DE2141803A1 - Trijodierte n-methyl-dicarbonsaeureani-lide und verfahren zu iher herstellung - Google Patents

Trijodierte n-methyl-dicarbonsaeureani-lide und verfahren zu iher herstellung

Info

Publication number
DE2141803A1
DE2141803A1 DE2141803A DE2141803A DE2141803A1 DE 2141803 A1 DE2141803 A1 DE 2141803A1 DE 2141803 A DE2141803 A DE 2141803A DE 2141803 A DE2141803 A DE 2141803A DE 2141803 A1 DE2141803 A1 DE 2141803A1
Authority
DE
Germany
Prior art keywords
triiodo
methylanilide
acid
diglycolic acid
carboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE2141803A
Other languages
German (de)
English (en)
Inventor
Heinz Dr Gries
Heinrich Dr Pfeiffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE787669D priority Critical patent/BE787669A/xx
Application filed by Schering AG filed Critical Schering AG
Priority to DE2141803A priority patent/DE2141803A1/de
Priority to AR243597A priority patent/AR204073A1/es
Priority to NL7209286A priority patent/NL7209286A/xx
Priority to DD164237A priority patent/DD100156A5/xx
Priority to DK340372A priority patent/DK132375C/da
Priority to SU1817911A priority patent/SU474974A3/ru
Priority to GB3673472A priority patent/GB1409733A/en
Priority to IL40088A priority patent/IL40088A/en
Priority to ES405770A priority patent/ES405770A1/es
Priority to ES405769A priority patent/ES405769A1/es
Priority to AT700972A priority patent/AT317417B/de
Priority to AT713473*7A priority patent/AT329543B/de
Priority to HU72SE405A priority patent/HU164151B/hu
Priority to AU45650/72A priority patent/AU476763B2/en
Priority to FR7229332A priority patent/FR2150784B1/fr
Priority to JP47082447A priority patent/JPS4829736A/ja
Priority to US05/281,379 priority patent/US4001298A/en
Priority to ZA725664A priority patent/ZA725664B/xx
Priority to CA149,662A priority patent/CA977759A/en
Publication of DE2141803A1 publication Critical patent/DE2141803A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE2141803A 1971-08-17 1971-08-17 Trijodierte n-methyl-dicarbonsaeureani-lide und verfahren zu iher herstellung Pending DE2141803A1 (de)

Priority Applications (20)

Application Number Priority Date Filing Date Title
BE787669D BE787669A (fr) 1971-08-17 Anilides d'acide n-methyl-dicarboxylique triiodes, et leur procede de preparation
DE2141803A DE2141803A1 (de) 1971-08-17 1971-08-17 Trijodierte n-methyl-dicarbonsaeureani-lide und verfahren zu iher herstellung
AR243597A AR204073A1 (es) 1971-08-17 1972-01-01 Procedimiento para la produccion de nuevos di-(3-carboxi-2,4,6-triyodo-n-metilanilidas)de acidos oxaalcandioicos y de sus cloruros y esteres de propiedades productoras de sombra para composiciones de contraste radiologico
NL7209286A NL7209286A (enExample) 1971-08-17 1972-06-30
DD164237A DD100156A5 (enExample) 1971-08-17 1972-07-06
DK340372A DK132375C (da) 1971-08-17 1972-07-07 Di-(3-carboxy-2,4,6-triiodanilider) til anvendelse som rontgenkontrastmiddel
SU1817911A SU474974A3 (ru) 1971-08-17 1972-08-03 Способ получени трийодированных анилидов -метил-дикарбоновой кислоты
GB3673472A GB1409733A (en) 1971-08-17 1972-08-07 Triiodinated n-methyl-dicarboxylic acid anilides and process for their manufacture
IL40088A IL40088A (en) 1971-08-17 1972-08-09 Tri-iodinated n-methyldicarboxylic acid anilides and process for their manufacture
ES405770A ES405770A1 (es) 1971-08-17 1972-08-11 Procedimiento para la preparacion de n-metil-anilidas tri- yodadas de acido dicarboxilico.
ES405769A ES405769A1 (es) 1971-08-17 1972-08-11 Procedimiento para la obtencion de medios de contraste de rayos x.
AT700972A AT317417B (de) 1971-08-17 1972-08-14 Röntgenkontrastmittel
AT713473*7A AT329543B (de) 1971-08-17 1972-08-14 Verfahren zur herstellung von neuen n,n'-bis-2',4',6'-trijodphenyl-n,n'-dimethyloxa- oder -thiaalkansaurediamiden und ihren salzen
HU72SE405A HU164151B (enExample) 1971-08-17 1972-08-16
AU45650/72A AU476763B2 (en) 1971-08-17 1972-08-16 Tri-iodinated n-methyl-dicarboxylic acid anilide process for their manufacture
FR7229332A FR2150784B1 (enExample) 1971-08-17 1972-08-16
JP47082447A JPS4829736A (enExample) 1971-08-17 1972-08-17
US05/281,379 US4001298A (en) 1971-08-17 1972-08-17 Triiodized n-methyldicarboxylic acid anilides
ZA725664A ZA725664B (en) 1971-08-17 1972-08-17 Tri-iodinated n-methyl-dicarboxylic acid anilides and process for their manufacture
CA149,662A CA977759A (en) 1971-08-17 1972-08-17 Process for producing tri-iodinated n-methyl-dicarboxylic acid anilides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2141803A DE2141803A1 (de) 1971-08-17 1971-08-17 Trijodierte n-methyl-dicarbonsaeureani-lide und verfahren zu iher herstellung

