DE10042058A1 - Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung - Google Patents

Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Info

Publication number
DE10042058A1
DE10042058A1 DE10042058A DE10042058A DE10042058A1 DE 10042058 A1 DE10042058 A1 DE 10042058A1 DE 10042058 A DE10042058 A DE 10042058A DE 10042058 A DE10042058 A DE 10042058A DE 10042058 A1 DE10042058 A1 DE 10042058A1
Authority
DE
Germany
Prior art keywords
amino
phenyl
quinazoline
chloro
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE10042058A
Other languages
German (de)
English (en)
Inventor
Frank Himmelsbach
Elke Langkopf
Birgit Jung
Stefan Blech
Flavio Solca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to DE10042058A priority Critical patent/DE10042058A1/de
Priority to JP2002523469A priority patent/JP4834282B2/ja
Priority to PCT/EP2001/009532 priority patent/WO2002018351A1/de
Priority to CNB01814635XA priority patent/CN100404517C/zh
Priority to CZ20030870A priority patent/CZ302567B6/cs
Priority to CA002417897A priority patent/CA2417897C/en
Priority to PL36024801A priority patent/PL360248A1/xx
Priority to HU0300819A priority patent/HUP0300819A3/hu
Priority to MXPA03001483A priority patent/MXPA03001483A/es
Priority to EEP200300077A priority patent/EE05269B1/xx
Priority to KR1020037002744A priority patent/KR100862873B1/ko
Priority to YU14003A priority patent/RS52279B/en
Priority to IL15460201A priority patent/IL154602A0/xx
Priority to UA2003032533A priority patent/UA73004C2/uk
Priority to MEP-587/08A priority patent/MEP58708A/xx
Priority to SK231-2003A priority patent/SK287747B6/sk
Priority to NZ524668A priority patent/NZ524668A/en
Priority to EA200300219A priority patent/EA005679B1/ru
Priority to BR0113519-8A priority patent/BR0113519A/pt
Priority to AU8769401A priority patent/AU8769401A/xx
Priority to AU2001287694A priority patent/AU2001287694B2/en
Priority to EP01967285A priority patent/EP1315705A1/de
Priority to US09/934,772 priority patent/US6656946B2/en
Priority to UY26903A priority patent/UY26903A1/es
Priority to ARP010104041A priority patent/AR033562A1/es
Priority to TW090120905A priority patent/TWI294422B/zh
Priority to MYPI20013985A priority patent/MY126132A/en
Publication of DE10042058A1 publication Critical patent/DE10042058A1/de
Priority to EC2003004464A priority patent/ECSP034464A/es
Priority to ZA200300991A priority patent/ZA200300991B/en
Priority to BG107559A priority patent/BG107559A/bg
Priority to HR20030138A priority patent/HRP20030138A2/hr
Priority to IL154602A priority patent/IL154602A/en
Priority to NO20030870A priority patent/NO324866B1/no
Priority to HK04100462A priority patent/HK1057557A1/xx
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE10042058A 2000-08-26 2000-08-26 Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung Ceased DE10042058A1 (de)

Priority Applications (34)

