UY26659A1 - Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación - Google Patents
Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparaciónInfo
- Publication number
- UY26659A1 UY26659A1 UY26659A UY26659A UY26659A1 UY 26659 A1 UY26659 A1 UY 26659A1 UY 26659 A UY26659 A UY 26659A UY 26659 A UY26659 A UY 26659A UY 26659 A1 UY26659 A1 UY 26659A1
- Authority
- UY
- Uruguay
- Prior art keywords
- preparation
- procedures
- compounds
- diseases
- medicines containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
La presente invención se refiere a heterociclos bicíclicos de la fórmula general en la que Ra a Rd, A a C y X están definidos como en las reivindicaciones 1 a 5, a sus tautómeros, sus sales fisiológicamente compatibles con ácidos o bases inórganicos u orgánicos, que presentan valiosas propiedades farmacológicas, en particular un efecto inhibidor sobre la transducción de senales inducida por tirosina-quinasas, a su empleo para el tratamiento de enfermedades, en particular de enfermedades tumorales, de enfermedades de los pulmones y de las vías respiratorias, y a su preparación.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2000117539 DE10017539A1 (de) | 2000-04-08 | 2000-04-08 | Bicyclische Heterocyclen, diese Verbingungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE10040525A DE10040525A1 (de) | 2000-08-18 | 2000-08-18 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
UY26659A1 true UY26659A1 (es) | 2001-12-28 |
Family
ID=26005236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY26659A UY26659A1 (es) | 2000-04-08 | 2001-04-06 | Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1280798B1 (es) |
JP (1) | JP4939716B2 (es) |
AR (1) | AR028317A1 (es) |
AT (1) | ATE350378T1 (es) |
AU (1) | AU6383101A (es) |
CA (1) | CA2403152C (es) |
DE (1) | DE50111799D1 (es) |
ES (1) | ES2280375T3 (es) |
MX (1) | MXPA02009855A (es) |
UY (1) | UY26659A1 (es) |
WO (1) | WO2001077104A1 (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU760766B2 (en) | 1998-08-18 | 2003-05-22 | Regents Of The University Of California, The | Preventing airway mucus production by administration of EGF-R antagonists |
US7354894B2 (en) | 1998-08-18 | 2008-04-08 | The Regents Of The University Of California | Preventing airway mucus production by administration of EGF-R antagonists |
EA004981B1 (ru) | 1999-06-21 | 2004-10-28 | Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг | Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения |
DE10063435A1 (de) * | 2000-12-20 | 2002-07-04 | Boehringer Ingelheim Pharma | Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
US20040044014A1 (en) | 2002-04-19 | 2004-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof |
DE10217689A1 (de) * | 2002-04-19 | 2003-11-13 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung |
DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
EP1539744A4 (en) | 2002-07-11 | 2007-06-06 | Vicuron Pharm Inc | N-HYDROXYAMIDE DERIVATIVES WITH ANTIBACTERIAL EFFECT |
US7223749B2 (en) | 2003-02-20 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
US7456189B2 (en) | 2003-09-30 | 2008-11-25 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation |
ES2374553T3 (es) | 2004-05-06 | 2012-02-17 | Warner-Lambert Company Llc | 4-fenilamino-quinazolin-6-il-amidas. |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
EP1833482A4 (en) | 2005-01-03 | 2011-02-16 | Myriad Genetics Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
KR100832594B1 (ko) * | 2005-11-08 | 2008-05-27 | 한미약품 주식회사 | 다중저해제로서의 퀴나졸린 유도체 및 이의 제조방법 |
WO2007055513A1 (en) * | 2005-11-08 | 2007-05-18 | Hanmi Pharm. Co., Ltd. | Quinazoline derivatives as a signal transduction inhibitor and method for the preparation thereof |
EP1948179A1 (en) | 2005-11-11 | 2008-07-30 | Boehringer Ingelheim International GmbH | Quinazoline derivatives for the treatment of cancer diseases |
RU2492864C2 (ru) | 2006-09-18 | 2013-09-20 | Бёрингер Ингельхайм Интернациональ Гмбх | Способ лечения рака, несущего мутации egfr |
EP1921070A1 (de) | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
EA200901041A1 (ru) | 2007-02-06 | 2010-02-26 | Бёрингер Ингельхайм Интернациональ Гмбх | Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения |
EA019709B1 (ru) | 2008-02-07 | 2014-05-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Спирогетероциклы и их применение в качестве лекарственных средств |
US8648191B2 (en) | 2008-08-08 | 2014-02-11 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
CN102264745B (zh) | 2008-11-10 | 2015-07-22 | 财团法人卫生研究院 | 作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物 |
HUE044629T2 (hu) | 2009-07-06 | 2019-11-28 | Boehringer Ingelheim Int | Eljárás BIBW2992, annak sói, valamint e hatóanyagot tartalmazó szilárd gyógyászati készítmények szárítására |
CN102020639A (zh) * | 2009-09-14 | 2011-04-20 | 上海恒瑞医药有限公司 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
HUE033575T2 (hu) * | 2011-05-26 | 2017-12-28 | Xuanzhu Pharma Co Ltd | Tirozin-kináz inhibitor kinazolin származék, elõállítási eljárása és alkalmazása |
US9388160B2 (en) | 2011-10-12 | 2016-07-12 | Teligene Ltd | Quinazoline derivatives as kinases inhibitors and methods of use thereof |
KR20150005698A (ko) | 2012-05-07 | 2015-01-14 | 텔리진 엘티디. | 키나제 저해제로서 유용한 치환된 아미노퀴나졸린 |
US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
JP6139782B2 (ja) | 2013-05-21 | 2017-05-31 | チャンスー メドリューション リミテッド | 置換ピラゾロピリミジン化合物、及びその薬学的に許容される塩、並びにこれらの溶媒和物、立体異性体、及び互変異性体、並びにこれらを含む医薬組成物 |
