SE388855B - Forfarande for framstellning av 2,5-disubstituerade imidazoler avsedda att anvendas som antigiktmedel och antihyperuricemiskt medel - Google Patents
Forfarande for framstellning av 2,5-disubstituerade imidazoler avsedda att anvendas som antigiktmedel och antihyperuricemiskt medelInfo
- Publication number
- SE388855B SE388855B SE7016885A SE1688570A SE388855B SE 388855 B SE388855 B SE 388855B SE 7016885 A SE7016885 A SE 7016885A SE 1688570 A SE1688570 A SE 1688570A SE 388855 B SE388855 B SE 388855B
- Authority
- SE
- Sweden
- Prior art keywords
- hyperuricemic
- procedure
- preparation
- intended
- disubstituted imidazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/93—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by halogen atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88536269A | 1969-12-15 | 1969-12-15 | |
US26501572A | 1972-06-21 | 1972-06-21 | |
US00265016A US3818014A (en) | 1969-12-15 | 1972-06-21 | 2-quinolyl-4(5)-trifluoromethylimidazoles |
US45610274A | 1974-03-29 | 1974-03-29 | |
US61090375A | 1975-09-05 | 1975-09-05 | |
US05/610,904 US4032522A (en) | 1969-12-15 | 1975-09-05 | 2-pyrazinyl-trifluoromethylimidazoles and a method for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
SE388855B true SE388855B (sv) | 1976-10-18 |
Family
ID=27559450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7016885A SE388855B (sv) | 1969-12-15 | 1970-12-14 | Forfarande for framstellning av 2,5-disubstituerade imidazoler avsedda att anvendas som antigiktmedel och antihyperuricemiskt medel |
Country Status (10)
Country | Link |
---|---|
US (4) | US3786061A (sv) |
AT (1) | AT300788B (sv) |
BE (1) | BE760289A (sv) |
CA (1) | CA945161A (sv) |
CH (1) | CH566994A5 (sv) |
DE (2) | DE2061515A1 (sv) |
FR (1) | FR2081360B1 (sv) |
GB (1) | GB1301754A (sv) |
NL (1) | NL7017486A (sv) |
SE (1) | SE388855B (sv) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7017486A (sv) * | 1969-12-15 | 1971-06-17 | ||
US3707475A (en) * | 1970-11-16 | 1972-12-26 | Pfizer | Antiinflammatory imidazoles |
GB1481512A (en) * | 1973-07-12 | 1977-08-03 | Lucas Electrical Ltd | Radiation-sensitive switching circuits |
US4058614A (en) * | 1973-12-04 | 1977-11-15 | Merck & Co., Inc. | Substituted imidazole compounds and therapeutic compositions therewith |
DE2414280C2 (de) * | 1974-03-25 | 1981-12-17 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von 1-Methyl-5-nitroimidazolen |
US4134983A (en) * | 1975-03-03 | 1979-01-16 | Merck & Co., Inc. | 3-amino-2-or-propoxyaryl substituted imidazoles |
US4199580A (en) * | 1975-03-03 | 1980-04-22 | Merck & Co., Inc. | 3-Amino-2-or-propoxy-tetrahydronaphthyl or indanyl-substituted imidazoles and use |
US4853383A (en) * | 1975-03-03 | 1989-08-01 | Merck & Co., Inc. | β-blocking substituted imidazoles |
US4179512A (en) * | 1977-03-01 | 1979-12-18 | Merck & Co., Inc. | 4-Substituted-2-arylimidazoles |
US4314844A (en) * | 1979-01-11 | 1982-02-09 | Rohm And Haas Company | Herbicidal substituted imidazoles |
US4281005A (en) * | 1979-03-05 | 1981-07-28 | Merck & Co., Inc. | Novel 2-pyridylimidazole compounds |
DE3121736C2 (de) * | 1980-06-02 | 1994-04-07 | American Cyanamid Co | 2-(2-Imidazolin-2-yl)-pyridine und -chinoline, Verfahren und Zwischenstufen zur Herstellung derselben und Verwendung derselben als herbizide Wirkstoffe |
IL62794A0 (en) * | 1980-06-02 | 1981-07-31 | American Cyanamid Co | Substituted nicotinic acid esters and salts thereof and their use as herbicidal agents |
US4315021A (en) * | 1980-12-03 | 1982-02-09 | Syntex (U.S.A.) Inc. | 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles |
US4499097A (en) * | 1983-03-10 | 1985-02-12 | American Cyanamid Company | 2-(Pyridyl)imidazolyl ketones |
US4602093A (en) * | 1984-02-08 | 1986-07-22 | Merck & Co., Inc. | Novel substituted imidazoles, their preparation and use |
FR2576308B1 (fr) * | 1985-01-18 | 1987-02-20 | Synthelabo | Derives de tetrahydroquinoleine, leur preparation et leur application en therapeutique |
GB8705183D0 (en) * | 1987-03-05 | 1987-04-08 | May & Baker Ltd | Compositions of matter |
US4914207A (en) * | 1989-05-09 | 1990-04-03 | Pfizer Inc. | Arylthiazolylimidazoles |
