DE2652678A1 - Antibiotica und verfahren zur herstellung derselben - Google Patents

Antibiotica und verfahren zur herstellung derselben

Info

Publication number
DE2652678A1
DE2652678A1 DE19762652678 DE2652678A DE2652678A1 DE 2652678 A1 DE2652678 A1 DE 2652678A1 DE 19762652678 DE19762652678 DE 19762652678 DE 2652678 A DE2652678 A DE 2652678A DE 2652678 A1 DE2652678 A1 DE 2652678A1
Authority
DE
Germany
Prior art keywords
fractions
solution
amidohydrolase
medium
column
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19762652678
Other languages
German (de)
English (en)
Inventor
Frederick Marvin Kahan
Jean Sawyer Kahan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2652678A1 publication Critical patent/DE2652678A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE19762652678 1975-11-24 1976-11-19 Antibiotica und verfahren zur herstellung derselben Withdrawn DE2652678A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63456075A 1975-11-24 1975-11-24

Publications (1)

Publication Number Publication Date
DE2652678A1 true DE2652678A1 (de) 1977-06-02

Family

ID=24544292

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19762652678 Withdrawn DE2652678A1 (de) 1975-11-24 1976-11-19 Antibiotica und verfahren zur herstellung derselben

Country Status (16)

Country Link
JP (1) JPS5265295A (es)
AR (1) AR224224A1 (es)
AU (1) AU510252B2 (es)
BE (1) BE848349A (es)
CH (1) CH625803A5 (es)
DE (1) DE2652678A1 (es)
DK (1) DK497476A (es)
ES (1) ES453508A1 (es)
FR (1) FR2351979A1 (es)
GB (1) GB1561108A (es)
GR (1) GR61407B (es)
HU (1) HU175266B (es)
NL (1) NL7612932A (es)
PT (1) PT65845B (es)
SE (1) SE7612295L (es)
ZA (1) ZA766986B (es)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000931A1 (en) * 1977-08-19 1979-03-07 Merck & Co. Inc. Enzymatic cleavage of N-acyl-thienamycins
EP0080166A1 (de) * 1981-11-21 1983-06-01 Hoechst Aktiengesellschaft Isolierung von chemisch instabilen Antibiotika aus Fermentationslösungen
WO2017132321A1 (en) * 2016-01-29 2017-08-03 The Johns Hopkins University Novel inhibitors of bacterial growth

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7800979L (sv) * 1977-02-11 1978-08-12 Merck & Co Inc Antibiotikum
SE7800978L (sv) * 1977-02-11 1978-08-12 Merck & Co Inc Antibiotikum
NZ190994A (en) 1978-07-24 1981-10-19 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates
ATE4224T1 (de) * 1979-08-28 1983-08-15 Merck & Co. Inc. Verfahren zur reinigung von thienamycin.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000931A1 (en) * 1977-08-19 1979-03-07 Merck & Co. Inc. Enzymatic cleavage of N-acyl-thienamycins
EP0080166A1 (de) * 1981-11-21 1983-06-01 Hoechst Aktiengesellschaft Isolierung von chemisch instabilen Antibiotika aus Fermentationslösungen
WO2017132321A1 (en) * 2016-01-29 2017-08-03 The Johns Hopkins University Novel inhibitors of bacterial growth
US10695322B2 (en) 2016-01-29 2020-06-30 The Johns Hopkins University Inhibitors of bacterial growth

Also Published As

Publication number Publication date
PT65845A (en) 1976-12-01
FR2351979A1 (fr) 1977-12-16
ZA766986B (en) 1978-06-28
AU510252B2 (en) 1980-06-19
PT65845B (en) 1978-10-10
GB1561108A (en) 1980-02-13
GR61407B (en) 1978-11-11
AU1964576A (en) 1978-05-25
DK497476A (da) 1977-05-25
AR224224A1 (es) 1981-11-13
HU175266B (hu) 1980-06-28
SE7612295L (sv) 1977-05-25
BE848349A (fr) 1977-05-16
CH625803A5 (en) 1981-10-15
FR2351979B1 (es) 1982-08-13
NL7612932A (nl) 1977-05-26
JPS5265295A (en) 1977-05-30
ES453508A1 (es) 1978-03-01

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8181 Inventor (new situation)

Free format text: SAWYER KAHAN, GEB. SAWYER, JEAN KAHAN, FREDERICK MARVIN, RAHWAY, N.J., US

8139 Disposal/non-payment of the annual fee