DE2845770A1 - Neue prostacyclin-derivate und verfahren zu ihrer herstellung - Google Patents

Neue prostacyclin-derivate und verfahren zu ihrer herstellung

Info

Publication number
DE2845770A1
DE2845770A1 DE19782845770 DE2845770A DE2845770A1 DE 2845770 A1 DE2845770 A1 DE 2845770A1 DE 19782845770 DE19782845770 DE 19782845770 DE 2845770 A DE2845770 A DE 2845770A DE 2845770 A1 DE2845770 A1 DE 2845770A1
Authority
DE
Germany
Prior art keywords
hydroxy
bicyclo
octan
pentanoic acid
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19782845770
Other languages
German (de)
English (en)
Inventor
Jorge Dr Casals
Wolfgang Prof Losert
Gerda Dr Mannesmann
Bernd Dr Raduechel
Werner Dr Skuballa
Helmut Prof Vorbrueggen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE19782845770 priority Critical patent/DE2845770A1/de
Priority to GR60293A priority patent/GR72247B/el
Priority to DD79216259A priority patent/DD146594B3/de
Priority to IL58475A priority patent/IL58475A/xx
Priority to PH23193A priority patent/PH20359A/en
Priority to YU2530/79A priority patent/YU41668B/xx
Priority to MX79101239U priority patent/MX5713E/es
Priority to AT79710099T priority patent/ATE1283T1/de
Priority to DE7979710099T priority patent/DE2963260D1/de
Priority to SU792837202A priority patent/SU1003754A3/ru
Priority to NO793353A priority patent/NO151318C/no
Priority to HU79SCHE698A priority patent/HU184926B/hu
Priority to EP79710099A priority patent/EP0011591B1/de
Priority to JP13503779A priority patent/JPS5557559A/ja
Priority to CA000338081A priority patent/CA1181747A/en
Priority to DK441479A priority patent/DK160246C/da
Priority to NZ191827A priority patent/NZ191827A/xx
Priority to ES485199A priority patent/ES485199A1/es
Priority to FI793263A priority patent/FI69056C/fi
Priority to IE1993/79A priority patent/IE49085B1/en
Priority to CS797108A priority patent/CS219260B2/cs
Priority to AU51987/79A priority patent/AU534090B2/en
Priority to ZA00795598A priority patent/ZA795598B/xx
Publication of DE2845770A1 publication Critical patent/DE2845770A1/de
Priority to SU813242701A priority patent/SU1310390A1/ru
Priority to US06/352,411 priority patent/US4692464A/en
Priority to MX9203690A priority patent/MX9203690A/es
Priority to LU88288C priority patent/LU88288I2/fr
Priority to NL930070C priority patent/NL930070I2/nl
Priority to NO1995010C priority patent/NO1995010I1/no
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
DE19782845770 1978-10-19 1978-10-19 Neue prostacyclin-derivate und verfahren zu ihrer herstellung Withdrawn DE2845770A1 (de)

Priority Applications (29)

Application Number Priority Date Filing Date Title
DE19782845770 DE2845770A1 (de) 1978-10-19 1978-10-19 Neue prostacyclin-derivate und verfahren zu ihrer herstellung
GR60293A GR72247B (enExample) 1978-10-19 1979-10-07
DD79216259A DD146594B3 (de) 1978-10-19 1979-10-16 Verfahren zur herstellung von prostanderivaten
IL58475A IL58475A (en) 1978-10-19 1979-10-17 Carbaprostacyclin derivatives,process for their preparation and pharmaceutical compositions containing them
PH23193A PH20359A (en) 1978-10-19 1979-10-18 Carbacylin derivatives, pharmaceutical preparations containing same and process of preparing same
YU2530/79A YU41668B (en) 1978-10-19 1979-10-18 Process for obtaining prostane derivatives
MX79101239U MX5713E (es) 1978-10-19 1979-10-18 Procedimiento para la preparacion de derivados de prostaciclina
AT79710099T ATE1283T1 (de) 1978-10-19 1979-10-18 Neue prostanderivate, ihre herstellung und sie enthaltende arzneimittel.
DE7979710099T DE2963260D1 (en) 1978-10-19 1979-10-18 Prostane derivatives, their production and pharmaceutical compositions containing them
SU792837202A SU1003754A3 (ru) 1978-10-19 1979-10-18 Способ получени производных простациклина или их солей
NO793353A NO151318C (no) 1978-10-19 1979-10-18 Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive carbacyclinderivater
HU79SCHE698A HU184926B (en) 1978-10-19 1979-10-18 Process for producing new carbo-prostacyclin derivatives
EP79710099A EP0011591B1 (de) 1978-10-19 1979-10-18 Neue Prostanderivate, ihre Herstellung und sie enthaltende Arzneimittel
DK441479A DK160246C (da) 1978-10-19 1979-10-19 Analogifremgangsmaade til fremstilling af carbacyclinderivater
ZA00795598A ZA795598B (en) 1978-10-19 1979-10-19 Prostacyclin derivatives
JP13503779A JPS5557559A (en) 1978-10-19 1979-10-19 Prostane derivative*its manufacture and antihypertensive drug containing it
NZ191827A NZ191827A (en) 1978-10-19 1979-10-19 Prostacyclin derivatives and pharmaceutical compositions
ES485199A ES485199A1 (es) 1978-10-19 1979-10-19 Procedimiento para la preparacion de derivados prostanicos
FI793263A FI69056C (fi) 1978-10-19 1979-10-19 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara karbacyklinderivat
IE1993/79A IE49085B1 (en) 1978-10-19 1979-10-19 Improvements in or relating to prostacyclin derivatives
CS797108A CS219260B2 (en) 1978-10-19 1979-10-19 Method of making the prostacycline derivatives
AU51987/79A AU534090B2 (en) 1978-10-19 1979-10-19 Prostacyclins
CA000338081A CA1181747A (en) 1978-10-19 1979-10-19 Prostacyclin derivatives
SU813242701A SU1310390A1 (ru) 1978-10-19 1981-02-12 Производное простагландина,обладающее снижающим давление крови и бронхорасшир ющим действием
US06/352,411 US4692464A (en) 1978-10-19 1982-02-26 Novel prostacyclin derivatives and a process for the preparation thereof
MX9203690A MX9203690A (es) 1978-10-19 1992-06-29 Nuevos derivados de prostano, su obtencion y medicamentos que los contienen.
LU88288C LU88288I2 (fr) 1978-10-19 1993-06-09 Lloprost, sel de trometamol (llomedin
NL930070C NL930070I2 (nl) 1978-10-19 1993-06-14 Nieuwe prostaanderivaten, de bereiding daarvan, alsmede deze verbindingen bevattende geneesmiddelen.
NO1995010C NO1995010I1 (no) 1978-10-19 1995-12-19 Iloprost trometamol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782845770 DE2845770A1 (de) 1978-10-19 1978-10-19 Neue prostacyclin-derivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DE2845770A1 true DE2845770A1 (de) 1980-04-30