Publications (1)

Publication Number Publication Date
DE2141803A1 true DE2141803A1 (de) 1973-03-01

Family

ID=5817319

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2141803A Pending DE2141803A1 (de) 1971-08-17 1971-08-17 Trijodierte n-methyl-dicarbonsaeureani-lide und verfahren zu iher herstellung

Country Status (18)

Country Link
US (1) US4001298A (enExample)
JP (1) JPS4829736A (enExample)
AR (1) AR204073A1 (enExample)
AT (2) AT317417B (enExample)
AU (1) AU476763B2 (enExample)
BE (1) BE787669A (enExample)
CA (1) CA977759A (enExample)
DD (1) DD100156A5 (enExample)
DE (1) DE2141803A1 (enExample)
DK (1) DK132375C (enExample)
ES (2) ES405769A1 (enExample)
FR (1) FR2150784B1 (enExample)
GB (1) GB1409733A (enExample)
HU (1) HU164151B (enExample)
IL (1) IL40088A (enExample)
NL (1) NL7209286A (enExample)
SU (1) SU474974A3 (enExample)
ZA (1) ZA725664B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0079397A1 (de) * 1981-11-13 1983-05-25 Schering Aktiengesellschaft Unsymmetrisch substituierte Dicarbonsäure-bis-(2,4,-6-trijodanilide), deren Herstellung und diese enthaltende Röntgenkontrastmittel

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4225725A (en) * 1975-10-20 1980-09-30 Mallinckrodt, Inc. Lower alkoxymethyl esters of 2,4,6-triiodobenzoic acid derivatives
GB1539791A (en) * 1976-04-08 1979-02-07 Guerbet Sa X-ray contrast media
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
DE2629228C2 (de) * 1976-06-25 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung
CA1327600C (en) * 1987-05-22 1994-03-08 Ernest Felder Process for the preparation of 5-acylamino-2,4,6- triiodo-or tribromo-benzoic acid derivatives and corresponding novel 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives obtained by said process
US5614638A (en) * 1989-11-29 1997-03-25 Bracco International B.V. Nonionic radiographic contrast agents
US5869024A (en) * 1989-11-29 1999-02-09 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
US5527926A (en) * 1990-11-26 1996-06-18 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
US5278311A (en) * 1992-06-05 1994-01-11 E. R. Squibb & Sons, Inc. Nonionic radiographic contrast agents
US5463080A (en) * 1992-08-27 1995-10-31 Bracco International B.V. 2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as radiolabelling reagents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3542861A (en) * 1967-05-08 1970-11-24 Sterling Drug Inc 3-amino-5-cycloalkylcarbonylamino-2,4,6-triiodobenzoic acids
US3732293A (en) * 1968-03-15 1973-05-08 Sterling Drug Inc Iodinated bis(aminobenzoic acids) and esters thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0079397A1 (de) * 1981-11-13 1983-05-25 Schering Aktiengesellschaft Unsymmetrisch substituierte Dicarbonsäure-bis-(2,4,-6-trijodanilide), deren Herstellung und diese enthaltende Röntgenkontrastmittel

Also Published As

Publication number Publication date
DD100156A5 (enExample) 1973-09-12
ES405770A1 (es) 1975-09-16
AU4565072A (en) 1974-02-21
DK132375B (da) 1975-12-01
AR204073A1 (es) 1975-11-20
AT329543B (de) 1976-05-10
IL40088A0 (en) 1972-10-29
DK132375C (da) 1976-05-03
GB1409733A (en) 1975-10-15
IL40088A (en) 1976-05-31
ATA713473A (de) 1975-08-15
FR2150784A1 (enExample) 1973-04-13
FR2150784B1 (enExample) 1975-06-20
AU476763B2 (en) 1976-10-07
NL7209286A (enExample) 1973-02-20
BE787669A (fr) 1973-02-19
ES405769A1 (es) 1975-09-16
HU164151B (enExample) 1973-12-28
JPS4829736A (enExample) 1973-04-19
ZA725664B (en) 1973-05-30
US4001298A (en) 1977-01-04
CA977759A (en) 1975-11-11
AT317417B (de) 1974-08-26
SU474974A3 (ru) 1975-06-25

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Legal Events

Date Code Title Description
OHA Expiration of time for request for examination