DD233125A5 - Verfahren zur herstellung von in 1-stellung substituierte 4-hydroxymethyl-pyrrolidinonen - Google Patents

Verfahren zur herstellung von in 1-stellung substituierte 4-hydroxymethyl-pyrrolidinonen Download PDF

Info

Publication number
DD233125A5
DD233125A5 DD84265563A DD26556384A DD233125A5 DD 233125 A5 DD233125 A5 DD 233125A5 DD 84265563 A DD84265563 A DD 84265563A DD 26556384 A DD26556384 A DD 26556384A DD 233125 A5 DD233125 A5 DD 233125A5
Authority
DD
German Democratic Republic
Prior art keywords
hydroxymethyl
pyrrolidin
carbon atoms
substituted
general formula
Prior art date
Application number
DD84265563A
Other languages
German (de)
English (en)
Inventor
Karl-Heinz Weber
Gerhard Walther
Claus Schneider
Dieter Hinzen
Franz J Kuhn
Erich Lehr
Original Assignee
�������@������������@��k��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by �������@������������@��k�� filed Critical �������@������������@��k��
Publication of DD233125A5 publication Critical patent/DD233125A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • C07D207/2732-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Catalysts (AREA)
DD84265563A 1983-07-25 1984-07-23 Verfahren zur herstellung von in 1-stellung substituierte 4-hydroxymethyl-pyrrolidinonen DD233125A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833326724 DE3326724A1 (de) 1983-07-25 1983-07-25 In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte

Publications (1)

Publication Number Publication Date
DD233125A5 true DD233125A5 (de) 1986-02-19

Family

ID=6204831

Family Applications (1)

Application Number Title Priority Date Filing Date
DD84265563A DD233125A5 (de) 1983-07-25 1984-07-23 Verfahren zur herstellung von in 1-stellung substituierte 4-hydroxymethyl-pyrrolidinonen

Country Status (24)

Country Link
US (1) US4581364A (pt)
EP (1) EP0132811B1 (pt)
JP (1) JPS6051172A (pt)
KR (1) KR910003613B1 (pt)
AT (1) ATE37537T1 (pt)
AU (1) AU568863B2 (pt)
CA (1) CA1253159A (pt)
CS (1) CS244447B2 (pt)
DD (1) DD233125A5 (pt)
DE (2) DE3326724A1 (pt)
DK (1) DK362584A (pt)
ES (1) ES8602649A1 (pt)
FI (1) FI78463C (pt)
GR (1) GR82221B (pt)
HU (1) HU192039B (pt)
IL (1) IL72477A (pt)
NO (1) NO163814C (pt)
NZ (1) NZ208990A (pt)
PH (1) PH21119A (pt)
PL (1) PL142583B1 (pt)
PT (1) PT78968B (pt)
SU (1) SU1498385A3 (pt)
YU (1) YU42901B (pt)
ZA (1) ZA845697B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3336024A1 (de) * 1983-10-04 1985-04-18 Boehringer Ingelheim KG, 6507 Ingelheim 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
DE3420193A1 (de) * 1984-05-30 1985-12-05 Boehringer Ingelheim KG, 6507 Ingelheim Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel
JPH066571B2 (ja) * 1985-05-09 1994-01-26 エーザイ株式会社 2−ピロリドン誘導体
US4700244A (en) * 1986-02-14 1987-10-13 Hewlett-Packard Company Process and system for compensating for information shifts on disc storage media
DE3706399A1 (de) * 1987-02-27 1988-09-08 Boehringer Ingelheim Kg Mittel mit antidepressiver wirkung
US4981974A (en) * 1989-05-08 1991-01-01 Gaf Chemicals Corporation Polymerizable pyrrolidonyl oxazoline monomers
IT1231921B (it) * 1989-06-12 1992-01-15 Sigma Tau Ind Farmaceuti 1-acil-2-pirrolidoni quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
IT1231477B (it) * 1989-07-12 1991-12-07 Sigma Tau Ind Farmaceuti (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
DE69025840T2 (de) * 1989-09-29 1996-10-17 Seagate Technology Verfahren und Gerät zum Erfassen von Positionierungsfehlern eines Schreib/Lesekopfes
CA2842660C (en) * 2011-07-21 2019-05-28 The Lubrizol Corporation Carboxylic pyrrolidinones and methods of use thereof
EP2734502B1 (en) * 2011-07-21 2017-07-05 The Lubrizol Corporation Overbased friction modifiers and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams
DE2454325C2 (de) * 1974-11-15 1987-03-26 Bayer Ag, 5090 Leverkusen Verwendung von Zusatzbeschleunigern zur Härtung ungesättigter Polyesterharze
US4119637A (en) * 1975-09-23 1978-10-10 A. H. Robins Company, Inc. 4-Hydroxymethyl-2-pyrrolidinones
JPS5246067A (en) * 1975-10-07 1977-04-12 Teijin Ltd Reduction of optically active 5-oxo-2-pyrrolidinacetic acid esters
US4144245A (en) * 1977-05-11 1979-03-13 A. H. Robins Company, Inc. 4-Hydroxymethyl-2-pyrrolidinones
DE2757680A1 (de) * 1977-12-23 1979-06-28 Troponwerke Gmbh & Co Kg Neue 2-oxo-1-pyrrolidinessigsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CU21107A3 (es) * 1978-02-10 1988-02-01 Hoffmann La Roche Pyrrolidines derivatives
DE2923975A1 (de) * 1979-06-13 1980-12-18 Nattermann A & Cie Pyrrolidinone, verfahren zu deren herstellung und diese enthaltende arzneimittel
CH657527A5 (de) * 1980-02-13 1986-09-15 Ciba Geigy Ag Verwendung von zentralnervoes-wirksamen verbindungen in einem mittel, welches zur verhinderung oder linderung von nebenwirkungen bestimmt ist.
DE3031118A1 (de) * 1980-08-18 1982-04-01 Meditest Institut für medizinisch-pharmazeutische Untersuchungen GmbH & Co KG, 7958 Laupheim N,n'-bis(5-oxo-1-methyl-pyrrolidin-2-yl-essigsaeure)-hydrazid, verfahren zu dessen herstellung und seine verwendung als arzneimittel
DE3336024A1 (de) * 1983-10-04 1985-04-18 Boehringer Ingelheim KG, 6507 Ingelheim 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel

Also Published As

Publication number Publication date
DE3474300D1 (en) 1988-11-03
FI78463C (fi) 1989-08-10
YU42901B (en) 1988-12-31
DE3326724A1 (de) 1985-02-07
GR82221B (pt) 1984-12-13
JPH0463872B2 (pt) 1992-10-13
NO163814C (no) 1990-07-25
FI842955A (fi) 1985-01-26
ZA845697B (en) 1986-03-26
PT78968A (de) 1984-08-01
PL142583B1 (en) 1987-11-30
SU1498385A3 (ru) 1989-07-30
DK362584D0 (da) 1984-07-24
ES534587A0 (es) 1985-12-01
CS244447B2 (en) 1986-07-17
PH21119A (en) 1987-07-27
EP0132811A1 (de) 1985-02-13
US4581364A (en) 1986-04-08
EP0132811B1 (de) 1988-09-28
KR910003613B1 (ko) 1991-06-07
CA1253159A (en) 1989-04-25
FI842955A0 (fi) 1984-07-25
CS571084A2 (en) 1985-08-15
DK362584A (da) 1985-01-26
NO163814B (no) 1990-04-17
ATE37537T1 (de) 1988-10-15
AU568863B2 (en) 1988-01-14
IL72477A (en) 1988-02-29
YU130884A (en) 1986-10-31
ES8602649A1 (es) 1985-12-01
JPS6051172A (ja) 1985-03-22
AU3110184A (en) 1985-01-31
NO843004L (no) 1985-01-28
KR850001166A (ko) 1985-03-16
PT78968B (de) 1986-10-21
IL72477A0 (en) 1984-11-30
HU192039B (en) 1987-04-28
FI78463B (fi) 1989-04-28
NZ208990A (en) 1987-10-30
PL248898A1 (en) 1985-07-16
HUT36454A (en) 1985-09-30

Similar Documents

Publication Publication Date Title
EP0136658B1 (de) 1-Benzyl-aminoalkyl-pyrrolidinone und ihre Säureadditionssalze, Verfahren zu ihrer Herstellung und Arzneimittel
DE10046029A1 (de) Indazole
EP0132811B1 (de) In 1-Stellung substituierte 4-Hydroxymethyl-pyrrolidinone, Verfahren zu ihrer Herstellung, pharmazeutische Zusammensetzungen und Zwischenprodukte
DE3329628C2 (pt)
EP0163260B1 (de) Neue substituierte Pyrrolidinone, Verfahren zu ihrer Herstellung und Arzneimittel
DE2162011C3 (de) 2-Phenyl-3-(4-methyl-piperazinocarbonyloxy)-1-isoindolinon-derivate, ihre Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE3216843C2 (de) 3-Thiomethyl-pyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE1770163A1 (de) Neue Glyzerinester,Verfahren zu ihrer Herstellung und diese Ester enthaltende pharmazeutische Zusammensetzungen
DE2460929C2 (pt)
DE1940566C3 (de) 1- (2-Nitrilophenoxy)-2-hydroxy-3äthylaminopropan, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel
DE2348973C3 (de) 1 -(m-Trifluormethylphenyl)-4-propyIpiperazin-derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
CH618439A5 (pt)
EP0072960A2 (de) 1,5-Diphenylpyrazolin-3-on-Verbindungen sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DD205682A5 (de) Verfahren zur herstellung von (-)-2-(1-(2,6-dichlorphenoxy)-ethyl)-1,3-diazacyclopent-2-en und seinen salzen
EP0280290B1 (de) Mittel mit antidepressiver Wirkung
DE2705949C2 (de) 4-(Benzoylamino)-piperidinderivate, ein Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE2004301A1 (de) Phenylserinderivate
DE4218159C2 (de) 4,4,4-Trifluoracetessigsäureamide, Verfahren zu ihrer Herstellung und Arzneimittel
EP0266563B1 (de) Verwendung von 1-Benzyl-amino-alkyl-pyrrolidinonen als Antidepressiva
DE2600538C3 (de) 1 -Methyl-2-nitroimidazolderivate und deren Verwendung
DE2410201A1 (de) 6-substituierte 3-carbaethoxyhydrazinopyridazine beziehungsweise ihre salze sowie ihre verwendung und verfahren zur herstellung derselben
DE2756852A1 (de) 1-amino-niedrig-alkyl-3,4-diphenyl- 1h-pyrazole
EP0000479B1 (de) Substituierte 1-Piperazinyl-4H-s-triazolo (3,4-c)thieno(2,3-e)1,4-diazepine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE1950351C3 (de) l-(2-Cyano-5-methylphenoxy)-2-hydroxy-3-aIkylaminopropane, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
DE2722399A1 (de) Anti-inflammatorisches mittel, verfahren zu seiner herstellung und daraus hergestellte arzneimittel