UY26492A1 - Bencimidazoles, su preparación y su empleo como medicamentos. - Google Patents
Bencimidazoles, su preparación y su empleo como medicamentos.Info
- Publication number
- UY26492A1 UY26492A1 UY26492A UY26492A UY26492A1 UY 26492 A1 UY26492 A1 UY 26492A1 UY 26492 A UY26492 A UY 26492A UY 26492 A UY26492 A UY 26492A UY 26492 A1 UY26492 A1 UY 26492A1
- Authority
- UY
- Uruguay
- Prior art keywords
- bencimidazoles
- medicines
- preparation
- tautomers
- stereoisomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a nuevos bencimidazoles de la fórmula general (I) sus tautómeros, sus estereoisómeros, sus mezclas, sus pro fármacos, sus derivados que, en lugar de un grupo carboxi, contiene un grupo cargado negativamente en condiciones fisiológicamente compatibles, con ácidos o bases inorgánicas u orgánicos, que presentan valiosas propiedades.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19962329A DE19962329A1 (de) | 1999-12-23 | 1999-12-23 | Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
UY26492A1 true UY26492A1 (es) | 2001-07-31 |
Family
ID=7934028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY26492A UY26492A1 (es) | 1999-12-23 | 2000-12-20 | Bencimidazoles, su preparación y su empleo como medicamentos. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1244636A1 (es) |
JP (1) | JP2003519129A (es) |
AR (1) | AR027050A1 (es) |
AU (1) | AU2011501A (es) |
CA (1) | CA2393916A1 (es) |
DE (1) | DE19962329A1 (es) |
MX (1) | MXPA02006299A (es) |
PE (1) | PE20010954A1 (es) |
UY (1) | UY26492A1 (es) |
WO (1) | WO2001047896A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10125478A1 (de) * | 2001-05-25 | 2002-11-28 | Boehringer Ingelheim Pharma | Verwendung bicyclischer Heterocyclen zur Behandlung und Vorbeugung arterieller thrombotischer Erkrankungen |
US7169934B2 (en) | 2002-06-20 | 2007-01-30 | Boehringer Ingelheim International Gmbh | (R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition |
DE10227666A1 (de) * | 2002-06-20 | 2004-01-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | (R)-2-(4-Amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)- ethyl]-benzimidazol, dessen Monohydrochlorid, Verfahren zu deren Herstellung sowie Verwendung als Arzneimittel |
PE20040804A1 (es) | 2002-12-19 | 2004-12-31 | Boehringer Ingelheim Pharma | DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa |
US7371743B2 (en) | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
EP1609784A1 (de) * | 2004-06-25 | 2005-12-28 | Boehringer Ingelheim Pharma GmbH & Co.KG | Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen |
DE102005061624A1 (de) * | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von Salzen von 4-(Benzimidazolylmethylamino)-Benzamidinen |
DE102005061623A1 (de) | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen |
WO2014068587A2 (en) * | 2012-10-29 | 2014-05-08 | Biophore India Pharmaceuticals Pvt. Ltd. | An improved process for the synthesis of dabigatran and its intermediates |
US10077251B2 (en) | 2012-10-29 | 2018-09-18 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the synthesis of Dabigatran Etexilate and its intermediates |
RU2623439C1 (ru) * | 2016-10-14 | 2017-06-26 | федеральное государственное автономное образовательное учреждение высшего образования "Южный федеральный университет" | Бромиды 1-замещенных-3-{ [2-(3,5-ди-трет-4-гидроксифенил)-2-оксоэтил]} -2-аминобензимидазолия, обладающие антиагрегантными и антиоксидантными свойствами |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4129603A1 (de) * | 1991-09-06 | 1993-03-11 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
AU2720199A (en) * | 1998-02-03 | 1999-08-23 | Boehringer Ingelheim Pharma Kg | Five-membered, benzo-condensed heterocycles used as antithrombotic agents |
TWI248435B (en) * | 1998-07-04 | 2006-02-01 | Boehringer Ingelheim Pharma | Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions |
DE19829964A1 (de) * | 1998-07-04 | 2000-01-05 | Boehringer Ingelheim Pharma | Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel |
-
1999
- 1999-12-23 DE DE19962329A patent/DE19962329A1/de not_active Withdrawn
-
2000
- 2000-12-16 JP JP2001549368A patent/JP2003519129A/ja active Pending
- 2000-12-16 WO PCT/EP2000/012841 patent/WO2001047896A1/de not_active Application Discontinuation
- 2000-12-16 AU AU20115/01A patent/AU2011501A/en not_active Abandoned
- 2000-12-16 CA CA002393916A patent/CA2393916A1/en not_active Abandoned
- 2000-12-16 MX MXPA02006299A patent/MXPA02006299A/es unknown
- 2000-12-16 EP EP00983342A patent/EP1244636A1/de not_active Withdrawn
- 2000-12-19 PE PE2000001365A patent/PE20010954A1/es not_active Application Discontinuation
- 2000-12-20 UY UY26492A patent/UY26492A1/es not_active Application Discontinuation
- 2000-12-21 AR ARP000106819A patent/AR027050A1/es not_active Suspension/Interruption
Also Published As
Publication number | Publication date |
---|---|
WO2001047896A1 (de) | 2001-07-05 |
EP1244636A1 (de) | 2002-10-02 |
JP2003519129A (ja) | 2003-06-17 |
MXPA02006299A (es) | 2002-12-09 |
PE20010954A1 (es) | 2001-10-09 |
AU2011501A (en) | 2001-07-09 |
AR027050A1 (es) | 2003-03-12 |
CA2393916A1 (en) | 2001-07-05 |
DE19962329A1 (de) | 2001-06-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20121105 |