EA200300219A1 - Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения - Google Patents

Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения

Info

Publication number
EA200300219A1
EA200300219A1 EA200300219A EA200300219A EA200300219A1 EA 200300219 A1 EA200300219 A1 EA 200300219A1 EA 200300219 A EA200300219 A EA 200300219A EA 200300219 A EA200300219 A EA 200300219A EA 200300219 A1 EA200300219 A1 EA 200300219A1
Authority
EA
Eurasian Patent Office
Prior art keywords
application
diseases
compounds
bicyclic heterocycles
obtaining
Prior art date
Application number
EA200300219A
Other languages
English (en)
Other versions
EA005679B1 (ru
Inventor
Франк Химмельсбах
Эльке Лангкопф
Биргит Юнг
Штефан Блех
Флавио Золька
Original Assignee
БЁРИНГЕР ИНГЕЛЬХАЙМ ФАРМА ГМБХ УНД Ко.КГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by БЁРИНГЕР ИНГЕЛЬХАЙМ ФАРМА ГМБХ УНД Ко.КГ filed Critical БЁРИНГЕР ИНГЕЛЬХАЙМ ФАРМА ГМБХ УНД Ко.КГ
Publication of EA200300219A1 publication Critical patent/EA200300219A1/ru
Publication of EA005679B1 publication Critical patent/EA005679B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

В заявке описаны бициклические гетероциклы общей формулыв которой R-Rимеют указанные в пп.1-7 формулы изобретения значения, их таутомеры, их стереоизомеры и их соли, прежде всего их физиологически приемлемые соли с неорганическими или органическими кислотами или основаниями, при этом такие соединения обладают ценными фармакологическими свойствами, прежде всего ингибирующим действием на опосредуемую тирозинкиназами передачу сигналов, а также описано применение этих соединений для лечения заболеваний различного рода, прежде всего опухолевых заболеваний, заболеваний легких и дыхательных путей, и их получение.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300219A 2000-08-26 2001-08-18 Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения EA005679B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10042058A DE10042058A1 (de) 2000-08-26 2000-08-26 Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
PCT/EP2001/009532 WO2002018351A1 (de) 2000-08-26 2001-08-18 Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und vefahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
EA200300219A1 true EA200300219A1 (ru) 2003-08-28
EA005679B1 EA005679B1 (ru) 2005-04-28

Family

ID=7653945

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300219A EA005679B1 (ru) 2000-08-26 2001-08-18 Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения

Country Status (31)

