DE19962329A1 - Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel - Google Patents

Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel

Info

Publication number
DE19962329A1
DE19962329A1 DE19962329A DE19962329A DE19962329A1 DE 19962329 A1 DE19962329 A1 DE 19962329A1 DE 19962329 A DE19962329 A DE 19962329A DE 19962329 A DE19962329 A DE 19962329A DE 19962329 A1 DE19962329 A1 DE 19962329A1
Authority
DE
Germany
Prior art keywords
group
alkyl
substituted
methyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19962329A
Other languages
German (de)
English (en)
Inventor
Uwe Ries
Iris Kauffmann
Norbert Hauel
Henning Priepke
Herbert Nar
Jean Marie Stassen
Wolfgang Wienen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to DE19962329A priority Critical patent/DE19962329A1/de
Priority to US09/735,159 priority patent/US6451832B2/en
Priority to PCT/EP2000/012841 priority patent/WO2001047896A1/de
Priority to CA002393916A priority patent/CA2393916A1/en
Priority to EP00983342A priority patent/EP1244636A1/de
Priority to JP2001549368A priority patent/JP2003519129A/ja
Priority to MXPA02006299A priority patent/MXPA02006299A/es
Priority to AU20115/01A priority patent/AU2011501A/en
Priority to PE2000001365A priority patent/PE20010954A1/es
Priority to UY26492A priority patent/UY26492A1/es
Priority to ARP000106819A priority patent/AR027050A1/es
Publication of DE19962329A1 publication Critical patent/DE19962329A1/de
Priority to US10/188,952 priority patent/US6593355B2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19962329A 1999-12-23 1999-12-23 Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel Withdrawn DE19962329A1 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DE19962329A DE19962329A1 (de) 1999-12-23 1999-12-23 Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel
US09/735,159 US6451832B2 (en) 1999-12-23 2000-12-12 Benzimidazoles with antithrombotic activity
JP2001549368A JP2003519129A (ja) 1999-12-23 2000-12-16 ベンズイミダゾール、その調製及び医薬組成物としての使用
CA002393916A CA2393916A1 (en) 1999-12-23 2000-12-16 Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
EP00983342A EP1244636A1 (de) 1999-12-23 2000-12-16 Benzimidazole, deren herstellung und deren verwendung als antithrombotika
PCT/EP2000/012841 WO2001047896A1 (de) 1999-12-23 2000-12-16 Benzimidazole, deren herstellung und deren verwendung als antithrombotika
MXPA02006299A MXPA02006299A (es) 1999-12-23 2000-12-16 Bencimidazoles, su obtencion y uso como antibioticos.
AU20115/01A AU2011501A (en) 1999-12-23 2000-12-16 Benzimidazoles, production thereof and the use thereof as antithrombotic
PE2000001365A PE20010954A1 (es) 1999-12-23 2000-12-19 Bencimidazoles, su preparacion y su empleo como medicamentos
UY26492A UY26492A1 (es) 1999-12-23 2000-12-20 Bencimidazoles, su preparación y su empleo como medicamentos.
ARP000106819A AR027050A1 (es) 1999-12-23 2000-12-21 Bencimidazoles, su preparacion y su empleo como medicamentos
US10/188,952 US6593355B2 (en) 1999-12-23 2002-07-03 Benzimidazoles with antithrombotic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19962329A DE19962329A1 (de) 1999-12-23 1999-12-23 Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
DE19962329A1 true DE19962329A1 (de) 2001-06-28

Family

ID=7934028

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19962329A Withdrawn DE19962329A1 (de) 1999-12-23 1999-12-23 Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel

Country Status (10)

Country Link
EP (1) EP1244636A1 (es)
JP (1) JP2003519129A (es)
AR (1) AR027050A1 (es)
AU (1) AU2011501A (es)
CA (1) CA2393916A1 (es)
DE (1) DE19962329A1 (es)
MX (1) MXPA02006299A (es)
PE (1) PE20010954A1 (es)
UY (1) UY26492A1 (es)
WO (1) WO2001047896A1 (es)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1609784A1 (de) * 2004-06-25 2005-12-28 Boehringer Ingelheim Pharma GmbH & Co.KG Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen
WO2007071742A1 (en) * 2005-12-21 2007-06-28 Boehringer Ingelheim International Gmbh Improved process for the preparation of 4-(benzimidazolylmethylamino)-benzamides and the salts thereof
WO2014068587A2 (en) * 2012-10-29 2014-05-08 Biophore India Pharmaceuticals Pvt. Ltd. An improved process for the synthesis of dabigatran and its intermediates
US10077251B2 (en) 2012-10-29 2018-09-18 Biophore India Pharmaceuticals Pvt. Ltd. Process for the synthesis of Dabigatran Etexilate and its intermediates

