SE388855B - Forfarande for framstellning av 2,5-disubstituerade imidazoler avsedda att anvendas som antigiktmedel och antihyperuricemiskt medel - Google Patents

Forfarande for framstellning av 2,5-disubstituerade imidazoler avsedda att anvendas som antigiktmedel och antihyperuricemiskt medel

Info

Publication number
SE388855B
SE388855B SE7016885A SE1688570A SE388855B SE 388855 B SE388855 B SE 388855B SE 7016885 A SE7016885 A SE 7016885A SE 1688570 A SE1688570 A SE 1688570A SE 388855 B SE388855 B SE 388855B
Authority
SE
Sweden
Prior art keywords
hyperuricemic
procedure
preparation
intended
disubstituted imidazoles
Prior art date
Application number
SE7016885A
Other languages
English (en)
Swedish (sv)
Inventor
J J Baldwin
F C Novello
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SE388855B publication Critical patent/SE388855B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/93—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by halogen atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE7016885A 1969-12-15 1970-12-14 Forfarande for framstellning av 2,5-disubstituerade imidazoler avsedda att anvendas som antigiktmedel och antihyperuricemiskt medel SE388855B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US88536269A 1969-12-15 1969-12-15
US26501572A 1972-06-21 1972-06-21
US00265016A US3818014A (en) 1969-12-15 1972-06-21 2-quinolyl-4(5)-trifluoromethylimidazoles
US45610274A 1974-03-29 1974-03-29
US61090375A 1975-09-05 1975-09-05
US05/610,904 US4032522A (en) 1969-12-15 1975-09-05 2-pyrazinyl-trifluoromethylimidazoles and a method for their preparation

Publications (1)

Publication Number Publication Date
SE388855B true SE388855B (sv) 1976-10-18

Family

ID=27559450

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7016885A SE388855B (sv) 1969-12-15 1970-12-14 Forfarande for framstellning av 2,5-disubstituerade imidazoler avsedda att anvendas som antigiktmedel och antihyperuricemiskt medel

Country Status (10)