Country Link
EP (1) EP1315705A1 (ru)
JP (1) JP4834282B2 (ru)
KR (1) KR100862873B1 (ru)
CN (1) CN100404517C (ru)
AR (1) AR033562A1 (ru)
AU (2) AU2001287694B2 (ru)
BG (1) BG107559A (ru)
BR (1) BR0113519A (ru)
CA (1) CA2417897C (ru)
CZ (1) CZ302567B6 (ru)
DE (1) DE10042058A1 (ru)
EA (1) EA005679B1 (ru)
EC (1) ECSP034464A (ru)
EE (1) EE05269B1 (ru)
HK (1) HK1057557A1 (ru)
HR (1) HRP20030138A2 (ru)
HU (1) HUP0300819A3 (ru)
IL (2) IL154602A0 (ru)
ME (1) MEP58708A (ru)
MX (1) MXPA03001483A (ru)
MY (1) MY126132A (ru)
NO (1) NO324866B1 (ru)
NZ (1) NZ524668A (ru)
PL (1) PL360248A1 (ru)
RS (1) RS52279B (ru)
SK (1) SK287747B6 (ru)
TW (1) TWI294422B (ru)
UA (1) UA73004C2 (ru)
UY (1) UY26903A1 (ru)
WO (1) WO2002018351A1 (ru)
ZA (1) ZA200300991B (ru)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01012899A (es) 1999-06-21 2002-07-30 Boehringer Ingelheim Pharma Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion.
DE10042059A1 (de) * 2000-08-26 2002-03-07 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US7019012B2 (en) 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
TWI324597B (en) 2002-03-28 2010-05-11 Astrazeneca Ab Quinazoline derivatives
PL371188A1 (en) * 2002-03-30 2005-06-13 Boehringer Ingelheim Pharma Gmbh & Co.Kg 4-(n-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors
DE10214412A1 (de) * 2002-03-30 2003-10-09 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
EP2277867B1 (en) 2002-07-15 2012-12-05 Symphony Evolution, Inc. Compounds, pharmaceutical compositions thereof and their use in treating cancer
DE10326186A1 (de) * 2003-06-06 2004-12-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE10334226A1 (de) * 2003-07-28 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse
GB0317665D0 (en) 2003-07-29 2003-09-03 Astrazeneca Ab Qinazoline derivatives
AU2004274227B2 (en) 2003-09-19 2008-04-24 Astrazeneca Ab Quinazoline derivatives
EP2609919A3 (en) 2003-09-26 2014-02-26 Exelixis, Inc. c-Met modulators and methods of use
DE10345875A1 (de) * 2003-09-30 2005-04-21 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Vewendung und Verfahren zu ihrer Herstellung
US7456189B2 (en) 2003-09-30 2008-11-25 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
DE10350717A1 (de) * 2003-10-30 2005-06-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
CA2599210A1 (en) 2005-02-26 2006-08-31 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors
KR100673775B1 (ko) * 2005-04-08 2007-01-24 엘지전자 주식회사 냉장고용 홈바
US20100234371A1 (en) * 2005-08-22 2010-09-16 Frank Himmelsbach Bicyclic heterocycles, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof
WO2007054550A1 (en) 2005-11-11 2007-05-18 Boehringer Ingelheim International Gmbh Quinazoline derivatives for the treatment of cancer diseases
WO2007101782A1 (de) * 2006-03-09 2007-09-13 Boehringer Ingelheim International Gmbh Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
EP2068880B1 (en) 2006-09-18 2012-04-11 Boehringer Ingelheim International GmbH Method for treating cancer harboring egfr mutations
EP1921070A1 (de) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
AU2008212999A1 (en) 2007-02-06 2008-08-14 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
CA2711582A1 (en) 2008-02-07 2009-08-13 Boehringer Ingelheim International Gmbh Spirocyclic heterocycles, formulations containing said compounds, use thereof and processes for the preparation thereof
JP5739802B2 (ja) 2008-05-13 2015-06-24 アストラゼネカ アクチボラグ ４−（３−クロロ−２−フルオロアニリノ）−７−メトキシ−６−｛［１−（ｎ−メチルカルバモイルメチル）ピペリジン−４−イル］オキシ｝キナゾリンのフマル酸塩
JP5539351B2 (ja) 2008-08-08 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング シクロヘキシルオキシ置換ヘテロ環、これらの化合物を含有する医薬、およびそれらを生成するための方法
TWI577664B (zh) 2009-01-16 2017-04-11 艾克塞里克斯公司 Ｎ-（４-｛〔６，７-雙（甲氧基）喹啉-４-基〕氧基｝苯基）-ｎ’-（４-氟苯基）環丙烷-１，１-二甲醯胺蘋果酸鹽、包含其之醫藥組合物及其用途
EP2451445B1 (en) 2009-07-06 2019-04-03 Boehringer Ingelheim International GmbH Process for drying of bibw2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
KR101317809B1 (ko) 2011-06-07 2013-10-16 한미약품 주식회사 암세포의 성장을 억제하는 아마이드 유도체 및 비금속염 활택제를 포함하는 약학 조성물
KR20140096571A (ko) 2013-01-28 2014-08-06 한미약품 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법
LT2964638T (lt) 2013-03-06 2017-12-27 Astrazeneca Ab Epidermio augimo faktoriaus receptoriaus aktyvinančių mutacijų formų chinazolino inhibitoriai
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
PT3126354T (pt) * 2014-04-04 2020-03-17 H Lundbeck As Quinazolina-thf-aminas halogenadas como inibidores de pde1
US20170176028A1 (en) 2015-12-18 2017-06-22 Lg Electronics Inc. Air conditioner
CN110291104B (zh) 2016-11-17 2023-11-03 得克萨斯州大学系统董事会 具有针对携带egfr或her2外显子20突变之癌细胞的抗肿瘤活性的化合物
CN112321814B (zh) * 2020-12-30 2021-03-23 广州初曲科技有限公司 一种吉非替尼艾地苯醌轭合物的制备及用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
US6184225B1 (en) * 1996-02-13 2001-02-06 Zeneca Limited Quinazoline derivatives as VEGF inhibitors
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
DE69709319T2 (de) * 1996-03-05 2002-08-14 Astrazeneca Ab 4-anilinochinazolin derivate
BR9708640B1 (pt) * 1996-04-12 2013-06-11 inibidores irreversÍveis de tirosina-cinases e composiÇço farmacÊutica compreendendo os mesmo.
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
DE19911509A1 (de) * 1999-03-15 2000-09-21 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
JP2004507529A (ja) 2004-03-11
SK287747B6 (sk) 2011-08-04
KR100862873B1 (ko) 2008-10-15
EE05269B1 (et) 2010-02-15
KR20030024914A (ko) 2003-03-26
AU8769401A (en) 2002-03-13
HUP0300819A2 (hu) 2003-09-29
MY126132A (en) 2006-09-29
YU14003A (sh) 2006-01-16
EA005679B1 (ru) 2005-04-28
IL154602A0 (en) 2003-09-17
BR0113519A (pt) 2003-07-01
BG107559A (bg) 2003-10-31
CZ302567B6 (cs) 2011-07-13
AU2001287694B2 (en) 2007-09-06
RS52279B (en) 2012-10-31
NO20030870L (no) 2003-02-25
WO2002018351A1 (de) 2002-03-07
DE10042058A1 (de) 2002-03-07
NO324866B1 (no) 2007-12-17
JP4834282B2 (ja) 2011-12-14
CA2417897C (en) 2009-03-31
TWI294422B (en) 2008-03-11
NZ524668A (en) 2006-06-30
CN100404517C (zh) 2008-07-23
CN1449390A (zh) 2003-10-15
CA2417897A1 (en) 2003-01-30
ECSP034464A (es) 2003-03-31
UY26903A1 (es) 2002-03-22
HUP0300819A3 (en) 2008-03-28
ZA200300991B (en) 2004-04-16
EE200300077A (et) 2004-12-15
HRP20030138A2 (en) 2005-04-30
PL360248A1 (en) 2004-09-06
EP1315705A1 (de) 2003-06-04
HK1057557A1 (en) 2004-04-08
IL154602A (en) 2008-07-08
UA73004C2 (ru) 2005-05-16
AR033562A1 (es) 2003-12-26
SK2312003A3 (en) 2003-10-07
NO20030870D0 (no) 2003-02-25
MEP58708A (en) 2011-05-10
MXPA03001483A (es) 2003-06-06

