DE2502621C3 - Messung elastischer und dielektrischer Eigenschaften der Membran lebender Zellen - Google Patents
Messung elastischer und dielektrischer Eigenschaften der Membran lebender ZellenInfo
- Publication number
- DE2502621C3 DE2502621C3 DE2502621A DE2502621A DE2502621C3 DE 2502621 C3 DE2502621 C3 DE 2502621C3 DE 2502621 A DE2502621 A DE 2502621A DE 2502621 A DE2502621 A DE 2502621A DE 2502621 C3 DE2502621 C3 DE 2502621C3
- Authority
- DE
- Germany
- Prior art keywords
- cells
- electrodes
- voltage
- membrane
- measuring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N15/134—Devices using two or more apertures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R27/00—Arrangements for measuring resistance, reactance, impedance, or electric characteristics derived therefrom
- G01R27/02—Measuring real or complex resistance, reactance, impedance, or other two-pole characteristics derived therefrom, e.g. time constant
- G01R27/26—Measuring inductance or capacitance; Measuring quality factor, e.g. by using the resonance method; Measuring loss factor; Measuring dielectric constants ; Measuring impedance or related variables
- G01R27/2617—Measuring dielectric properties, e.g. constants
- G01R27/2635—Sample holders, electrodes or excitation arrangements, e.g. sensors or measuring cells
- G01R27/2658—Cavities, resonators, free space arrangements, reflexion or interference arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/012—Red blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Sustainable Development (AREA)
- Cell Biology (AREA)
- Electromagnetism (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Hematology (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2502621A DE2502621C3 (de) | 1975-01-23 | 1975-01-23 | Messung elastischer und dielektrischer Eigenschaften der Membran lebender Zellen |
| CH1463175A CH594888A5 (enExample) | 1975-01-23 | 1975-11-12 | |
| US05/651,337 US4055799A (en) | 1975-01-23 | 1976-01-22 | Method of and device for measuring elastic and di-electric properties of the diaphragm of living cells |
| JP51005512A JPS6013140B2 (ja) | 1975-01-23 | 1976-01-22 | 生細胞膜の弾性および誘電特性の測定方法 |
| FR7601679A FR2298797A1 (fr) | 1975-01-23 | 1976-01-22 | Procede et disp |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2502621A DE2502621C3 (de) | 1975-01-23 | 1975-01-23 | Messung elastischer und dielektrischer Eigenschaften der Membran lebender Zellen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2502621A1 DE2502621A1 (de) | 1976-08-05 |
| DE2502621B2 DE2502621B2 (de) | 1978-01-12 |
| DE2502621C3 true DE2502621C3 (de) | 1978-09-14 |
Family
ID=5937086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2502621A Expired DE2502621C3 (de) | 1975-01-23 | 1975-01-23 | Messung elastischer und dielektrischer Eigenschaften der Membran lebender Zellen |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4055799A (enExample) |
| JP (1) | JPS6013140B2 (enExample) |
| CH (1) | CH594888A5 (enExample) |
| DE (1) | DE2502621C3 (enExample) |
| FR (1) | FR2298797A1 (enExample) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4271001A (en) * | 1978-03-23 | 1981-06-02 | Asahi Kasei Kogyo Kabushiki Kaisha | Apparatus for measuring membrane characteristics of vesicles |
| US4343782A (en) * | 1978-04-20 | 1982-08-10 | Shapiro Howard M | Cytological assay procedure |
| DE2828232C2 (de) * | 1978-06-28 | 1986-04-17 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Vorrichtung zur Bestimmung des dielektrischen Durchbruches und der Größe von als Umhüllung eine Membran aufweisenden Partikeln |
| US4368423A (en) * | 1981-01-13 | 1983-01-11 | Liburdy Robert P | Apparatus for determining cell membrane dielectric breakdown |