Country Link
US (4) US3786061A (no)
AT (1) AT300788B (no)
BE (1) BE760289A (no)
CA (1) CA945161A (no)
CH (1) CH566994A5 (no)
DE (2) DE2061515A1 (no)
FR (1) FR2081360B1 (no)
GB (1) GB1301754A (no)
NL (1) NL7017486A (no)
SE (1) SE388855B (no)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7017486A (no) * 1969-12-15 1971-06-17
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
GB1481512A (en) * 1973-07-12 1977-08-03 Lucas Electrical Ltd Radiation-sensitive switching circuits
US4058614A (en) * 1973-12-04 1977-11-15 Merck & Co., Inc. Substituted imidazole compounds and therapeutic compositions therewith
DE2414280C2 (de) * 1974-03-25 1981-12-17 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 1-Methyl-5-nitroimidazolen
US4134983A (en) * 1975-03-03 1979-01-16 Merck & Co., Inc. 3-amino-2-or-propoxyaryl substituted imidazoles
US4199580A (en) * 1975-03-03 1980-04-22 Merck & Co., Inc. 3-Amino-2-or-propoxy-tetrahydronaphthyl or indanyl-substituted imidazoles and use
US4853383A (en) * 1975-03-03 1989-08-01 Merck & Co., Inc. β-blocking substituted imidazoles
US4179512A (en) * 1977-03-01 1979-12-18 Merck & Co., Inc. 4-Substituted-2-arylimidazoles
US4314844A (en) * 1979-01-11 1982-02-09 Rohm And Haas Company Herbicidal substituted imidazoles
US4281005A (en) * 1979-03-05 1981-07-28 Merck & Co., Inc. Novel 2-pyridylimidazole compounds
DE3121736C2 (de) * 1980-06-02 1994-04-07 American Cyanamid Co 2-(2-Imidazolin-2-yl)-pyridine und -chinoline, Verfahren und Zwischenstufen zur Herstellung derselben und Verwendung derselben als herbizide Wirkstoffe
IL62794A0 (en) * 1980-06-02 1981-07-31 American Cyanamid Co Substituted nicotinic acid esters and salts thereof and their use as herbicidal agents
US4315021A (en) * 1980-12-03 1982-02-09 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles
US4499097A (en) * 1983-03-10 1985-02-12 American Cyanamid Company 2-(Pyridyl)imidazolyl ketones
US4602093A (en) * 1984-02-08 1986-07-22 Merck & Co., Inc. Novel substituted imidazoles, their preparation and use
FR2576308B1 (fr) * 1985-01-18 1987-02-20 Synthelabo Derives de tetrahydroquinoleine, leur preparation et leur application en therapeutique
GB8705183D0 (en) * 1987-03-05 1987-04-08 May & Baker Ltd Compositions of matter
US4914207A (en) * 1989-05-09 1990-04-03 Pfizer Inc. Arylthiazolylimidazoles
FR2649999B1 (fr) * 1989-07-21 1991-09-20 Payen Cie L Procede et machine pour la fabrication en continu d'un fil elastique a base d'elasthane
US5189053A (en) * 1989-08-10 1993-02-23 Schering Agrochemicals Limited Imidazol(in)e substituted haloarylpyrazole pesticides
YU47834B (sr) * 1989-08-10 1996-01-09 Schering Agrochemical Limited Azolni pesticid
JP3393891B2 (ja) * 1992-08-18 2003-04-07 塩野義製薬株式会社 イミダゾール類の製造方法
WO1995033730A1 (fr) * 1994-06-09 1995-12-14 Nippon Soda Co., Ltd. Derive d'imidazole, procede de production et herbicide
GB2344588B (en) * 1997-07-25 2001-11-14 Black James Foundation 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands
GB9715814D0 (en) 1997-07-25 1997-10-01 Black James Foundation Histamine H3 receptor ligands
WO1999024038A1 (en) 1997-11-07 1999-05-20 Johns Hopkins University Methods for treatment of disorders of cardiac contractility
WO2000018763A2 (en) * 1998-09-29 2000-04-06 Neurogen Corporation 2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands
US6288230B1 (en) 1998-09-29 2001-09-11 Neurogen Corporation 2-(2, 3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands
US6284759B1 (en) 1998-09-30 2001-09-04 Neurogen Corporation 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands
US7799794B2 (en) * 2000-06-28 2010-09-21 Merck Sharp & Dohme Corp. Treatment for cardiovascular disease
EP2324830A1 (en) * 2002-03-05 2011-05-25 TransTech Pharma Inc. Process for the preparation of a monocyclic azole derivative that inhibits the interaction of ligands with rage
CN1805743A (zh) * 2003-05-20 2006-07-19 特兰斯泰克制药公司 用作逆转淀粉样变性及其他与之相关疾病的rage拮抗剂
CN101282936B (zh) * 2005-10-07 2012-05-16 橘生药品工业株式会社 氮化杂环化合物及包含其的药物组合物
TWI517850B (zh) 2009-09-30 2016-01-21 Ｖｔｖ治療有限責任公司 經取代之咪唑衍生物及其使用方法
HU1000676D0 (en) 2010-12-17 2011-02-28 Pharmahungary 2000 Kft Inhibitors of matrix metalloproteinase, pharmaceutical compositions thereof and use of them for preventing and treating diseases where the activation of mmp is involved
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3202674A (en) * 1960-03-05 1965-08-24 American Home Prod Phenethylamine derivatives
US3399211A (en) * 1964-03-10 1968-08-27 Merck & Co Inc Production of 2-aryl-4(5)-nitroimidazoles
NL6816241A (no) * 1967-12-01 1969-06-03
US3652579A (en) * 1969-06-26 1972-03-28 Hoffmann La Roche 1-methyl-2-substituted 5-nitroimidazoles
NL7017486A (no) * 1969-12-15 1971-06-17
US3691178A (en) * 1970-03-16 1972-09-12 Merck & Co Inc Substituted imidazoles

Also Published As

Publication number Publication date
NL7017486A (no) 1971-06-17
US3818014A (en) 1974-06-18
DE2061515A1 (de) 1971-06-24
CA945161A (en) 1974-04-09
US4032522A (en) 1977-06-28
FR2081360A1 (no) 1971-12-03
DE2061489A1 (de) 1971-07-29
US4125530A (en) 1978-11-14
AT300788B (de) 1972-08-10
BE760289A (fr) 1971-06-14
FR2081360B1 (no) 1974-08-23
US3786061A (en) 1974-01-15
DE2061489C2 (de) 1982-04-01
CH566994A5 (no) 1975-09-30
GB1301754A (no) 1973-01-04

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