DE1299796B - Oberflaechenanaesthetikum - Google Patents
OberflaechenanaesthetikumInfo
- Publication number
- DE1299796B DE1299796B DEA34981A DEA0034981A DE1299796B DE 1299796 B DE1299796 B DE 1299796B DE A34981 A DEA34981 A DE A34981A DE A0034981 A DEA0034981 A DE A0034981A DE 1299796 B DE1299796 B DE 1299796B
- Authority
- DE
- Germany
- Prior art keywords
- methyl
- duration
- minutes
- anesthetic
- action
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003444 anaesthetic effect Effects 0.000 title claims description 8
- -1 2 - diethylaminoethyl ester Chemical class 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 2
- IJIJQLMEXOONTM-UHFFFAOYSA-N 1-[4-(butylamino)phenyl]-2-(dimethylamino)-2-hydroxypropan-1-one Chemical compound CCCCNC1=CC=C(C(=O)C(C)(O)N(C)C)C=C1 IJIJQLMEXOONTM-UHFFFAOYSA-N 0.000 claims 1
- 125000002004 n-butylamino group Chemical group [H]N(*)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 description 10
- 241000283973 Oryctolagus cuniculus Species 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 239000003193 general anesthetic agent Substances 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 239000003589 local anesthetic agent Substances 0.000 description 6
- 229940035674 anesthetics Drugs 0.000 description 5
- 231100000419 toxicity Toxicity 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 229960005015 local anesthetics Drugs 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 229960004050 aminobenzoic acid Drugs 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000007086 side reaction Methods 0.000 description 2
- 235000002639 sodium chloride Nutrition 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- HXEACLLIILLPRG-YFKPBYRVSA-N L-pipecolic acid Chemical compound [O-]C(=O)[C@@H]1CCCC[NH2+]1 HXEACLLIILLPRG-YFKPBYRVSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 229960001290 butanilicaine Drugs 0.000 description 1
- VWYQKFLLGRBICZ-UHFFFAOYSA-N butanilicaine Chemical compound CCCCNCC(=O)NC1=C(C)C=CC=C1Cl VWYQKFLLGRBICZ-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003920 cocaine Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229960002887 deanol Drugs 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 229960002660 mepivacaine hydrochloride Drugs 0.000 description 1
- RETIMRUQNCDCQB-UHFFFAOYSA-N mepivacaine hydrochloride Chemical compound Cl.CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C RETIMRUQNCDCQB-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical compound C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- DLRJIFUOBPOJNS-UHFFFAOYSA-N phenetole Chemical compound CCOC1=CC=CC=C1 DLRJIFUOBPOJNS-UHFFFAOYSA-N 0.000 description 1
- HXEACLLIILLPRG-UHFFFAOYSA-N pipecolic acid Chemical compound OC(=O)C1CCCCN1 HXEACLLIILLPRG-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE6204/59A SE306139B (enrdf_load_stackoverflow) | 1959-07-01 | 1959-07-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1299796B true DE1299796B (de) | 1969-07-24 |
Family
ID=20268139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEA34981A Pending DE1299796B (de) | 1959-07-01 | 1960-06-27 | Oberflaechenanaesthetikum |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3038835A (enrdf_load_stackoverflow) |
| DE (1) | DE1299796B (enrdf_load_stackoverflow) |
| FR (1) | FR13M (enrdf_load_stackoverflow) |
| GB (1) | GB889225A (enrdf_load_stackoverflow) |
| SE (1) | SE306139B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4529601A (en) * | 1977-12-01 | 1985-07-16 | Astra Lakemedel Aktiebolag | Local anesthetic mixture for topical application and method for obtaining local anesthesia |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1425559A (en) * | 1972-09-01 | 1976-02-18 | Wyeth John & Brother Ltd | Pyridine tetrahydropyridine and piperidine derivatives |
| US4344965A (en) * | 1978-10-13 | 1982-08-17 | Raymond Stone | Anesthetic compositions containing benzocaine |
| SE431092B (sv) * | 1979-07-10 | 1984-01-16 | Thuresson Af Ekenstam Bo | Terapeutiskt aktiva, substituerade piperidinkarboxianilider |
| EP0031603A1 (en) * | 1979-12-31 | 1981-07-08 | American Cyanamid Company | Pharmaceutical composition of matter |
| FR2528834B1 (fr) * | 1982-06-16 | 1986-03-07 | Sanofi Sa | Sels d'ammonium quaternaires d'amines cycliques disubstituees en a et a' par des groupes phenylcarbamoyle eventuellement substitues sur le phenyl, et medicaments a action antiarythmique comportant lesdits sels |
| ES2082703B1 (es) * | 1993-11-04 | 1996-12-16 | Inst Investigacion Desarrollo | Nuevos derivados de ciclopropilo, procedimientos para su preparacion y aplicaciones. |
| US5834490A (en) * | 1993-11-04 | 1998-11-10 | Instituto De Investigacion Y Desarrolo Quimico Biologico, S.A. | Cyclopropyl derivatives, preparation method there-of and applications |
| US5715572A (en) * | 1994-01-04 | 1998-02-10 | Amiram Steinberg & Dalia Lapidot | Hinge |
| US5776859A (en) * | 1995-11-15 | 1998-07-07 | Nickel; Alfred A. | Sodium channel active novel compounds and related processes and bioassay techniques |
| WO1997018813A1 (en) * | 1995-11-22 | 1997-05-29 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US6127366A (en) * | 1995-11-22 | 2000-10-03 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| GB9604311D0 (en) * | 1996-02-29 | 1996-05-01 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB805523A (en) * | 1955-08-08 | 1958-12-10 | Cook Waite Lab Inc | Local anesthetic composition and preparation thereof |
| GB799780A (en) * | 1956-02-22 | 1958-08-13 | Bofors Ab | New n-alkyl-alkyl-piperidine-ª‡-monocarboxylic acid amides and n-alkyl-alkyl-pyrrolidine-ª‡-monocarboxylic acid amides |
| GB799779A (en) * | 1956-02-22 | 1958-08-13 | Bofors Ab | Method of producing n-alkyl-alkyl-piperidine monocarboxylic acid amides and n-alkyl-alkyl-pyrrolidine monocarboxylic acid amides |
-
0
- GB GB889225D patent/GB889225A/en active Active
-
1959
- 1959-07-01 SE SE6204/59A patent/SE306139B/xx unknown
-
1960
- 1960-06-27 DE DEA34981A patent/DE1299796B/de active Pending
- 1960-06-28 US US39211A patent/US3038835A/en not_active Expired - Lifetime
- 1960-06-29 FR FR831499A patent/FR13M/fr not_active Expired
Non-Patent Citations (1)
| Title |
|---|
| None * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4529601A (en) * | 1977-12-01 | 1985-07-16 | Astra Lakemedel Aktiebolag | Local anesthetic mixture for topical application and method for obtaining local anesthesia |
| US4562060A (en) * | 1977-12-01 | 1985-12-31 | Astra Lakemedel Aktiebolag | Local anesthetic mixture for topical application, process for its preparation, as well as method for obtaining local anesthesia |
Also Published As
| Publication number | Publication date |
|---|---|
| GB889225A (enrdf_load_stackoverflow) | |
| SE306139B (enrdf_load_stackoverflow) | 1968-11-18 |
| FR13M (fr) | 1960-11-28 |
| US3038835A (en) | 1962-06-12 |
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