DE1767891C3 - Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat - Google Patents

Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat

Info

Publication number
DE1767891C3
DE1767891C3 DE1767891A DE1767891A DE1767891C3 DE 1767891 C3 DE1767891 C3 DE 1767891C3 DE 1767891 A DE1767891 A DE 1767891A DE 1767891 A DE1767891 A DE 1767891A DE 1767891 C3 DE1767891 C3 DE 1767891C3
Authority
DE
Germany
Prior art keywords
doxycycline
solution
parenteral
water
peroral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1767891A
Other languages
German (de)
English (en)
Other versions
DE1767891A1 (de
DE1767891B2 (de
Inventor
R E Beutel
K C Lohlbach
H W Raaf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=5699525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE1767891(C3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Priority to DE1767891A priority Critical patent/DE1767891C3/de
Priority to GB1228629D priority patent/GB1228629A/en
Priority to IL32350A priority patent/IL32350A/en
Priority to NL6908919A priority patent/NL6908919A/xx
Priority to BE734723D priority patent/BE734723A/xx
Priority to FI1809/69A priority patent/FI44395B/fi
Priority to NO2515/69A priority patent/NO130624C/no
Priority to ES368496A priority patent/ES368496A1/es
Priority to CH933769A priority patent/CH522407A/fr
Priority to FR696920595A priority patent/FR2011764B1/fr
Priority to MX100333U priority patent/MX3351E/es
Priority to BR209929/69A priority patent/BR6909929D0/pt
Priority to AT586269A priority patent/AT291441B/de
Priority to IE845/69A priority patent/IE33167B1/xx
Priority to SE6908788A priority patent/SE373036B/xx
Priority to DK329869AA priority patent/DK127168B/da
Priority to US836591A priority patent/US3674859A/en
Publication of DE1767891A1 publication Critical patent/DE1767891A1/de
Priority to MY15/73A priority patent/MY7300015A/xx
Publication of DE1767891B2 publication Critical patent/DE1767891B2/de
Publication of DE1767891C3 publication Critical patent/DE1767891C3/de
Application granted granted Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE1767891A 1968-06-28 1968-06-28 Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat Expired DE1767891C3 (de)

Priority Applications (18)

Application Number Priority Date Filing Date Title
DE1767891A DE1767891C3 (de) 1968-06-28 1968-06-28 Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
GB1228629D GB1228629A (https=) 1968-06-28 1968-10-22
IL32350A IL32350A (en) 1968-06-28 1969-06-05 Doxycycline solution for parenteral,oral and topical uses
NL6908919A NL6908919A (https=) 1968-06-28 1969-06-11
BE734723D BE734723A (https=) 1968-06-28 1969-06-18
FI1809/69A FI44395B (https=) 1968-06-28 1969-06-18
NO2515/69A NO130624C (https=) 1968-06-28 1969-06-18
ES368496A ES368496A1 (es) 1968-06-28 1969-06-18 Procedimiento para la preparacion de soluciones acuosas de doxiciclina, para uso parenteral, oral y local.
CH933769A CH522407A (fr) 1968-06-28 1969-06-18 Procédé pour la préparation de solutions pour usages parentéral, oral et topique de la doxycycline
MX100333U MX3351E (es) 1968-06-28 1969-06-19 Procedimiento mejorado para la preparacion de una solucion acuosa de doxiciclina
FR696920595A FR2011764B1 (https=) 1968-06-28 1969-06-19
BR209929/69A BR6909929D0 (pt) 1968-06-28 1969-06-19 Solucao de doxiciclina para usos parenteral oral e topico
AT586269A AT291441B (de) 1968-06-28 1969-06-19 Verfahren zur Herstellung von wässerigen Lösungen von α-6-Desoxy-5-hydroxytetracyclin
IE845/69A IE33167B1 (en) 1968-06-28 1969-06-19 Doxycycline solution for parenteral,oral and topical uses
SE6908788A SE373036B (https=) 1968-06-28 1969-06-19
DK329869AA DK127168B (da) 1968-06-28 1969-06-19 Fremgangsmåde til fremstilling af klare, stabile vandige opløsninger af doxycyclin, som er egnede til parenteral, oral og topisk brug.
US836591A US3674859A (en) 1968-06-28 1969-06-25 Aqueous doxycycline compositions
MY15/73A MY7300015A (en) 1968-06-28 1973-12-30 Doxycycline solution for parenteral,oral and topical use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1767891A DE1767891C3 (de) 1968-06-28 1968-06-28 Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat

