DE1252364B - Verfah ren zur Gewinnung des Kallikrem Inakti vators in kristallisierter Form - Google Patents
Verfah ren zur Gewinnung des Kallikrem Inakti vators in kristallisierter FormInfo
- Publication number
- DE1252364B DE1252364B DENDAT1252364D DE1252364DA DE1252364B DE 1252364 B DE1252364 B DE 1252364B DE NDAT1252364 D DENDAT1252364 D DE NDAT1252364D DE 1252364D A DE1252364D A DE 1252364DA DE 1252364 B DE1252364 B DE 1252364B
- Authority
- DE
- Germany
- Prior art keywords
- inactivator
- kie
- crystals
- crystallized form
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000937 inactivator Effects 0.000 title claims description 24
- 238000000034 method Methods 0.000 title claims description 7
- 102000001399 Kallikrein Human genes 0.000 claims description 17
- 108060005987 Kallikrein Proteins 0.000 claims description 17
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 12
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 6
- 229910021529 ammonia Inorganic materials 0.000 claims description 6
- 150000001450 anions Chemical class 0.000 claims description 5
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims description 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 4
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 3
- 150000007530 organic bases Chemical class 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims 2
- 239000013078 crystal Substances 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
- 238000002425 crystallisation Methods 0.000 description 6
- 230000008025 crystallization Effects 0.000 description 6
- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 6
- 239000000243 solution Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 3
- 235000011130 ammonium sulphate Nutrition 0.000 description 3
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 3
- 235000019341 magnesium sulphate Nutrition 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 239000003929 acidic solution Substances 0.000 description 2
- 239000012670 alkaline solution Substances 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 229920001429 chelating resin Polymers 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- 101710126321 Pancreatic trypsin inhibitor Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 229910052601 baryte Inorganic materials 0.000 description 1
- 239000010428 baryte Substances 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Purses, Travelling Bags, Baskets, Or Suitcases (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF0048504 | 1966-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1252364B true DE1252364B (de) | 1967-10-19 |
Family
ID=7102287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT1252364D Pending DE1252364B (de) | 1966-02-23 | Verfah ren zur Gewinnung des Kallikrem Inakti vators in kristallisierter Form |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3558773A (enEXAMPLES) |
| AT (1) | AT267050B (enEXAMPLES) |
| BE (1) | BE694474A (enEXAMPLES) |
| CH (1) | CH483258A (enEXAMPLES) |
| DE (1) | DE1252364B (enEXAMPLES) |
| DK (1) | DK116675B (enEXAMPLES) |
| ES (1) | ES337146A1 (enEXAMPLES) |
| FI (1) | FI45827C (enEXAMPLES) |
| FR (2) | FR1512258A (enEXAMPLES) |
| GB (1) | GB1134486A (enEXAMPLES) |
| IL (1) | IL27383A (enEXAMPLES) |
| LU (1) | LU53052A1 (enEXAMPLES) |
| NL (1) | NL6702824A (enEXAMPLES) |
| NO (1) | NO119755B (enEXAMPLES) |
| SE (1) | SE325369B (enEXAMPLES) |
| YU (2) | YU33199B (enEXAMPLES) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1517753B2 (de) * | 1966-05-26 | 1973-11-29 | Bayer Ag, 5090 Leverkusen | Verfahren zur Anreicherung von Enzym Inhibitoren |
| BE754278A (fr) * | 1969-08-02 | 1971-02-01 | Bayer Ag | Procede d'utilisation d'inhibiteurs biologiques de proteases comme desodorisants |
| US3951939A (en) * | 1972-01-08 | 1976-04-20 | Behringwerke Aktiengesellschaft | Polypeptides, process for their manufacture and their use as polyvalent isoinhibitors |
| JPS5544726B2 (enEXAMPLES) * | 1973-05-17 | 1980-11-13 | ||
| NL7411563A (nl) * | 1973-09-06 | 1975-03-10 | Hoechst Ag | Werkwijze voor het bereiden van synthetisch gemodificeerde trypsine-inhibitoren. |
| US4190573A (en) * | 1974-02-14 | 1980-02-26 | Behringwerke Aktiengesellschaft | Process for the isolation of the polyvalent proteinase inhibitor |
| FR2701258B1 (fr) * | 1993-02-09 | 1995-04-28 | Inst Francais Du Petrole | Procédé continu pour l'isomérisation des oléfines. |
| WO1998003537A2 (en) * | 1996-07-24 | 1998-01-29 | Novartis Ag | Hirustasin and a hirustasin/kallikrein complex in crystalline form |
| US7552776B2 (en) * | 1998-12-07 | 2009-06-30 | Enventure Global Technology, Llc | Anchor hangers |
-
0
- DE DENDAT1252364D patent/DE1252364B/de active Pending
-
1967
- 1967-01-17 CH CH65667A patent/CH483258A/de not_active IP Right Cessation
- 1967-02-01 AT AT95567A patent/AT267050B/de active
- 1967-02-03 IL IL27383A patent/IL27383A/xx unknown
- 1967-02-15 GB GB7268/67A patent/GB1134486A/en not_active Expired
- 1967-02-18 YU YU0234/67A patent/YU33199B/xx unknown
- 1967-02-18 YU YU00294/67A patent/YU29467A/xx unknown
- 1967-02-21 US US617652A patent/US3558773A/en not_active Expired - Lifetime
- 1967-02-21 FI FI670512A patent/FI45827C/fi active
- 1967-02-22 ES ES337146A patent/ES337146A1/es not_active Expired
- 1967-02-22 DK DK96367AA patent/DK116675B/da unknown
- 1967-02-22 BE BE694474D patent/BE694474A/xx unknown
- 1967-02-22 NO NO166967A patent/NO119755B/no unknown
- 1967-02-23 NL NL6702824A patent/NL6702824A/xx unknown
- 1967-02-23 SE SE02502/67A patent/SE325369B/xx unknown
- 1967-02-23 LU LU53052D patent/LU53052A1/xx unknown
- 1967-02-23 FR FR96283A patent/FR1512258A/fr not_active Expired
- 1967-05-22 FR FR107241A patent/FR7027M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| LU53052A1 (enEXAMPLES) | 1967-04-24 |
| IL27383A (en) | 1970-09-17 |
| SE325369B (enEXAMPLES) | 1970-06-29 |
| NO119755B (enEXAMPLES) | 1970-06-29 |
| NL6702824A (enEXAMPLES) | 1967-08-24 |
| FR1512258A (fr) | 1968-02-02 |
| BE694474A (enEXAMPLES) | 1967-08-22 |
| AT267050B (de) | 1968-12-10 |
| GB1134486A (en) | 1968-11-27 |
| FI45827C (fi) | 1972-10-10 |
| YU29467A (en) | 1975-12-31 |
| FR7027M (enEXAMPLES) | 1969-06-09 |
| ES337146A1 (es) | 1968-06-01 |
| US3558773A (en) | 1971-01-26 |
| FI45827B (enEXAMPLES) | 1972-06-30 |
| DK116675B (da) | 1970-02-02 |
| CH483258A (de) | 1969-12-31 |
| YU33199B (en) | 1976-06-30 |
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