CA2393916A1 - Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions - Google Patents

Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions Download PDF

Info

Publication number
CA2393916A1
CA2393916A1 CA002393916A CA2393916A CA2393916A1 CA 2393916 A1 CA2393916 A1 CA 2393916A1 CA 002393916 A CA002393916 A CA 002393916A CA 2393916 A CA2393916 A CA 2393916A CA 2393916 A1 CA2393916 A1 CA 2393916A1
Authority
CA
Canada
Prior art keywords
group
methyl
denotes
amino
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002393916A
Other languages
English (en)
French (fr)
Inventor
Uwe Ries
Iris Kauffmann-Hefner
Norbert Hauel
Henning Priepke
Herbert Nar
Jean Marie Stassen
Wolfgang Wienen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2393916A1 publication Critical patent/CA2393916A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002393916A 1999-12-23 2000-12-16 Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions Abandoned CA2393916A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19962329.5 1999-12-23
DE19962329A DE19962329A1 (de) 1999-12-23 1999-12-23 Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel
PCT/EP2000/012841 WO2001047896A1 (de) 1999-12-23 2000-12-16 Benzimidazole, deren herstellung und deren verwendung als antithrombotika

Publications (1)

Publication Number Publication Date
CA2393916A1 true CA2393916A1 (en) 2001-07-05

Family

ID=7934028

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002393916A Abandoned CA2393916A1 (en) 1999-12-23 2000-12-16 Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions

Country Status (10)

Country Link
EP (1) EP1244636A1 (es)
JP (1) JP2003519129A (es)
AR (1) AR027050A1 (es)
AU (1) AU2011501A (es)
CA (1) CA2393916A1 (es)
DE (1) DE19962329A1 (es)
MX (1) MXPA02006299A (es)
PE (1) PE20010954A1 (es)
UY (1) UY26492A1 (es)
WO (1) WO2001047896A1 (es)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7326791B2 (en) 2002-12-19 2008-02-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg Carboxylic acid amides, the preparation thereof, and their use as pharmaceutical compositions
US7371743B2 (en) 2004-02-28 2008-05-13 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
US7880016B2 (en) 2005-12-21 2011-02-01 Boehringer Ingelheim International Gmbh Process for the preparation of the salts of 4-(benzimidazolylmethylamino)-benzamides
CN1972919B (zh) * 2004-06-25 2012-06-27 贝林格尔·英格海姆国际有限公司 制备4-(苯并咪唑基甲氨基)-苯甲脒的方法
US8354543B2 (en) 2005-12-21 2013-01-15 Boehringer Ingelheim International Gmbh Process for the preparation of 4-(benzimidazolylmethylamino)-benzamides and the salts thereof

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10125478A1 (de) * 2001-05-25 2002-11-28 Boehringer Ingelheim Pharma Verwendung bicyclischer Heterocyclen zur Behandlung und Vorbeugung arterieller thrombotischer Erkrankungen
DE10227666A1 (de) * 2002-06-20 2004-01-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg (R)-2-(4-Amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)- ethyl]-benzimidazol, dessen Monohydrochlorid, Verfahren zu deren Herstellung sowie Verwendung als Arzneimittel
US7169934B2 (en) 2002-06-20 2007-01-30 Boehringer Ingelheim International Gmbh (R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition
US9533971B2 (en) 2012-10-29 2017-01-03 Biophore India Pharmaceuticals Pvt. Ltd Process for the synthesis of dabigatran and its intermediates
US10077251B2 (en) 2012-10-29 2018-09-18 Biophore India Pharmaceuticals Pvt. Ltd. Process for the synthesis of Dabigatran Etexilate and its intermediates
RU2623439C1 (ru) * 2016-10-14 2017-06-26 федеральное государственное автономное образовательное учреждение высшего образования "Южный федеральный университет" Бромиды 1-замещенных-3-{ [2-(3,5-ди-трет-4-гидроксифенил)-2-оксоэтил]} -2-аминобензимидазолия, обладающие антиагрегантными и антиоксидантными свойствами

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4129603A1 (de) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
WO1999040072A1 (de) * 1998-02-03 1999-08-12 Boehringer Ingelheim Pharma Kg 5-gliedrige benzokondensierte heterocyclen als antithrombotika
TWI248435B (en) * 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
DE19829964A1 (de) * 1998-07-04 2000-01-05 Boehringer Ingelheim Pharma Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7326791B2 (en) 2002-12-19 2008-02-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg Carboxylic acid amides, the preparation thereof, and their use as pharmaceutical compositions
US7371743B2 (en) 2004-02-28 2008-05-13 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
US7947700B2 (en) 2004-02-28 2011-05-24 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
US8445525B2 (en) 2004-02-28 2013-05-21 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
US8791103B2 (en) 2004-02-28 2014-07-29 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
CN1972919B (zh) * 2004-06-25 2012-06-27 贝林格尔·英格海姆国际有限公司 制备4-(苯并咪唑基甲氨基)-苯甲脒的方法
US7880016B2 (en) 2005-12-21 2011-02-01 Boehringer Ingelheim International Gmbh Process for the preparation of the salts of 4-(benzimidazolylmethylamino)-benzamides
US8354543B2 (en) 2005-12-21 2013-01-15 Boehringer Ingelheim International Gmbh Process for the preparation of 4-(benzimidazolylmethylamino)-benzamides and the salts thereof

Also Published As

Publication number Publication date
UY26492A1 (es) 2001-07-31
WO2001047896A1 (de) 2001-07-05
MXPA02006299A (es) 2002-12-09
AU2011501A (en) 2001-07-09
PE20010954A1 (es) 2001-10-09
EP1244636A1 (de) 2002-10-02
JP2003519129A (ja) 2003-06-17
DE19962329A1 (de) 2001-06-28
AR027050A1 (es) 2003-03-12

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Legal Events

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FZDE Dead