Similar Documents

Publication Publication Date Title
EA200300219A1 (ru) Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения
EA200200008A1 (ru) Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения
EA200100922A1 (ru) Бициклические гетероциклы, фармацевтические композиции, содержащие эти соединения, и способы их получения
EA200300671A1 (ru) Производные хиназолина, содержащие эти соединения лекарственные средства, их применение и способ их получения
EA200401191A1 (ru) 4-(n-фениламино)хиназолины/-хинолины в качестве ингибиторов тирозинкиназы
UY26659A1 (es) Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación
FI970968A (fi) Pyrimido/5,4-d/pyrimidiinit, näitä yhdisteitä sisältävät lääkeaineet, niiden käyttö ja menetelmä niiden valmistamiseksi
EA200200208A1 (ru) Синергитическая композиция
ATE316077T1 (de) Pyrimidin-essigsäure derivate geeignet zur behandlung von crth2-bedingten krankheiten
EA201001241A1 (ru) Спирогетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения
UY26902A1 (es) Heterocíclicos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación
EA200500600A1 (ru) Выбранные cgrp-антагонисты, способ их получения, а также их применение в качестве лекарственных средств
EA200500377A1 (ru) Пиразольные производные как ингибиторы трансформирующего фактора роста (tgf)
EA200200876A1 (ru) Алкилированные производные имидазопиридина
UY27767A1 (es) Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su empleo, y procedimientos para su preparación.
EA200901041A1 (ru) Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения
EA200200742A1 (ru) 1,2-диарилбензимидазолы для лечения заболеваний, связанных с активацией микроглии
UY28347A1 (es) Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su utilización y procedimientos para su preparación
EA200200875A1 (ru) Пролекарства производных имидазопиридина
UY26067A1 (es) Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimiento
EA200200883A1 (ru) Производные пирано[2,3-с]имидазо[1,2-а]пиридина для лечения заболеваний желудочно-кишечного тракта
EA200100830A1 (ru) Производные 4-аминохиназолина и хинолина, оказывающие ингибирующее действие на преобразование сигнала, опосредованное тирозинкиназой
UY26900A1 (es) Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación
UY32855A (es) Heterocíclicos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación
UY26214A1 (es) Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU