DE2619686C2 - Verwendung eines Lysolecithins zur Tumorbehandlung - Google Patents
Verwendung eines Lysolecithins zur TumorbehandlungInfo
- Publication number
- DE2619686C2 DE2619686C2 DE2619686A DE2619686A DE2619686C2 DE 2619686 C2 DE2619686 C2 DE 2619686C2 DE 2619686 A DE2619686 A DE 2619686A DE 2619686 A DE2619686 A DE 2619686A DE 2619686 C2 DE2619686 C2 DE 2619686C2
- Authority
- DE
- Germany
- Prior art keywords
- tumor
- lysolecithin
- tumors
- treatment
- animals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 206010028980 Neoplasm Diseases 0.000 title description 20
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 title description 4
- 241001465754 Metazoa Species 0.000 description 11
- 239000002246 antineoplastic agent Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 5
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 210000004881 tumor cell Anatomy 0.000 description 4
- 238000005684 Liebig rearrangement reaction Methods 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 206010003445 Ascites Diseases 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical class CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- PPQNQXQZIWHJRB-UHFFFAOYSA-N Methylcholanthrene Chemical compound C1=CC=C2C3=CC4=CC=C(C)C(CC5)=C4C5=C3C=CC2=C1 PPQNQXQZIWHJRB-UHFFFAOYSA-N 0.000 description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 201000000050 myeloid neoplasm Diseases 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 238000011735 C3H mouse Methods 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000568 immunological adjuvant Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- -1 lysolecithin compound Chemical class 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 210000003024 peritoneal macrophage Anatomy 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 229950004354 phosphorylcholine Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2619686A DE2619686C2 (de) | 1976-05-04 | 1976-05-04 | Verwendung eines Lysolecithins zur Tumorbehandlung |
NLAANVRAGE7704723,A NL189672C (nl) | 1976-05-04 | 1977-04-29 | Werkwijze voor het bereiden of vervaardigen van een farmaceutisch preparaat met anti-tumoractiviteit en werkwijze voor het bereiden van een verbinding met anti-tumoractiviteit. |
SE7705071A SE7705071L (sv) | 1976-05-04 | 1977-05-02 | Antitumormedel |
IT23094/77A IT1071329B (it) | 1976-05-04 | 1977-05-02 | Mezzo antitumorale |
IL51988A IL51988A (en) | 1976-05-04 | 1977-05-02 | Anti-tumor agents containing lysolecithin analogues |
NZ183981A NZ183981A (en) | 1976-05-04 | 1977-05-02 | Tumour antidotes containing lysolecithintype compounds |
AU24819/77A AU517586B2 (en) | 1976-05-04 | 1977-05-03 | Tumor antidote |
CA277,458A CA1094455A (en) | 1976-05-04 | 1977-05-03 | Tumor antidote |
IE888/77A IE44927B1 (en) | 1976-05-04 | 1977-05-03 | Tumor antidote |
ZA00772649A ZA772649B (en) | 1976-05-04 | 1977-05-03 | Tumor antidote |
LU77248A LU77248A1 (nl) | 1976-05-04 | 1977-05-03 | |
GB18431/77A GB1583661A (en) | 1976-05-04 | 1977-05-03 | Tumour antidote |
BE177280A BE854270A (fr) | 1976-05-04 | 1977-05-04 | Medicament anti-tumeur a base de compose du type lysolecithine |
FR7713522A FR2364656A1 (fr) | 1976-05-04 | 1977-05-04 | Medicament anti-tumeur a base de compose du type lysolecithine |
JP5194477A JPS52134027A (en) | 1976-05-04 | 1977-05-04 | Antiitumor agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2619686A DE2619686C2 (de) | 1976-05-04 | 1976-05-04 | Verwendung eines Lysolecithins zur Tumorbehandlung |
Publications (2)
Publication Number | Publication Date |
---|---|
DE2619686A1 DE2619686A1 (de) | 1977-11-24 |
DE2619686C2 true DE2619686C2 (de) | 1986-08-07 |
Family
ID=5977045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2619686A Expired DE2619686C2 (de) | 1976-05-04 | 1976-05-04 | Verwendung eines Lysolecithins zur Tumorbehandlung |
Country Status (15)
Country | Link |
---|---|