| US4472506A (en) * | 1981-01-13 | 1984-09-18 | Liburdy Robert P | Method for determining cell membrane dielectric breakdown |
| JPS5822946A (ja) * | 1981-08-03 | 1983-02-10 | Olympus Optical Co Ltd | 境界面検出装置 |
| US5310674A (en) * | 1982-05-10 | 1994-05-10 | Bar-Ilan University | Apertured cell carrier |
| IL68507A (en) * | 1982-05-10 | 1986-01-31 | Univ Bar Ilan | System and methods for cell selection |
| US5272081A (en) * | 1982-05-10 | 1993-12-21 | Bar-Ilan University | System and methods for cell selection |
| US4528270A (en) * | 1982-11-02 | 1985-07-09 | Kabushiki Kaisya Advance Kaihatsu Kenkyujo | Electrochemical method for detection and classification of microbial cell |
| DE3485462D1 (de) * | 1983-11-08 | 1992-02-27 | Scient Diagnostics Inc | System und verfahren fuer zellenauslese. |
| FR2569477B1 (fr) * | 1984-08-24 | 1987-01-02 | Descartes Universite Rene | Appareil et procede pour la determination de la deformabilite des globules rouges du sang |
| SE461499B (sv) * | 1986-11-21 | 1990-02-26 | Nobelpharma Ab | Beninvaextkammare |
| US5389069A (en) * | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
| US5278048A (en) * | 1988-10-21 | 1994-01-11 | Molecular Devices Corporation | Methods for detecting the effect of cell affecting agents on living cells |
| EP0394406B1 (en) * | 1988-10-21 | 1995-04-26 | Molecular Devices Corporation | Methods and apparatus for detecting the effect of cell affecting agents on living cells |
| GB2232769B (en) * | 1989-06-13 | 1994-06-22 | Timothy Charles Fisher | Counting and volume measurement of particles and biological cells,and determination of their deformability |
| GB9215733D0 (en) * | 1992-07-24 | 1992-09-09 | British Tech Group | Method of and apparatus for determining a property of a sample |
| AUPM851694A0 (en) * | 1994-09-30 | 1994-10-27 | Barsamian, Sergei T | New methods for diagnosis, detection of cell abnormalities and morphology of living systems |
| AU747114B2 (en) * | 1994-09-30 | 2002-05-09 | Electronic Diagnostics Pty Ltd | Method and apparatus for diagnosis, detection of cell abnormalities and morphology of living systems |
| US5983131A (en) * | 1995-08-11 | 1999-11-09 | Massachusetts Institute Of Technology | Apparatus and method for electroporation of tissue |
| US6010613A (en) * | 1995-12-08 | 2000-01-04 | Cyto Pulse Sciences, Inc. | Method of treating materials with pulsed electrical fields |
| US6387707B1 (en) * | 1996-04-25 | 2002-05-14 | Bioarray Solutions | Array Cytometry |
| WO1997040385A1 (en) | 1996-04-25 | 1997-10-30 | Bioarray Solutions, Llc | Light-controlled electrokinetic assembly of particles near surfaces |
| US5911223A (en) * | 1996-08-09 | 1999-06-15 | Massachusetts Institute Of Technology | Introduction of modifying agents into skin by electroporation |
| US6085115A (en) * | 1997-05-22 | 2000-07-04 | Massachusetts Institite Of Technology | Biopotential measurement including electroporation of tissue surface |
| WO1998056893A1 (en) * | 1997-06-10 | 1998-12-17 | Walters Richard E | Method and apparatus for treating materials with electrical fields having varying orientations |
| CN1109101C (zh) * | 1997-06-10 | 2003-05-21 | 塞托·帕尔斯科技公司 | 处理带有可变方向的电场的物质的方法和装置 |
| US6163719A (en) * | 1997-09-09 | 2000-12-19 | Sherman; Adam Jacob | Biological membrane voltage estimator |
| AU746580B2 (en) | 1997-12-17 | 2002-05-02 | Ecole Polytechnique Federale De Lausanne | Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers |
| US20020144905A1 (en) | 1997-12-17 | 2002-10-10 | Christian Schmidt | Sample positioning and analysis system |
| US7244349B2 (en) * | 1997-12-17 | 2007-07-17 | Molecular Devices Corporation | Multiaperture sample positioning and analysis system |
| GB9812783D0 (en) * | 1998-06-12 | 1998-08-12 | Cenes Ltd | High throuoghput screen |