Application Number Priority Date Filing Date Title
DE10042058A DE10042058A1 (de) 2000-08-26 2000-08-26 Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
EA200300219A EA005679B1 (ru) 2000-08-26 2001-08-18 Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения
BR0113519-8A BR0113519A (pt) 2000-08-26 2001-08-18 Heterociclos bicìclicos, composições farmacêuticas contendo esses compostos, seu uso e processos para sua preparação
CNB01814635XA CN100404517C (zh) 2000-08-26 2001-08-18 双环杂环、含这些化合物的药物组合物,其用途及制备方法
PCT/EP2001/009532 WO2002018351A1 (de) 2000-08-26 2001-08-18 Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und vefahren zu ihrer herstellung
CA002417897A CA2417897C (en) 2000-08-26 2001-08-18 Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
AU8769401A AU8769401A (en) 2000-08-26 2001-08-18 Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof
HU0300819A HUP0300819A3 (en) 2000-08-26 2001-08-18 Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof
MXPA03001483A MXPA03001483A (es) 2000-08-26 2001-08-18 Heterociclos biciclicos medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion.
EEP200300077A EE05269B1 (et) 2000-08-26 2001-08-18 Bitsüklilised heterotsüklilised ühendid, neid ühendeid sisaldavad ravimid, nende kasutamine ja meetodid nende valmistamiseks
KR1020037002744A KR100862873B1 (ko) 2000-08-26 2001-08-18 이환식 헤테로사이클, 당해 화합물을 함유하는 약제 및 이의 제조방법
YU14003A RS52279B (en) 2000-08-26 2001-08-18 BICYCLIC HETEROCYCLIC COMPOUNDS, THE MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS, THEIR USE AND THE PROCEDURE FOR OBTAINING THEM
IL15460201A IL154602A0 (en) 2000-08-26 2001-08-18 Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof
UA2003032533A UA73004C2 (uk) 2000-08-26 2001-08-18 Біциклічні гетероцикли та лікувальний засіб на їх основі
MEP-587/08A MEP58708A (en) 2000-08-26 2001-08-18 Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof
SK231-2003A SK287747B6 (sk) 2000-08-26 2001-08-18 4-Aminochinazolíny, spôsob ich výroby a farmaceutický prostriedok s ich obsahom
NZ524668A NZ524668A (en) 2000-08-26 2001-08-18 Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use, and processes for preparing them.
JP2002523469A JP4834282B2 (ja) 2000-08-26 2001-08-18 二環式複素環、それを含む医薬組成物、その使用及びその製造方法
CZ20030870A CZ302567B6 (cs) 2000-08-26 2001-08-18 Aminochinazoliny, farmaceutický prostredek obsahující tyto slouceniny, jejich použití a zpusob jejich výroby
PL36024801A PL360248A1 (en) 2000-08-26 2001-08-18 Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof
AU2001287694A AU2001287694B2 (en) 2000-08-26 2001-08-18 Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof
EP01967285A EP1315705A1 (de) 2000-08-26 2001-08-18 Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und vefahren zu ihrer herstellung
US09/934,772 US6656946B2 (en) 2000-08-26 2001-08-22 Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases
UY26903A UY26903A1 (es) 2000-08-26 2001-08-23 Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación
ARP010104041A AR033562A1 (es) 2000-08-26 2001-08-24 Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion
TW090120905A TWI294422B (en) 2000-08-26 2001-08-24 Bicyclic heteocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
MYPI20013985A MY126132A (en) 2000-08-26 2001-08-24 Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases
EC2003004464A ECSP034464A (es) 2000-08-26 2003-02-03 Heterociclicos bicilcicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion
ZA200300991A ZA200300991B (en) 2000-08-26 2003-02-05 Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof.
BG107559A BG107559A (bg) 2000-08-26 2003-02-14 Бициклени хетероцикли, лекарствени средства съдържащи тези съединения, приложението им и метод за тяхното получаване
IL154602A IL154602A (en) 2000-08-26 2003-02-24 Aminoquinazolines inhibit signaling mediated by tyrosine kinases
HR20030138A HRP20030138A2 (en) 2000-08-26 2003-02-24 Bicyclic heterocycles, medicaments containing these compound, their use, and methods for the production thereof
NO20030870A NO324866B1 (no) 2000-08-26 2003-02-25 Bicykliske heterocykler, medikamenter inneholdende disse, deres anvendelse for fremstilling av legemidler for behandling av sykdommer og fremgangsmater for fremstilling derav
HK04100462A HK1057557A1 (en) 2000-08-26 2004-01-21 Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10042058A DE10042058A1 (de) 2000-08-26 2000-08-26 Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
DE10042058A1 true DE10042058A1 (de) 2002-03-07

Family

ID=7653945

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10042058A Ceased DE10042058A1 (de) 2000-08-26 2000-08-26 Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Country Status (31)