FR2649999B1 (fr) * | 1989-07-21 | 1991-09-20 | Payen Cie L | Procede et machine pour la fabrication en continu d'un fil elastique a base d'elasthane |
US5189053A (en) * | 1989-08-10 | 1993-02-23 | Schering Agrochemicals Limited | Imidazol(in)e substituted haloarylpyrazole pesticides |
YU47834B (sr) * | 1989-08-10 | 1996-01-09 | Schering Agrochemical Limited | Azolni pesticid |
JP3393891B2 (ja) * | 1992-08-18 | 2003-04-07 | 塩野義製薬株式会社 | イミダゾール類の製造方法 |
WO1995033730A1 (fr) * | 1994-06-09 | 1995-12-14 | Nippon Soda Co., Ltd. | Derive d'imidazole, procede de production et herbicide |
GB2344588B (en) * | 1997-07-25 | 2001-11-14 | Black James Foundation | 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands |
GB9715814D0 (en) | 1997-07-25 | 1997-10-01 | Black James Foundation | Histamine H3 receptor ligands |
WO1999024038A1 (en) | 1997-11-07 | 1999-05-20 | Johns Hopkins University | Methods for treatment of disorders of cardiac contractility |
WO2000018763A2 (en) * | 1998-09-29 | 2000-04-06 | Neurogen Corporation | 2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands |
US6288230B1 (en) | 1998-09-29 | 2001-09-11 | Neurogen Corporation | 2-(2, 3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands |
US6284759B1 (en) | 1998-09-30 | 2001-09-04 | Neurogen Corporation | 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands |
US7799794B2 (en) * | 2000-06-28 | 2010-09-21 | Merck Sharp & Dohme Corp. | Treatment for cardiovascular disease |
EP2324830A1 (en) * | 2002-03-05 | 2011-05-25 | TransTech Pharma Inc. | Process for the preparation of a monocyclic azole derivative that inhibits the interaction of ligands with rage |
CN1805743A (zh) * | 2003-05-20 | 2006-07-19 | 特兰斯泰克制药公司 | 用作逆转淀粉样变性及其他与之相关疾病的rage拮抗剂 |
CN101282936B (zh) * | 2005-10-07 | 2012-05-16 | 橘生药品工业株式会社 | 氮化杂环化合物及包含其的药物组合物 |
TWI517850B (zh) | 2009-09-30 | 2016-01-21 | Vtv治療有限責任公司 | 經取代之咪唑衍生物及其使用方法 |
HU1000676D0 (en) | 2010-12-17 | 2011-02-28 | Pharmahungary 2000 Kft | Inhibitors of matrix metalloproteinase, pharmaceutical compositions thereof and use of them for preventing and treating diseases where the activation of mmp is involved |
US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3202674A (en) * | 1960-03-05 | 1965-08-24 | American Home Prod | Phenethylamine derivatives |
US3399211A (en) * | 1964-03-10 | 1968-08-27 | Merck & Co Inc | Production of 2-aryl-4(5)-nitroimidazoles |
NL6816241A (sv) * | 1967-12-01 | 1969-06-03 | ||
US3652579A (en) * | 1969-06-26 | 1972-03-28 | Hoffmann La Roche | 1-methyl-2-substituted 5-nitroimidazoles |
NL7017486A (sv) * | 1969-12-15 | 1971-06-17 | ||
US3691178A (en) * | 1970-03-16 | 1972-09-12 | Merck & Co Inc | Substituted imidazoles |
-
1970
- 1970-11-30 NL NL7017486A patent/NL7017486A/xx not_active Application Discontinuation
- 1970-12-02 CA CA099,661A patent/CA945161A/en not_active Expired
- 1970-12-07 GB GB5794270A patent/GB1301754A/en not_active Expired
- 1970-12-10 CH CH1827770A patent/CH566994A5/xx not_active IP Right Cessation
- 1970-12-14 DE DE19702061515 patent/DE2061515A1/de active Pending
- 1970-12-14 SE SE7016885A patent/SE388855B/sv unknown
- 1970-12-14 DE DE2061489A patent/DE2061489C2/de not_active Expired
- 1970-12-14 FR FR7044962A patent/FR2081360B1/fr not_active Expired
- 1970-12-14 BE BE760289A patent/BE760289A/xx unknown
- 1970-12-15 AT AT1126970A patent/AT300788B/de active
-
1972
- 1972-06-21 US US00265015A patent/US3786061A/en not_active Expired - Lifetime
- 1972-06-21 US US00265016A patent/US3818014A/en not_active Expired - Lifetime
-
1975
- 1975-09-05 US US05/610,904 patent/US4032522A/en not_active Expired - Lifetime
-
1977
- 1977-02-02 US US05/764,796 patent/US4125530A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
NL7017486A (sv) | 1971-06-17 |
US3818014A (en) | 1974-06-18 |
DE2061515A1 (de) | 1971-06-24 |
CA945161A (en) | 1974-04-09 |
US4032522A (en) | 1977-06-28 |
FR2081360A1 (sv) | 1971-12-03 |
DE2061489A1 (de) | 1971-07-29 |
US4125530A (en) | 1978-11-14 |
AT300788B (de) | 1972-08-10 |
BE760289A (fr) | 1971-06-14 |
FR2081360B1 (sv) | 1974-08-23 |
US3786061A (en) | 1974-01-15 |
DE2061489C2 (de) | 1982-04-01 |
CH566994A5 (sv) | 1975-09-30 |
GB1301754A (sv) | 1973-01-04 |
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