| JP4294142B2 (ja) | 1999-02-02 | 2009-07-08 | 株式会社日立製作所 | ディスクサブシステム |
| US6488829B1 (en) * | 1999-08-05 | 2002-12-03 | Essen Instruments Inc | High-throughput electrophysiological measurement apparatus |
| DE19946458C2 (de) * | 1999-09-28 | 2002-10-24 | Fraunhofer Ges Forschung | Vorrichtung und Verfahren zur Charakterisierung von Sphäroiden |
| US6682649B1 (en) * | 1999-10-01 | 2004-01-27 | Sophion Bioscience A/S | Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels |
| GB9930719D0 (en) * | 1999-12-24 | 2000-02-16 | Central Research Lab Ltd | Apparatus for and method of making electrical measurements on an object in a m edium |
| GB9930718D0 (en) * | 1999-12-24 | 2000-02-16 | Central Research Lab Ltd | Apparatus for and method of making electrical measurements on objects |
| JP4744778B2 (ja) | 2000-06-21 | 2011-08-10 | バイオアレイ ソルーションズ リミテッド | 特定のランダム粒子アレイを適用した複数の被検体分子の分析方法 |
| US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
| EP1178315A1 (de) * | 2000-07-31 | 2002-02-06 | Albrecht Dr.med. Priv.Doz. Lepple-Wienhues | Verfahren und Vorrichtung zur Untersuchung von Zellen mit Hilfe der Patch Clamp-Methode |
| US7270730B2 (en) * | 2000-08-04 | 2007-09-18 | Essen Instruments, Inc. | High-throughput electrophysiological measurement system |
| US7067046B2 (en) | 2000-08-04 | 2006-06-27 | Essen Instruments, Inc. | System for rapid chemical activation in high-throughput electrophysiological measurements |
| US20050058990A1 (en) * | 2001-03-24 | 2005-03-17 | Antonio Guia | Biochip devices for ion transport measurement, methods of manufacture, and methods of use |
| US20060029955A1 (en) * | 2001-03-24 | 2006-02-09 | Antonio Guia | High-density ion transport measurement biochip devices and methods |
| US20040146849A1 (en) * | 2002-01-24 | 2004-07-29 | Mingxian Huang | Biochips including ion transport detecting structures and methods of use |
| EP1372828A4 (en) * | 2001-03-24 | 2008-10-29 | Aviva Biosciences Corp | BIOCHIPS WITH ION TRANSPORTATION STRUCTURES AND USE METHOD |
| US20050196746A1 (en) * | 2001-03-24 | 2005-09-08 | Jia Xu | High-density ion transport measurement biochip devices and methods |
| US20050009004A1 (en) * | 2002-05-04 | 2005-01-13 | Jia Xu | Apparatus including ion transport detecting structures and methods of use |
| US7262063B2 (en) | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
| WO2003011553A1 (en) * | 2001-07-31 | 2003-02-13 | Massachusetts Institute Of Technology | On-chip membrane maker |
| ES2712173T3 (es) | 2001-10-15 | 2019-05-09 | Bioarray Solutions Ltd | Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas |
| CA2485099C (en) * | 2002-05-04 | 2017-09-26 | Aviva Biosciences Corporation | Apparatus including ion transport detecting structures and methods of use |
| EP1569510B1 (en) | 2002-09-27 | 2011-11-02 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
| US7526114B2 (en) | 2002-11-15 | 2009-04-28 | Bioarray Solutions Ltd. | Analysis, secure access to, and transmission of array images |
| AU2003902363A0 (en) * | 2003-05-15 | 2003-05-29 | Life Therapeutics Limited | Cell separation |
| WO2005029705A2 (en) | 2003-09-18 | 2005-03-31 | Bioarray Solutions, Ltd. | Number coding for identification of subtypes of coded types of solid phase carriers |
| NZ546072A (en) | 2003-09-22 | 2009-08-28 | Bioarray Solutions Ltd | Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules |
| US8123924B2 (en) * | 2003-10-07 | 2012-02-28 | Newcastle Innovation Limited | Sperm cell separation by electrophoresis |
| JP2007521017A (ja) | 2003-10-28 | 2007-08-02 | バイオアレイ ソリューションズ リミテッド | 固定化捕捉プローブを用いる遺伝子発現分析法の最適化 |
| JP2007509629A (ja) | 2003-10-29 | 2007-04-19 | バイオアレイ ソリューションズ リミテッド | 二本鎖dnaの切断による複合核酸分析 |