Family

ID=6052699

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19782845770 Withdrawn DE2845770A1 (de) 1978-10-19 1978-10-19 Neue prostacyclin-derivate und verfahren zu ihrer herstellung
DE7979710099T Expired DE2963260D1 (en) 1978-10-19 1979-10-18 Prostane derivatives, their production and pharmaceutical compositions containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE7979710099T Expired DE2963260D1 (en) 1978-10-19 1979-10-18 Prostane derivatives, their production and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US4692464A (enExample)
EP (1) EP0011591B1 (enExample)
JP (1) JPS5557559A (enExample)
AT (1) ATE1283T1 (enExample)
AU (1) AU534090B2 (enExample)
CA (1) CA1181747A (enExample)
CS (1) CS219260B2 (enExample)
DD (1) DD146594B3 (enExample)
DE (2) DE2845770A1 (enExample)
DK (1) DK160246C (enExample)
ES (1) ES485199A1 (enExample)
FI (1) FI69056C (enExample)
GR (1) GR72247B (enExample)
HU (1) HU184926B (enExample)
IE (1) IE49085B1 (enExample)
IL (1) IL58475A (enExample)
LU (1) LU88288I2 (enExample)
MX (1) MX9203690A (enExample)
NL (1) NL930070I2 (enExample)
NO (2) NO151318C (enExample)
NZ (1) NZ191827A (enExample)
PH (1) PH20359A (enExample)
SU (2) SU1003754A3 (enExample)
YU (1) YU41668B (enExample)
ZA (1) ZA795598B (enExample)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2902442A1 (de) * 1978-01-26 1979-08-30 Erba Farmitalia 9-deoxy-9a-methylen-isostere von pgi tief 2 , verfahren zu ihrer herstellung und sie enthaltende pharmazeutische und veterinaermedizinische mittel
DE3121155A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2954373A1 (enExample) * 1978-01-06 1985-03-21
US4533749A (en) * 1982-02-16 1985-08-06 The Upjohn Company 9-Substituted carbacyclin analogs
US4708963A (en) * 1980-12-19 1987-11-24 Schering Aktiengesellschaft Novel carbacyclins, their preparation and use
DE3839155A1 (de) * 1988-11-17 1990-05-23 Schering Ag Verfahren zur herstellung von carbacyclin-derivaten durch stereoselektive einfuehrung der 5,6-doppelbindung
DE4104606C1 (enExample) * 1991-02-12 1992-10-15 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De
US5221763A (en) * 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3021895A1 (de) * 1980-06-06 1981-12-24 Schering Ag Berlin Und Bergkamen, 1000 Berlin Neues verfahren zur herstellung von carbacyclin-zwischenprodukten
DE3104044A1 (de) * 1981-02-02 1982-08-26 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue prostacyclin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3204443A1 (de) * 1982-02-08 1983-08-18 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3306125A1 (de) * 1983-02-18 1984-08-23 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
GB2129427B (en) * 1982-10-01 1986-01-08 Erba Farmitalia 15-cycloaliphatic derivatives of 13,14-didehydrocarboprostacyclins and process for their preparation
HU191110B (en) * 1982-10-01 1987-01-28 Farmitala Carlo Erba Spa,It Process for the production of the 15-cycloaliphatic derivatives 13,14-didehydro-carbaprostacyclines
ES8705382A1 (es) * 1983-07-26 1987-05-01 Sankyo Co Un procedimiento para la preparacion de nuevos derivados de carbaciclina.
DE3408699A1 (de) * 1984-03-08 1985-09-12 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB2156341B (en) * 1984-03-26 1987-10-21 Erba Farmitalia Furyl and imidazolyl derivatives of carboprostacyclins and process for their preparation
GB2156343B (en) * 1984-03-26 1988-01-13 Erbo Spa Farmitalia Carlo 13,14,19,19,20,20-hexadehydro derivatives of carboprostacyclins and process for their preparation
DE3427797A1 (de) * 1984-07-25 1986-02-06 Schering AG, 1000 Berlin und 4709 Bergkamen Zytoprotektive wirkung von prostacyclin-derivaten an leber, bauchspeicheldruese und niere
DE3448256C2 (en) * 1984-07-25 1988-08-18 Schering Ag, 1000 Berlin Und 4709 Bergkamen, De Cytoprotective action of prostacyclin derivatives on the pancreas
DE3428266A1 (de) * 1984-07-27 1986-01-30 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0195379B1 (en) * 1985-03-18 1991-04-03 G.D. Searle & Co. Allenic prostacyclins