Publications (3)

Publication Number Publication Date
DE1767891A1 DE1767891A1 (de) 1971-07-08
DE1767891B2 DE1767891B2 (de) 1980-02-21
DE1767891C3 true DE1767891C3 (de) 1980-10-30

Family

ID=5699525

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1767891A Expired DE1767891C3 (de) 1968-06-28 1968-06-28 Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat

Country Status (18)

Country Link
US (1) US3674859A (https=)
AT (1) AT291441B (https=)
BE (1) BE734723A (https=)
BR (1) BR6909929D0 (https=)
CH (1) CH522407A (https=)
DE (1) DE1767891C3 (https=)
DK (1) DK127168B (https=)
ES (1) ES368496A1 (https=)
FI (1) FI44395B (https=)
FR (1) FR2011764B1 (https=)
GB (1) GB1228629A (https=)
IE (1) IE33167B1 (https=)
IL (1) IL32350A (https=)
MX (1) MX3351E (https=)
MY (1) MY7300015A (https=)
NL (1) NL6908919A (https=)
NO (1) NO130624C (https=)
SE (1) SE373036B (https=)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1350196A (en) * 1972-10-26 1974-04-18 Pfizer Doxycyline parenteral composition
US3957980A (en) * 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
US3928592A (en) * 1974-02-22 1975-12-23 Lilly Co Eli Antibiotic pharmaceutical compositions
GB1538903A (en) * 1975-04-11 1979-01-24 Nelson Res & Dev Carrier for a topically applied physiologically active agent or cosmetic agent
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
GB1592053A (en) * 1976-12-16 1981-07-01 Norbrook Lab Ltd Oxytetracycline compositions
US4213963A (en) * 1978-12-14 1980-07-22 Janssen Pharmaceutica N.V. Fluspirilene-containing compositions
IE74244B1 (en) * 1985-10-01 1997-07-16 Bimeda Res Dev Ltd A process for preparing an antibiotic composition
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
EA016099B1 (ru) * 1999-09-14 2012-02-28 Трастис Оф Тафтс Коллидж Замещенный аналог тетрациклина (варианты) и способ получения замещенного аналога тетрациклина
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
AU3105801A (en) 2000-01-24 2001-07-31 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
EA200201046A1 (ru) * 2000-03-31 2003-04-24 Трастис Оф Тафтс Коллидж 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное
CA2409063A1 (en) * 2000-05-15 2001-11-22 Mark L. Nelson 7-substituted fused ring tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
EA009175B1 (ru) 2000-07-07 2007-12-28 Трастис Оф Тафтс Коллидж Замещенные соединения миноциклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего
WO2002004404A2 (en) 2000-07-07 2002-01-17 Trustees Of Tufts College 7,8 and 9-substituted tetracycline compounds
ATE465989T1 (de) 2000-07-07 2010-05-15 Tufts College 13-substituierte methacyclinverbindungen
IL153672A0 (en) * 2000-07-07 2003-07-06 Tufts College 7-substituted tetracycline compounds
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
EA013835B1 (ru) 2001-03-13 2010-08-30 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта
EP1381372A2 (en) 2001-03-14 2004-01-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
US6841546B2 (en) * 2001-03-14 2005-01-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
ES2338994T3 (es) 2001-04-24 2010-05-14 Paratek Pharmaceuticals, Inc. Compuestos de tetraciclina sustituida para el tratamiento de la malaria.
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
ES2551708T3 (es) 2002-01-08 2015-11-23 Paratek Pharmaceuticals, Inc. Compuestos de 4-desdimetilamino tetraciclina
EP1467673A4 (en) * 2002-01-23 2013-04-17 Dentsply Int Inc Irrigation solution and methods for use
EP2311451A1 (en) 2002-03-08 2011-04-20 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
EP1503981A4 (en) 2002-03-21 2007-08-15 Paratek Pharm Innc SUBSTITUTED TETRACYCLINE COMPOUNDS
AU2003261161B2 (en) 2002-07-12 2009-09-10 Paratek Pharmaceuticals, Inc 3, 10, and 12a substituted tetracycline compounds
EP1556007A4 (en) 2002-10-24 2008-12-17 Paratek Pharm Innc SUBSTITUTED TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF MALARIA
AU2004259661B2 (en) 2003-07-09 2011-11-10 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
US20050143352A1 (en) 2003-07-09 2005-06-30 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2004261143B2 (en) * 2003-07-25 2009-11-05 Allergan Pharmaceuticals International Limited A doxycycline metal complex in a solid dosage form
JP5010284B2 (ja) * 2004-01-15 2012-08-29 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の芳香族ａ環誘導体
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
EP2033950A1 (en) 2004-10-25 2009-03-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP1805134B1 (en) * 2004-10-25 2012-06-20 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
AU2006206359B2 (en) * 2005-01-21 2011-03-31 Allergan Pharmaceuticals International Limited A tetracycline metal complex in a solid dosage form
CA2597212A1 (en) 2005-02-04 2006-08-10 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
US20070093455A1 (en) * 2005-07-21 2007-04-26 Paul Abato 10-substituted tetracyclines and methods of use thereof
AU2007208214B2 (en) * 2006-01-24 2013-02-14 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
JP4205731B2 (ja) * 2006-04-05 2009-01-07 株式会社日本触媒 ポリビニルピロリドン粉体組成物およびその製造方法
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
ES2622356T3 (es) * 2006-04-24 2017-07-06 Teva Pharmaceutical Industries, Ltd. Formas cristalinas de tigeciclina y procesos para su preparación
EP2431469A3 (en) * 2006-05-15 2012-05-30 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
CA2892739A1 (en) 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
WO2008079339A2 (en) 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
JP5121470B2 (ja) * 2007-01-26 2013-01-16 株式会社日本触媒 ポリビニルピロリドン粉体組成物
AU2008239606A1 (en) 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
EP2216323A3 (en) * 2007-04-27 2010-12-29 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
EP2176216B1 (en) 2007-07-06 2012-04-25 Paratek Pharmaceuticals, Inc. Methods for synthesizing 9-substituted minocycline
CA2717703A1 (en) * 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Minocycline compounds and methods of use thereof
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
WO2009128913A1 (en) * 2008-04-14 2009-10-22 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
TWI680117B (zh) 2008-05-19 2019-12-21 派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
US20100190755A1 (en) * 2008-09-19 2010-07-29 Paul Abato Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment
EP3061460A1 (en) 2009-04-10 2016-08-31 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (mmp-1)
PT2568987T (pt) 2010-05-12 2017-02-03 Rempex Pharmaceuticals Inc Composições de tetraciclina
CN101862293B (zh) * 2010-06-22 2012-02-29 华南农业大学 盐酸多西环素的油混悬液及其制备方法和应用
US9255068B2 (en) 2011-05-12 2016-02-09 Warner Chilcott Company, Llc Crystalline salts of (4S,4AS,5AR,12AS)-4-dimethylamino-3,10,12,12A-tetrahydroxy-7-[methoxy(methyl)amino)-methyl] acid amide and methods of using the same
PT108978B (pt) 2015-11-24 2020-03-09 Hovione Farm S A Sais de tetraciclinas
BR112019008897A2 (pt) 2016-11-01 2019-08-13 Paratek Pharm Innc método para tratar pneumonia bacteriana adquirida na comunidade.
CN111343991A (zh) 2017-07-21 2020-06-26 阿尔米雷尔有限责任公司 非炎性病变的治疗

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1430859A (https=) * 1960-05-23 1966-05-25

Also Published As

Publication number Publication date
MY7300015A (en) 1973-12-31
US3674859A (en) 1972-07-04
FR2011764B1 (https=) 1973-07-13
FR2011764A1 (https=) 1970-03-06
CH522407A (fr) 1972-06-30
GB1228629A (https=) 1971-04-15
DK127168B (da) 1973-10-01
NO130624B (https=) 1974-10-07
MX3351E (es) 1980-10-08
IE33167B1 (en) 1974-04-03
FI44395B (https=) 1971-08-02
NO130624C (https=) 1975-01-15
NL6908919A (https=) 1969-12-30
AT291441B (de) 1971-07-12
DE1767891A1 (de) 1971-07-08
BR6909929D0 (pt) 1973-02-08
IL32350A (en) 1972-05-30
IL32350A0 (en) 1969-08-27
BE734723A (https=) 1969-12-18
SE373036B (https=) 1975-01-27
DE1767891B2 (de) 1980-02-21
IE33167L (en) 1969-12-28
ES368496A1 (es) 1971-05-01

Similar Documents

Publication Publication Date Title
DE1767891C3 (de) Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
DE1617576C3 (de) Verfahren zur Herstellung eines Injektionspräparates auf Basis einer wäßrigen Lösung eines Oxytetracyclin-Magnesium-Komplexes
DE2332878C2 (de) Salze von Cephalosporinen mit Arginin und Lysin, ihre Herstellung und injizierbare pharmazeutische Zubereitungen
DE2659152A1 (de) Neue antibiotische praeparate zur pharmazeutischen verwendung
DE2817335A1 (de) Antibiotische tetracyclinhaltige mittel
DE1417343A1 (de) Verfahren zur Herstellung einer antibiotechnischen Zusammensetzung
DE2323187A1 (de) Verfahren zur herstellung einer stabilisierten, pulverfoermigen secretinzubereitung durch gefriertrocknung
DE1802162A1 (de) Neue N-Pyridylmethyliden-homocystein-thiolacton-Verbindung und Verfahren zu ihrer Herstellung
CH647677A5 (de) 4'-(acridinylamino)-methansulfon-anisidid enthaltende pharmazeutische zusammensetzung.
DE2501805A1 (de) Arzneimittelzubereitungen und verfahren zu ihrer herstellung
DE2754882A1 (de) Pharmazeutische zusammensetzungen
DE1965343A1 (de) Arzneimittel,insbesondere zur Herabsetzung der Schleimviskositaet und Anwendung als hustenstillendes Mittel,und Verfahren zu seiner Herstellung
DE1620177C3 (de) N-(2-Hydroxyäthyl)-piperazinocarboxymethyl-tetracyclin, dessen pharmakologisch verwendbaren Salze, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE1568519B1 (de) Herstellung von Laurylsulfaten von Tetracyclinen
DE2352910A1 (de) Waessrige pharmazeutische zusammensetzung
EP0152860B1 (de) Verwendung von Cephemverbindungen zur Herstellung eines Arzneimittels für die Modulation des Immunsystems
DE1053734B (de) Verfahren zur Loeslichmachung und Stabilisierung der Tetracyclinantibiotika
DE899702C (de) Verfahren zur Herstellung von Penicillinloesungen mit langdauernder Wirkung
DE1670936C3 (de) 3-Carbonsäureamido-chinoxalin-di-Nojdde-0,4), ein Verfahren zu ihrer Herstellung und diese enthaltende antibakterielle Mittel
DE1593015C3 (de) N.N'-Dimethyl-NJ'i'-di-detracyclinomethyl)-äthylendiamin und dessen Salze mit pharmakologisch unbedenklichen Mineral- und organischen Säuren sowie Verfahren zu deren Herstellung
DE1019050B (de) Verfahren zur Herstellung von konzentrierten waessrigen Loesungen von Salzen von Tetracyclinen
AT274241B (de) Verfahren zur Herstellung von Tetracyclin-Zubereitungen
DE3701461C2 (https=)
DE954726C (de) Verfahren zur Herstellung von Komplexverbindungen des Calciums
DE862341C (de) Verfahren zur Herstellung von waessrigen Loesungen von Derivaten des p-Aminobenzolsulfonamids

Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)