JPS54119441A - Novel bicyclooctane derivative - Google Patents
Novel bicyclooctane derivativeInfo
- Publication number
- JPS54119441A JPS54119441A JP2733278A JP2733278A JPS54119441A JP S54119441 A JPS54119441 A JP S54119441A JP 2733278 A JP2733278 A JP 2733278A JP 2733278 A JP2733278 A JP 2733278A JP S54119441 A JPS54119441 A JP S54119441A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- endo
- group
- hydroxymethyl
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NLUNLVTVUDIHFE-UHFFFAOYSA-N cyclooctylcyclooctane Chemical class C1CCCCCCC1C1CCCCCCC1 NLUNLVTVUDIHFE-UHFFFAOYSA-N 0.000 title abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Chemical group 0.000 abstract 1
- 241000282320 Panthera leo Species 0.000 abstract 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
- C07C49/507—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
- C07C49/513—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
NEW MATERIAL:A bicyclooctane devivative of formula I: (R is 4W7C alkyl group; R1 is H or lower alkyl group; X is vinylene or ethylene chain; A is lowe alkylene or single bond).
EXAMPLE: Bicyclo[2.2.1] heptane-endo-2-hydroxymethyl-endo-3-caroboxy -endo-5- hydroxymethyl-γ-lactone.
USE: Medicines expected to have anti-agglutinating actions on the blood platelet.
PROCESS: A compound of formula II: (Y is H or OH-protecting group) is reacted with a phosphorane of formula III: (R' is aryl group) prepared from the witting reagent in the presence of a solvent, e.g. diethyl ether, and, if present, the OH- protecing group is removed, and , if desired, the reaction product is esterified to give the objective compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2733278A JPS54119441A (en) | 1978-03-09 | 1978-03-09 | Novel bicyclooctane derivative |
FR7905846A FR2419271A1 (en) | 1978-03-09 | 1979-03-07 | NEW BICYCLO-OCTANIC DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS |
ES478384A ES478384A1 (en) | 1978-03-09 | 1979-03-07 | Bicyclooctanes, processes for producing them and pharmaceutical compositions containing them |
NL7901818A NL7901818A (en) | 1978-03-09 | 1979-03-07 | NEW BICYCLO-OCTAAN DERIVATIVES, METHOD FOR PREPARING THESE COMPOUNDS, AND PHARMACEUTICAL PREPARATIONS CONTAINING SUCH COMPOUND. |
AT0172179A AT364097B (en) | 1978-03-09 | 1979-03-07 | METHOD FOR PRODUCING NEW BICYCLOOCTAN DERIVATIVES |
AU44930/79A AU4493079A (en) | 1978-03-09 | 1979-03-08 | Bicyclooctane derivatives |
GB7908169A GB2019847B (en) | 1978-03-09 | 1979-03-08 | Bicyclooctanes processes for producing them and pharmaceutical compositions containing them |
SE7902083A SE7902083L (en) | 1978-03-09 | 1979-03-08 | BICYCLE LOCK DERIVATIVES FOR USE AS AN AGAINST THROMBOSIS |
IT7948266A IT7948266A0 (en) | 1978-03-09 | 1979-03-08 | PROCEDURE FOR THE PREPARATION OF BICYCLOOTTANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE PRODUCT OBTAINED |
DK97179A DK97179A (en) | 1978-03-09 | 1979-03-08 | BICYCLOOCTAN DERIVATIVES AND THEIR MANUFACTURE AND USE |
BE0/193893A BE874683A (en) | 1978-03-09 | 1979-03-08 | NEW BICYCLO-OCTANIC DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS |
DE19792909088 DE2909088A1 (en) | 1978-03-09 | 1979-03-08 | BICYCLOOCTAN DERIVATIVES, THE PROCESS FOR THEIR PRODUCTION AND THEIR USE IN THE CONTROL OF THROMBOSIS |
GB7935144A GB2030144B (en) | 1978-03-09 | 1979-03-08 | Keto-bicyclooctanes |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2733278A JPS54119441A (en) | 1978-03-09 | 1978-03-09 | Novel bicyclooctane derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54119441A true JPS54119441A (en) | 1979-09-17 |
Family
