DE156900C - - Google Patents
Info
- Publication number
- DE156900C DE156900C DE1903156900D DE156900DA DE156900C DE 156900 C DE156900 C DE 156900C DE 1903156900 D DE1903156900 D DE 1903156900D DE 156900D A DE156900D A DE 156900DA DE 156900 C DE156900 C DE 156900C
- Authority
- DE
- Germany
- Prior art keywords
- aminotheophylline
- chlorotheophylline
- ammonia
- heated
- colorless
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 10
- 229910021529 ammonia Inorganic materials 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 150000001412 amines Chemical class 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- ZZESAIGPDOBLKZ-UHFFFAOYSA-N 8-amino-1,3-dimethyl-7h-purine-2,6-dione Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC(N)=N2 ZZESAIGPDOBLKZ-UHFFFAOYSA-N 0.000 claims 1
- YIUIVFFUEVPRIU-UHFFFAOYSA-N 8-chlorotheophylline Chemical compound O=C1N(C)C(=O)N(C)C2=NC(Cl)=N[C]21 YIUIVFFUEVPRIU-UHFFFAOYSA-N 0.000 claims 1
- JRWTUNWYTGOKBU-UHFFFAOYSA-N 1-(aminomethyl)-3-methyl-7h-purine-2,6-dione Chemical compound O=C1N(CN)C(=O)N(C)C2=C1NC=N2 JRWTUNWYTGOKBU-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- RYIGNEOBDRVTHA-UHFFFAOYSA-N 8-chlorotheophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC(Cl)=N2 RYIGNEOBDRVTHA-UHFFFAOYSA-N 0.000 description 4
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000155 melt Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- PQEIUJGJYPUELF-UHFFFAOYSA-N 8-amino-1,3,7-trimethylpurine-2,6-dione Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=C(N)N2C PQEIUJGJYPUELF-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 229940068190 chlorotheophylline Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- WGVHXOUOLFNIDM-UHFFFAOYSA-N 1-(aminomethyl)-3,7-dimethylpurine-2,6-dione Chemical compound NCN1C(=O)N(C)C=2N=CN(C)C2C1=O WGVHXOUOLFNIDM-UHFFFAOYSA-N 0.000 description 1
- SDPHGRJWGULUFP-UHFFFAOYSA-N 1-(chloromethyl)-3,7-dimethylpurine-2,6-dione Chemical compound CN1C(=O)N(CCl)C(=O)C2=C1N=CN2C SDPHGRJWGULUFP-UHFFFAOYSA-N 0.000 description 1
- JBMBVWROWJGFMG-UHFFFAOYSA-N 2-chloro-7h-purine Chemical class ClC1=NC=C2NC=NC2=N1 JBMBVWROWJGFMG-UHFFFAOYSA-N 0.000 description 1
- MWAMGTOITZRWMI-UHFFFAOYSA-N 8-amino-3,7-dihydropurine-2,6-dione Chemical class N1C(=O)NC(=O)C2=C1N=C(N)N2 MWAMGTOITZRWMI-UHFFFAOYSA-N 0.000 description 1
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 1
- -1 Amino compound Chemical class 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 150000005840 aryl radicals Chemical class 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001804 chlorine Chemical class 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT21550D AT21550B (de) | 1903-09-01 | 1904-12-09 | Verfahren zur Herstellung von 8-Aminotheophyllin und dessen Alkyl- oder Arylderivaten. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE164425T |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE156900C true DE156900C (en:Method) |
Family
ID=33035644
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT164425D Active DE164425C (en:Method) | |||
| DE1903156900D Expired - Lifetime DE156900C (en:Method) | 1903-09-01 | 1903-09-01 | |
| DE1903156901D Expired - Lifetime DE156901C (en:Method) | 1903-09-01 | 1903-09-01 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT164425D Active DE164425C (en:Method) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1903156901D Expired - Lifetime DE156901C (en:Method) | 1903-09-01 | 1903-09-01 |
Country Status (1)
| Country | Link |
