DE2623314C2 - 1-Aryloxy-2-Hydroxy-3-aminopropane, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel - Google Patents

1-Aryloxy-2-Hydroxy-3-aminopropane, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Info

Publication number
DE2623314C2
DE2623314C2 DE2623314A DE2623314A DE2623314C2 DE 2623314 C2 DE2623314 C2 DE 2623314C2 DE 2623314 A DE2623314 A DE 2623314A DE 2623314 A DE2623314 A DE 2623314A DE 2623314 C2 DE2623314 C2 DE 2623314C2
Authority
DE
Germany
Prior art keywords
formula
acid
meaning given
hydroxy
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2623314A
Other languages
German (de)
English (en)
Other versions
DE2623314A1 (de
Inventor
Werner Dr. 6232 Neuenhain Fritsch
Ernst Prof. Dr. 6230 Frankfurt Lindner
Ulrich Dr. 6238 Hofheim Stache
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE2623314A priority Critical patent/DE2623314C2/de
Priority to ES458957A priority patent/ES458957A1/es
Priority to CH624077A priority patent/CH637105A5/de
Priority to NL7705587A priority patent/NL7705587A/xx
Priority to FI771630A priority patent/FI67698C/fi
Priority to IT23892/77A priority patent/IT1077193B/it
Priority to ZA00773120A priority patent/ZA773120B/xx
Priority to IL52148A priority patent/IL52148A/xx
Priority to AT370177A priority patent/AT354421B/de
Priority to AU25434/77A priority patent/AU511704B2/en
Priority to SE7706059A priority patent/SE440903B/xx
Priority to CA278,974A priority patent/CA1108633A/en
Priority to DK227177A priority patent/DK227177A/da
Priority to HU77HO1987A priority patent/HU179198B/hu
Priority to BE177909A priority patent/BE855041A/xx
Priority to JP6000477A priority patent/JPS5312827A/ja
Priority to FR7715881A priority patent/FR2353520A1/fr
Priority to GB22051/77A priority patent/GB1577670A/en
Publication of DE2623314A1 publication Critical patent/DE2623314A1/de
Priority to US05/932,504 priority patent/US4191765A/en
Priority to AT519879A priority patent/AT367742B/de
Priority to AT519979A priority patent/AT367743B/de
Priority to AT519779A priority patent/AT367757B/de
Priority to AT520079A priority patent/AT368484B/de
Priority to CH655581A priority patent/CH637108A5/de
Priority to CH655481A priority patent/CH637107A5/de
Priority to CH655681A priority patent/CH637109A5/de
Priority to CH655781A priority patent/CH640507A5/de
Application granted granted Critical
Publication of DE2623314C2 publication Critical patent/DE2623314C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyridine Compounds (AREA)
DE2623314A 1976-05-25 1976-05-25 1-Aryloxy-2-Hydroxy-3-aminopropane, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel Expired DE2623314C2 (de)

Priority Applications (27)

Application Number Priority Date Filing Date Title
DE2623314A DE2623314C2 (de) 1976-05-25 1976-05-25 1-Aryloxy-2-Hydroxy-3-aminopropane, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
ES458957A ES458957A1 (es) 1976-05-25 1977-05-19 Procedimiento para la preparacion de nuevos 1-ariloxi-2-hi- droxi-3-aminopropanos.
NL7705587A NL7705587A (nl) 1976-05-25 1977-05-20 Werkwijze voor het bereiden van 1-aryloxy-2-hy- droxy-3-aminopropanen.
CH624077A CH637105A5 (en) 1976-05-25 1977-05-20 Process for preparing novel 1-aryloxy-2-hydroxy-3-aminopropanes
FI771630A FI67698C (fi) 1976-05-25 1977-05-23 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-aryloxi-2-hydroxi-3-aminopropaner
IT23892/77A IT1077193B (it) 1976-05-25 1977-05-23 1-arilossi-2-idrossi-3-aminopropani e processo per la loro preparazione
IL52148A IL52148A (en) 1976-05-25 1977-05-24 Substituted 1-phenoxy-2-hydroxy-3-aminopropanes,process for preparing same and pharmaceutical compositions containing them
AT370177A AT354421B (de) 1976-05-25 1977-05-24 Verfahren zur herstellung von neuen substituierten 3-(3'-amino-2'-hydroxy- propoxyphenyl)-acrylsaeurederivaten
AU25434/77A AU511704B2 (en) 1976-05-25 1977-05-24 1-aryloxy-2-hydroxy-3-aminopropanes
SE7706059A SE440903B (sv) 1976-05-25 1977-05-24 Forfarande for framstellning av nya 1-aryloxi-2-hydroxi-3-aminopropaner
CA278,974A CA1108633A (en) 1976-05-25 1977-05-24 1-aryloxy-2-hydroxy-3-aminopropanes and process for preparing same
DK227177A DK227177A (da) 1976-05-25 1977-05-24 1-aryloxy-2-hydroxy-3-aminopropaner samt deres fremstilling og anvendelse
HU77HO1987A HU179198B (en) 1976-05-25 1977-05-24 Process for producing new 1-aryloxy-2-hydroxy-3-amino-propane derivatives
ZA00773120A ZA773120B (en) 1976-05-25 1977-05-24 Novel 1-aryloxy-2-hydroxy-3-aminopropanes and process for preparing same
BE177909A BE855041A (fr) 1976-05-25 1977-05-25 1-aryloxy-2-hydroxy-3-aminopropanes, leur procede de preparation et leurs applications
JP6000477A JPS5312827A (en) 1976-05-25 1977-05-25 Novell11aryloxyy22hydroxyy33 aminopropane compound and producing the same
FR7715881A FR2353520A1 (fr) 1976-05-25 1977-05-25 1-aryloxy-2-hydroxy-3-aminopropanes, leur procede de preparation et leurs applications therapeutiques
GB22051/77A GB1577670A (en) 1976-05-25 1977-05-25 1-aryloxy-2 - hydroxy - 3 - aminopropanes and process for their preparation
US05/932,504 US4191765A (en) 1976-05-25 1978-08-10 1-Aryloxy-2-hydroxy-3-aminopropanes
AT520079A AT368484B (de) 1976-05-25 1979-07-27 Verfahren zur herstellung von neuen substituierten 3-(3'-amino-2'-hydroxypropoxyphenyl)acryls[urederivaten
AT519979A AT367743B (de) 1976-05-25 1979-07-27 Verfahren zur herstellung von neuen substituierten 3-(3'-amino-2'-hydroxypropoxyphenyl)-acrylsaeure derivaten sowie deren saeureadditionssalzen
AT519779A AT367757B (de) 1976-05-25 1979-07-27 Verfahren zur herstellung von neuen substituierten 3-(3'-amino-2'-hydroxypropoxyphenyl)-acrylsaeure derivaten sowie deren saeureadditionssalzen
AT519879A AT367742B (de) 1976-05-25 1979-07-27 Verfahren zur herstellung von neuen substituierten 3-(3'-amino-2'-hydroxypropoxyphenyl)-acrylsaeure derivaten sowie deren saeureadditionssalzen
CH655581A CH637108A5 (en) 1976-05-25 1981-10-13 Process for preparing novel 1-aryloxy-2-hydroxy-3-aminopropanes
CH655481A CH637107A5 (en) 1976-05-25 1981-10-13 Process for preparing novel 1-aryloxy-2-hydroxy-3-aminopropanes
CH655681A CH637109A5 (en) 1976-05-25 1981-10-13 Process for preparing novel 1-aryloxy-2-hydroxy-3-aminopropanes
CH655781A CH640507A5 (en) 1976-05-25 1981-10-13 Process for preparing novel 1-aryloxy-2-hydroxy-3-aminopropanes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2623314A DE2623314C2 (de) 1976-05-25 1976-05-25 1-Aryloxy-2-Hydroxy-3-aminopropane, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
DE2623314A1 DE2623314A1 (de) 1977-12-08
DE2623314C2 true DE2623314C2 (de) 1984-08-02

Family

ID=5978907

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2623314A Expired DE2623314C2 (de) 1976-05-25 1976-05-25 1-Aryloxy-2-Hydroxy-3-aminopropane, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Country Status (18)

