DE1620215A1 - Verfahren zur Herstellung von 7-Chlor-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-Benzodiazepin-2-on - Google Patents

Verfahren zur Herstellung von 7-Chlor-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-Benzodiazepin-2-on

Info

Publication number
DE1620215A1
DE1620215A1 DE19661620215 DE1620215A DE1620215A1 DE 1620215 A1 DE1620215 A1 DE 1620215A1 DE 19661620215 DE19661620215 DE 19661620215 DE 1620215 A DE1620215 A DE 1620215A DE 1620215 A1 DE1620215 A1 DE 1620215A1
Authority
DE
Germany
Prior art keywords
azide
chlorobenzophenone
phenyl
dihydro
azido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19661620215
Other languages
German (de)
English (en)
Inventor
Petersen John Brammer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rexolin Chemicals AB
Original Assignee
Rexolin Chemicals AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rexolin Chemicals AB filed Critical Rexolin Chemicals AB
Publication of DE1620215A1 publication Critical patent/DE1620215A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19661620215 1965-09-17 1966-09-15 Verfahren zur Herstellung von 7-Chlor-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-Benzodiazepin-2-on Pending DE1620215A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK478365AA DK120901B (da) 1965-09-17 1965-09-17 Fremgangsmåde til fremstilling af 7-chlor-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-on.

Publications (1)

Publication Number Publication Date
DE1620215A1 true DE1620215A1 (de) 1970-03-26

Family

ID=8136617

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19661620215 Pending DE1620215A1 (de) 1965-09-17 1966-09-15 Verfahren zur Herstellung von 7-Chlor-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-Benzodiazepin-2-on

Country Status (8)

Country Link
US (2) US3520878A ( )
AT (1) AT267530B ( )
BR (1) BR6682929D0 ( )
DE (1) DE1620215A1 ( )
DK (1) DK120901B ( )
GB (1) GB1170055A ( )
NL (1) NL158179B ( )
SE (2) SE351213B ( )

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU34997B (en) * 1970-03-27 1980-06-30 Hiroyuki Tawada Process for preparing benzodiazepine derivatives
RU2687556C1 (ru) * 2018-12-24 2019-05-15 Акционерное общество "Федеральный научно-производственный центр "Алтай" Способ получения 7-хлор-1,3-дигидро-1-метил-5-фенил-2Н-1,4-бензодиазепин-2-она
WO2024023268A1 (en) * 2022-07-29 2024-02-01 F. Hoffmann-La Roche Ag Characterisation of neurological dysfunction

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3030388A (en) * 1958-06-23 1962-04-17 Parke Davis & Co Amino acid compounds and methods for producing the same
US3297755A (en) * 1960-12-02 1967-01-10 Hoffmann La Roche 2-chloro-5-trifluoromethylbenzo-phenone compounds

Also Published As

Publication number Publication date
AT267530B (de) 1969-01-10
US3520878A (en) 1970-07-21
NL158179B (nl) 1978-10-16
GB1170055A (en) 1969-11-12
SE351213B ( ) 1972-11-20
SE7502790L ( ) 1975-03-12
BR6682929D0 (pt) 1973-12-26
US3567745A (en) 1971-03-02
NL6613087A ( ) 1967-03-20
DK120901B (da) 1971-08-02

Similar Documents

Publication Publication Date Title
DE2845417C2 ( )
CN108727334A (zh) 一种甲磺酸达比加群酯的生产工艺
CH632511A5 (de) Verfahren zur herstellung von diazepinderivaten.
WO2005080398A1 (de) Verfahren zur herstellung von anagrelid hydrochlorid
EP0090978A2 (de) Imidazolylphenyl-tetrahydropyridazine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE1812205B2 (de) Verfahren zur herstellung von 1(2-diaethylaminoaethyl)-5-phenyl-7-chlor- 1,3-dihydro-2h-1,4-benzodiazepin-2-onen und 1-(2-diaethylaminoaethyl)-2-aminomethyl- 3-phenyl-5-chlorindol-zwischenprodukte
DE1620215A1 (de) Verfahren zur Herstellung von 7-Chlor-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-Benzodiazepin-2-on
DE3433953A1 (de) Neue, eine imidazol-gruppe enthaltende 3,4-dihydro-2(1h)-pyridone und2(1h)-pyridone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE69603419T3 (de) Verfahren zur Herstellung von optisch aktiven Amiden
DE1257790B (de) Verfahren zur Herstellung von 2-Amino-benzophenonen
DE2342479A1 (de) Ribonucleosid-5'-nitrate und verfahren zu ihrer herstellung
DE2640831A1 (de) 1,5-dihydro-2h-1,4-benzodiazepin-2- on-derivate, verfahren zu ihrer herstellung und arzneimittel
DE1445908A1 (de) Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten
EP0066303B1 (de) 2-Azidomethyl-1,4-benzodiazepine und deren Salze sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
AT299207B (de) Verfahren zur Herstellung neuer Benzodiazepin-Derivaten und ihren Salzen
AT308115B (de) Verfahren zur Herstellung von Benzodiazepinderivaten sowie von Säureadditionssalzen dieser Verbindungen
EP0030015A2 (de) Triazolobenzazepine, Zwischenprodukte und Verfahren zu ihrer Herstellung, sowie diese enthaltende Präparate
AT276400B (de) Verfahren zur Herstellung von neuen Benzodiazepin-Derivaten und von deren Säureadditionssalzen und quaternären Salzen
AT262296B (de) Verfahren zur Herstellung von Benzodiazepin-Derivaten
CH558370A (de) Verfahren zur herstellung von 1,3,4,5-tetrahydro-2h-1, 4-benzodiazepin-2-on-derivaten.
AT301552B (de) Verfahren zur Herstellung von Benzodiazepinen bzw. von Salzen hievon
DE1445872C (de) 5 Phenyl 1,2 dihydro 3H 1,4 benzodi azepinon (2) derivate
DE2852606A1 (de) 3-di-n-propyl-acetoxy-benzodiazepin-2-one und verfahren zu deren herstellung
AT351528B (de) Verfahren zur herstellung von neuen indazol- derivaten
DE1470009C (de) 3,5 Dihydro 5 phenyl 4,1 benzoxaze pin 2 one