FI833697L - Foerfarande foer framstaellning av nya 6-amino-7-hydroxi-4,5,6,7-tetrahydro-imidazo-/4,5,l-j-k/-/1/benzazepin-2(1h)-on-derivat och deras salter - Google Patents

Foerfarande foer framstaellning av nya 6-amino-7-hydroxi-4,5,6,7-tetrahydro-imidazo-/4,5,l-j-k/-/1/benzazepin-2(1h)-on-derivat och deras salter Download PDF

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Publication number
FI833697L
FI833697L FI833697A FI833697A FI833697L FI 833697 L FI833697 L FI 833697L FI 833697 A FI833697 A FI 833697A FI 833697 A FI833697 A FI 833697A FI 833697 L FI833697 L FI 833697L
Authority
FI
Finland
Prior art keywords
hydroxi
derivat
nya
benzazepin
imidazo
Prior art date
Application number
FI833697A
Other languages
English (en)
Other versions
FI76340B (fi
FI76340C (fi
FI833697A0 (fi
Inventor
Daniel Frechet
Lucien Nedelec
Guy Plassard
Neil Leslie Brown
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Priority to FI870930A priority Critical patent/FI870930A7/fi
Publication of FI833697A0 publication Critical patent/FI833697A0/fi
Publication of FI833697L publication Critical patent/FI833697L/fi
Priority to FI861730A priority patent/FI76341C/fi
Publication of FI76340B publication Critical patent/FI76340B/fi
Application granted granted Critical
Publication of FI76340C publication Critical patent/FI76340C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI833697A 1982-10-12 1983-10-11 Foerfarande foer framstaellning av terapeutiskt anvaendbara nya 6-amino-7-hydroxi-4,5,6,7-tetrahydroimidazo- /4,5,1-j-k/-/1/bensazepin-2-(1h)-on-derivat och deras salter. FI76340C (fi)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI870930A FI870930A7 (fi) 1982-10-12 1983-10-11 Menetelmä 4,5-dihydroimidatso/4,5,1-j-k //1/bentsatsepiini-2,7(1H,6H)dionin valmistamiseksi.
FI861730A FI76341C (fi) 1982-10-12 1986-04-24 Foerfarande foer framstaellning av 5,6-dihydroimidazo/4,5,1-j-k//1/benzazepin-2,7(1h,4h)-dion.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8217054A FR2534257A1 (fr) 1982-10-12 1982-10-12 Nouveaux derives de la 6-amino 7-hydroxy 4,5,6,7-tetrahydro-imidazo/4,5,1-j-k/ /1/ benzazepin-2(1h)-one, leurs sels, application a titre de medicaments, compositions les renfermant et un intermediaire
FR8217054 1982-10-12

Publications (4)

Publication Number Publication Date
FI833697A0 FI833697A0 (fi) 1983-10-11
FI833697L true FI833697L (fi) 1984-04-13
FI76340B FI76340B (fi) 1988-06-30
FI76340C FI76340C (fi) 1988-10-10

Family

ID=9278183

Family Applications (1)

Application Number Title Priority Date Filing Date
FI833697A FI76340C (fi) 1982-10-12 1983-10-11 Foerfarande foer framstaellning av terapeutiskt anvaendbara nya 6-amino-7-hydroxi-4,5,6,7-tetrahydroimidazo- /4,5,1-j-k/-/1/bensazepin-2-(1h)-on-derivat och deras salter.

Country Status (23)

