DE2507989A1 - N-(2-pyrrolidinylalkyl)-substituierte benzamide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel - Google Patents

N-(2-pyrrolidinylalkyl)-substituierte benzamide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Info

Publication number
DE2507989A1
DE2507989A1 DE19752507989 DE2507989A DE2507989A1 DE 2507989 A1 DE2507989 A1 DE 2507989A1 DE 19752507989 DE19752507989 DE 19752507989 DE 2507989 A DE2507989 A DE 2507989A DE 2507989 A1 DE2507989 A1 DE 2507989A1
Authority
DE
Germany
Prior art keywords
group
hydrogen atom
formula
atom
handed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19752507989
Other languages
German (de)
English (en)
Inventor
Gerard Dr Bulteau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Original Assignee
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7407535A external-priority patent/FR2262966A1/fr
Priority claimed from FR7503800A external-priority patent/FR2299863B1/fr
Application filed by Societe dEtudes Scientifiques et Industrielles de lIle de France SA filed Critical Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Publication of DE2507989A1 publication Critical patent/DE2507989A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19752507989 1974-03-05 1975-02-25 N-(2-pyrrolidinylalkyl)-substituierte benzamide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel Withdrawn DE2507989A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7407535A FR2262966A1 (en) 1974-03-05 1974-03-05 N-(2-azacycloalkyl-alkyl)-benzamide derivs. - with antiemetic, antiulcer and CNS activity
FR7503800A FR2299863B1 (fr) 1975-02-07 1975-02-07 Nouveaux N-(Z-pyrrolidiny alkyl) benzamides substitués, leurs dérivés et leur procédé de préparation

Publications (1)

Publication Number Publication Date
DE2507989A1 true DE2507989A1 (de) 1975-09-11

Family

ID=26218210

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19752507989 Withdrawn DE2507989A1 (de) 1974-03-05 1975-02-25 N-(2-pyrrolidinylalkyl)-substituierte benzamide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Country Status (27)

Country Link
JP (1) JPS6015616B2 (xx)
AR (1) AR206621A1 (xx)
AT (1) AT358570B (xx)
BG (1) BG24666A3 (xx)
CA (1) CA1047504A (xx)
CH (1) CH605794A5 (xx)
CS (1) CS189692B2 (xx)
DD (1) DD119420A5 (xx)
DE (1) DE2507989A1 (xx)
DK (1) DK145377C (xx)
EG (1) EG12577A (xx)
ES (1) ES435274A1 (xx)
FI (1) FI750620A (xx)
GB (1) GB1466822A (xx)
HK (1) HK14078A (xx)
HU (1) HU170637B (xx)
IE (1) IE40818B1 (xx)
IL (1) IL46696A (xx)
LU (1) LU71949A1 (xx)
NL (1) NL7502608A (xx)
NO (1) NO750713L (xx)
OA (1) OA04966A (xx)
PH (1) PH14197A (xx)
PL (1) PL97091B1 (xx)
RO (2) RO70647A (xx)
SE (1) SE411754B (xx)
SU (1) SU609464A3 (xx)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154137B (da) * 1977-01-27 1988-10-17 Shionogi & Co Analogifremgangsmaade til fremstilling af meta-sulfonamido-benzamidderivater
EP0314483A1 (en) * 1987-10-29 1989-05-03 Erbamont, Inc. Preparation of benzamides
FR2699533A1 (fr) * 1992-12-21 1994-06-24 Mouhtaram Mohamed Dérivés de N-((1,4-dialkyl-6-arylpipérazine-2-yl)méthyl)benzamides. (Isomères cis et trans) Propriétés pharmacologiques et applications.

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8503054D0 (sv) * 1985-06-19 1985-06-19 Astra Laekemedel Ab Catecholcarboxamides
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3078497A (en) * 1960-12-29 1963-02-26 Leeds And Mieallef Dispensing containers

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154137B (da) * 1977-01-27 1988-10-17 Shionogi & Co Analogifremgangsmaade til fremstilling af meta-sulfonamido-benzamidderivater
EP0314483A1 (en) * 1987-10-29 1989-05-03 Erbamont, Inc. Preparation of benzamides
FR2699533A1 (fr) * 1992-12-21 1994-06-24 Mouhtaram Mohamed Dérivés de N-((1,4-dialkyl-6-arylpipérazine-2-yl)méthyl)benzamides. (Isomères cis et trans) Propriétés pharmacologiques et applications.

Also Published As

Publication number Publication date
DK145377C (da) 1983-04-11
SU609464A1 (xx) 1978-05-30
JPS50123668A (xx) 1975-09-29
BG24666A3 (en) 1978-04-12
ES435274A1 (es) 1976-12-16
LU71949A1 (xx) 1976-02-04
CH605794A5 (xx) 1978-10-13
IL46696A (en) 1978-07-31
CS189692B2 (en) 1979-04-30
IE40818B1 (en) 1979-08-29
HU170637B (xx) 1977-07-28
RO70647A (ro) 1980-04-15
PL97091B1 (pl) 1978-02-28
OA04966A (fr) 1980-10-31
JPS6015616B2 (ja) 1985-04-20
AT358570B (de) 1980-09-25
IE40818L (en) 1975-09-05
ATA160775A (de) 1980-02-15
HK14078A (en) 1978-03-23
DD119420A5 (xx) 1976-04-20
NL7502608A (nl) 1975-09-09
CA1047504A (en) 1979-01-30
FI750620A (xx) 1975-09-06
IL46696A0 (en) 1975-04-25
GB1466822A (en) 1977-03-09
DK145377B (da) 1982-11-08
EG12577A (en) 1979-09-30
RO72844A (ro) 1981-09-24
SE7502342L (xx) 1975-09-08
AU7874075A (en) 1976-09-09
SE411754B (sv) 1980-02-04
SU609464A3 (ru) 1978-05-30
DK86975A (xx) 1975-11-03
NO750713L (xx) 1975-09-08
AR206621A1 (es) 1976-08-06
PH14197A (en) 1981-03-26

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8110 Request for examination paragraph 44
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