ID=12218104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2733278A Pending JPS54119441A (en) | 1978-03-09 | 1978-03-09 | Novel bicyclooctane derivative |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS54119441A (en) |
AT (1) | AT364097B (en) |
AU (1) | AU4493079A (en) |
BE (1) | BE874683A (en) |
DE (1) | DE2909088A1 (en) |
DK (1) | DK97179A (en) |
ES (1) | ES478384A1 (en) |
FR (1) | FR2419271A1 (en) |
GB (2) | GB2030144B (en) |
IT (1) | IT7948266A0 (en) |
NL (1) | NL7901818A (en) |
SE (1) | SE7902083L (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5557559A (en) * | 1978-10-19 | 1980-04-28 | Schering Ag | Prostane derivative*its manufacture and antihypertensive drug containing it |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2040928B (en) * | 1978-01-26 | 1982-12-08 | Erba Farmitalia | Bicycloalkane derivatives useful as intermediates in preparing pg1 isosteres |
CA1201712A (en) * | 1980-02-28 | 1986-03-11 | Paul A. Aristoff | Carbacyclin analogs |
DE3021895A1 (en) * | 1980-06-06 | 1981-12-24 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | NEW METHOD FOR PRODUCING CARBACYCLIN INTERMEDIATE PRODUCTS |
DE3048906A1 (en) * | 1980-12-19 | 1982-07-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
DE3121155A1 (en) * | 1981-05-22 | 1982-12-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
US4689349A (en) * | 1982-05-06 | 1987-08-25 | Cbd Corporation | Anti-tumor halo bicyclo alkanones |
AU546158B2 (en) * | 1982-05-06 | 1985-08-15 | Cbd Corp. | Cycloaliphatic pharmaceutical compounds |
US4689345A (en) * | 1982-05-06 | 1987-08-25 | Cbd Corporation | Oxygenated alkyl substituted bicyclo alkanes |
DE3225287A1 (en) * | 1982-07-02 | 1984-01-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | NEW CARBACYCLINAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5495552A (en) * | 1978-01-06 | 1979-07-28 | Sankyo Co Ltd | Prostacyline derivative and its preparation |
-
1978
- 1978-03-09 JP JP2733278A patent/JPS54119441A/en active Pending
-
1979
- 1979-03-07 NL NL7901818A patent/NL7901818A/en not_active Application Discontinuation
- 1979-03-07 ES ES478384A patent/ES478384A1/en not_active Expired
- 1979-03-07 FR FR7905846A patent/FR2419271A1/en active Granted
- 1979-03-07 AT AT0172179A patent/AT364097B/en not_active IP Right Cessation
- 1979-03-08 GB GB7935144A patent/GB2030144B/en not_active Expired
- 1979-03-08 DK DK97179A patent/DK97179A/en not_active Application Discontinuation
- 1979-03-08 IT IT7948266A patent/IT7948266A0/en unknown
- 1979-03-08 BE BE0/193893A patent/BE874683A/en not_active IP Right Cessation
- 1979-03-08 DE DE19792909088 patent/DE2909088A1/en not_active Withdrawn
- 1979-03-08 GB GB7908169A patent/GB2019847B/en not_active Expired
- 1979-03-08 SE SE7902083A patent/SE7902083L/en not_active Application Discontinuation
- 1979-03-08 AU AU44930/79A patent/AU4493079A/en not_active Abandoned
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5557559A (en) * | 1978-10-19 | 1980-04-28 | Schering Ag | Prostane derivative*its manufacture and antihypertensive drug containing it |
JPS6312051B2 (en) * | 1978-10-19 | 1988-03-17 | Schering Ag |
Also Published As
Publication number | Publication date |
---|---|
GB2030144B (en) | 1982-10-20 |
DE2909088A1 (en) | 1979-09-20 |
ES478384A1 (en) | 1979-08-01 |
GB2030144A (en) | 1980-04-02 |
GB2019847A (en) | 1979-11-07 |
ATA172179A (en) | 1981-02-15 |
AT364097B (en) | 1981-09-25 |
DK97179A (en) | 1979-09-10 |
SE7902083L (en) | 1979-09-10 |
BE874683A (en) | 1979-09-10 |
FR2419271A1 (en) | 1979-10-05 |
AU4493079A (en) | 1979-09-13 |
GB2019847B (en) | 1982-10-13 |
FR2419271B1 (en) | 1983-07-29 |
IT7948266A0 (en) | 1979-03-08 |
NL7901818A (en) | 1979-09-11 |
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