ES478384A1 - Bicyclooctanes, processes for producing them and pharmaceutical compositions containing them - Google Patents

Bicyclooctanes, processes for producing them and pharmaceutical compositions containing them

Info

Publication number
ES478384A1
ES478384A1 ES478384A ES478384A ES478384A1 ES 478384 A1 ES478384 A1 ES 478384A1 ES 478384 A ES478384 A ES 478384A ES 478384 A ES478384 A ES 478384A ES 478384 A1 ES478384 A1 ES 478384A1
Authority
ES
Spain
Prior art keywords
hydrogen
bicyclooctanes
processes
producing
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES478384A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of ES478384A1 publication Critical patent/ES478384A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
    • C07C49/507—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
    • C07C49/513—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The invention concerns a bicyclooctane derivative of the formula, < IMAGE > wherein A is optionally present and is C1-4 alkylene, R1 is hydrogen or C1-4 alkyl, R2 is hydrogen or C4-7 alkyl, R3 is hydrogen or C1-4 alkyl, X is optionally present and is ethylene or vinylene and R4 and R5 are each, independently of one another, hydrogen or a hydroxy-protecting group or a non- toxic salt. Such compounds wherein each of R4 and R5 is hydrogen are useful for prevention of thrombosis.
ES478384A 1978-03-09 1979-03-07 Bicyclooctanes, processes for producing them and pharmaceutical compositions containing them Expired ES478384A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2733278A JPS54119441A (en) 1978-03-09 1978-03-09 Novel bicyclooctane derivative

Publications (1)

Publication Number Publication Date
ES478384A1 true ES478384A1 (en) 1979-08-01

Family

ID=12218104

Family Applications (1)

Application Number Title Priority Date Filing Date
ES478384A Expired ES478384A1 (en) 1978-03-09 1979-03-07 Bicyclooctanes, processes for producing them and pharmaceutical compositions containing them

Country Status (12)

Country Link
JP (1) JPS54119441A (en)
AT (1) AT364097B (en)
AU (1) AU4493079A (en)
BE (1) BE874683A (en)
DE (1) DE2909088A1 (en)
DK (1) DK97179A (en)
ES (1) ES478384A1 (en)
FR (1) FR2419271A1 (en)
GB (2) GB2030144B (en)
IT (1) IT7948266A0 (en)
NL (1) NL7901818A (en)
SE (1) SE7902083L (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2038333B (en) * 1978-01-26 1982-10-06 Erba Farmitalia 12 -formyl- (20 12)octanor-9-deoxy-9 -methylene pgi derivatives
DE2845770A1 (en) * 1978-10-19 1980-04-30 Schering Ag NEW PROSTACYCLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
CA1201712A (en) * 1980-02-28 1986-03-11 Paul A. Aristoff Carbacyclin analogs
DE3021895A1 (en) * 1980-06-06 1981-12-24 Schering Ag Berlin Und Bergkamen, 1000 Berlin NEW METHOD FOR PRODUCING CARBACYCLIN INTERMEDIATE PRODUCTS
DE3048906A1 (en) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
DE3121155A1 (en) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
DE3378265D1 (en) * 1982-05-06 1988-11-24 Cbd Corp Cycloaliphatic pharmaceutical compounds
US4689345A (en) * 1982-05-06 1987-08-25 Cbd Corporation Oxygenated alkyl substituted bicyclo alkanes
US4689349A (en) * 1982-05-06 1987-08-25 Cbd Corporation Anti-tumor halo bicyclo alkanones
DE3225287A1 (en) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen NEW CARBACYCLINAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5495552A (en) * 1978-01-06 1979-07-28 Sankyo Co Ltd Prostacyline derivative and its preparation

Also Published As

Publication number Publication date
IT7948266A0 (en) 1979-03-08
FR2419271B1 (en) 1983-07-29
AT364097B (en) 1981-09-25
GB2030144B (en) 1982-10-20
AU4493079A (en) 1979-09-13
JPS54119441A (en) 1979-09-17
GB2019847B (en) 1982-10-13
BE874683A (en) 1979-09-10
FR2419271A1 (en) 1979-10-05
DE2909088A1 (en) 1979-09-20
GB2030144A (en) 1980-04-02
ATA172179A (en) 1981-02-15
GB2019847A (en) 1979-11-07
SE7902083L (en) 1979-09-10
NL7901818A (en) 1979-09-11
DK97179A (en) 1979-09-10

Similar Documents

Publication Publication Date Title
HUT36784A (en) Process for producing spasmolytic sulfanate derivatives and pharmaceutical compositions containing them as active agents
DE3069408D1 (en) 5-oxo- and 5-thioxoproline derivatives, process for their production and pharmaceutical compositions containing them
NO950849D0 (en) Derivatives of valproin and 2-valproic acid amides and use as anticonvulsants
ES8405398A1 (en) Diazabicyclo(3.3.1)nonanes.
DE2964211D1 (en) Complexes of 9-hydroxyalkyl-purines, processes for preparing them and therapeutical compositions containing the complexes as active ingredients
ES478384A1 (en) Bicyclooctanes, processes for producing them and pharmaceutical compositions containing them
GB1480995A (en) Germicidal disinfecting and antiseptic compositions
ES483289A1 (en) 1,2,3,5-Tetrahydroimidazothienopyrimidin-2-ones, a process for their preparation and pharmaceutical compositions.
HU9301388D0 (en) Method for producing hydroxy-ethylene-isoster type compounds of hiv-protease inhibiting effect containing dithiolamine-glycine
ES8304085A1 (en) Oxime esters, processes for their preparation, their use and compositions containing these esters.
ES8200689A1 (en) Acylated cephalosporin analogs, process for their preparation and pharmaceutical compositions comprising them.
IL80715A (en) Pyridine compounds,process for their preparation and pharmaceutical compositions containing them
JPS5746957A (en) Hydrophilic cotelomer and detergent composition containing same
ES2009925A6 (en) 5-Methoxy alkyl ammonium tetrahydrofurans and tetrahydrothiophenes as anti-PAF agents
DE3264556D1 (en) Sulfimines, their salts and their preparation, and pharmaceutical compositions containing them
ES8302702A1 (en) Lactam compounds, pharmaceutical preparations containing them, and processes for the preparation of these compounds and pharmaceutical preparations.
ES8406156A1 (en) N-pteridinyl ureas, process for their preparation and their use.
MY101628A (en) Sulfonamide compounds and salts thereof, herbicidal compositions containing them, and process for producing them.
ES471492A1 (en) Sulfur-containing derivatives of 4,4-dimethyl-2H,4H-isoquinoline-1,3-dione, and anticonvulsant and antihyperlipidemic compositions thereof
ES8506702A1 (en) Furyloxazolylacetic acid derivative, processes for preparing same and pharmaceutical composition.
ES8304540A1 (en) alpha -Substituted carboxamidoamine, process for its preparation and cleaning composition containing this compound
ES8101578A1 (en) Americanin
ES8402821A1 (en) New phenyloxoalkyl piperidines, methods for obtaining them and pharmaceutical compositions containing them.
GB1526938A (en) Derivatives of n-phenyl-n-aroylalanine and herbicidal compositions containing them
ES8203828A1 (en) Bis-(substituted phenoxyacetates) of N-alkyl-dialkanol amines, process for their preparation, and pharmaceutical compositions containing them.