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10125478A1 (de) * 2001-05-25 2002-11-28 Boehringer Ingelheim Pharma Verwendung bicyclischer Heterocyclen zur Behandlung und Vorbeugung arterieller thrombotischer Erkrankungen
DE10227666A1 (de) * 2002-06-20 2004-01-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg (R)-2-(4-Amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)- ethyl]-benzimidazol, dessen Monohydrochlorid, Verfahren zu deren Herstellung sowie Verwendung als Arzneimittel
US7169934B2 (en) 2002-06-20 2007-01-30 Boehringer Ingelheim International Gmbh (R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition
PE20040804A1 (es) 2002-12-19 2004-12-31 Boehringer Ingelheim Pharma DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa
US7371743B2 (en) 2004-02-28 2008-05-13 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
DE102005061624A1 (de) * 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verbessertes Verfahren zur Herstellung von Salzen von 4-(Benzimidazolylmethylamino)-Benzamidinen
RU2623439C1 (ru) * 2016-10-14 2017-06-26 федеральное государственное автономное образовательное учреждение высшего образования "Южный федеральный университет" Бромиды 1-замещенных-3-{ [2-(3,5-ди-трет-4-гидроксифенил)-2-оксоэтил]} -2-аминобензимидазолия, обладающие антиагрегантными и антиоксидантными свойствами

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4129603A1 (de) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
WO1999040072A1 (de) * 1998-02-03 1999-08-12 Boehringer Ingelheim Pharma Kg 5-gliedrige benzokondensierte heterocyclen als antithrombotika
TWI248435B (en) * 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
DE19829964A1 (de) * 1998-07-04 2000-01-05 Boehringer Ingelheim Pharma Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1609784A1 (de) * 2004-06-25 2005-12-28 Boehringer Ingelheim Pharma GmbH & Co.KG Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen
WO2006000353A1 (de) * 2004-06-25 2006-01-05 Boehringer Ingelheim International Gmbh Verfahren zur herstellung von 4-(benzimidazolylmethylamino)- benzamidinen
US7459566B2 (en) 2004-06-25 2008-12-02 Boehringer Ingelheim International Gmbh 1,2,4-oxadiazol-5-one-4-(benzimidazolylmethylamino)benzamidine compounds
AU2005256424B2 (en) * 2004-06-25 2011-12-08 Boehringer Ingelheim International Gmbh Method for producing 4-(benzimidazolylmethylamino)-benzamidines
WO2007071742A1 (en) * 2005-12-21 2007-06-28 Boehringer Ingelheim International Gmbh Improved process for the preparation of 4-(benzimidazolylmethylamino)-benzamides and the salts thereof
US8354543B2 (en) 2005-12-21 2013-01-15 Boehringer Ingelheim International Gmbh Process for the preparation of 4-(benzimidazolylmethylamino)-benzamides and the salts thereof
WO2014068587A2 (en) * 2012-10-29 2014-05-08 Biophore India Pharmaceuticals Pvt. Ltd. An improved process for the synthesis of dabigatran and its intermediates
WO2014068587A3 (en) * 2012-10-29 2014-07-17 Biophore India Pharmaceuticals Pvt. Ltd. An improved process for the synthesis of dabigatran and its intermediates
US9533971B2 (en) 2012-10-29 2017-01-03 Biophore India Pharmaceuticals Pvt. Ltd Process for the synthesis of dabigatran and its intermediates
US10077251B2 (en) 2012-10-29 2018-09-18 Biophore India Pharmaceuticals Pvt. Ltd. Process for the synthesis of Dabigatran Etexilate and its intermediates

Also Published As

Publication number Publication date
UY26492A1 (es) 2001-07-31
WO2001047896A1 (de) 2001-07-05
MXPA02006299A (es) 2002-12-09
AU2011501A (en) 2001-07-09
CA2393916A1 (en) 2001-07-05
PE20010954A1 (es) 2001-10-09
EP1244636A1 (de) 2002-10-02
JP2003519129A (ja) 2003-06-17
AR027050A1 (es) 2003-03-12

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG, 55218 IN

8139 Disposal/non-payment of the annual fee