US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
WO2018095353A1 (en) * | 2016-11-25 | 2018-05-31 | Sunshine Lake Pharma Co., Ltd. | Salts of aminoquinazoline derivative and uses thereof |
MX2021003517A (es) | 2018-09-25 | 2021-08-16 | Black Diamond Therapeutics Inc | Composiciones de inhibidor de tirosina quinasa, metodos de fabricacion y metodos de uso. |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100503580C (zh) * | 1996-04-12 | 2009-06-24 | 沃尼尔·朗伯公司 | 酪氨酸激酶的不可逆抑制剂 |
US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
UA73073C2 (uk) * | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
ZA986729B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
ZA986732B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
TW436485B (en) * | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
EP2896612A1 (en) * | 1998-09-29 | 2015-07-22 | Wyeth Holdings LLC | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors |
-
2001
- 2001-03-31 ES ES01938076T patent/ES2280375T3/es not_active Expired - Lifetime
- 2001-03-31 EP EP01938076A patent/EP1280798B1/de not_active Expired - Lifetime
- 2001-03-31 JP JP2001575577A patent/JP4939716B2/ja not_active Expired - Fee Related
- 2001-03-31 AU AU63831/01A patent/AU6383101A/en not_active Abandoned
- 2001-03-31 DE DE50111799T patent/DE50111799D1/de not_active Expired - Lifetime
- 2001-03-31 MX MXPA02009855A patent/MXPA02009855A/es unknown
- 2001-03-31 AT AT01938076T patent/ATE350378T1/de active
- 2001-03-31 CA CA002403152A patent/CA2403152C/en not_active Expired - Fee Related
- 2001-03-31 WO PCT/EP2001/003694 patent/WO2001077104A1/de active IP Right Grant
- 2001-04-06 UY UY26659A patent/UY26659A1/es not_active Application Discontinuation
- 2001-04-06 AR ARP010101646A patent/AR028317A1/es not_active Suspension/Interruption
Also Published As
Publication number | Publication date |
---|---|
ATE350378T1 (de) | 2007-01-15 |
WO2001077104A1 (de) | 2001-10-18 |
JP4939716B2 (ja) | 2012-05-30 |
AR028317A1 (es) | 2003-05-07 |
MXPA02009855A (es) | 2003-03-27 |
CA2403152C (en) | 2008-10-28 |
CA2403152A1 (en) | 2001-10-18 |
EP1280798B1 (de) | 2007-01-03 |
EP1280798A1 (de) | 2003-02-05 |
DE50111799D1 (de) | 2007-02-15 |
AU6383101A (en) | 2001-10-23 |
ES2280375T3 (es) | 2007-09-16 |
JP2003530395A (ja) | 2003-10-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UY26659A1 (es) | Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación | |
UY26903A1 (es) | Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación | |
UY26066A1 (es) | Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion | |
UY27078A1 (es) | Derivados de quinazolina, medicamentos que contienen estos compuestos, su empleo y procedimentos para su preparación | |
UY27737A1 (es) | Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su utilización y procedimientos para su preparación. | |
UY26902A1 (es) | Heterocíclicos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación | |
ECSP055746A (es) | Antagonistas de cgrp elegidos, procedimiento para su preparación, así como su empleo como medicamentos | |
ECSP055747A (es) | Antagonistas de cgrp elegidos, procedimiento para su preparación, así como su empleo como medicamentos | |
UY28191A1 (es) | Heterociclos biciclicos, medicamentos que contienen estos compuestos, su utilización y procedimientos para su preparación. | |
UY27767A1 (es) | Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su empleo, y procedimientos para su preparación. | |
YU90901A (sh) | Biciklični heterocikli, lekovi koji sadrže ta jedinjenja, njihova primena i postupci za njihovo pripremanje | |
UY27714A1 (es) | 2 - heteroaril - pirimidinas inhibidoras de cdk, su preparación y su uso como medicamentos. | |
ECSP066898A (es) | Antagonistas de cgrp seleccionados, procedimiento para su preparación así como su uso como medicamento | |
AR006108A1 (es) | Pirimido[5,4-d]pirimidinas, sus sales fisiologicamente compatibles, un procedimiento para su preparacion, su empleo para la preparacion de composiciones farmaceuticas, y las composiciones farmaceuticas que las contienen | |
SV2002000169A (es) | Nuevos derivados del acido aminodicarboxilico con propiedades farmaceuticas ref. lea 33878-sv | |
UY26067A1 (es) | Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimiento | |
AR006569A1 (es) | Derivados de acidos carboxilicos, medicamentos que contienen estos compuestos, su utilizacion y procedimientos para su preparacion | |
EA201001241A1 (ru) | Спирогетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения | |
UY28347A1 (es) | Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su utilización y procedimientos para su preparación | |
ECSP099562A (es) | Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su utilización y procedimientos para su preparación | |
ECSP045330A (es) | Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su utilización y procedimiento para su preparación | |
UY26492A1 (es) | Bencimidazoles, su preparación y su empleo como medicamentos. | |
UY26214A1 (es) | Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación | |
UY32855A (es) | Heterocíclicos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación | |
UY26904A1 (es) | Heterocíclos bicícliocos, medicamentos que contienen estos compuestos, su empleo y procedimiento para su preparación |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20130708 |