DE04010651T1 - Mikronisiertes Zolpidem-Hemitartrat - Google Patents

Mikronisiertes Zolpidem-Hemitartrat Download PDF

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Publication number
DE04010651T1
DE04010651T1 DE04010651T DE04010651T DE04010651T1 DE 04010651 T1 DE04010651 T1 DE 04010651T1 DE 04010651 T DE04010651 T DE 04010651T DE 04010651 T DE04010651 T DE 04010651T DE 04010651 T1 DE04010651 T1 DE 04010651T1
Authority
DE
Germany
Prior art keywords
zolpidem hemitartrate
micronized
theta
particles
measured
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE04010651T
Other languages
German (de)
English (en)
Inventor
Judith Aronhime
David Leonov
Ben-Zion Dolitzky
Erzebet Meszaros-Sos
Marco Kordova
Szaboles Salyi
Ancehl Schwartz
Shlomo Zavurov
Csaba Szabo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27394001&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE04010651(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of DE04010651T1 publication Critical patent/DE04010651T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Suspension Of Electric Lines Or Cables (AREA)
  • Amplifiers (AREA)
  • Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
  • Other Liquid Machine Or Engine Such As Wave Power Use (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE04010651T 2000-04-24 2001-04-24 Mikronisiertes Zolpidem-Hemitartrat Pending DE04010651T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US19929800P 2000-04-24 2000-04-24
US199298P 2000-04-24
US20602500P 2000-05-22 2000-05-22
US206025P 2000-05-22
US22536400P 2000-08-14 2000-08-14
US225364P 2000-08-14

Publications (1)

Publication Number Publication Date
DE04010651T1 true DE04010651T1 (de) 2005-09-01

Family

ID=27394001

Family Applications (7)

Application Number Title Priority Date Filing Date
DE04010651T Pending DE04010651T1 (de) 2000-04-24 2001-04-24 Mikronisiertes Zolpidem-Hemitartrat
DE04010435T Pending DE04010435T1 (de) 2000-04-24 2001-04-24 Zolpidem Hemitartrat Solvat
DE60122216T Expired - Fee Related DE60122216T2 (de) 2000-04-24 2001-04-24 Zolpidem Hemitartrat Solvat
DE60114617T Expired - Fee Related DE60114617T2 (de) 2000-04-24 2001-04-24 Zolpidem hemitartrat
DE20122435U Expired - Lifetime DE20122435U1 (de) 2000-04-24 2001-04-24 Mikronisiertes Zolpidem-Hemitartrat
DE60125429T Expired - Fee Related DE60125429T2 (de) 2000-04-24 2001-04-24 Zolpidem hemitartrat solvat
DE60122944T Expired - Fee Related DE60122944T2 (de) 2000-04-24 2001-04-24 Mikronisiertes Zolpidem-Hemitartrat

Family Applications After (6)

Application Number Title Priority Date Filing Date
DE04010435T Pending DE04010435T1 (de) 2000-04-24 2001-04-24 Zolpidem Hemitartrat Solvat
DE60122216T Expired - Fee Related DE60122216T2 (de) 2000-04-24 2001-04-24 Zolpidem Hemitartrat Solvat
DE60114617T Expired - Fee Related DE60114617T2 (de) 2000-04-24 2001-04-24 Zolpidem hemitartrat
DE20122435U Expired - Lifetime DE20122435U1 (de) 2000-04-24 2001-04-24 Mikronisiertes Zolpidem-Hemitartrat
DE60125429T Expired - Fee Related DE60125429T2 (de) 2000-04-24 2001-04-24 Zolpidem hemitartrat solvat
DE60122944T Expired - Fee Related DE60122944T2 (de) 2000-04-24 2001-04-24 Mikronisiertes Zolpidem-Hemitartrat

Country Status (21)