|---|---|
| DE (3) | DE156900C (en:Method) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1024968B (de) * | 1956-03-31 | 1958-02-27 | Asal Fabrik Biolog Und Pharmaz | Verfahren zur Herstellung von 7-Ketonyl-8-amino-theophyllinen |
| DE1085530B (de) * | 1958-08-15 | 1960-07-21 | Josef Klosa Dipl Chem Dr | Verfahren zur Herstellung von in 8-Stellung basisch substituierten Coffeinderivaten |
| US3443501A (en) * | 1966-03-09 | 1969-05-13 | Hans Wolfgang F Domnick | Photographic camera and film magazine therefor |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1005517B (de) * | 1955-12-30 | 1957-04-04 | Cassella Farbwerke Mainkur Ag | Verfahren zur Herstellung neuer quecksilberhaltiger Xanthinverbindungen |
-
0
- DE DENDAT164425D patent/DE164425C/de active Active
-
1903
- 1903-09-01 DE DE1903156900D patent/DE156900C/de not_active Expired - Lifetime
- 1903-09-01 DE DE1903156901D patent/DE156901C/de not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1024968B (de) * | 1956-03-31 | 1958-02-27 | Asal Fabrik Biolog Und Pharmaz | Verfahren zur Herstellung von 7-Ketonyl-8-amino-theophyllinen |
| DE1085530B (de) * | 1958-08-15 | 1960-07-21 | Josef Klosa Dipl Chem Dr | Verfahren zur Herstellung von in 8-Stellung basisch substituierten Coffeinderivaten |
| US3443501A (en) * | 1966-03-09 | 1969-05-13 | Hans Wolfgang F Domnick | Photographic camera and film magazine therefor |
Also Published As
| Publication number | Publication date |
|---|---|
| DE164425C (en:Method) | |
| DE156901C (en:Method) |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE156900C (en:Method) | ||
| DE2449492A1 (de) | Verfahren zur herstellung von optisch aktivem p-hydroxyphenylglycin | |
| DE915809C (de) | Verfahren zur Herstellung von heterocyclischen Sulfonamiden | |
| DE2065714A1 (de) | Neue benzodiazepinderivate | |
| DE2166270C3 (de) | Nicotinoylaminoäthansulfonyl-2amino-thiazol | |
| DE946804C (de) | Verfahren zur Herstellung von schwefelhaltigen Abkoemmlingen der Barbitursaeure | |
| DE1645977A1 (de) | Verfahren zur Herstellung von Molekularverbindungen von Inosin-Tryptophan | |
| AT21550B (de) | Verfahren zur Herstellung von 8-Aminotheophyllin und dessen Alkyl- oder Arylderivaten. | |
| DE3015834A1 (de) | Verfahren zur herstellung von 5-amino-1,2,3-thiadiazolen | |
| DE2111610C3 (de) | Verfahren zur Herstellung von Salzen von Pyrimidyl-pyridiniumderivaten | |
| DE957841C (de) | Verfahren zur Herstellung von Sulfonamiden | |
| DE1695894A1 (de) | Optisch aktive N-Acylproline und optisch aktives Prolin sowie Verfahren zu ihrer Herstellung | |
| DE2143720C3 (de) | Verfahren zur Herstellung von reinem DL-Tryptophan | |
| DE1670543B1 (de) | Substituierte 2-Morpholino-4-piperazino-6-amino-s-triazine | |
| DE1059458B (de) | Verfahren zur Herstellung von N-Trichlormethylthioimiden | |
| DE685032C (de) | Verfahren zur Darstellung von Thiazoliumrverbindungen | |
| DE121224C (en:Method) | ||
| DE514746C (de) | Verfahren zur Herstellung des Natriumsalzes der p-Oxyphenylarsinsaeure | |
| DE47600C (de) | Verfahren zur Darstellung von Hydrazinverbindungen | |
| DE77315C (en:Method) | ||
| AT164031B (de) | Verfahren zur Herstellung von 2,4,6-Triaminophenyl-mono-äthern | |
| DE869066C (de) | Verfahren zur Herstellung von substituierten Alkylthioschwefelsaeuren bzw. deren Salzen | |
| DE1545761A1 (de) | Stickstoffhaltige organische Phosphorylderivate und Verfahren zu deren Herstellung | |
| DE86562C (en:Method) | ||
| DE213713C (en:Method) |