FR2351979A1 - Nouvel antibiotique de type thienamycine utile comme medicament - Google Patents

Nouvel antibiotique de type thienamycine utile comme medicament

Info

Publication number
FR2351979A1
FR2351979A1 FR7634889A FR7634889A FR2351979A1 FR 2351979 A1 FR2351979 A1 FR 2351979A1 FR 7634889 A FR7634889 A FR 7634889A FR 7634889 A FR7634889 A FR 7634889A FR 2351979 A1 FR2351979 A1 FR 2351979A1
Authority
FR
France
Prior art keywords
thienamycin
new
medicinal product
type antibiotic
antibiotic useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7634889A
Other languages
English (en)
Other versions
FR2351979B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2351979A1 publication Critical patent/FR2351979A1/fr
Application granted granted Critical
Publication of FR2351979B1 publication Critical patent/FR2351979B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
FR7634889A 1975-11-24 1976-11-19 Nouvel antibiotique de type thienamycine utile comme medicament Granted FR2351979A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63456075A 1975-11-24 1975-11-24

Publications (2)

Publication Number Publication Date
FR2351979A1 true FR2351979A1 (fr) 1977-12-16
FR2351979B1 FR2351979B1 (fr) 1982-08-13

Family

ID=24544292

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7634889A Granted FR2351979A1 (fr) 1975-11-24 1976-11-19 Nouvel antibiotique de type thienamycine utile comme medicament

Country Status (16)

Country Link
JP (1) JPS5265295A (fr)
AR (1) AR224224A1 (fr)
AU (1) AU510252B2 (fr)
BE (1) BE848349A (fr)
CH (1) CH625803A5 (fr)
DE (1) DE2652678A1 (fr)
DK (1) DK497476A (fr)
ES (1) ES453508A1 (fr)
FR (1) FR2351979A1 (fr)
GB (1) GB1561108A (fr)
GR (1) GR61407B (fr)
HU (1) HU175266B (fr)
NL (1) NL7612932A (fr)
PT (1) PT65845B (fr)
SE (1) SE7612295L (fr)
ZA (1) ZA766986B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2380280A1 (fr) * 1977-02-11 1978-09-08 Merck & Co Inc Desacetyl 890 a10 antibiotique
FR2380277A1 (fr) * 1977-02-11 1978-09-08 Merck & Co Inc L'antibiotique desacetyl, dihydro 890 a9
EP0024447A1 (fr) * 1979-08-28 1981-03-11 Merck & Co. Inc. Procédé de purification de la thiénamycine

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4162193A (en) * 1977-08-19 1979-07-24 Merck & Co., Inc. Enzymatic cleavage of N-acyl-thienamycins
NZ190994A (en) 1978-07-24 1981-10-19 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates
DE3146190A1 (de) * 1981-11-21 1983-06-16 Hoechst Ag, 6230 Frankfurt Isolierung von chemisch instabilen antibiotika aus fermentationsloesungen
US10695322B2 (en) 2016-01-29 2020-06-30 The Johns Hopkins University Inhibitors of bacterial growth

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2380280A1 (fr) * 1977-02-11 1978-09-08 Merck & Co Inc Desacetyl 890 a10 antibiotique
FR2380277A1 (fr) * 1977-02-11 1978-09-08 Merck & Co Inc L'antibiotique desacetyl, dihydro 890 a9
EP0024447A1 (fr) * 1979-08-28 1981-03-11 Merck & Co. Inc. Procédé de purification de la thiénamycine

Also Published As

Publication number Publication date
AU1964576A (en) 1978-05-25
PT65845A (en) 1976-12-01
DK497476A (da) 1977-05-25
DE2652678A1 (de) 1977-06-02
FR2351979B1 (fr) 1982-08-13
CH625803A5 (en) 1981-10-15
AU510252B2 (en) 1980-06-19
JPS5265295A (en) 1977-05-30
BE848349A (fr) 1977-05-16
AR224224A1 (es) 1981-11-13
PT65845B (en) 1978-10-10
SE7612295L (sv) 1977-05-25
ES453508A1 (es) 1978-03-01
GR61407B (en) 1978-11-11
NL7612932A (nl) 1977-05-26
GB1561108A (en) 1980-02-13
HU175266B (hu) 1980-06-28
ZA766986B (en) 1978-06-28

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Legal Events

Date Code Title Description
ST Notification of lapse