AU2011501A - Benzimidazoles, production thereof and the use thereof as antithrombotic - Google Patents

Benzimidazoles, production thereof and the use thereof as antithrombotic

Info

Publication number
AU2011501A
AU2011501A AU20115/01A AU2011501A AU2011501A AU 2011501 A AU2011501 A AU 2011501A AU 20115/01 A AU20115/01 A AU 20115/01A AU 2011501 A AU2011501 A AU 2011501A AU 2011501 A AU2011501 A AU 2011501A
Authority
AU
Australia
Prior art keywords
benzimidazoles
antithrombotic
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU20115/01A
Other languages
English (en)
Inventor
Norbert Hauel
Iris Kauffmann-Hefner
Herbert Nar
Henning Priepke
Uwe Dr Ries
Jean-Marie Stassen
Wolfgang Wienen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER INGELHEIM PHARMA, Boehringer Ingelheim Pharma GmbH and Co KG filed Critical BOEHRINGER INGELHEIM PHARMA
Publication of AU2011501A publication Critical patent/AU2011501A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU20115/01A 1999-12-23 2000-12-16 Benzimidazoles, production thereof and the use thereof as antithrombotic Abandoned AU2011501A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19962329 1999-12-23
DE19962329A DE19962329A1 (de) 1999-12-23 1999-12-23 Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel
PCT/EP2000/012841 WO2001047896A1 (de) 1999-12-23 2000-12-16 Benzimidazole, deren herstellung und deren verwendung als antithrombotika

Publications (1)

Publication Number Publication Date
AU2011501A true AU2011501A (en) 2001-07-09

Family

ID=7934028

Family Applications (1)

Application Number Title Priority Date Filing Date
AU20115/01A Abandoned AU2011501A (en) 1999-12-23 2000-12-16 Benzimidazoles, production thereof and the use thereof as antithrombotic

Country Status (10)

Country Link
EP (1) EP1244636A1 (es)
JP (1) JP2003519129A (es)
AR (1) AR027050A1 (es)
AU (1) AU2011501A (es)
CA (1) CA2393916A1 (es)
DE (1) DE19962329A1 (es)
MX (1) MXPA02006299A (es)
PE (1) PE20010954A1 (es)
UY (1) UY26492A1 (es)
WO (1) WO2001047896A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10125478A1 (de) * 2001-05-25 2002-11-28 Boehringer Ingelheim Pharma Verwendung bicyclischer Heterocyclen zur Behandlung und Vorbeugung arterieller thrombotischer Erkrankungen
DE10227666A1 (de) * 2002-06-20 2004-01-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg (R)-2-(4-Amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)- ethyl]-benzimidazol, dessen Monohydrochlorid, Verfahren zu deren Herstellung sowie Verwendung als Arzneimittel
US7169934B2 (en) 2002-06-20 2007-01-30 Boehringer Ingelheim International Gmbh (R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition
PE20040804A1 (es) * 2002-12-19 2004-12-31 Boehringer Ingelheim Pharma DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa
US7371743B2 (en) 2004-02-28 2008-05-13 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
EP1609784A1 (de) * 2004-06-25 2005-12-28 Boehringer Ingelheim Pharma GmbH & Co.KG Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen
DE102005061623A1 (de) * 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen
DE102005061624A1 (de) 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verbessertes Verfahren zur Herstellung von Salzen von 4-(Benzimidazolylmethylamino)-Benzamidinen
WO2014068587A2 (en) * 2012-10-29 2014-05-08 Biophore India Pharmaceuticals Pvt. Ltd. An improved process for the synthesis of dabigatran and its intermediates
US10077251B2 (en) 2012-10-29 2018-09-18 Biophore India Pharmaceuticals Pvt. Ltd. Process for the synthesis of Dabigatran Etexilate and its intermediates
RU2623439C1 (ru) * 2016-10-14 2017-06-26 федеральное государственное автономное образовательное учреждение высшего образования "Южный федеральный университет" Бромиды 1-замещенных-3-{ [2-(3,5-ди-трет-4-гидроксифенил)-2-оксоэтил]} -2-аминобензимидазолия, обладающие антиагрегантными и антиоксидантными свойствами

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4129603A1 (de) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP1060166A1 (de) * 1998-02-03 2000-12-20 Boehringer Ingelheim Pharma KG 5-gliedrige benzokondensierte heterocyclen als antithrombotika
DE19829964A1 (de) * 1998-07-04 2000-01-05 Boehringer Ingelheim Pharma Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel
TWI248435B (en) * 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions

Also Published As

Publication number Publication date
UY26492A1 (es) 2001-07-31
WO2001047896A1 (de) 2001-07-05
PE20010954A1 (es) 2001-10-09
AR027050A1 (es) 2003-03-12
EP1244636A1 (de) 2002-10-02
CA2393916A1 (en) 2001-07-05
JP2003519129A (ja) 2003-06-17
DE19962329A1 (de) 2001-06-28
MXPA02006299A (es) 2002-12-09

Similar Documents

Publication Publication Date Title
AU1271201A (en) Azepinoindole derivatives, the production and use thereof
AU763094C (en) Benzimidazoles, production thereof and use thereof as medicaments
PL351558A1 (en) Heterocyclically substituted benzimidazoles, the production and application thereof
ZA200104196B (en) Azepinoindole derivatives, the production and use thereof.
AU3956900A (en) Substituted imidazoles, their preparation and use
IL142096A0 (en) Indeno-, naphtho-and benzocyclohepta dihydrothiazole derivatives, the production thereof and their use as anorectic medicaments
PL344467A1 (en) Substituted indolinones, the production thereof and their use as medicaments
AU3033100A (en) Substituted imidazoles, their preparation and use
AU1378500A (en) Novel pyrimidines, the production thereof and their use
HUP0203290A3 (en) Indeno-, naphto-, and benzocyclohepta-dihydrothiazole derivatives, the production thereof and their use as anorectic medicaments
SI1268522T1 (sl) Novi antagonisti lhrh, njihova priprava in uporaba kot zdravila
AU2011501A (en) Benzimidazoles, production thereof and the use thereof as antithrombotic
AU6442900A (en) Aminocarbonyl-substituted benzimidazole derivatives, method for producing same and the use thereof as medicaments
PL351616A1 (en) Polyolefin compositions, method for the production and use thereof
AU2298200A (en) Stabilized filler, its production and use
AU7904600A (en) Substituted piperazine derivatives, the production and use thereof as medicaments
AU5991400A (en) Manometer with direct passage
AU2001260110A1 (en) Novel LHRH-antagonists, Production and Use Thereof as Medicament
AU7563800A (en) Marsh-mallow and the marsh-mallow production technique
HU0001397D0 (en) 3-amino-3-arylpropan-1-ol derivatives, production and use thereof
AU2002331114A1 (en) Tetrahydroisochinolines, their production and the use thereof as analgesics
AU2155901A (en) Carboxamide-substituted benzimidazol derivatives, methods for the production thereof and their use as medicaments
AU7517800A (en) 3-vinylpyrrole derivatives, method for the production thereof and their use as medicaments
SI1230230T1 (en) Indeno-dihydrothiazole derivatives, the production thereof and their use as anorectic medicaments
SI1095025T1 (en) Benzimidazoles, production thereof and use thereof as medicaments

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase