DE2503815C2 - Indazol-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel - Google Patents

Indazol-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel

Info

Publication number
DE2503815C2
DE2503815C2 DE2503815A DE2503815A DE2503815C2 DE 2503815 C2 DE2503815 C2 DE 2503815C2 DE 2503815 A DE2503815 A DE 2503815A DE 2503815 A DE2503815 A DE 2503815A DE 2503815 C2 DE2503815 C2 DE 2503815C2
Authority
DE
Germany
Prior art keywords
phenyl
general formula
hydrochloride
compound
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2503815A
Other languages
German (de)
English (en)
Other versions
DE2503815A1 (de
Inventor
Yasuo Tokio/Tokyo Fujimura
Yugo Hoya Tokio/Tokyo Ikeda
Tsuneo Ageo Saitama Iwasaki
Morio Kawagoe Saitama Kakimoto
Hiroyuki Ageo Saitama Nagano
Minoru Higashi Kurume Tokio/Tokyo Shindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1218474A external-priority patent/JPS5637984B2/ja
Priority claimed from JP49055000A external-priority patent/JPS5922708B2/ja
Priority claimed from JP6185374A external-priority patent/JPS5652904B2/ja
Priority claimed from JP49129521A external-priority patent/JPS603063B2/ja
Priority claimed from JP49135184A external-priority patent/JPS5944313B2/ja
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of DE2503815A1 publication Critical patent/DE2503815A1/de
Application granted granted Critical
Publication of DE2503815C2 publication Critical patent/DE2503815C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE2503815A 1974-01-31 1975-01-30 Indazol-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel Expired DE2503815C2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP1218474A JPS5637984B2 (Direct) 1974-01-31 1974-01-31
JP49055000A JPS5922708B2 (ja) 1974-05-18 1974-05-18 インダゾ−ル誘導体の製法
JP6185374A JPS5652904B2 (Direct) 1974-06-03 1974-06-03
JP49129521A JPS603063B2 (ja) 1974-11-12 1974-11-12 インダゾ−ル誘導体の製法
JP49135184A JPS5944313B2 (ja) 1974-11-26 1974-11-26 インダゾ−ル誘導体の製法

Publications (2)

Publication Number Publication Date
DE2503815A1 DE2503815A1 (de) 1975-08-07
DE2503815C2 true DE2503815C2 (de) 1986-05-22

Family

ID=27519371

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2503815A Expired DE2503815C2 (de) 1974-01-31 1975-01-30 Indazol-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel

Country Status (4)

Country Link
US (1) US3994890A (Direct)
DE (1) DE2503815C2 (Direct)
FR (1) FR2259601B1 (Direct)
GB (1) GB1489280A (Direct)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3132916A1 (de) * 1981-08-20 1983-03-03 Kali-Chemie Pharma Gmbh, 3000 Hannover 1-phenylindazol-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5264576A (en) * 1992-10-22 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Pyrazolo[4,3-c]pyridines which are intermediates
AP2001002304A0 (en) * 1996-05-03 2001-12-31 Pfizer Substituted indazole derivatives and related compounds
ES2325045T3 (es) 1996-10-14 2009-08-24 Bayer Healthcare Ag Nuevos derivados de pirazol heterociclilmetil sustituidos y su uso en el tratamiento de enfermedades cardiovasculares.
WO1999064425A1 (en) * 1998-06-09 1999-12-16 Neurogen Corporation Substituted thienocycloalkylpyrazoles: dopamine receptor subtype specific ligands
PT1178981E (pt) 1999-05-14 2003-11-28 Ortho Mcneil Pharm Inc 3-piridil-4-arilpirrois substituidos e metodos terapeuticos e profilacticos
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
US6956036B1 (en) * 2000-03-17 2005-10-18 Alcon, Inc. 6-hydroxy-indazole derivatives for treating glaucoma
US6927233B1 (en) * 2000-03-17 2005-08-09 Alcon, Inc. 5ht2 agonists for controlling IOP and treating glaucoma
US20050009876A1 (en) * 2000-07-31 2005-01-13 Bhagwat Shripad S. Indazole compounds, compositions thereof and methods of treatment therewith
US6897231B2 (en) 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
US7211594B2 (en) 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
ES2281434T3 (es) * 2000-08-14 2007-10-01 Ortho-Mcneil Pharmaceutical, Inc. Pirazoles sustituidos.
HK1052705B (en) 2000-08-14 2006-09-29 Ortho-Mcneil Pharmaceutical, Inc. Substituted pyrazole
HU230538B1 (hu) 2000-08-14 2016-11-28 Ortho Mcneil Pharmaceutical, Inc. Szubsztituált pirazolok és ezeket tartalmazó gyógyszerkészítmények
US7332494B2 (en) * 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
US20070105841A1 (en) * 2000-08-14 2007-05-10 Breitenbucher J G Method for treating allergies using substituted pyrazoles
CN1642973A (zh) 2000-09-06 2005-07-20 奥索-麦克尼尔药品公司 治疗变态反应的方法
US7429599B2 (en) * 2000-12-06 2008-09-30 Signal Pharmaceuticals, Llc Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
RU2286343C2 (ru) * 2001-08-10 2006-10-27 Орто-Макнейл Фармасьютикал, Инк. Замещенные пиразолы
US20030073672A1 (en) * 2001-09-05 2003-04-17 Breitenbucher J. Guy Method for treating allergies using substituted pyrazoles
US20030109550A1 (en) * 2001-09-19 2003-06-12 Michael Clare Substituted indazole compounds for the treatment of inflammation
CA2478338A1 (en) * 2002-03-08 2003-09-18 Signal Pharmaceuticals, Inc. Combination therapy for treating, preventing or managing proliferative disorders and cancers
US20040034084A1 (en) * 2002-05-24 2004-02-19 Celgene Corporation Methods for using JNK inhibitors for treating or preventing disease-related wasting
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) * 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
DK1531822T3 (da) * 2002-06-12 2009-12-07 Chemocentryx Inc 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser
JP2007511618A (ja) 2003-11-19 2007-05-10 シグナル ファーマシューティカルズ，エルエルシー インダゾール化合物およびタンパク質キナーゼ阻害剤としてのその使用方法
CN100542534C (zh) * 2003-12-09 2009-09-23 凯莫森特里克斯股份有限公司 取代的哌嗪
JP4845873B2 (ja) * 2004-03-03 2011-12-28 ケモセントリックス インコーポレーティッド 二環式および架橋した窒素複素環
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US20070004777A1 (en) * 2005-03-23 2007-01-04 Bhagwat Shripad S Methods for treating or preventing acute myelogenous leukemia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641050A (en) * 1967-12-12 1972-02-08 Tenneco Chem 1 5-substituted indazoles
NL7000716A (Direct) * 1969-01-27 1970-07-29
DE1948793A1 (de) * 1969-09-26 1971-04-01 Rhein Chemie Rheinau Gmbh Verfahren zur Herstellung von 4,5,6,7-Tetrahydroindazolen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS-ERMITTELT

Also Published As

Publication number Publication date
US3994890A (en) 1976-11-30
GB1489280A (en) 1977-10-19
FR2259601B1 (Direct) 1980-01-11
DE2503815A1 (de) 1975-08-07
FR2259601A1 (Direct) 1975-08-29

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee