NL158179B - Werkwijze voor het bereiden van 7-chloor 1,3-dihydro 1-methyl 5-fenyl 2h-1,4-benzodiazepine 2-on. - Google Patents
Werkwijze voor het bereiden van 7-chloor 1,3-dihydro 1-methyl 5-fenyl 2h-1,4-benzodiazepine 2-on.Info
- Publication number
- NL158179B NL158179B NL6613087.A NL6613087A NL158179B NL 158179 B NL158179 B NL 158179B NL 6613087 A NL6613087 A NL 6613087A NL 158179 B NL158179 B NL 158179B
- Authority
- NL
- Netherlands
- Prior art keywords
- benzodiazepine
- dihydro
- chlorine
- phenyl
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK478365AA DK120901B (da) | 1965-09-17 | 1965-09-17 | Fremgangsmåde til fremstilling af 7-chlor-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-on. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL6613087A NL6613087A ( ) | 1967-03-20 |
| NL158179B true NL158179B (nl) | 1978-10-16 |
Family
ID=8136617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL6613087.A NL158179B (nl) | 1965-09-17 | 1966-09-16 | Werkwijze voor het bereiden van 7-chloor 1,3-dihydro 1-methyl 5-fenyl 2h-1,4-benzodiazepine 2-on. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US3520878A ( ) |
| AT (1) | AT267530B ( ) |
| BR (1) | BR6682929D0 ( ) |
| DE (1) | DE1620215A1 ( ) |
| DK (1) | DK120901B ( ) |
| GB (1) | GB1170055A ( ) |
| NL (1) | NL158179B ( ) |
| SE (2) | SE351213B ( ) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU34997B (en) * | 1970-03-27 | 1980-06-30 | Hiroyuki Tawada | Process for preparing benzodiazepine derivatives |
| RU2687556C1 (ru) * | 2018-12-24 | 2019-05-15 | Акционерное общество "Федеральный научно-производственный центр "Алтай" | Способ получения 7-хлор-1,3-дигидро-1-метил-5-фенил-2Н-1,4-бензодиазепин-2-она |
| WO2024023268A1 (en) * | 2022-07-29 | 2024-02-01 | F. Hoffmann-La Roche Ag | Characterisation of neurological dysfunction |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3030388A (en) * | 1958-06-23 | 1962-04-17 | Parke Davis & Co | Amino acid compounds and methods for producing the same |
| US3297755A (en) * | 1960-12-02 | 1967-01-10 | Hoffmann La Roche | 2-chloro-5-trifluoromethylbenzo-phenone compounds |
-
1965
- 1965-09-17 DK DK478365AA patent/DK120901B/da unknown
-
1966
- 1966-09-06 BR BR182929/66A patent/BR6682929D0/pt unknown
- 1966-09-15 DE DE19661620215 patent/DE1620215A1/de active Pending
- 1966-09-16 GB GB41545/66A patent/GB1170055A/en not_active Expired
- 1966-09-16 NL NL6613087.A patent/NL158179B/xx not_active Application Discontinuation
- 1966-09-19 SE SE12596/66A patent/SE351213B/xx unknown
- 1966-09-19 AT AT881366A patent/AT267530B/de active
-
1968
- 1968-10-15 US US767838A patent/US3520878A/en not_active Expired - Lifetime
-
1969
- 1969-08-05 US US864242A patent/US3567745A/en not_active Expired - Lifetime
-
1975
- 1975-03-12 SE SE7502790A patent/SE7502790L/ not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE1620215A1 (de) | 1970-03-26 |
| AT267530B (de) | 1969-01-10 |
| NL6613087A ( ) | 1967-03-20 |
| US3520878A (en) | 1970-07-21 |
| SE351213B ( ) | 1972-11-20 |
| DK120901B (da) | 1971-08-02 |
| BR6682929D0 (pt) | 1973-12-26 |
| SE7502790L ( ) | 1975-03-12 |
| US3567745A (en) | 1971-03-02 |
| GB1170055A (en) | 1969-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BI | The patent application has been withdrawn |