CA1047504A - N-(2-pyrrolidinyl alkyl) substitutes and derivatives thereof - Google Patents

N-(2-pyrrolidinyl alkyl) substitutes and derivatives thereof

Info

Publication number
CA1047504A
CA1047504A CA221,240A CA221240A CA1047504A CA 1047504 A CA1047504 A CA 1047504A CA 221240 A CA221240 A CA 221240A CA 1047504 A CA1047504 A CA 1047504A
Authority
CA
Canada
Prior art keywords
methoxy
group
pyrrolidinylmethyl
amino
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA221,240A
Other languages
English (en)
French (fr)
Inventor
Gerard Bulteau
Jacques Acher
Jean C. Monier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Original Assignee
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7407535A external-priority patent/FR2262966A1/fr
Priority claimed from FR7503800A external-priority patent/FR2299863B1/fr
Application filed by Societe dEtudes Scientifiques et Industrielles de lIle de France SA filed Critical Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Application granted granted Critical
Publication of CA1047504A publication Critical patent/CA1047504A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA221,240A 1974-03-05 1975-03-04 N-(2-pyrrolidinyl alkyl) substitutes and derivatives thereof Expired CA1047504A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7407535A FR2262966A1 (en) 1974-03-05 1974-03-05 N-(2-azacycloalkyl-alkyl)-benzamide derivs. - with antiemetic, antiulcer and CNS activity
FR7503800A FR2299863B1 (fr) 1975-02-07 1975-02-07 Nouveaux N-(Z-pyrrolidiny alkyl) benzamides substitués, leurs dérivés et leur procédé de préparation

Publications (1)

Publication Number Publication Date
CA1047504A true CA1047504A (en) 1979-01-30

Family

ID=26218210

Family Applications (1)

Application Number Title Priority Date Filing Date
CA221,240A Expired CA1047504A (en) 1974-03-05 1975-03-04 N-(2-pyrrolidinyl alkyl) substitutes and derivatives thereof

Country Status (27)

Country Link
JP (1) JPS6015616B2 (xx)
AR (1) AR206621A1 (xx)
AT (1) AT358570B (xx)
BG (1) BG24666A3 (xx)
CA (1) CA1047504A (xx)
CH (1) CH605794A5 (xx)
CS (1) CS189692B2 (xx)
DD (1) DD119420A5 (xx)
DE (1) DE2507989A1 (xx)
DK (1) DK145377C (xx)
EG (1) EG12577A (xx)
ES (1) ES435274A1 (xx)
FI (1) FI750620A (xx)
GB (1) GB1466822A (xx)
HK (1) HK14078A (xx)
HU (1) HU170637B (xx)
IE (1) IE40818B1 (xx)
IL (1) IL46696A (xx)
LU (1) LU71949A1 (xx)
NL (1) NL7502608A (xx)
NO (1) NO750713L (xx)
OA (1) OA04966A (xx)
PH (1) PH14197A (xx)
PL (1) PL97091B1 (xx)
RO (2) RO72844A (xx)
SE (1) SE411754B (xx)
SU (1) SU609464A3 (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ186175A (en) * 1977-01-27 1980-03-05 Shionogi & Co Meta-sulphonamidobenzamide derivatives
SE8503054D0 (sv) * 1985-06-19 1985-06-19 Astra Laekemedel Ab Catecholcarboxamides
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
EP0314483A1 (en) * 1987-10-29 1989-05-03 Erbamont, Inc. Preparation of benzamides
FR2699533A1 (fr) * 1992-12-21 1994-06-24 Mouhtaram Mohamed Dérivés de N-((1,4-dialkyl-6-arylpipérazine-2-yl)méthyl)benzamides. (Isomères cis et trans) Propriétés pharmacologiques et applications.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3078497A (en) * 1960-12-29 1963-02-26 Leeds And Mieallef Dispensing containers

Also Published As

Publication number Publication date
SU609464A3 (ru) 1978-05-30
JPS6015616B2 (ja) 1985-04-20
OA04966A (fr) 1980-10-31
AT358570B (de) 1980-09-25
ATA160775A (de) 1980-02-15
DK145377B (da) 1982-11-08
SE7502342L (xx) 1975-09-08
ES435274A1 (es) 1976-12-16
CS189692B2 (en) 1979-04-30
DK145377C (da) 1983-04-11
FI750620A (xx) 1975-09-06
JPS50123668A (xx) 1975-09-29
AR206621A1 (es) 1976-08-06
NO750713L (xx) 1975-09-08
IE40818B1 (en) 1979-08-29
IE40818L (en) 1975-09-05
HU170637B (xx) 1977-07-28
DE2507989A1 (de) 1975-09-11
RO72844A (ro) 1981-09-24
BG24666A3 (en) 1978-04-12
DD119420A5 (xx) 1976-04-20
EG12577A (en) 1979-09-30
PH14197A (en) 1981-03-26
DK86975A (xx) 1975-11-03
RO70647A (ro) 1980-04-15
NL7502608A (nl) 1975-09-09
AU7874075A (en) 1976-09-09
PL97091B1 (pl) 1978-02-28
SU609464A1 (xx) 1978-05-30
LU71949A1 (xx) 1976-02-04
IL46696A (en) 1978-07-31
HK14078A (en) 1978-03-23
CH605794A5 (xx) 1978-10-13
SE411754B (sv) 1980-02-04
IL46696A0 (en) 1975-04-25
GB1466822A (en) 1977-03-09

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