DE1595924A1 - alpha-Substituierte Indolylessigsaeure-Verbindungen und ein Verfahren zu deren Herstellung - Google Patents

alpha-Substituierte Indolylessigsaeure-Verbindungen und ein Verfahren zu deren Herstellung

Info

Publication number
DE1595924A1
DE1595924A1 DE19651595924 DE1595924A DE1595924A1 DE 1595924 A1 DE1595924 A1 DE 1595924A1 DE 19651595924 DE19651595924 DE 19651595924 DE 1595924 A DE1595924 A DE 1595924A DE 1595924 A1 DE1595924 A1 DE 1595924A1
Authority
DE
Germany
Prior art keywords
alkyl
methyl
amino
formula
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19651595924
Other languages
German (de)
English (en)
Inventor
Tsung-Ying Shen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE1595924A1 publication Critical patent/DE1595924A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DE19651595924 1964-02-28 1965-02-24 alpha-Substituierte Indolylessigsaeure-Verbindungen und ein Verfahren zu deren Herstellung Pending DE1595924A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34830264A 1964-02-28 1964-02-28
US523291A US3351630A (en) 1964-02-28 1966-01-27 Alpha-substituted-3-indolyl acetic acid compounds and processes for their preparation

Publications (1)

Publication Number Publication Date
DE1595924A1 true DE1595924A1 (de) 1970-02-12

Family

ID=26995638

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19651595924 Pending DE1595924A1 (de) 1964-02-28 1965-02-24 alpha-Substituierte Indolylessigsaeure-Verbindungen und ein Verfahren zu deren Herstellung

Country Status (6)

Country Link
US (1) US3351630A (https=)
BR (1) BR6567558D0 (https=)
DE (1) DE1595924A1 (https=)
FR (1) FR1460528A (https=)
GB (1) GB1089071A (https=)
NL (1) NL6502481A (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0164860A1 (en) * 1984-05-04 1985-12-18 Pfizer Inc. N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
WO1998009946A1 (de) * 1996-09-06 1998-03-12 Asta Medica Aktiengesellschaft N-substituierte indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender wirkung

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3390154A (en) * 1966-09-09 1968-06-25 Merck & Co Inc Process for preparing 3-indolyl acetic acids
US4690943A (en) * 1984-09-19 1987-09-01 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
BR9501404A (pt) 1994-04-01 1996-03-05 Lilly Co Eli 1H-indol-3 glioxilamida e formulação farmacèutica
US5641800A (en) * 1994-07-21 1997-06-24 Eli Lilly And Company 1H-indole-1-functional sPLA2 inhibitors
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
CZ302588B6 (cs) * 1998-04-02 2011-07-27 Ziopharm Oncology, Inc. Použití N-substituovaného indol-3-glyoxylamidu pro výrobu léciva
US6380397B1 (en) * 1999-04-15 2002-04-30 Eli Lilly And Company Process for preparing 4-substituted-1H-indole-3-glyoxamides
US6903104B2 (en) 2001-12-06 2005-06-07 National Health Research Institutes Indol-3-YL-2-oxoacetamide compounds and methods of use thereof
US7632955B2 (en) * 2001-12-13 2009-12-15 National Health Research Institutes Indole compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE621313A (https=) *
US2825734A (en) * 1955-04-11 1958-03-04 Upjohn Co Reduction of carbonylic radicals in indolyl-3 compounds
US3038002A (en) * 1957-08-19 1962-06-05 Fundamental Res Inc Syntheses of alpha-methoxyphenylacetates
US3078214A (en) * 1958-09-12 1963-02-19 Sandoz Ag Treatment of mental disturbances with esters of indoles
BE615395A (https=) * 1962-03-21

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0164860A1 (en) * 1984-05-04 1985-12-18 Pfizer Inc. N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
EP0244918A3 (en) * 1984-05-04 1989-02-22 Pfizer Inc. Substituted 2-oxindole-1-carboxamide intermediates
WO1998009946A1 (de) * 1996-09-06 1998-03-12 Asta Medica Aktiengesellschaft N-substituierte indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender wirkung
AU726521C (en) * 1996-09-06 1998-03-26 Ziopharm Oncology, Inc. N-substututed indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action
AU726521B2 (en) * 1996-09-06 2000-11-09 Ziopharm Oncology, Inc. N-substututed indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action
CN100376554C (zh) * 1996-09-06 2008-03-26 Asta药物股份公司 具有抗哮喘、抗过敏和免疫抑制/免疫调节作用的n-取代的吲哚-3-乙醛酰胺类化合物
CZ302301B6 (cs) * 1996-09-06 2011-02-09 Ziopharm Oncology, Inc. N-Substituovaný indol-3-glyoxylamid, zpusob jeho prípravy, farmaceutická kompozice obsahující tento glyoxylamid, zpusob výroby léciva obsahujícího tento glyoxylamid a použití tohoto glyoxylamidu pri výrobe léciva

Also Published As

Publication number Publication date
GB1089071A (en) 1967-11-01
BR6567558D0 (pt) 1973-08-02
FR1460528A (fr) 1966-12-02
NL6502481A (https=) 1965-08-30
US3351630A (en) 1967-11-07

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