DE102008009039B4 - Neue Verbindungen aus Antrodia camphorata - Google Patents

Neue Verbindungen aus Antrodia camphorata Download PDF

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Publication number
DE102008009039B4
DE102008009039B4 DE102008009039A DE102008009039A DE102008009039B4 DE 102008009039 B4 DE102008009039 B4 DE 102008009039B4 DE 102008009039 A DE102008009039 A DE 102008009039A DE 102008009039 A DE102008009039 A DE 102008009039A DE 102008009039 B4 DE102008009039 B4 DE 102008009039B4
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DE
Germany
Prior art keywords
cancer cells
antroquinone
cells
antroquinonol
antrodia camphorata
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE102008009039A
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German (de)
English (en)
Other versions
DE102008009039A1 (de
Inventor
Sheng-Yun Danshuei Liu
Mao-Tien Danshuei Kuo
Wu-Che Danshuei Wen
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Golden Biotechnology Corp
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Golden Biotechnology Corp
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Publication date
Application filed by Golden Biotechnology Corp filed Critical Golden Biotechnology Corp
Publication of DE102008009039A1 publication Critical patent/DE102008009039A1/de
Application granted granted Critical
Publication of DE102008009039B4 publication Critical patent/DE102008009039B4/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/10—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by etherified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic
    • C07C35/08—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings
    • C07C35/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings with unsaturation at least in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C07C7/005—Processes comprising at least two steps in series
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Water Supply & Treatment (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE102008009039A 2007-10-19 2008-02-14 Neue Verbindungen aus Antrodia camphorata Expired - Fee Related DE102008009039B4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TW096139241 2004-10-19
TW096139241A TW200918498A (en) 2007-10-19 2007-10-19 Novel compound isolated from Antrodia camphorate extracts

Publications (2)

Publication Number Publication Date
DE102008009039A1 DE102008009039A1 (de) 2009-04-23
DE102008009039B4 true DE102008009039B4 (de) 2009-11-12

Family

ID=39417715

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102008009039A Expired - Fee Related DE102008009039B4 (de) 2007-10-19 2008-02-14 Neue Verbindungen aus Antrodia camphorata

Country Status (7)

Country Link
US (1) US7385088B1 (https=)
JP (1) JP5014959B2 (https=)
KR (1) KR100897988B1 (https=)
DE (1) DE102008009039B4 (https=)
FR (1) FR2922549B1 (https=)
GB (1) GB2453808B (https=)
TW (1) TW200918498A (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101417934B (zh) * 2007-10-24 2012-04-18 国鼎生物科技股份有限公司 分离自牛樟芝萃取物的化合物
ES2574606T3 (es) * 2009-11-26 2016-06-21 National Taiwan University Una sustancia activa contra el cáncer de Antrodia camphorata, método de preparación de la misma y uso de la misma
US8309611B2 (en) 2010-09-20 2012-11-13 Golden Biotechnology Corporation Methods and compositions for treating lung cancer
TWI407100B (zh) * 2010-10-21 2013-09-01 Yew Min Tzeng 利用高效液相層析分析牛樟芝三萜類之方法
TWI452032B (zh) * 2011-01-21 2014-09-11 國鼎生物科技股份有限公司 治療腎病之醫藥組成物
EP2746268B1 (en) * 2011-08-10 2016-12-07 Yang, Zhen Method for chemical synthesis of antrocin
SE1350211A1 (sv) 2012-02-23 2013-08-24 Golden Biotechnology Corp Metoder och kompositioner för behandling av cancermetastaser
TWI460157B (zh) * 2012-07-13 2014-11-11 New Bellus Entpr Co Ltd 樟芝菌絲體之化合物及其用途
TWI597061B (zh) * 2013-02-20 2017-09-01 國鼎生物科技股份有限公司 治療白血病之方法及組成物
JP5908002B2 (ja) * 2013-03-20 2016-04-26 卉菱 曽 ベニクスノキタケに含まれる化合物及びその用途
TW201442700A (zh) * 2013-05-09 2014-11-16 曾卉菱 牛樟芝化合物、萃取物及其用途
CN103740772B (zh) * 2013-12-27 2015-08-19 江南大学 一种促进樟芝液态发酵生物合成安卓奎诺尔的方法
US9789153B2 (en) 2014-07-02 2017-10-17 Hsiu-Hsien Tsai Composition for preventing cancer and treating cancer and intensifying the effects of other anticancer drugs
CN105769834A (zh) * 2014-08-15 2016-07-20 曾泰霖 牛樟芝化合物、萃取物用于制备促进胰岛素分泌的药物的用途
PL3240772T3 (pl) 2014-12-30 2021-06-28 ONENESS BIOTECH CO., Ltd Związki z antrodia camphorata, sposoby ich otrzymywania i ich zastosowanie
CN105820956B (zh) * 2015-01-04 2019-09-06 上海理工大学 一株牛樟芝菌株及牛樟芝液态发酵方法
CN104906147A (zh) * 2015-05-12 2015-09-16 柳州市耕青科技有限公司 一种从牛樟芝中萃取萜类粉末的方法
TW201705947A (zh) * 2015-08-12 2017-02-16 Ma Shen Kai Ruei Co Ltd 用於治療罹患癌症的個體之醫藥組合物
JP6499740B2 (ja) * 2016-10-13 2019-04-10 フォーデイズ株式会社 食品組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070116787A1 (en) * 2005-11-21 2007-05-24 Chih-Jung Yao Cancer treatment
JP2007267685A (ja) * 2006-03-31 2007-10-18 Nissei Bio Kk 糸状菌を用いる乳酸菌の培養方法及び該培養方法により得られる培養物