JP (1) | JPS52134027A (nl) |
AU (1) | AU517586B2 (nl) |
BE (1) | BE854270A (nl) |
CA (1) | CA1094455A (nl) |
DE (1) | DE2619686C2 (nl) |
FR (1) | FR2364656A1 (nl) |
GB (1) | GB1583661A (nl) |
IE (1) | IE44927B1 (nl) |
IL (1) | IL51988A (nl) |
IT (1) | IT1071329B (nl) |
LU (1) | LU77248A1 (nl) |
NL (1) | NL189672C (nl) |
NZ (1) | NZ183981A (nl) |
SE (1) | SE7705071L (nl) |
ZA (1) | ZA772649B (nl) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3935580A1 (de) * | 1989-10-25 | 1991-05-02 | Medmark Pharma Gmbh | Pharmazeutische zubereitung zur behandlung von hiv-infektionen |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5396311A (en) * | 1977-01-29 | 1978-08-23 | Toyama Chem Co Ltd | Anti-cander drugs containing lysolecithins |
JPS5528955A (en) * | 1978-08-24 | 1980-02-29 | Toyama Chem Co Ltd | Novel glycerophosphoric acid derivative, its salt, their preparation, and carcinostatic agent containing the same. |
GB2046092B (en) | 1979-03-05 | 1983-11-02 | Toyama Chemical Co Ltd | Pharmaceutical composition containing a lysophospholid and a phospholipid |
US4408052A (en) * | 1980-02-27 | 1983-10-04 | Takeda Chemical Industries, Ltd. | Phospholipid carbamates |
US4551532A (en) * | 1980-05-08 | 1985-11-05 | Takeda Chemical Industries, Ltd. | Ethylene glycol derivatives having anti-protozoan, anti-fungal and anti-tumor activity |
US4444766A (en) * | 1980-10-21 | 1984-04-24 | Boehringer Mannheim Gmbh | Sulfur-containing phospholipid compounds and therapeutic compositions |
JPS5772914A (en) * | 1980-10-22 | 1982-05-07 | Takeda Chem Ind Ltd | Antitumor agent |
EP0061872B1 (en) * | 1981-03-30 | 1985-08-07 | Takeda Chemical Industries, Ltd. | Ethyleneglycol derivatives, their production and use |
DE3127503A1 (de) * | 1981-07-11 | 1983-02-17 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue phospholipide, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
DE3131524A1 (de) * | 1981-08-08 | 1983-02-24 | Röhm GmbH, 6100 Darmstadt | Verfahren zur herstellung physiologischer effektoren |
US4562179A (en) * | 1982-04-19 | 1985-12-31 | Fujisawa Pharmaceutical Co., Ltd. | Phospholipid derivatives, and pharmaceutical composition of the same |
DE3239817A1 (de) * | 1982-07-06 | 1984-01-12 | Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Neue glycerinderivate zur synthese von phospholipiden |
DE3239858A1 (de) * | 1982-07-06 | 1984-01-12 | Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Neue d-mannitderivate als ausgangsprodukte zur synthese von phospholipiden |
EP0103877B1 (en) * | 1982-09-21 | 1987-01-07 | Fujisawa Pharmaceutical Co., Ltd. | Phosphate derivatives, process for preparation thereof and pharmaceutical compositions of the same |
US4710579A (en) * | 1984-11-09 | 1987-12-01 | Takeda Chemical Industries, Ltd. | 2-(acetoacetyloxy)-3-(octadecyloxy)propyl-3-trimethylammoniopropyl phosphate or a pharmaceutically acceptable salt thereof |
US4761404A (en) * | 1985-07-01 | 1988-08-02 | Merck & Co., Inc. | Phospholipid analogs useful as PAF synthesis inhibitors |
EP0209239B1 (en) * | 1985-07-15 | 1989-03-01 | Takeda Chemical Industries, Ltd. | 2-alkanoyloxypropane derivatives, their production and use |
JPS6294A (ja) * | 1986-05-09 | 1987-01-06 | Toyama Chem Co Ltd | 新規なグリセロリン酸誘導体およびその塩並びにそれらの製造法 |
JP2561478B2 (ja) * | 1986-07-22 | 1996-12-11 | 武田薬品工業株式会社 | グリセリン誘導体 |
US5036152A (en) * | 1988-03-10 | 1991-07-30 | Hoechst-Roussel Pharmaceuticals Incorporated | Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphospholipids |
US4888328A (en) * | 1988-03-10 | 1989-12-19 | Hoeschst-Roussel Incorporated | Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphospholipids |
DE3906952A1 (de) * | 1989-03-04 | 1990-09-06 | Boehringer Mannheim Gmbh | (3-(c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)6(pfeil abwaerts)-c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)8(pfeil abwaerts))alkansulfinyl- und sulfonyl-2-methoxymethyl-propyl)-(2-trimethylammonio-ethyl) phosphate, verfahren zu deren herstellung diese verbindungen enthaltende arzneimittel |
