DD215784A5 - Verfahren zur herstellung von neuen 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo (4,5,1-j-k)-(1)-benzazepin-2-) (1h)-on-derivaten und ihren salzen - Google Patents

Verfahren zur herstellung von neuen 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo (4,5,1-j-k)-(1)-benzazepin-2-) (1h)-on-derivaten und ihren salzen Download PDF

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Publication number
DD215784A5
DD215784A5 DD83255575A DD25557583A DD215784A5 DD 215784 A5 DD215784 A5 DD 215784A5 DD 83255575 A DD83255575 A DD 83255575A DD 25557583 A DD25557583 A DD 25557583A DD 215784 A5 DD215784 A5 DD 215784A5
Authority
DD
German Democratic Republic
Prior art keywords
formula
product
hydroxy
benzazepine
trans
Prior art date
Application number
DD83255575A
Other languages
German (de)
English (en)
Inventor
Daniel Frechet
Lucien Nedelec
Guy Plassard
Neil L Brown
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of DD215784A5 publication Critical patent/DD215784A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DD83255575A 1982-10-12 1983-10-11 Verfahren zur herstellung von neuen 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo (4,5,1-j-k)-(1)-benzazepin-2-) (1h)-on-derivaten und ihren salzen DD215784A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8217054A FR2534257A1 (fr) 1982-10-12 1982-10-12 Nouveaux derives de la 6-amino 7-hydroxy 4,5,6,7-tetrahydro-imidazo/4,5,1-j-k/ /1/ benzazepin-2(1h)-one, leurs sels, application a titre de medicaments, compositions les renfermant et un intermediaire

Publications (1)

Publication Number Publication Date
DD215784A5 true DD215784A5 (de) 1984-11-21

Family

ID=9278183

Family Applications (1)

Application Number Title Priority Date Filing Date
DD83255575A DD215784A5 (de) 1982-10-12 1983-10-11 Verfahren zur herstellung von neuen 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo (4,5,1-j-k)-(1)-benzazepin-2-) (1h)-on-derivaten und ihren salzen

Country Status (23)