JPS6216A (ja) * 1985-03-19 1987-01-06 Sankyo Co Ltd カルバサイクリン類及びこれを有効成分とする抗潰瘍剤
DE3608088C2 (de) * 1986-03-07 1995-11-16 Schering Ag Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
US5663203A (en) * 1986-09-11 1997-09-02 Schering Aktiengesellschaft Agents containing prostacyclin derivatives for topical application
DE3631169A1 (de) * 1986-09-11 1988-03-24 Schering Ag Prostacyclinderivate enthaltende mittel fuer die topische anwendung
IL87116A (en) 1987-07-17 1993-03-15 Schering Ag 9-halogen-(z)-prostaglandin derivatives and pharmaceutical compositions containing the same
US5891910A (en) * 1987-07-17 1999-04-06 Schering Aktiengesellschaft 9-halogen-(Z) prostaglandin derivatives, process for their production and their use as pharmaceutical agents
DE4010355A1 (de) * 1990-03-28 1991-10-02 Schering Ag Bicyclo(3.3.0)octan-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DE4104607A1 (de) * 1991-02-12 1992-08-13 Schering Ag Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen
DE4135193C1 (enExample) * 1991-10-22 1993-03-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De
US5654339A (en) * 1992-08-07 1997-08-05 Schering Aktiengesellschaft Use of prostane derivatives of formulate I and II for treatment of chronic polyarthritis
DE4226615C1 (de) * 1992-08-07 1994-05-19 Schering Ag Verwendung von Prostan-Derivaten zur Behandlung von chronischer Polyarthritis
US5534589A (en) * 1994-05-04 1996-07-09 Minnesota Mining And Manufacturing Company Repulpable plastic films
DE69534075T2 (de) * 1994-06-07 2005-07-21 Chugai Seiyaku K.K. Vorbeugungs- und heilmittel für erkrankungen, die durch fibrin- oder thrombusbildung hervorgerufen werden
DE19530884C2 (de) * 1995-08-11 1997-07-31 Schering Ag Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis
DE19828881A1 (de) * 1998-06-22 1999-12-23 Schering Ag Oxidationsinhibitor bei Prostan-Derivaten
WO2000002450A1 (en) * 1998-07-08 2000-01-20 Fibrogen, Inc. Method for treatment of fibrosis related diseases by the administration of prostacyclin derivatives
RS20050106A (sr) 2002-08-19 2007-11-15 Pfizer Products Inc., Kombinovana terapija hiperproliferativnih bolesti
JPWO2004032964A1 (ja) * 2002-10-10 2006-02-09 国立大学法人京都大学 アレルギー性疾患治療剤
US20050043391A1 (en) * 2003-07-17 2005-02-24 Fong Benson M. Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
US20070270489A1 (en) 2003-07-25 2007-11-22 Ono Pharmaceutical Co., Ltd. Remedy for Cartilage-Related Diseases
US20090124697A1 (en) 2003-12-16 2009-05-14 United Therapeutics Corporation Inhalation formulations of treprostinil
CN101647792B (zh) * 2003-12-16 2012-11-28 联合治疗公司 曲前列环素在制备治疗和预防缺血性损害的药物中的用途
CN101090714A (zh) * 2004-07-26 2007-12-19 康泽里克斯公司 通过吸入伊洛前列素和微粒制剂治疗肺动脉高血压症
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
ATE551059T1 (de) * 2005-10-26 2012-04-15 Asahi Kasei Pharma Corp Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie
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DK160246C (da) 1991-07-22
DD146594B3 (de) 1989-09-06
IL58475A (en) 1989-09-10
IL58475A0 (en) 1980-01-31
NL930070I2 (nl) 1994-01-03
JPS5557559A (en) 1980-04-28
EP0011591A1 (de) 1980-05-28
ATE1283T1 (de) 1982-07-15
ES485199A1 (es) 1980-05-16
HU184926B (en) 1984-11-28
NZ191827A (en) 1982-05-25
JPS6312051B2 (enExample) 1988-03-17
CA1181747A (en) 1985-01-29
PH20359A (en) 1986-12-04
US4692464A (en) 1987-09-08
DE2963260D1 (en) 1982-08-19
NO151318B (no) 1984-12-10
YU253079A (en) 1983-01-21
DK441479A (da) 1980-04-20
DK160246B (da) 1991-02-18
LU88288I2 (fr) 1994-05-04
NL930070I1 (nl) 1993-09-01
SU1003754A3 (ru) 1983-03-07
GR72247B (enExample) 1983-10-05
SU1310390A1 (ru) 1987-05-15
NO1995010I1 (no) 1995-12-19
EP0011591B1 (de) 1982-06-30
FI69056B (fi) 1985-08-30
MX9203690A (es) 1992-09-01
AU534090B2 (en) 1984-01-05
IE791993L (en) 1980-04-19
YU41668B (en) 1987-12-31
CS219260B2 (en) 1983-03-25
DD146594A5 (de) 1981-02-18
ZA795598B (en) 1980-10-29
NO793353L (no) 1980-04-22
AU5198779A (en) 1980-04-24
IE49085B1 (en) 1985-07-24
FI69056C (fi) 1985-12-10
NO151318C (no) 1985-03-20
FI793263A7 (fi) 1980-04-20

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