DE2061489C2 - Anti-Gichtmittel und anti-hyperurikämische Mittel - Google Patents

Anti-Gichtmittel und anti-hyperurikämische Mittel

Info

Publication number
DE2061489C2
DE2061489C2 DE2061489A DE2061489A DE2061489C2 DE 2061489 C2 DE2061489 C2 DE 2061489C2 DE 2061489 A DE2061489 A DE 2061489A DE 2061489 A DE2061489 A DE 2061489A DE 2061489 C2 DE2061489 C2 DE 2061489C2
Authority
DE
Germany
Prior art keywords
gout
salts
uric acid
agents
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2061489A
Other languages
German (de)
English (en)
Other versions
DE2061489A1 (de
Inventor
John James Lansdale Pa. Baldwin
Frederick Charles Berwyn Pa. Novello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2061489A1 publication Critical patent/DE2061489A1/de
Application granted granted Critical
Publication of DE2061489C2 publication Critical patent/DE2061489C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/93—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by halogen atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE2061489A 1969-12-15 1970-12-14 Anti-Gichtmittel und anti-hyperurikämische Mittel Expired DE2061489C2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US88536269A 1969-12-15 1969-12-15
US26501572A 1972-06-21 1972-06-21
US00265016A US3818014A (en) 1969-12-15 1972-06-21 2-quinolyl-4(5)-trifluoromethylimidazoles
US45610274A 1974-03-29 1974-03-29
US61090375A 1975-09-05 1975-09-05
US05/610,904 US4032522A (en) 1969-12-15 1975-09-05 2-pyrazinyl-trifluoromethylimidazoles and a method for their preparation

Publications (2)

Publication Number Publication Date
DE2061489A1 DE2061489A1 (de) 1971-07-29
DE2061489C2 true DE2061489C2 (de) 1982-04-01

Family

ID=27559450

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19702061515 Pending DE2061515A1 (de) 1969-12-15 1970-12-14 2,5 disubstituierte Imidazole und Ver fahren zur Herstellung derselben
DE2061489A Expired DE2061489C2 (de) 1969-12-15 1970-12-14 Anti-Gichtmittel und anti-hyperurikämische Mittel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19702061515 Pending DE2061515A1 (de) 1969-12-15 1970-12-14 2,5 disubstituierte Imidazole und Ver fahren zur Herstellung derselben

Country Status (10)