Country Link
US (1) US4585770A (enExample)
EP (1) EP0107569B1 (enExample)
JP (1) JPS59130289A (enExample)
KR (1) KR900006753B1 (enExample)
AT (1) ATE25981T1 (enExample)
AU (1) AU559422B2 (enExample)
CA (2) CA1216847A (enExample)
DD (1) DD215784A5 (enExample)
DE (1) DE3370332D1 (enExample)
DK (1) DK163734C (enExample)
ES (1) ES526390A0 (enExample)
FI (1) FI76340C (enExample)
FR (1) FR2534257A1 (enExample)
GR (1) GR78731B (enExample)
HU (1) HU188499B (enExample)
IE (1) IE59441B1 (enExample)
IL (1) IL69993A (enExample)
MX (1) MX8495A (enExample)
NZ (1) NZ205918A (enExample)
PH (1) PH20031A (enExample)
PT (1) PT77469B (enExample)
SU (2) SU1287753A3 (enExample)
ZA (1) ZA837480B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE60964B1 (en) * 1986-12-11 1994-09-07 Roussel Uclaf Zootechnical compositions containing a beta-adrenergic
FR2608046B1 (fr) * 1986-12-11 1989-03-31 Roussel Uclaf Compositions zootechniques renfermant un derive de la 6-amino 7-hydroxy 4,5,6,7-tetrahydroimidazo /4,5, 1-j-k/ /1/benzazepin-2-(1h)-one
AU616390B2 (en) * 1986-12-11 1991-10-31 Hoechst Roussel Vet S.A. Zootechnical compositions containing a beta-adrenergic
FR2608047B1 (fr) * 1986-12-11 1990-08-31 Roussel Uclaf Compositions zootechniques renfermant un derive de la 6-amino 7-hydroxy 4,5,6,7-tetrahydroimidazo /4,5,1-j-k/ /1/ benzazepin-2-(1h)-one
GB8806449D0 (en) * 1988-03-18 1988-04-20 Janssen Pharmaceutica Nv Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones
IL93136A (en) * 1989-02-23 1995-01-24 Janssen Pharmaceutica Nv Tetrahydroimidazo (1,4) benzodiazepin-2-thione derivatives, their preparation and pharmaceutical compositions containing them
EP0708776B1 (en) * 1993-07-13 2001-01-03 Janssen Pharmaceutica N.V. Antiallergic imidazoazepines
FR2735474B1 (fr) * 1995-06-13 1997-08-08 Roussel Uclaf Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre
US7207289B2 (en) * 2004-05-20 2007-04-24 Intervet International B.V. Method of feeding the cattle with feed additives that increases beef production and reduces liver abscess
MX2009003916A (es) * 2006-10-13 2009-04-23 Pfizer Ltd Compuestos heterociclicos utiles como agentes anabolicos para animales de ganado.
WO2008050207A1 (en) * 2006-10-25 2008-05-02 Pfizer Limited Heterocyclic compounds useful as anabolic agents for livestock animals
AU2008209743B2 (en) * 2007-02-01 2011-03-24 Intervet International B.V. Enantioselective synthesis of 6-amino-7-hydroxy-4, 5, 6, 7-tetrahydro-imidazo [4, 5, 1-jk] [1] -benzazepin-2 [1H] -one and zilpaterol
RU2442786C2 (ru) * 2007-03-31 2012-02-20 Интервет Интернэшнл Б.В. Способы получения зилпатерола и его солей
MX2009010499A (es) * 2007-03-31 2009-10-19 Intervet Int Bv Procesos para elaborar zilpaterol y sales del mismo.
JP5856990B2 (ja) * 2007-03-31 2016-02-10 インターベット インターナショナル ベー． フェー． ジルパテロールおよびこの塩の製造方法
AU2008234880B2 (en) * 2007-03-31 2011-10-20 Intervet International B.V. Processes for making zilpaterol and salts thereof
EP1995248A1 (en) * 2007-05-23 2008-11-26 Evonik Degussa GmbH Process for the production of amino alcohols by asymmetric hydrogenation
CN101918001B (zh) 2007-12-06 2016-11-16 英特威国际有限公司 使用醋酸美仑孕酮和齐帕特罗或其盐的联合治疗
TW201033217A (en) * 2008-12-17 2010-09-16 Intervet Int Bv Process for making a crystalline zilpaterol salt
UA115445C2 (uk) 2012-05-18 2017-11-10 Інтервет Інтернешнл Б.В. Спосіб збільшення приросту бройлерних курей
KR102214967B1 (ko) * 2012-12-18 2021-02-10 인터벳 인터내셔널 비.브이. 개선된 질파테롤 제조 공정
CA2902257A1 (en) 2013-03-15 2014-09-18 Intervet International B.V. A method of improving the efficiency of beef production from bovine animals
CN104418808A (zh) * 2013-09-11 2015-03-18 中美华世通生物医药科技（武汉）有限公司 一种适于工业化生产的中间体Buzolic acid的制备方法
CN103554113B (zh) * 2013-09-25 2016-04-27 湖北美天生物科技有限公司 一种盐酸齐帕特罗的合成方法
CN107835643A (zh) 2015-07-21 2018-03-23 英特维特国际股份有限公司 一种新颖的齐帕特罗动物预混物制剂
EP3488705A1 (en) 2017-11-23 2019-05-29 Saviela AG Solubilized growth promoting product to be applied orally to animals and method for the respective feed preparation
CN108752352B (zh) * 2018-04-18 2019-11-26 江苏凌云药业股份有限公司 一种盐酸齐帕特罗的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2320439A (en) * 1943-06-01 Bottle carrier
US3200123A (en) * 1962-01-26 1965-08-10 Richardson Merreil Inc Imidazoquinolines
DE3161072D1 (en) * 1980-02-26 1983-11-10 Roussel Uclaf Cycloheptindolol derivatives and their acid-addition salts, their preparation, their use as medicines and composition containing them

Also Published As

Publication number Publication date
JPH0454671B2 (enExample) 1992-08-31
HU188499B (en) 1986-04-28
FR2534257A1 (fr) 1984-04-13
PH20031A (en) 1986-09-04
DK466483D0 (da) 1983-10-11
EP0107569A1 (fr) 1984-05-02
ATE25981T1 (de) 1987-04-15
KR840006484A (ko) 1984-11-30
US4585770A (en) 1986-04-29
FI76340B (fi) 1988-06-30
PT77469B (fr) 1986-05-07
MX8495A (es) 1993-09-01
AU559422B2 (en) 1987-03-12
SU1384201A3 (ru) 1988-03-23
DK163734B (da) 1992-03-30
KR900006753B1 (ko) 1990-09-20
IE59441B1 (en) 1994-02-23
ZA837480B (en) 1984-11-28
IL69993A0 (en) 1984-01-31
ES8405802A1 (es) 1984-06-16
IE832387L (en) 1984-04-12
DE3370332D1 (en) 1987-04-23
EP0107569B1 (fr) 1987-03-18
FI833697A0 (fi) 1983-10-11
DK163734C (da) 1992-08-31
ES526390A0 (es) 1984-06-16
GR78731B (enExample) 1984-10-02
PT77469A (fr) 1983-11-01
CA1222246A (fr) 1987-05-26
JPS59130289A (ja) 1984-07-26
FI76340C (fi) 1988-10-10
NZ205918A (en) 1985-12-13
SU1287753A3 (ru) 1987-01-30
IL69993A (en) 1987-10-30
FR2534257B1 (enExample) 1984-12-28
AU2005383A (en) 1984-04-19
CA1216847A (fr) 1987-01-20
FI833697L (fi) 1984-04-13
DK466483A (da) 1984-04-13

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