Country Link
JP (1) JPS5312827A (hu)
AT (1) AT354421B (hu)
AU (1) AU511704B2 (hu)
BE (1) BE855041A (hu)
CA (1) CA1108633A (hu)
CH (5) CH637105A5 (hu)
DE (1) DE2623314C2 (hu)
DK (1) DK227177A (hu)
ES (1) ES458957A1 (hu)
FI (1) FI67698C (hu)
FR (1) FR2353520A1 (hu)
GB (1) GB1577670A (hu)
HU (1) HU179198B (hu)
IL (1) IL52148A (hu)
IT (1) IT1077193B (hu)
NL (1) NL7705587A (hu)
SE (1) SE440903B (hu)
ZA (1) ZA773120B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2415622A1 (fr) * 1978-01-25 1979-08-24 Lipha Amino alcools derives de l'ortho-hydroxy cinnamate de methyle applicables notamment comme medicaments
DE2824764A1 (de) * 1978-06-06 1979-12-20 Hoechst Ag Neue pyridylpiperazinderivate und verfahren zu ihrer herstellung
DE2961251D1 (en) * 1978-08-15 1982-01-14 Smithkline Beckman Corp A method of preparing a 2-hydroxy-3-isopropyl or a 2-hydroxy-3-tert-butylaminopropyl aromatic ether
FR2459235A1 (fr) * 1979-06-14 1981-01-09 Sanofi Sa Nouveaux derives de sulfonyl-aniline, leur procede de preparation et leur application therapeutique
JPH0629833B2 (ja) * 1984-06-15 1994-04-20 株式会社島津製作所 疲労試験機
GB8603120D0 (en) * 1986-02-07 1986-03-12 Pfizer Ltd Anti-dysrhythmia agents
CA2716369C (en) 1999-05-24 2013-05-14 Mitsubishi Tanabe Pharma Corporation Phenoxypropylamine compounds
DE19941657A1 (de) * 1999-09-01 2001-03-08 Schwabe Willmar Gmbh & Co Zimtsäurenitrile, Verfahren zu ihrer Herstellung und Verwendung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA945172A (en) * 1969-02-21 1974-04-09 Imperial Chemical Industries Limited Alkanolamine derivatives
FR2132570B1 (hu) * 1971-04-09 1974-08-02 Lipha
BE791650R (fr) * 1971-11-18 1973-05-21 Ici Ltd Derives d'alkanolamines.
ES411826A1 (es) * 1973-02-20 1976-01-01 Liade Sa Lab Procedimiento de obtencion de 1-ariloxi - 2 - propanolami- nas farmacologicamente activos.

Also Published As

Publication number Publication date
ATA370177A (de) 1979-06-15
IT1077193B (it) 1985-05-04
NL7705587A (nl) 1977-11-29
JPS6214545B2 (hu) 1987-04-02
ZA773120B (en) 1978-04-26
FI67698C (fi) 1985-05-10
CA1108633A (en) 1981-09-08
AU2543477A (en) 1978-11-30
CH637105A5 (en) 1983-07-15
CH637109A5 (en) 1983-07-15
BE855041A (fr) 1977-11-25
AU511704B2 (en) 1980-09-04
DE2623314A1 (de) 1977-12-08
JPS5312827A (en) 1978-02-04
FR2353520A1 (fr) 1977-12-30
AT354421B (de) 1979-01-10
SE440903B (sv) 1985-08-26
HU179198B (en) 1982-09-28
CH637107A5 (en) 1983-07-15
SE7706059L (sv) 1977-11-26
IL52148A0 (en) 1977-07-31
FI771630A (hu) 1977-11-26
GB1577670A (en) 1980-10-29
ES458957A1 (es) 1978-07-16
FI67698B (fi) 1985-01-31
IL52148A (en) 1982-07-30
CH640507A5 (en) 1984-01-13
DK227177A (da) 1977-11-26
FR2353520B1 (hu) 1980-07-25
CH637108A5 (en) 1983-07-15

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Legal Events

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8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: C07C121/70

D2 Grant after examination
8364 No opposition during term of opposition
8320 Willingness to grant licences declared (paragraph 23)
8339 Ceased/non-payment of the annual fee