Country Link
US (4) US3786061A (no)
AT (1) AT300788B (no)
BE (1) BE760289A (no)
CA (1) CA945161A (no)
CH (1) CH566994A5 (no)
DE (2) DE2061515A1 (no)
FR (1) FR2081360B1 (no)
GB (1) GB1301754A (no)
NL (1) NL7017486A (no)
SE (1) SE388855B (no)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7017486A (no) * 1969-12-15 1971-06-17
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
GB1481512A (en) * 1973-07-12 1977-08-03 Lucas Electrical Ltd Radiation-sensitive switching circuits
US4058614A (en) * 1973-12-04 1977-11-15 Merck & Co., Inc. Substituted imidazole compounds and therapeutic compositions therewith
DE2414280C2 (de) * 1974-03-25 1981-12-17 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 1-Methyl-5-nitroimidazolen
US4199580A (en) * 1975-03-03 1980-04-22 Merck & Co., Inc. 3-Amino-2-or-propoxy-tetrahydronaphthyl or indanyl-substituted imidazoles and use
US4134983A (en) * 1975-03-03 1979-01-16 Merck & Co., Inc. 3-amino-2-or-propoxyaryl substituted imidazoles
US4853383A (en) * 1975-03-03 1989-08-01 Merck & Co., Inc. β-blocking substituted imidazoles
US4179512A (en) * 1977-03-01 1979-12-18 Merck & Co., Inc. 4-Substituted-2-arylimidazoles
US4314844A (en) * 1979-01-11 1982-02-09 Rohm And Haas Company Herbicidal substituted imidazoles
US4281005A (en) * 1979-03-05 1981-07-28 Merck & Co., Inc. Novel 2-pyridylimidazole compounds
IL62794A0 (en) * 1980-06-02 1981-07-31 American Cyanamid Co Substituted nicotinic acid esters and salts thereof and their use as herbicidal agents
DE3121736C2 (de) * 1980-06-02 1994-04-07 American Cyanamid Co 2-(2-Imidazolin-2-yl)-pyridine und -chinoline, Verfahren und Zwischenstufen zur Herstellung derselben und Verwendung derselben als herbizide Wirkstoffe
US4315021A (en) * 1980-12-03 1982-02-09 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles
US4499097A (en) * 1983-03-10 1985-02-12 American Cyanamid Company 2-(Pyridyl)imidazolyl ketones
US4602093A (en) * 1984-02-08 1986-07-22 Merck & Co., Inc. Novel substituted imidazoles, their preparation and use
FR2576308B1 (fr) * 1985-01-18 1987-02-20 Synthelabo Derives de tetrahydroquinoleine, leur preparation et leur application en therapeutique
GB8705183D0 (en) * 1987-03-05 1987-04-08 May & Baker Ltd Compositions of matter
US4914207A (en) * 1989-05-09 1990-04-03 Pfizer Inc. Arylthiazolylimidazoles
FR2649999B1 (fr) * 1989-07-21 1991-09-20 Payen Cie L Procede et machine pour la fabrication en continu d'un fil elastique a base d'elasthane
US5189053A (en) * 1989-08-10 1993-02-23 Schering Agrochemicals Limited Imidazol(in)e substituted haloarylpyrazole pesticides
YU47834B (sr) * 1989-08-10 1996-01-09 Schering Agrochemical Limited Azolni pesticid
JP3393891B2 (ja) * 1992-08-18 2003-04-07 塩野義製薬株式会社 イミダゾール類の製造方法
WO1995033730A1 (fr) * 1994-06-09 1995-12-14 Nippon Soda Co., Ltd. Derive d'imidazole, procede de production et herbicide
GB2344588B (en) * 1997-07-25 2001-11-14 Black James Foundation 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands
GB9715814D0 (en) * 1997-07-25 1997-10-01 Black James Foundation Histamine H3 receptor ligands
WO1999024038A1 (en) 1997-11-07 1999-05-20 Johns Hopkins University Methods for treatment of disorders of cardiac contractility
AU6503899A (en) * 1998-09-29 2000-04-17 Neurogen Corporation 2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands
US6288230B1 (en) 1998-09-29 2001-09-11 Neurogen Corporation 2-(2, 3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands
US6284759B1 (en) 1998-09-30 2001-09-04 Neurogen Corporation 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands
US20050026811A1 (en) * 2003-05-20 2005-02-03 Mjalli Adnan M. M. Rage antagonists as agents to reverse amyloidosis and diseases associated therewith
JP2004517804A (ja) * 2000-06-28 2004-06-17 メルク・アンド・カンパニー・インコーポレーテッド 心臓血管病の治療法
ES2373875T3 (es) 2002-03-05 2012-02-09 Transtech Pharma, Inc. Derivados de azol mono y bicíclicos que inhiben la interacción de ligandos con rage.
KR20080066938A (ko) * 2005-10-07 2008-07-17 깃세이 야쿠힌 고교 가부시키가이샤 질소 함유 복소환 화합물 및 그것을 함유하는 의약 조성물
WO2011041198A1 (en) 2009-09-30 2011-04-07 Transtech Pharma, Inc. Substituted imidazole derivatives for treatment of alzheimers disease
HU1000676D0 (en) * 2010-12-17 2011-02-28 Pharmahungary 2000 Kft Inhibitors of matrix metalloproteinase, pharmaceutical compositions thereof and use of them for preventing and treating diseases where the activation of mmp is involved
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3202674A (en) * 1960-03-05 1965-08-24 American Home Prod Phenethylamine derivatives
US3399211A (en) * 1964-03-10 1968-08-27 Merck & Co Inc Production of 2-aryl-4(5)-nitroimidazoles
NL6816241A (no) * 1967-12-01 1969-06-03
US3652579A (en) * 1969-06-26 1972-03-28 Hoffmann La Roche 1-methyl-2-substituted 5-nitroimidazoles
NL7017486A (no) * 1969-12-15 1971-06-17
US3691178A (en) * 1970-03-16 1972-09-12 Merck & Co Inc Substituted imidazoles

Also Published As

Publication number Publication date
CA945161A (en) 1974-04-09
US4125530A (en) 1978-11-14
US4032522A (en) 1977-06-28
US3818014A (en) 1974-06-18
DE2061515A1 (de) 1971-06-24
US3786061A (en) 1974-01-15
NL7017486A (no) 1971-06-17
FR2081360B1 (no) 1974-08-23
SE388855B (sv) 1976-10-18
DE2061489A1 (de) 1971-07-29
BE760289A (fr) 1971-06-14
FR2081360A1 (no) 1971-12-03
AT300788B (de) 1972-08-10
GB1301754A (no) 1973-01-04
CH566994A5 (no) 1975-09-30

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Legal Events

Date Code Title Description
OD Request for examination
D2 Grant after examination
8339 Ceased/non-payment of the annual fee