Country Link
EP (1) EP1315705A1 (hr)
JP (1) JP4834282B2 (hr)
KR (1) KR100862873B1 (hr)
CN (1) CN100404517C (hr)
AR (1) AR033562A1 (hr)
AU (2) AU8769401A (hr)
BG (1) BG107559A (hr)
BR (1) BR0113519A (hr)
CA (1) CA2417897C (hr)
CZ (1) CZ302567B6 (hr)
DE (1) DE10042058A1 (hr)
EA (1) EA005679B1 (hr)
EC (1) ECSP034464A (hr)
EE (1) EE05269B1 (hr)
HK (1) HK1057557A1 (hr)
HR (1) HRP20030138A2 (hr)
HU (1) HUP0300819A3 (hr)
IL (2) IL154602A0 (hr)
ME (1) MEP58708A (hr)
MX (1) MXPA03001483A (hr)
MY (1) MY126132A (hr)
NO (1) NO324866B1 (hr)
NZ (1) NZ524668A (hr)
PL (1) PL360248A1 (hr)
RS (1) RS52279B (hr)
SK (1) SK287747B6 (hr)
TW (1) TWI294422B (hr)
UA (1) UA73004C2 (hr)
UY (1) UY26903A1 (hr)
WO (1) WO2002018351A1 (hr)
ZA (1) ZA200300991B (hr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005011701A1 (de) * 2003-07-28 2005-02-10 Boehringer Ingelheim International Gmbh Verwendung von chinazolin tyrosinkinase-inhibitoren zur behandlung inflammatorischer prozesse
WO2005041973A1 (de) * 2003-10-30 2005-05-12 Boehringer Ingelheim International Gmbh Verwendung von tyrosinkinase-inhibitoren zur behandlung inflammatorischer prozesse
WO2007023073A2 (de) * 2005-08-22 2007-03-01 Boehringer Ingelheim International Gmbh Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
US7998949B2 (en) 2007-02-06 2011-08-16 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
US8399461B2 (en) 2006-11-10 2013-03-19 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for production of same
US8497369B2 (en) 2008-02-07 2013-07-30 Boehringer Ingelheim International Gmbh Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production
US8648191B2 (en) 2008-08-08 2014-02-11 Boehringer Ingelheim International Gmbh Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MEP45508A (en) 1999-06-21 2011-02-10 Boehringer Ingelheim Pharma Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof
DE10042059A1 (de) * 2000-08-26 2002-03-07 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US7019012B2 (en) 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
TWI324597B (en) * 2002-03-28 2010-05-11 Astrazeneca Ab Quinazoline derivatives
DE10214412A1 (de) * 2002-03-30 2003-10-09 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
PL371188A1 (en) * 2002-03-30 2005-06-13 Boehringer Ingelheim Pharma Gmbh & Co.Kg 4-(n-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
EP2277867B1 (en) 2002-07-15 2012-12-05 Symphony Evolution, Inc. Compounds, pharmaceutical compositions thereof and their use in treating cancer
DE10326186A1 (de) * 2003-06-06 2004-12-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
GB0317665D0 (en) 2003-07-29 2003-09-03 Astrazeneca Ab Qinazoline derivatives
PL1667992T3 (pl) 2003-09-19 2007-05-31 Astrazeneca Ab Pochodne chinazoliny
ES2371383T3 (es) 2003-09-26 2011-12-30 Exelixis, Inc. N-[3-fluoro-4-({6-(metiloxi)-7-[(3-morfolin-4-ilpropil)oxi]quinolin-4-il}oxi)fenil]-n'-(4-fluorofenil)ciclopropan-1,1-dicarboxamida para el tratamiento del cáncer.
US7456189B2 (en) 2003-09-30 2008-11-25 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
DE10345875A1 (de) * 2003-09-30 2005-04-21 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Vewendung und Verfahren zu ihrer Herstellung
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
WO2006090163A1 (en) 2005-02-26 2006-08-31 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors
KR100673775B1 (ko) * 2005-04-08 2007-01-24 엘지전자 주식회사 냉장고용 홈바
EP3173084B1 (en) 2005-11-11 2019-10-23 Boehringer Ingelheim International GmbH Quinazoline derivatives for the treatment of cancer diseases
WO2007101782A1 (de) * 2006-03-09 2007-09-13 Boehringer Ingelheim International Gmbh Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
RU2492864C2 (ru) 2006-09-18 2013-09-20 Бёрингер Ингельхайм Интернациональ Гмбх Способ лечения рака, несущего мутации egfr
ES2444128T3 (es) 2008-05-13 2014-02-24 Astrazeneca Ab Nueva SAL-554
TW202241853A (zh) 2009-01-16 2022-11-01 美商艾克塞里克斯公司 包含n-(4-{[6,7-雙(甲氧基)喹啉-4-基]氧基}苯基)-n'-(4-氟苯基)環丙烷-1,1-二甲醯胺之蘋果酸鹽之醫藥組合物及其用途
US9545381B2 (en) 2009-07-06 2017-01-17 Boehringer Ingelheim International Gmbh Process for drying of BIBW2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient
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