Country Link
US (8) US20020077332A1 (https=)
EP (1) EP1292304B1 (https=)
JP (3) JP2003531173A (https=)
KR (1) KR20030069796A (https=)
AT (4) ATE335481T1 (https=)
AU (2) AU5721301A (https=)
CA (1) CA2406982A1 (https=)
CZ (1) CZ20023775A3 (https=)
DE (7) DE04010651T1 (https=)
DK (1) DK1292304T3 (https=)
ES (4) ES2238941T3 (https=)
HR (1) HRP20020909A2 (https=)
HU (1) HUP0300701A2 (https=)
IL (1) IL152411A0 (https=)
NZ (1) NZ522015A (https=)
PL (1) PL358548A1 (https=)
PT (3) PT1541146E (https=)
SE (1) SE5292304T3 (https=)
SK (1) SK16372002A3 (https=)
WO (1) WO2001080857A1 (https=)
YU (1) YU79402A (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001284322A1 (en) 2000-08-29 2002-03-13 Ranbaxy Laboratories Limited Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem
US6869970B2 (en) 2002-02-04 2005-03-22 Novartis Ag Crystalline salt forms of valsartan
EP1575952B1 (en) 2002-12-18 2009-02-18 Mallinckrodt Inc. Synthesis of heteroaryl acetamides
WO2004087703A1 (en) * 2003-03-12 2004-10-14 Sun Pharmaceutical Industries Limited Process for the preparation of n,n,6-trimethyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine-3-acetamide
WO2005010002A1 (en) * 2003-07-31 2005-02-03 Ranbaxy Laboratories Limited Process for the synthesis of zolpidem
JP5179757B2 (ja) * 2004-02-17 2013-04-10 トランセプト ファーマシューティカルズ， インコーポレイティド 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法
WO2006008636A2 (en) * 2004-07-16 2006-01-26 Ranbaxy Laboratories Limited Processes for the preparation of zolpidem and its hemitartrate
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
EP1883408A4 (en) * 2005-05-25 2009-11-11 Transcept Pharmaceuticals Inc SOLID COMPOSITIONS AND METHODS FOR TREATMENT OF INSOMNIA IN THE NIGHT
KR20080038416A (ko) * 2005-08-19 2008-05-06 아벤티스 파마슈티칼스 인크. 수면제와 치환된 비스 아릴 및 헤테로아릴 화합물의 배합물및 이의 치료요법적 용도
AU2006283702A1 (en) * 2005-08-19 2007-03-01 Aventis Pharmaceuticals Inc. Comination of a hypnotic agent and R(+)-alpha-(2,3-dimethoxy-phenyl)-1-(2-(4-fluorophenl)ethyl)-4-piperidinemethanol and therapeutic application thereof
EP1948655A1 (en) * 2005-10-03 2008-07-30 Mallinckrodt, Inc. Process for preparing zolpidem hemitartrate and tartrate polymorphs
WO2007047047A2 (en) * 2005-10-17 2007-04-26 Mallinckrodt Inc. Polymorph transformation of zolpidem in tablet matrix
US20070098788A1 (en) * 2005-10-28 2007-05-03 Gore Subhash P Non-benzodiazepine hypnotic compositions
WO2007117399A2 (en) 2006-03-31 2007-10-18 Janssen Pharmaceutica N.V. Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor
WO2008067549A2 (en) * 2006-11-30 2008-06-05 Transcept Pharmaceuticals, Inc. Stabilized zolpidem pharmaceutical compositions
US20080145425A1 (en) * 2006-12-15 2008-06-19 Pliva Research & Development Limited Pharmaceutical composition of zolpidem
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
SG192446A1 (en) * 2008-06-30 2013-08-30 Janssen Pharmaceutica Nv Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
WO2011066352A1 (en) 2009-11-27 2011-06-03 Genzyme Corporation An amorphous and a crystalline form of genz 112638 hemitartrat as inhibitor of glucosylceramide synthase
WO2011115069A1 (ja) * 2010-03-19 2011-09-22 第一三共株式会社 結晶の網羅的探索
PT2964229T (pt) 2013-03-06 2020-03-23 Janssen Pharmaceutica Nv Moduladores de piridina benzimidazol-2-ilo do recetor h4 de histamina
CN116283957A (zh) * 2021-12-03 2023-06-23 山东新时代药业有限公司 唑吡坦水合物及其制备方法
CN116283958B (zh) * 2021-12-03 2026-02-24 山东新时代药业有限公司 唑吡坦共晶体及其制备方法
CN117907368A (zh) * 2024-01-27 2024-04-19 鲁南贝特制药有限公司 一种酒石酸唑吡坦药用晶型d中晶型a、e的定量测定方法
CN118750459B (zh) * 2024-07-22 2025-04-01 常州市武进中医医院 一种酒石酸唑吡坦片及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151273A (en) * 1974-10-31 1979-04-24 The Regents Of The University Of California Increasing the absorption rate of insoluble drugs
FR2408345A1 (fr) * 1976-11-30 1979-06-08 Besins Jean Louis Nouvelle composition a action anti-conceptionnelle
US4302446A (en) * 1979-10-02 1981-11-24 Bristol-Myers Company Pharmaceutical compositions
IT1130924B (it) * 1980-03-06 1986-06-18 Secifarma Spa Procedimento per la preparazione di spironolattone micronizzato
DE3018940A1 (de) * 1980-05-17 1981-11-26 Hoechst Ag, 6000 Frankfurt Verwendung eines vinylchlorid-pfropf-copolymerisates in der plastisolverarbeitung
FR2492382A1 (fr) * 1980-10-22 1982-04-23 Synthelabo Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
FR2525601A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Derives d'imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
US4675323A (en) * 1985-08-06 1987-06-23 Synthelabo Imidazo(1,2-a)quinoline derivatives useful as anxiolytic agents
SE457326B (sv) * 1986-02-14 1988-12-19 Lejus Medical Ab Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa
FR2600650B1 (fr) * 1986-06-27 1988-09-09 Synthelabo Procede de preparation d'imidazopyridines et composes intermediaires
FR2606410B1 (fr) * 1986-11-07 1989-02-24 Synthelabo Imidazopyridines, leur preparation et leur application en therapeutique
EP0289371B1 (fr) * 1987-03-27 1991-09-25 Synthelabo Dérivés d'imidazopyridines, leur préparation et leur application en thérapeutique
US5271944A (en) * 1991-04-05 1993-12-21 Biofor, Ltd. Pharmacologically enhanced formulations
IT1276522B1 (it) * 1995-04-07 1997-10-31 Elena Benincasa Uso dello zolpidem per il trattamento terapeudico di sindromi neuropsichiatriche associate a disfunsione e di circuiti neurali dei
PT1038875E (pt) * 1999-03-25 2003-10-31 Synthon Bv Derivados de imidazopiridina e processo para os preparar
ATE297924T1 (de) * 1999-03-25 2005-07-15 Synthon Bv Zolpidem salze
WO2001042239A1 (en) * 1999-12-13 2001-06-14 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound

Also Published As

Publication number Publication date
US20040220212A1 (en) 2004-11-04
ES2277301T3 (es) 2007-07-01
PT1541146E (pt) 2007-01-31
ES2248321T3 (es) 2006-03-16
JP2003531173A (ja) 2003-10-21
SK16372002A3 (sk) 2003-04-01
ES2239558T3 (es) 2007-04-01
CZ20023775A3 (cs) 2003-10-15
ATE308324T1 (de) 2005-11-15
US20020077332A1 (en) 2002-06-20
DE60122216D1 (de) 2006-09-21
DE60122944D1 (de) 2006-10-19
IL152411A0 (en) 2003-05-29
DE04010435T1 (de) 2005-09-01
DE60114617D1 (de) 2005-12-08
ES2238941T3 (es) 2007-04-01
US20040220210A1 (en) 2004-11-04
EP1292304B1 (en) 2005-11-02
US20040214858A1 (en) 2004-10-28
ATE335481T1 (de) 2006-09-15
DE60114617T2 (de) 2006-07-27
PT1475093E (pt) 2006-11-30
PL358548A1 (en) 2004-08-09
JP2006249105A (ja) 2006-09-21
ES2239558T1 (es) 2005-10-01
US20040220213A1 (en) 2004-11-04
HRP20020909A2 (en) 2004-08-31
JP2006137778A (ja) 2006-06-01
DK1292304T3 (da) 2005-12-19
DE60122944T2 (de) 2007-04-12
EP1292304A1 (en) 2003-03-19
HUP0300701A2 (hu) 2003-07-28
AU2001257213B2 (en) 2005-09-29
WO2001080857A1 (en) 2001-11-01
YU79402A (sh) 2006-03-03
DE60125429D1 (de) 2007-02-01
SE5292304T3 (https=) 2005-11-02
CA2406982A1 (en) 2001-11-01
US20070037843A1 (en) 2007-02-15
ES2238941T1 (es) 2005-09-16
US20040220211A1 (en) 2004-11-04
AU5721301A (en) 2001-11-07
DE60125429T2 (de) 2007-09-27
DE60122216T2 (de) 2007-08-30
PT1473036E (pt) 2006-10-31
KR20030069796A (ko) 2003-08-27
ATE338550T1 (de) 2006-09-15
ATE348613T1 (de) 2007-01-15
US20040214859A1 (en) 2004-10-28
DE20122435U1 (de) 2005-10-06
WO2001080857A9 (en) 2002-06-27
EP1292304A4 (en) 2003-07-23
NZ522015A (en) 2004-08-27

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