| US7169609B2 (en) * | 2004-03-31 | 2007-01-30 | Vertex Pharmaceutcals, Inc. | Multiwell plate assembly for use in high throughput assays |
| DE102004017474A1 (de) * | 2004-04-08 | 2005-10-27 | Evotec Technologies Gmbh | Messeinrichtung zur Impedanzspektroskopie und zugehöriges Messverfahren |
| US7622934B2 (en) * | 2004-07-23 | 2009-11-24 | Electronic Bio Sciences, Llc | Method and apparatus for sensing a time varying current passing through an ion channel |
| US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
| WO2006031612A2 (en) * | 2004-09-10 | 2006-03-23 | Molecular Devices Corporation | Parallel patch clamp system |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| US8486629B2 (en) | 2005-06-01 | 2013-07-16 | Bioarray Solutions, Ltd. | Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation |
| US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| WO2007108773A1 (en) * | 2006-03-23 | 2007-09-27 | Agengy For Science, Technology And Research | Device for analyzing the status of a particle |
| JP5758989B2 (ja) * | 2011-04-28 | 2015-08-05 | 株式会社日立製作所 | 細胞培養容器および細胞培養装置 |
| BR112014009346B1 (pt) * | 2011-10-17 | 2020-09-15 | Massachusetts Institute Of Technology | Entrega intracelular |
| KR102243597B1 (ko) | 2013-08-16 | 2021-04-26 | 메사추세츠 인스티튜트 오브 테크놀로지 | 세포로의 선택적 물질 전달 |
| CN104232478A (zh) * | 2014-09-24 | 2014-12-24 | 昆山超强光电设备有限公司 | 一种细菌数量采集器 |
| CN107109362A (zh) | 2014-10-31 | 2017-08-29 | 麻省理工学院 | 递送生物分子至免疫细胞 |
| CN107002089B (zh) | 2014-11-14 | 2021-09-07 | 麻省理工学院 | 化合物和组合物向细胞中的破坏和场实现的递送 |
| WO2016115179A1 (en) | 2015-01-12 | 2016-07-21 | Massachusetts Institute Of Technology | Gene editing through microfluidic delivery |
| WO2017008063A1 (en) | 2015-07-09 | 2017-01-12 | Massachusetts Institute Of Technology | Delivery of materials to anucleate cells |
| US11613759B2 (en) | 2015-09-04 | 2023-03-28 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| AU2017259987B2 (en) | 2016-05-03 | 2023-10-19 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
| SG11202109333SA (en) | 2019-02-28 | 2021-09-29 | Sqz Biotechnologies Co | Delivery of biomolecules to pbmcs to modify an immune response |
| KR20210149791A (ko) | 2019-04-08 | 2021-12-09 | 에스큐지 바이오테크놀로지스 컴퍼니 | 페이로드를 세포 내로 전달하기 위한 시스템에서 이용하기 위한 카트리지 |
| CN112525792A (zh) * | 2020-11-05 | 2021-03-19 | 中国电子科技集团公司第十八研究所 | 一种基于压力控制的锂电池隔膜温度测试装置及测试方法 |
| CN118032535B (zh) * | 2024-01-12 | 2024-10-22 | 天科新能源有限责任公司 | 一种聚合物固态电池的隔膜力学性能模拟测试系统 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3560754A (en) * | 1965-11-17 | 1971-02-02 | Ibm | Photoelectric particle separator using time delay |
| GB1262749A (en) * | 1969-02-24 | 1972-02-02 | Nat Res Dev | Methods and apparatus for determining the condition of food |
| US3772593A (en) * | 1971-11-03 | 1973-11-13 | P Sidhu | Resistance measurement system |
-
1975
- 1975-01-23 DE DE2502621A patent/DE2502621C3/de not_active Expired
- 1975-11-12 CH CH1463175A patent/CH594888A5/xx not_active IP Right Cessation
-
1976
- 1976-01-22 FR FR7601679A patent/FR2298797A1/fr active Granted
- 1976-01-22 JP JP51005512A patent/JPS6013140B2/ja not_active Expired
- 1976-01-22 US US05/651,337 patent/US4055799A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5197495A (enExample) | 1976-08-27 |
| DE2502621A1 (de) | 1976-08-05 |
| DE2502621B2 (de) | 1978-01-12 |
| JPS6013140B2 (ja) | 1985-04-05 |
| FR2298797A1 (fr) | 1976-08-20 |
| FR2298797B1 (enExample) | 1980-01-11 |
| US4055799A (en) | 1977-10-25 |
| CH594888A5 (enExample) | 1978-01-31 |
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| C3 | Grant after two publication steps (3rd publication) | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BAYERISCHE JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBU |
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