DE3918082A1 (de) * | 1989-06-02 | 1991-01-24 | Max Planck Gesellschaft | Mittel gegen autoimmunerkrankungen |
WO1992019627A2 (en) * | 1991-04-25 | 1992-11-12 | The University Of British Columbia | Phosphonates and phosphinates as anti-cancer, -inflammatory, -allergy and -myocarditis agents |
ES2034885B1 (es) * | 1991-07-10 | 1994-03-01 | Menarini Lab | Procedimiento para la preparacion de cetoalquilglicerofosfolipidos. |
DK0785773T3 (da) * | 1994-10-14 | 2001-01-29 | Liposome Co Inc | Etherlipidliposomer og deres terapeutiske anvendelse |
US5965159A (en) * | 1996-02-16 | 1999-10-12 | The Liposome Company, Inc. | Etherlipid-containing multiple lipid liposomes |
US6667053B1 (en) | 1996-02-16 | 2003-12-23 | Elan Pharmaceuticals, Inc. | D and L etherlipid stereoisomers and liposomes |
US5942246A (en) * | 1996-02-16 | 1999-08-24 | The Liposome Company, Inc. | Etherlipid containing multiple lipid liposomes |
USRE39042E1 (en) * | 1996-02-16 | 2006-03-28 | The Liposome Company, Inc. | Etherlipid-containing multiple lipid liposomes |
US6007839A (en) * | 1996-02-16 | 1999-12-28 | The Liposome Company, Inc. | Preparation of pharmaceutical compositions containing etherlipid-containing multiple lipid liposomes |
US6135426A (en) * | 1998-01-07 | 2000-10-24 | Briggs And Stratton Corporation | Priming system for internal combustion engines |
JP5773569B2 (ja) * | 2006-11-10 | 2015-09-02 | アルファプトーゼ ゲーエムベーハーAlphaptose Gnbh | 受容体リガンド模倣体を検出する方法 |
EP2091520B1 (en) | 2006-11-10 | 2012-02-22 | Alphaptose Gmbh | Oral dosage form comprising tri-substituted glycerol compounds |
EP2120873B1 (en) * | 2006-12-20 | 2012-06-27 | Alphaptose Gmbh | Topical dosage form comprising tri-substituted glycerol compounds |
AU2007334775A1 (en) * | 2006-12-20 | 2008-06-26 | Universitatsklinikum Hamburg-Eppendorf | Use of tri-substituted glycerol compounds for the treatment of hematological malignancies |
WO2013156630A1 (en) | 2012-04-20 | 2013-10-24 | Alphaptose Gmbh | S-enantiomer of a tri-substituted glycerol compound |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2009343C3 (de) * | 1970-02-27 | 1980-10-23 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | Verwendung von Lysolecithinen als immunologische Adjuvantien |
DE2009341C3 (de) * | 1970-02-27 | 1979-06-21 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | 3-Octadecyloxy-propanol-(l)-phosphorsäure-monocholinester und Verfahren zu dessen Herstellung |
DE2009342C3 (de) * | 1970-02-27 | 1980-12-18 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | Verwendung von Glycerin-alkyläther-(l)-phosphorsäure-(3)-monocholinestern |
DE2033361C3 (de) * | 1970-07-06 | 1980-02-21 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | Acylpropandiol-(13)-phosphorsäurecholinester und Verfahren zu deren Herstellung |
-
1976
- 1976-05-04 DE DE2619686A patent/DE2619686C2/de not_active Expired
-
1977
- 1977-04-29 NL NLAANVRAGE7704723,A patent/NL189672C/nl not_active IP Right Cessation
- 1977-05-02 NZ NZ183981A patent/NZ183981A/xx unknown
- 1977-05-02 IL IL51988A patent/IL51988A/xx unknown
- 1977-05-02 IT IT23094/77A patent/IT1071329B/it active
- 1977-05-02 SE SE7705071A patent/SE7705071L/xx unknown
- 1977-05-03 ZA ZA00772649A patent/ZA772649B/xx unknown
- 1977-05-03 GB GB18431/77A patent/GB1583661A/en not_active Expired
- 1977-05-03 CA CA277,458A patent/CA1094455A/en not_active Expired
- 1977-05-03 AU AU24819/77A patent/AU517586B2/en not_active Expired
- 1977-05-03 LU LU77248A patent/LU77248A1/xx unknown
- 1977-05-03 IE IE888/77A patent/IE44927B1/en not_active IP Right Cessation
- 1977-05-04 JP JP5194477A patent/JPS52134027A/ja active Granted
- 1977-05-04 FR FR7713522A patent/FR2364656A1/fr active Granted