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Cherng, I.H. et al.: Three new Triterpenoids from Antrodia Cinnamomea, In: J. Nat. Prod. 58, No. 3 (1995), p. 365-371 *
Cherng, I.H. et al.: Triterpenoids from Antrodia Cinnamomea, In: Phytochemistry 41 (1996), p. 263-267 *
Cherng, I.H. et al.: Triterpenoids from Antrodia Cinnamomea, In: Phytochemistry 41 (1996), p. 263-267 Yang, S.W. et al.: Steroids and Triterpenoids of Antrodia Cinnamomea - a Fungus Parasitic on Cinnamomum Micranthum, In: Phytochemistry 41 (1996), p. 1389-1392 Chiang, H.C. et al.: A Sesquiterpene Lactone, Phenyl and Biphenyl Compounds from Antrodia Cinnamomea, In: Phytochemistry 39, No. 3 (1996), p. 613-616 Yang, S.W. et al.: New Steroic Acids from Antrodia Cinnamomea - a Fungal Parasit of Cinnamomum Micranthum, In: J. Nat. Prod. 58, No 11 (1995), p. 1655-1661 Cherng, I.H. et al.: Three new Triterpenoids from Antrodia Cinnamomea, In: J. Nat. Prod. 58, No. 3 (1995), p. 365-371
Chiang, H.C. et al.: A Sesquiterpene Lactone, Phenyl and Biphenyl Compounds from Antrodia Cinnamomea, In: Phytochemistry 39, No. 3 (1996), p. 613-616 *
Yang, S.W. et al.: New Steroic Acids from Antrodia Cinnamomea - a Fungal Parasit of Cinnamomum Micranthum, In: J. Nat. Prod. 58, No 11 (1995), p. 1655-1661 *
Yang, S.W. et al.: Steroids and Triterpenoids of Antrodia Cinnamomea - a Fungus Parasitic on Cinnamomum Micranthum, In: Phytochemistry 41 (1996), p. 1389-1392 *

Also Published As

Publication number Publication date
FR2922549A1 (fr) 2009-04-24
TW200918498A (en) 2009-05-01
JP5014959B2 (ja) 2012-08-29
KR100897988B1 (ko) 2009-05-18
FR2922549B1 (fr) 2013-08-23
KR20090040194A (ko) 2009-04-23
GB2453808B (en) 2009-09-16
GB2453808A8 (en) 2009-05-06
DE102008009039A1 (de) 2009-04-23
US7385088B1 (en) 2008-06-10
JP2009102286A (ja) 2009-05-14
US20080119565A1 (en) 2008-05-22
TWI335314B (https=) 2011-01-01
GB2453808A (en) 2009-04-22
GB0801621D0 (en) 2008-03-05

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R082 Change of representative

Representative=s name: VIERING, JENTSCHURA & PARTNER MBB PATENT- UND , DE

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R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee