IT1231921B - 1-acil-2-pirrolidoni quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti - Google Patents

1-acil-2-pirrolidoni quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Info

Publication number
IT1231921B
IT1231921B IT8948072A IT4807289A IT1231921B IT 1231921 B IT1231921 B IT 1231921B IT 8948072 A IT8948072 A IT 8948072A IT 4807289 A IT4807289 A IT 4807289A IT 1231921 B IT1231921 B IT 1231921B
Authority
IT
Italy
Prior art keywords
memory
pharmaceutical compositions
substituted
pyrolidones
acil
Prior art date
Application number
IT8948072A
Other languages
English (en)
Other versions
IT8948072A0 (it
Inventor
Maria Ornella Tinti
Fabio Giannessi
Orlando Ghirardi
Domenico Misiti
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Priority to IT8948072A priority Critical patent/IT1231921B/it
Publication of IT8948072A0 publication Critical patent/IT8948072A0/it
Priority to ES90830256T priority patent/ES2058874T3/es
Priority to DE69011781T priority patent/DE69011781T2/de
Priority to DK90830256.5T priority patent/DK0412058T3/da
Priority to EP90830256A priority patent/EP0412058B1/en
Priority to AT90830256T priority patent/ATE110363T1/de
Priority to JP2152510A priority patent/JPH0324054A/ja
Priority to US07/536,275 priority patent/US5102896A/en
Application granted granted Critical
Publication of IT1231921B publication Critical patent/IT1231921B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT8948072A 1989-06-12 1989-06-12 1-acil-2-pirrolidoni quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti IT1231921B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT8948072A IT1231921B (it) 1989-06-12 1989-06-12 1-acil-2-pirrolidoni quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
ES90830256T ES2058874T3 (es) 1989-06-12 1990-06-08 1-acil-2-pirrolidinonas como mejoradores del entendimiento y memoria y composiciones farmaceuticas que las contienen.
DE69011781T DE69011781T2 (de) 1989-06-12 1990-06-08 1-acyl-2-pyrrolidinone zur Verbesserung der Lernfähigkeit und des Gedächtnisses und diese enthaltende pharmazeutische Zubereitungen.
DK90830256.5T DK0412058T3 (da) 1989-06-12 1990-06-08 1-Acyl-2-pyrrolidinoner som indlærings- og hukommelsesforstærkende midler og farmaceutiske præparater indeholdende disse forbindelser
EP90830256A EP0412058B1 (en) 1989-06-12 1990-06-08 1-acyl-2-pyrrolidinones as enhancers of learning and memory and pharmaceutical compositions containing same
AT90830256T ATE110363T1 (de) 1989-06-12 1990-06-08 1-acyl-2-pyrrolidinone zur verbesserung der lernfähigkeit und des gedächtnisses und diese enthaltende pharmazeutische zubereitungen.
JP2152510A JPH0324054A (ja) 1989-06-12 1990-06-11 学習・記憶力増強のための１―アシル―２―ピロリジノンおよびその組成物
US07/536,275 US5102896A (en) 1989-06-12 1990-06-11 1-acyl-2-pyrrolidinones as enhancers of learning and memory

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8948072A IT1231921B (it) 1989-06-12 1989-06-12 1-acil-2-pirrolidoni quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Publications (2)

Publication Number Publication Date
IT8948072A0 IT8948072A0 (it) 1989-06-12
IT1231921B true IT1231921B (it) 1992-01-15

Family

ID=11264356

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8948072A IT1231921B (it) 1989-06-12 1989-06-12 1-acil-2-pirrolidoni quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Country Status (8)

Country Link
US (1) US5102896A (it)
EP (1) EP0412058B1 (it)
JP (1) JPH0324054A (it)
AT (1) ATE110363T1 (it)
DE (1) DE69011781T2 (it)
DK (1) DK0412058T3 (it)
ES (1) ES2058874T3 (it)
IT (1) IT1231921B (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1247698B (it) * 1990-06-21 1994-12-30 Sigma Tau Ind Farmaceuti 1-alchil-3-(acilammino)-e-caprolattami quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
IT1249728B (it) * 1991-11-06 1995-03-09 Sigma Tau Ind Farmaceuti Derivati delle prolinammide quali attivatori della memoria e dei processi di apprendimento e composizioni farmaceutiche che li contengono
ATE253909T1 (de) * 1992-07-24 2003-11-15 Univ California Arzneimittel die den durch ampa rezeptoren vermittelten synaptischen response erhöhen
AU1074295A (en) * 1993-11-25 1995-06-13 Warwick International Group Limited Bleaching compositions
CA2165919A1 (en) * 1994-12-26 1996-06-27 Koichi Katsuyama Agents for inhibiting the production of il-1.beta. and the release of tnf.
CN103910712B (zh) * 2014-04-02 2016-09-07 江南大学 一种过氧化氢活化剂及其应用
CN104032563B (zh) * 2014-05-27 2016-03-23 浙江莱美纺织印染科技有限公司 一种涤纶混纺织物漂白前处理方法
US11878971B2 (en) * 2020-12-29 2024-01-23 Huscion Co., Ltd. Piperlongumine-based compound and immuno regulator comprising the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU21107A3 (es) * 1978-02-10 1988-02-01 Hoffmann La Roche Pyrrolidines derivatives
CA1115212A (en) * 1978-02-10 1981-12-29 Emilio Kyburz Pyrrolidine derivatives
DE3326724A1 (de) * 1983-07-25 1985-02-07 Boehringer Ingelheim KG, 6507 Ingelheim In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte
JPS61229801A (ja) * 1985-04-03 1986-10-14 Taki Chem Co Ltd 植物生長調節剤

Also Published As

Publication number Publication date
JPH0324054A (ja) 1991-02-01
ATE110363T1 (de) 1994-09-15
ES2058874T3 (es) 1994-11-01
EP0412058A1 (en) 1991-02-06
IT8948072A0 (it) 1989-06-12
DK0412058T3 (da) 1994-09-19
US5102896A (en) 1992-04-07
EP0412058B1 (en) 1994-08-24
DE69011781T2 (de) 1995-01-05
DE69011781D1 (de) 1994-09-29

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950518