D1 (de) | 1999-10-21 |
| CA2220217A1 (en) | 1996-11-21 |
| EP0826158B1 (en) | 1999-09-15 |
| IL118237A0 (en) | 1996-09-12 |
| SI0819258T1 (en) | 2002-04-30 |
| HUP9801139A2 (hu) | 1998-09-28 |
| KR19990021832A (ko) | 1999-03-25 |
| JP2011225884A (ja) | 2011-11-10 |
| CZ363997A3 (cs) | 1998-03-18 |
| ATE184708T1 (de) | 1999-10-15 |
| CN1186550A (zh) | 1998-07-01 |
| ZA963937B (en) | 1997-01-06 |
| DE69604285T2 (de) | 2000-03-23 |
| BR9608824A (pt) | 1999-06-15 |
| EP0826158A1 (en) | 1998-03-04 |
| AU5814496A (en) | 1996-11-29 |
| JP5048173B2 (ja) | 2012-10-17 |
| WO1996036890A1 (en) | 1996-11-21 |
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