Country Link
US (1) US4585770A (fi)
EP (1) EP0107569B1 (fi)
JP (1) JPS59130289A (fi)
KR (1) KR900006753B1 (fi)
AT (1) ATE25981T1 (fi)
AU (1) AU559422B2 (fi)
CA (2) CA1216847A (fi)
DD (1) DD215784A5 (fi)
DE (1) DE3370332D1 (fi)
DK (1) DK163734C (fi)
ES (1) ES8405802A1 (fi)
FI (1) FI76340C (fi)
FR (1) FR2534257A1 (fi)
GR (1) GR78731B (fi)
HU (1) HU188499B (fi)
IE (1) IE59441B1 (fi)
IL (1) IL69993A (fi)
MX (1) MX8495A (fi)
NZ (1) NZ205918A (fi)
PH (1) PH20031A (fi)
PT (1) PT77469B (fi)
SU (2) SU1287753A3 (fi)
ZA (1) ZA837480B (fi)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2608046B1 (fr) * 1986-12-11 1989-03-31 Roussel Uclaf Compositions zootechniques renfermant un derive de la 6-amino 7-hydroxy 4,5,6,7-tetrahydroimidazo /4,5, 1-j-k/ /1/benzazepin-2-(1h)-one
AU616390B2 (en) * 1986-12-11 1991-10-31 Hoechst Roussel Vet S.A. Zootechnical compositions containing a beta-adrenergic
FR2608047B1 (fr) * 1986-12-11 1990-08-31 Roussel Uclaf Compositions zootechniques renfermant un derive de la 6-amino 7-hydroxy 4,5,6,7-tetrahydroimidazo /4,5,1-j-k/ /1/ benzazepin-2-(1h)-one
IE60964B1 (en) * 1986-12-11 1994-09-07 Roussel Uclaf Zootechnical compositions containing a beta-adrenergic
GB8806449D0 (en) * 1988-03-18 1988-04-20 Janssen Pharmaceutica Nv Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones
IL93136A (en) * 1989-02-23 1995-01-24 Janssen Pharmaceutica Nv Tetrahydroimidazo (1,4) benzodiazepin-2-thione derivatives, their preparation and pharmaceutical compositions containing them
JP3681388B2 (ja) * 1993-07-13 2005-08-10 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗アレルギー性イミダゾアゼピン
FR2735474B1 (fr) * 1995-06-13 1997-08-08 Roussel Uclaf Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre
US7207289B2 (en) * 2004-05-20 2007-04-24 Intervet International B.V. Method of feeding the cattle with feed additives that increases beef production and reduces liver abscess
CN101535315A (zh) * 2006-10-13 2009-09-16 辉瑞有限公司 用作家畜动物的同化激素类药的杂环化合物
WO2008050207A1 (en) * 2006-10-25 2008-05-02 Pfizer Limited Heterocyclic compounds useful as anabolic agents for livestock animals
EP2109614B1 (en) * 2007-02-01 2014-08-06 Intervet International B.V. Enantioselective synthesis of 6-amino-7-hydroxy-4, 5, 6, 7-tetrahydro-imidazo [4, 5, 1-jk][1]-benzazepin-2 [1h]-one and zilpaterol
RU2442786C2 (ru) * 2007-03-31 2012-02-20 Интервет Интернэшнл Б.В. Способы получения зилпатерола и его солей
EP2535340B1 (en) 2007-03-31 2016-04-27 Intervet International B.V. Process for making zilpaterol and salts thereof
US8362006B2 (en) * 2007-03-31 2013-01-29 Intervet International B.V. Processes for making zilpaterol and salts thereof
JP5856990B2 (ja) * 2007-03-31 2016-02-10 インターベット インターナショナル ベー． フェー． ジルパテロールおよびこの塩の製造方法
EP1995248A1 (en) * 2007-05-23 2008-11-26 Evonik Degussa GmbH Process for the production of amino alcohols by asymmetric hydrogenation
MX2010006223A (es) 2007-12-06 2010-08-10 Intervet Int Bv Terapias de combinacion usando acetato de melengestrol y zilpaterol o sus sales.
TW201033217A (en) * 2008-12-17 2010-09-16 Intervet Int Bv Process for making a crystalline zilpaterol salt
US20130310367A1 (en) 2012-05-18 2013-11-21 John A. Rogers Method of enhancing performance in broiler chickens
KR102214967B1 (ko) * 2012-12-18 2021-02-10 인터벳 인터내셔널 비.브이. 개선된 질파테롤 제조 공정
CA2902257A1 (en) 2013-03-15 2014-09-18 Intervet International B.V. A method of improving the efficiency of beef production from bovine animals
CN104418808A (zh) * 2013-09-11 2015-03-18 中美华世通生物医药科技（武汉）有限公司 一种适于工业化生产的中间体Buzolic acid的制备方法
CN103554113B (zh) * 2013-09-25 2016-04-27 湖北美天生物科技有限公司 一种盐酸齐帕特罗的合成方法
US10231472B2 (en) 2015-07-21 2019-03-19 Intervet Inc. Zilpaterol animal premix formulation
EP3488705A1 (en) 2017-11-23 2019-05-29 Saviela AG Solubilized growth promoting product to be applied orally to animals and method for the respective feed preparation
CN108752352B (zh) * 2018-04-18 2019-11-26 江苏凌云药业股份有限公司 一种盐酸齐帕特罗的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2320439A (en) * 1943-06-01 Bottle carrier
US3200123A (en) * 1962-01-26 1965-08-10 Richardson Merreil Inc Imidazoquinolines
EP0034989B1 (fr) * 1980-02-26 1983-10-05 Roussel-Uclaf Nouveaux dérivés du cycloheptindolol et leurs sels avec les acides, leur préparation, leur application comme médicaments et les compositions les renfermant

Also Published As

Publication number Publication date
DK163734B (da) 1992-03-30
EP0107569B1 (fr) 1987-03-18
DK466483A (da) 1984-04-13
US4585770A (en) 1986-04-29
ATE25981T1 (de) 1987-04-15
MX8495A (es) 1993-09-01
DK163734C (da) 1992-08-31
IL69993A0 (en) 1984-01-31
PT77469B (fr) 1986-05-07
IE832387L (en) 1984-04-12
CA1216847A (fr) 1987-01-20
IL69993A (en) 1987-10-30
DK466483D0 (da) 1983-10-11
IE59441B1 (en) 1994-02-23
HU188499B (en) 1986-04-28
CA1222246A (fr) 1987-05-26
PH20031A (en) 1986-09-04
SU1384201A3 (ru) 1988-03-23
GR78731B (fi) 1984-10-02
ES526390A0 (es) 1984-06-16
DD215784A5 (de) 1984-11-21
FR2534257A1 (fr) 1984-04-13
DE3370332D1 (en) 1987-04-23
ZA837480B (en) 1984-11-28
PT77469A (fr) 1983-11-01
KR900006753B1 (ko) 1990-09-20
FR2534257B1 (fi) 1984-12-28
FI76340B (fi) 1988-06-30
EP0107569A1 (fr) 1984-05-02
JPS59130289A (ja) 1984-07-26
JPH0454671B2 (fi) 1992-08-31
NZ205918A (en) 1985-12-13
AU559422B2 (en) 1987-03-12
FI76340C (fi) 1988-10-10
KR840006484A (ko) 1984-11-30
AU2005383A (en) 1984-04-19
SU1287753A3 (ru) 1987-01-30
ES8405802A1 (es) 1984-06-16
FI833697A0 (fi) 1983-10-11

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Legal Events

Date Code Title Description
MA Patent expired

Owner name: HOECHST ROUSSEL VET S.A.