AU1964576A - N-acetyl thienamycin type antibiotics - Google Patents

N-acetyl thienamycin type antibiotics

Info

Publication number
AU1964576A
AU1964576A AU19645/76A AU1964576A AU1964576A AU 1964576 A AU1964576 A AU 1964576A AU 19645/76 A AU19645/76 A AU 19645/76A AU 1964576 A AU1964576 A AU 1964576A AU 1964576 A AU1964576 A AU 1964576A
Authority
AU
Australia
Prior art keywords
type antibiotics
acetyl thienamycin
acetyl
thienamycin type
antibiotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU19645/76A
Other versions
AU510252B2 (en
Inventor
J. S. and Kahan F. M Kanan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU1964576A publication Critical patent/AU1964576A/en
Application granted granted Critical
Publication of AU510252B2 publication Critical patent/AU510252B2/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
AU19645/76A 1975-11-24 1976-11-15 N-acetyl thienamycin type antibiotics Expired AU510252B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63456075A 1975-11-24 1975-11-24
USUS634,560 1975-11-24

Publications (2)

Publication Number Publication Date
AU1964576A true AU1964576A (en) 1978-05-25
AU510252B2 AU510252B2 (en) 1980-06-19

Family

ID=24544292

Family Applications (1)

Application Number Title Priority Date Filing Date
AU19645/76A Expired AU510252B2 (en) 1975-11-24 1976-11-15 N-acetyl thienamycin type antibiotics

Country Status (16)

Country Link
JP (1) JPS5265295A (en)
AR (1) AR224224A1 (en)
AU (1) AU510252B2 (en)
BE (1) BE848349A (en)
CH (1) CH625803A5 (en)
DE (1) DE2652678A1 (en)
DK (1) DK497476A (en)
ES (1) ES453508A1 (en)
FR (1) FR2351979A1 (en)
GB (1) GB1561108A (en)
GR (1) GR61407B (en)
HU (1) HU175266B (en)
NL (1) NL7612932A (en)
PT (1) PT65845B (en)
SE (1) SE7612295L (en)
ZA (1) ZA766986B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7800979L (en) * 1977-02-11 1978-08-12 Merck & Co Inc ANTIBIOTIC
SE7800978L (en) * 1977-02-11 1978-08-12 Merck & Co Inc ANTIBIOTIC
US4162193A (en) * 1977-08-19 1979-07-24 Merck & Co., Inc. Enzymatic cleavage of N-acyl-thienamycins
NZ190994A (en) 1978-07-24 1981-10-19 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates
DE2965923D1 (en) * 1979-08-28 1983-08-25 Merck & Co Inc Process for purifying thienamycin
DE3146190A1 (en) * 1981-11-21 1983-06-16 Hoechst Ag, 6230 Frankfurt INSULATION OF CHEMICALLY UNSTABLE ANTIBIOTICS FROM FERMENTATION SOLUTIONS
US10695322B2 (en) 2016-01-29 2020-06-30 The Johns Hopkins University Inhibitors of bacterial growth

Also Published As

Publication number Publication date
PT65845A (en) 1976-12-01
DK497476A (en) 1977-05-25
DE2652678A1 (en) 1977-06-02
FR2351979B1 (en) 1982-08-13
CH625803A5 (en) 1981-10-15
AU510252B2 (en) 1980-06-19
JPS5265295A (en) 1977-05-30
BE848349A (en) 1977-05-16
AR224224A1 (en) 1981-11-13
FR2351979A1 (en) 1977-12-16
PT65845B (en) 1978-10-10
SE7612295L (en) 1977-05-25
ES453508A1 (en) 1978-03-01
GR61407B (en) 1978-11-11
NL7612932A (en) 1977-05-26
GB1561108A (en) 1980-02-13
HU175266B (en) 1980-06-28
ZA766986B (en) 1978-06-28

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