- 1977-05-04 BE BE177280A patent/BE854270A/xx not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3935580A1 (de) * | 1989-10-25 | 1991-05-02 | Medmark Pharma Gmbh | Pharmazeutische zubereitung zur behandlung von hiv-infektionen |
DE3935580C2 (de) * | 1989-10-25 | 1998-05-28 | Medmark Pharma Gmbh | Verwendung eines pharmazeutischen Wirkstoffes zur Behandlung von HIV-Infektionen |
Also Published As
Publication number | Publication date |
---|---|
DE2619686A1 (de) | 1977-11-24 |
GB1583661A (en) | 1981-01-28 |
IL51988A (en) | 1981-05-20 |
JPS6146455B2 (nl) | 1986-10-14 |
ZA772649B (en) | 1978-04-26 |
NZ183981A (en) | 1980-04-28 |
FR2364656A1 (fr) | 1978-04-14 |
AU2481977A (en) | 1978-11-09 |
AU517586B2 (en) | 1981-08-13 |
IE44927B1 (en) | 1982-05-19 |
IL51988A0 (en) | 1977-07-31 |
SE7705071L (sv) | 1977-11-05 |
NL7704723A (nl) | 1977-11-08 |
LU77248A1 (nl) | 1977-12-13 |
NL189672B (nl) | 1993-01-18 |
JPS52134027A (en) | 1977-11-09 |
CA1094455A (en) | 1981-01-27 |
IT1071329B (it) | 1985-04-02 |
NL189672C (nl) | 1993-06-16 |
BE854270A (fr) | 1977-11-04 |
FR2364656B1 (nl) | 1980-03-07 |
IE44927L (en) | 1977-11-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE2619686C2 (de) | Verwendung eines Lysolecithins zur Tumorbehandlung | |
DE69217056T4 (de) | Taxan-Derivate enthaltende Arzneimittel | |
DE2329485C3 (de) | Platinkoordinationsverbindungen und ein diese Verbindungen enthaltendes Antitumormittel | |
DE2721171C3 (de) | Vincamin-5-pyridoxalphosphat, seine Herstellung und enthaltende Zubereitungen | |
CH686868A5 (de) | Infusionsloesung fuer die Verabreichung von Taxol. | |
DE3207472A1 (de) | Platin-diamin-komplexe, ein verfahren zu ihrer herstellung, ein verfahren zur herstellung eines arzneimittels unter einsatz eines derartigen platin-diamin-komplexes fuer die behandlung von krebs sowie das dabei erhaltene arzneimittel | |
DE2707934C2 (nl) | ||
DE2208787C3 (de) | Mittel zur Behandlung von Herpes-Virusinfektionen | |
DE3130912A1 (de) | Analgetische arzneimittelkombination | |
DE2609399C2 (de) | 9-Desoxy-9-methylen-16,16-dimethyl-prostaglandinderivate und Verfahren zu deren Herstellung | |
DE102007014375A1 (de) | Oleylphosphocholin | |
DE2145359A1 (de) | Neue Phthalazindenvate | |
DE69735383T2 (de) | Methode zur Inhibierung von HEREGULIN und seines Rezeptors sowie Verwendung zur Inhibierung von Krebszellen | |
DE19953517C1 (de) | Verwendung von Treosulfan zur Konditionierung von Patienten vor Knochemarktransplantation oder Blutstammzelltransplantation | |
DE2953309C2 (de) | Cytostatisch wirkende Arzneimittel beziehungsweise pharmazeutische Zubereitungen | |
DE3786682T2 (de) | ACTH-Fragmente enthaltende pharmazeutische Zusammensetzungen zur Behandlung von Schockzuständen sowie von respiratorischen und Herz-Kreislauf-Insuffizienzen. | |
DE4115559A1 (de) | Antitumormittel mit verminderter toxizitaet auf der basis von cytostatika und xanthogenaten | |
DE1518443C (de) | 2-(2,6-Dimethoxyphenoxyäthyl)-aminomethyl-l,4-benzodioxan und dessen Hydrochlorid sowie Verfahren zu deren Herstellung | |
DE2314387A1 (de) | Arzneimittel zur behandlung boesartiger neubildungen, vorzugsweise von haemoblastosen und chorionepitheliom | |
DE966040C (de) | Haarpflegemittel | |
DD283931A5 (de) | Verfahren zur herstellung einer pharmazeutischen zusammensetzung zur behandlung von herzrhythmusstoerungen | |
DE2645873C3 (de) | Ajmalinderivate und ein Verfahren zu deren Herstellung | |
DE1792788A1 (de) | Peripher vasodilatorisch wirksames arzneimittel | |
DE3390386T1 (de) | Antitumor-Mittel, Verfahren zur Tumor-Therapie und Verwendung zur Tumor-Therapie | |
DE2800508C3 (de) | 6,77-Dimethoxy-2-thiomorpholino-4chinazolinamin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8110 | Request for examination paragraph 44 | ||
8181 | Inventor (new situation) |
Free format text: MUNDER, PAUL GERHARD, DR., 7830 EMMENDINGEN, DE WESTPHAL, OTTO, PROF. DR., 7808 WALDKIRCH, DE |
|
D2 | Grant after examination | ||
8364 | No opposition during term of opposition |